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Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7549, pp. 692 - 696
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 413 - 418
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are... 
MELANOMA | T-CELL IMMUNITY | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | CD94/NKG2A | BLOCKADE | EXPRESSION | PD-1 | HLA-E | Tumor Escape - drug effects | Immunotherapy - methods | Loss of Function Mutation | Tumor Escape - genetics | Genomics | Humans | NF-kappa B - metabolism | Interferons - immunology | Melanoma, Experimental - immunology | T-Lymphocytes - drug effects | Tumor Escape - immunology | Melanoma, Experimental - therapy | Melanoma, Experimental - pathology | Antigen Presentation - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Antigen Presentation - immunology | Unfolded Protein Response | CRISPR-Cas Systems - genetics | Gene Editing | Xenograft Model Antitumor Assays | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Animals | Melanoma, Experimental - genetics | T-Lymphocytes - immunology | Mice | Care and treatment | Analysis | Immunotherapy | Diagnosis | Genetic screening | Methods | Cancer | Animal models | PD-1 protein | Genes | Genomes | Synergism | Proteins | Signal transduction | Clonal deletion | Lymphocytes | Protein folding | Tyrosine | Antigen presentation | NF-κB protein | CRISPR | Melanoma | Medical screening | Patients | Screening | Signaling | Immune checkpoint | PD-L1 protein | Interferon | Genetic testing | Tumors | Protein-tyrosine-phosphatase | PTPN2 protein | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2008, Volume 118, Issue 12, pp. 3930 - 3942
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 508 - 512
Tumour metastasis is the primary cause of mortality in cancer patients and remains the key challenge for cancer therapy(1). New therapeutic approaches to block... 
ACTIVATION | MOUSE NK CELLS | WARFARIN | AXL | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | TYROSINE KINASES | IDENTIFICATION | CELLULAR TARGETS | Mammary Neoplasms, Experimental - immunology | Proto-Oncogene Proteins c-cbl - metabolism | Melanoma, Experimental - drug therapy | Male | Mammary Neoplasms, Experimental - genetics | Warfarin - pharmacology | Warfarin - therapeutic use | Ubiquitination | Melanoma, Experimental - immunology | Neoplasm Metastasis - drug therapy | Neoplasm Metastasis - immunology | Neoplasm Metastasis - prevention & control | c-Mer Tyrosine Kinase | Mammary Neoplasms, Experimental - pathology | Killer Cells, Natural - immunology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-cbl - deficiency | Mammary Neoplasms, Experimental - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Ubiquitin-Protein Ligases - metabolism | Melanoma, Experimental - pathology | Anticoagulants - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Animals | Melanoma, Experimental - genetics | Adaptor Proteins, Signal Transducing - deficiency | Anticoagulants - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Cell receptors | Killer cells | Ligases | Physiological aspects | Development and progression | Genetic aspects | Metastasis | Research | Proteins | Lungs | Rodents | Melanoma | Cytotoxicity | Ligands | Kinases | Immune system | Tumors | Cancer | Index Medicus
Journal Article
Journal Article
by Fu, X and Meng, Z and Liang, W and Tian, Y and Wang, X and Han, W and Lou, G and Wang, X and Lou, F and Yen, Y and Yu, H and Jove, R and Huang, W
Oncogene, ISSN 0950-9232, 08/2014, Volume 33, Issue 34, pp. 4296 - 4306
Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway... 
Zcchc11 | miR-26a | miRNA biogenesis | tumorigenesis | let-7 | metastasis | TRANSFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMGA2 | PROLIFERATION | MATURATION | CELL BIOLOGY | REGULATOR | ONCOLOGY | GENETICS & HEREDITY | ABSENCE | BLOCKADE | MICRORNA EXPRESSION | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | RNA-Binding Proteins - genetics | Colorectal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Male | Melanoma, Experimental - metabolism | DNA-Binding Proteins - metabolism | Liver Neoplasms, Experimental - metabolism | Prostatic Neoplasms - genetics | Lung Neoplasms - secondary | RNA Interference | Female | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Colorectal Neoplasms - metabolism | Lung Neoplasms - genetics | Prostatic Neoplasms - pathology | Melanoma, Experimental - pathology | MicroRNAs - biosynthesis | Tumor Burden | DNA-Binding Proteins - genetics | Mice, SCID | Animals | Melanoma, Experimental - genetics | Cell Line, Tumor | Mice, Inbred NOD | Mice | MicroRNAs - genetics | MicroRNAs - physiology | RNA-Binding Proteins - metabolism | Apoptosis | MicroRNA | Melanoma | Physiological aspects | Genetic aspects | Biosynthesis | Research | Metastasis | Biology | Ribonucleic acid--RNA | Genes | Tumors | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2016, Volume 30, Issue 2, pp. 243 - 256
Journal Article
Science, ISSN 0036-8075, 02/2018, Volume 359, Issue 6377, pp. 770 - 775
Many human cancers are resistant to immunotherapy, for reasons that are poorly understood. We used a genome-scale CRISPR-Cas9 screen to identify mechanisms of... 
IMMUNE-SYSTEM | MELANOMA | MULTIDISCIPLINARY SCIENCES | GENES | ACQUIRED-RESISTANCE | B7 FAMILY | CANCER-IMMUNOTHERAPY | MUTATIONS | ANTITUMOR-ACTIVITY | COMBINATION | BLOCKADE | T-Lymphocytes, Cytotoxic - immunology | Cytotoxicity, Immunologic - genetics | Genetic Testing | Chromosomal Proteins, Non-Histone - metabolism | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Interferon-gamma - therapeutic use | Humans | Melanoma, Experimental - therapy | Transcription Factors - genetics | Bacterial Proteins | Chromosomal Proteins, Non-Histone - genetics | Transcription Factors - metabolism | Animals | Melanoma, Experimental - genetics | Melanoma, Experimental - immunology | Immunotherapy | Skin Neoplasms - genetics | CRISPR-Cas Systems | Endonucleases | HMGB Proteins - genetics | Cell Line, Tumor | HMGB Proteins - metabolism | Mice | Drugs | Toxicity | Genes | Effector cells | Cytotoxicity | Genomes | Lymphocytes T | Remodeling | Inactivation | Immunity | Immunosuppressive agents | Metastases | Lymphocytes | Killing | CRISPR | Deactivation | Cytokines | Secretion | Tumor cells | Melanoma | Gene expression | Patients | Chromatin remodeling | Sensitivity | Inhibitors | Immune checkpoint | SWI/SNF complex | Antitumor activity | Interferon | Mutation | Chemokines | Clear cell-type renal cell carcinoma | Tumors | Cancer | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2013, Volume 190, Issue 5, pp. 2415 - 2423
IL-35 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p35 subunit and an IL-12 p40-related protein subunit, EBV-induced gene 3... 
CARCINOMA-CELLS | COMPLETE REGRESSION | REGULATORY T-CELLS | INDUCED GENE 3 | IL-27 | CYTOKINE | SUPPRESSOR-CELLS | IMMUNOLOGY | EXPRESSION | CANCER | EPSTEIN-BARR-VIRUS | Nasopharyngeal Neoplasms - genetics | Carcinoma | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Cytokine Receptor gp130 - genetics | Humans | Neovascularization, Pathologic | Plasmacytoma - genetics | Plasmacytoma - immunology | Plasmacytoma - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - immunology | Nasopharyngeal Neoplasms - pathology | Interleukins - genetics | CD11b Antigen - genetics | Melanoma, Experimental - immunology | Melanoma - genetics | Myeloid Cells - immunology | Interleukins - immunology | Nasopharyngeal Neoplasms - immunology | Lymphoma, Large B-Cell, Diffuse - immunology | Myeloid Cells - drug effects | Interleukins - pharmacology | Tumor Cells, Cultured | Tumor Microenvironment - drug effects | Nasopharyngeal Carcinoma | CD11b Antigen - immunology | Lymphoma, Large B-Cell, Diffuse - pathology | Melanoma, Experimental - blood supply | Cytokine Receptor gp130 - immunology | Melanoma, Experimental - pathology | Melanoma - pathology | Plasmacytoma - blood supply | Receptors, Cell Surface - immunology | Mice, Knockout | Tumor Microenvironment - immunology | Animals | Melanoma, Experimental - genetics | Melanoma - immunology | Mice | Mice, Inbred BALB C | Myeloid Cells - pathology | Lymphoma, Large B-Cell, Diffuse - genetics | Cytotoxicity, Immunologic | Receptors, Cell Surface - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 09/2015, Volume 75, Issue 18, pp. 3771 - 3787
Journal Article