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The Journal of clinical investigation, ISSN 0021-9738, 2011, Volume 121, Issue 6, pp. 2350 - 2360
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 50, pp. 15408 - 15413
Spontaneous CD8 T-cell responses occur in growing tumors but are usually poorly effective. Understanding the molecular and cellular mechanisms that drive these... 
Antitumor immunity | STING | Type I IFNs | Tumor endothelial cells | CD8 T cells | type I IFNs | DENDRITIC CELLS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | SENSOR | antitumor immunity | I INTERFERON | 2ND-MESSENGER | tumor endothelial cells | RESPONSES | INTRACELLULAR DNA | MELANOMA | IMMUNOGENIC TUMORS | IPILIMUMAB | Dose-Response Relationship, Immunologic | Dendritic Cells - immunology | Immunity | Neoplasms - therapy | Melanoma, Experimental - immunology | Injections, Intralesional | Interferon Type I - metabolism | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Nucleotides, Cyclic - pharmacology | Antigens, Neoplasm - immunology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | CTLA-4 Antigen - immunology | Animals | Signal Transduction - drug effects | Melanoma - immunology | Neoplasms - immunology | Cell Proliferation - drug effects | Nucleotides, Cyclic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Endothelial Cells - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Growth | Cancer cells | Physiological aspects | Genetic aspects | T cells | Health aspects | Tumors | Endothelium | Biological Sciences
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 38, Issue 2, pp. 275 - 284
Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here... 
CETUXIMAB | RESPONSES | TOLERANCE | MAST-CELLS | DISEASE | MODEL | IMMUNOLOGY | CARCINOMA | EXPRESSION | METASTATIC COLORECTAL-CANCER | EGF RECEPTOR | Forkhead Transcription Factors - immunology | Cell Communication - immunology | Receptor, Epidermal Growth Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Humans | Colitis - pathology | Homeodomain Proteins - immunology | Amphiregulin | Glycoproteins - pharmacology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma, Experimental - immunology | EGF Family of Proteins | Colitis - chemically induced | Peptide Fragments - immunology | Mast Cells - metabolism | Colitis - immunology | Glycoproteins - genetics | Mast Cells - immunology | Receptor, Epidermal Growth Factor - immunology | Peptide Fragments - administration & dosage | Glycoproteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Melanoma, Experimental - pathology | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Mice, Transgenic | Forkhead Transcription Factors - genetics | Mast Cells - drug effects | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Membrane Proteins - administration & dosage | Glycoproteins - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Melanoma, Experimental - genetics | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Lymphocyte Activation - drug effects | Colitis - metabolism | Mice | Intercellular Signaling Peptides and Proteins - immunology | Epidermal growth factor | Universities and colleges | T cells | Analysis | Vaccination | Cells | Flow cytometry | Cytokines | Cloning | Melanoma | Kinases | Experiments | Cancer therapies | Rodents | Bone marrow | Software | Tumors | Cancer
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2018, Volume 155, Issue 1, pp. 33 - 37.e6
We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon... 
Immune Regulation | Tumor Promotion | Gut Bacteria | Metastases | GASTROENTEROLOGY & HEPATOLOGY | IL-17 | T-Lymphocyte Subsets - immunology | Neoplasm Transplantation | Interleukin-17 - immunology | Soft Tissue Neoplasms - immunology | Dysbiosis - immunology | Melanoma, Experimental - immunology | Neoplasm Metastasis - immunology | Melanoma, Experimental - secondary | Liver Neoplasms - secondary | Carcinoma - secondary | Disease Models, Animal | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Soft Tissue Neoplasms - secondary | Pancreatic Neoplasms - pathology | Liver Neoplasms - immunology | Melanoma - secondary | Mice, Knockout | Tumor Microenvironment - immunology | Animals | Gastrointestinal Microbiome - drug effects | Melanoma - immunology | Neoplasms - immunology | Colonic Neoplasms - pathology | Interferon-gamma - immunology | Pancreatic Neoplasms - immunology | Cell Line, Tumor | T-Lymphocytes - immunology | Anti-Bacterial Agents - pharmacology | Mice | Gastrointestinal Microbiome - immunology | Interleukin-10 - immunology | Medical colleges | Microbiota (Symbiotic organisms) | Growth | Liver | Melanoma | Metastasis | B cells | T cells | Biological response modifiers | Liver cancer | Colon cancer | Interleukins | Immunotherapy | Pancreatic cancer | Bacteria | Interferon gamma | metastases | gut bacteria | immune regulation | tumor promotion
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 1319 - 12
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 2012, Volume 209, Issue 11, pp. 2001 - 2016
Infiltration of Foxp3(+) regulatory T (T reg) cells is considered to be a critical step during tumor development and progression. T reg cells supposedly... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | ANTI-VEGF | DENDRITIC CELLS | ANGIOGENESIS | AUTOIMMUNITY | RECEPTOR | SELECTIVE DEPLETION | MALIGNANT-MELANOMA | IMMUNOLOGY | EXPRESSION | TUMOR-IMMUNITY | Forkhead Transcription Factors - immunology | Immunohistochemistry | Neuropilin-1 - genetics | T-Lymphocytes, Regulatory - metabolism | Vascular Endothelial Growth Factor A - deficiency | Tumor Escape - genetics | Humans | Gene Expression Regulation, Neoplastic | Melanoma, Experimental - metabolism | Vascular Endothelial Growth Factor A - genetics | Cell Movement - genetics | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Melanoma, Experimental - immunology | Forkhead Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Tumor Burden - genetics | Neuropilin-1 - immunology | Tumor Escape - immunology | Skin Neoplasms - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Vascular Endothelial Growth Factor A - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Skin Neoplasms - metabolism | Animals | Melanoma, Experimental - genetics | Skin Neoplasms - genetics | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Neuropilin-1 - deficiency | Tumor Burden - immunology
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2013, Volume 190, Issue 5, pp. 2415 - 2423
IL-35 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p35 subunit and an IL-12 p40-related protein subunit, EBV-induced gene 3... 
CARCINOMA-CELLS | COMPLETE REGRESSION | REGULATORY T-CELLS | INDUCED GENE 3 | IL-27 | CYTOKINE | SUPPRESSOR-CELLS | IMMUNOLOGY | EXPRESSION | CANCER | EPSTEIN-BARR-VIRUS | Nasopharyngeal Neoplasms - genetics | Carcinoma | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Cytokine Receptor gp130 - genetics | Humans | Neovascularization, Pathologic | Plasmacytoma - genetics | Plasmacytoma - immunology | Plasmacytoma - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - immunology | Nasopharyngeal Neoplasms - pathology | Interleukins - genetics | CD11b Antigen - genetics | Melanoma, Experimental - immunology | Melanoma - genetics | Myeloid Cells - immunology | Interleukins - immunology | Nasopharyngeal Neoplasms - immunology | Lymphoma, Large B-Cell, Diffuse - immunology | Myeloid Cells - drug effects | Interleukins - pharmacology | Tumor Cells, Cultured | Tumor Microenvironment - drug effects | Nasopharyngeal Carcinoma | CD11b Antigen - immunology | Lymphoma, Large B-Cell, Diffuse - pathology | Melanoma, Experimental - blood supply | Cytokine Receptor gp130 - immunology | Melanoma, Experimental - pathology | Melanoma - pathology | Plasmacytoma - blood supply | Receptors, Cell Surface - immunology | Mice, Knockout | Tumor Microenvironment - immunology | Animals | Melanoma, Experimental - genetics | Melanoma - immunology | Mice | Mice, Inbred BALB C | Myeloid Cells - pathology | Lymphoma, Large B-Cell, Diffuse - genetics | Cytotoxicity, Immunologic | Receptors, Cell Surface - genetics
Journal Article
Journal Article
Nature immunology, ISSN 1529-2916, 2013, Volume 14, Issue 11, pp. 1173 - 1182
Cytolytic activity by CD8(+) cytotoxic T lymphocytes (CTLs) is a powerful strategy for the elimination of intracellular pathogens and tumor cells. The... 
SELECTIVE EXPRESSION | GENE | MEMORY | INFLAMMATION | DISEASE | TUMOR-SUPPRESSOR | CHUVASH POLYCYTHEMIA | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | CANCER | EXHAUSTION | Lymphocytic choriomeningitis virus - immunology | Oxygen - pharmacology | Transcription, Genetic - drug effects | Cell Hypoxia - immunology | Humans | Lymphocytic Choriomeningitis - immunology | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | T-Lymphocytes, Cytotoxic - pathology | Melanoma, Experimental - immunology | Skin Neoplasms - mortality | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Basic Helix-Loop-Helix Transcription Factors - deficiency | Melanoma, Experimental - virology | Hypoxia-Inducible Factor 1, alpha Subunit - immunology | Skin Neoplasms - pathology | T-Lymphocytes, Cytotoxic - immunology | Lymphocytic Choriomeningitis - virology | Basic Helix-Loop-Helix Transcription Factors - genetics | Melanoma, Experimental - mortality | Skin Neoplasms - immunology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Lymphocytic Choriomeningitis - pathology | Melanoma, Experimental - pathology | Mice, Knockout | Gene Expression Regulation - drug effects | Von Hippel-Lindau Tumor Suppressor Protein - immunology | Animals | Signal Transduction - drug effects | Skin Neoplasms - virology | Survival Analysis | Basic Helix-Loop-Helix Transcription Factors - immunology | Mice | Immunologi inom det medicinska området | Klinisk medicin | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer och onkologi
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2012, Volume 209, Issue 11, pp. 2113 - 2126
Harnessing the adaptive immune response to treat malignancy is now a clinical reality. Several strategies are used to treat melanoma; however, very few result... 
OX40 | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | TRANSCRIPTION FACTOR EOMESODERMIN | CYCLOPHOSPHAMIDE | FACILITATED ADOPTIVE IMMUNOTHERAPY | TUMOR | CANCER-IMMUNOTHERAPY | ANTITUMOR IMMUNITY | IMMUNOLOGY | LARGE ESTABLISHED MELANOMA | CUTTING EDGE | Cyclophosphamide - administration & dosage | Humans | T-Box Domain Proteins - immunology | Th2 Cells - immunology | Th1 Cells - immunology | Receptors, OX40 - immunology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Receptors, OX40 - metabolism | Melanoma, Experimental - immunology | RNA Interference | Antigens, Neoplasm - metabolism | Membrane Proteins - metabolism | Cytotoxicity, Immunologic - drug effects | Immunologic Memory - immunology | Cytokines - immunology | Cytokines - metabolism | Immunotherapy, Adoptive | Oxidoreductases - metabolism | Antigens, Neoplasm - immunology | Oxidoreductases - genetics | Melanoma, Experimental - therapy | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Melanoma, Experimental - pathology | Membrane Proteins - immunology | Mice, Transgenic | Combined Modality Therapy | T-Box Domain Proteins - genetics | Th2 Cells - metabolism | T-Box Domain Proteins - metabolism | Mice, Knockout | Cell Differentiation - immunology | Oxidoreductases - immunology | Animals | CD4-Positive T-Lymphocytes - transplantation | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Mice | Cytotoxicity, Immunologic - immunology
Journal Article