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animals (237) 237
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Journal Article
Toxicological Sciences, ISSN 1096-6080, 7/2009, Volume 110, Issue 1, pp. 138 - 155
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 03/2013, Volume 26, Issue 2, pp. 205 - 217
We present here the positional cloning of the D anio rerio albino mutant and show that the affected gene encodes S lc45a2. The human orthologous gene has... 
ase | melanosome | melanocyte | retinal pigment epithelium | ATP | skin color variation | albinism | slc45a2 | V-ATPase | PROTEIN | OCULOCUTANEOUS ALBINISM | ORGANELLES | TYROSINASE | IDENTIFICATION | CELL BIOLOGY | DERMATOLOGY | MUTANTS | POLYMORPHISMS | GENE | ONCOLOGY | MUTATIONS | EXCHANGER | Organ Specificity - drug effects | Retina - drug effects | Melanophores - metabolism | Melanosomes - ultrastructure | Retina - metabolism | Humans | Neural Crest - pathology | Molecular Sequence Data | Melanocytes - metabolism | Vacuolar Proton-Translocating ATPases - metabolism | Protein Subunits - metabolism | Monophenol Monooxygenase - metabolism | Neural Crest - metabolism | Visual Acuity - drug effects | Hydrogen-Ion Concentration - drug effects | Melanocytes - pathology | Cloning, Molecular | Membrane Transport Proteins - metabolism | Homeostasis - drug effects | Melanosomes - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Pigmentation - drug effects | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | Mutation - genetics | Membrane Transport Proteins - chemistry | Neural Crest - drug effects | Biological Evolution | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Animals | Models, Biological | Zebrafish - metabolism | Alleles | Morpholinos - pharmacology | Melanophores - drug effects | Protein Subunits - chemistry | Melanosomes - metabolism | Retina - pathology | Skin color variation | Slc45a2 | Albinism | Melanocyte | Melanosome | Retinal pigment epithelium | Proteins | Skin | Hydrogen-ion concentration | Analysis | Adenosine triphosphatase | Zebrafish
Journal Article
Journal Article
American Journal of Ophthalmology, ISSN 0002-9394, 2007, Volume 143, Issue 6, pp. 995 - 1002.e2
Journal Article
Journal Article
Experimental Dermatology, ISSN 0906-6705, 03/2011, Volume 20, Issue 3, pp. 242 - 248
Tyrosinase is known to be the first two and rate‐limiting enzyme in the synthesis of melanin pigments responsible for colouring skin, hair and eyes. Tyrosinase... 
tyrosinase inhibitor | human skin cells | molecular docking | zebrafish | Cinnamomum subavenium | Zebrafish | Tyrosinase inhibitor | Human skin cells | Molecular docking | ACID | MELANOSOME TRANSFER | QUALITY-CONTROL | MELANIN | DERMATOLOGY | CYTOTOXIC CONSTITUENTS | MELANOCYTE-STIMULATING HORMONE | HUMAN EPIDERMAL MELANOCYTES | B16F10 CELLS | SKIN | Humans | Cosmetics - chemistry | Melanocytes - metabolism | Monophenol Monooxygenase - antagonists & inhibitors | Embryo, Nonmammalian - drug effects | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | 4-Butyrolactone - metabolism | Cosmetics - metabolism | Melanocytes - cytology | Melanocytes - drug effects | Enzyme Inhibitors - chemistry | 4-Butyrolactone - chemistry | Monophenol Monooxygenase - chemistry | Cell Survival - drug effects | Cosmetics - pharmacology | Drug Evaluation, Preclinical - methods | Catalytic Domain | Enzyme Inhibitors - metabolism | 4-Butyrolactone - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Molecular Dynamics Simulation | Enzyme Inhibitors - isolation & purification | Skin Pigmentation - drug effects | Cell Shape - drug effects | Animals | Keratinocytes - drug effects | Fibroblasts - drug effects | Cinnamomum - chemistry | 4-Butyrolactone - analogs & derivatives | Protein Binding - physiology | Tyrosine | Enzymes | Analysis
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e103762 - e103762
Hypericin, an extract from St John's Wort (Hypericum perforatum L.), is a promising photosensitizer in the context of clinical photodynamic therapy due to its... 
CYTOCHROME-C | IN-VITRO | ACTIVATION | HELA-CELLS | SUBCELLULAR-DISTRIBUTION | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | ENDOPLASMIC-RETICULUM | MELANOGENESIS | MOLECULAR EFFECTORS | CANCER | Perylene - analogs & derivatives | Skin Neoplasms - pathology | Pigmentation - drug effects | Skin Neoplasms - drug therapy | Apoptosis - drug effects | Cell Size - drug effects | Humans | Middle Aged | Transcriptional Activation | Photosensitizing Agents - metabolism | Melanoma - pathology | Perylene - metabolism | Photochemotherapy | Perylene - pharmacology | Apoptosis Regulatory Proteins - metabolism | Endoplasmic Reticulum - pathology | Photosensitizing Agents - pharmacology | Endoplasmic Reticulum - drug effects | Melanoma - drug therapy | Apoptosis Regulatory Proteins - genetics | Cell Line, Tumor | Female | Drug Screening Assays, Antitumor | Hypericum - chemistry | Chemotherapy | Melanoma | Biochemistry | Metastasis | Health aspects | Apoptosis | Cancer | Cell culture | Health sciences | Laboratories | Melanosomes | Toxicity | Tissue culture | Lysosomes | Cytotoxicity | Biology | Autophagy | Cancer therapies | Nuclei | Metastases | Skin cancer | Mitochondria | Light | Localization | Lymphatic system | Photodynamic therapy | Mortality | Apoptosis-inducing factor | Caspase | Shrinkage | Radiation therapy | Organelles | Pigmentation | Hypericin | Cell death | Morphology | Photosensitization | Mutation | Endoplasmic reticulum | Phagocytosis | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2012, Volume 125, Issue 18, pp. 4306 - 4319
Bone morphogenetic proteins (BMPs) are a large family of multi-functional secreted signalling molecules. Previously BMP2/4 were shown to inhibit skin... 
Noggin | UV radiation | Sclerostin | Melanin transfer | Pigmentation | SERINE/THREONINE KINASE RECEPTORS | FILOPODIA FORMATION | MYOSIN-X | MELANOSOME TRANSFER | HUMAN MELANOCYTES | HAIR FOLLICLE GROWTH | CELL BIOLOGY | CROSS-TALK | SIGNAL-TRANSDUCTION | TRANSCRIPTION FACTOR | Skin - cytology | Keratinocytes - radiation effects | Coculture Techniques | Humans | Middle Aged | Up-Regulation - radiation effects | Bone Morphogenetic Protein 4 - antagonists & inhibitors | Melanocytes - metabolism | Bone Morphogenetic Protein 6 - pharmacology | Bone Morphogenetic Protein 4 - metabolism | Gene Knockdown Techniques | Melanins - biosynthesis | Melanocytes - radiation effects | Monophenol Monooxygenase - metabolism | Pseudopodia - drug effects | Pigmentation - radiation effects | Ultraviolet Rays | Melanocytes - drug effects | Adult | Female | Myosins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Signal Transduction - radiation effects | Keratinocytes - enzymology | Epidermis - metabolism | Epidermis - radiation effects | Pigmentation - drug effects | Epidermis - drug effects | Bone Morphogenetic Protein 6 - antagonists & inhibitors | Bone Morphogenetic Protein Receptors - metabolism | Melanocytes - ultrastructure | Bone Morphogenetic Protein 4 - pharmacology | Up-Regulation - drug effects | Bone Morphogenetic Protein 6 - metabolism | Keratinocytes - drug effects | Pseudopodia - metabolism | Signal Transduction - drug effects | Keratinocytes - metabolism | Models, Biological | Aged | Smad Proteins - metabolism
Journal Article
Journal Article