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Cancer discovery, ISSN 2159-8290, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Circulation research, ISSN 1524-4571, 04/2012, Volume 110, Issue 9, pp. 1202 - 1210
RATIONALE:Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous... 
Experimental autoimmune encephalomyelitis | Autoimmune disease | Vascular inflammation | Platelets | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Platelet Adhesiveness | Blood Platelets - immunology | Central Nervous System - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Central Nervous System - immunology | Leukocytes - immunology | Membrane Glycoproteins - antagonists & inhibitors | Platelet Glycoprotein GPIb-IX Complex - metabolism | Time Factors | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Inflammation Mediators - metabolism | Platelet Aggregation Inhibitors - pharmacology | Female | Blood Platelets - drug effects | Anti-Inflammatory Agents - pharmacology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Cells, Cultured | Encephalomyelitis, Autoimmune, Experimental - blood | Membrane Glycoproteins - blood | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Animals | Blood Platelets - metabolism | Central Nervous System - drug effects | Platelet Glycoprotein GPIb-IX Complex - antagonists & inhibitors | Leukocytes - drug effects | Mice | Index Medicus | Animal models | Multiple sclerosis | Leukocyte migration | Microscopy | Central nervous system | Glycoproteins | Inflammation | Experimental allergic encephalomyelitis | Inflammatory diseases | EAE | inflammation | autoimmune disease
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 02/2019, Volume 363, Issue 6428, pp. 753 - 756
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 02/2004, Volume 172, Issue 4, pp. 2225 - 2231
The recently discovered cytokine IL-27 belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Antigens, CD - immunology | NIH 3T3 Cells | Phosphorylation | Membrane Glycoproteins - metabolism | Antigens, CD - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | Transcriptional Activation | Monocytes - metabolism | Antibodies, Blocking - pharmacology | Monocytes - immunology | Receptors, Interleukin | Receptors, Cytokine - physiology | Antigens, CD - metabolism | DNA-Binding Proteins - metabolism | RNA, Messenger - biosynthesis | Signal Transduction - immunology | Membrane Glycoproteins - physiology | Autocrine Communication - immunology | Interleukins - physiology | Inflammation Mediators - metabolism | Mast Cells - metabolism | Membrane Glycoproteins - immunology | Cytokines - genetics | Mast Cells - immunology | DNA-Binding Proteins - antagonists & inhibitors | Cytokine Receptor gp130 | Gene Expression Regulation - immunology | Receptors, Cytokine - biosynthesis | Antibodies, Monoclonal - pharmacology | Cells, Cultured | Interleukins - antagonists & inhibitors | Tyrosine - metabolism | Animals | Cell Line, Tumor | STAT1 Transcription Factor | Transcription, Genetic - immunology | Antigens, CD - physiology | Trans-Activators - metabolism | Mice | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Cytokines - biosynthesis | WSX-1 protein | gp130 glycoprotein | Interleukin 27 | CD4 antigen | Index Medicus | Abridged Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 06/2016, Volume 535, Issue 7610, pp. 169 - 172
Journal Article
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 07/2011, Volume 118, Issue 2, pp. 163 - 175
... (CAR) have been recognized as xenobiotic‐sensors which can up‐regulate the functional expression of drug transporters, such as P‐glycoprotein (P‐gp... 
P‐glycoprotein | pregnane X receptor | blood–brain barrier | orphan nuclear receptor | constitutive androstane receptor | human brain microvessel endothelial cells | blood-brain barrier | P-glycoprotein | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Blood-Brain Barrier - cytology | Humans | RNA, Messenger - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Microvessels - metabolism | Receptors, Steroid - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Brain - metabolism | Brain - blood supply | Orphan Nuclear Receptors - physiology | Blood-Brain Barrier - physiology | Endothelial Cells - physiology | Microvessels - cytology | Brain - cytology | Endothelial Cells - metabolism | Cells, Cultured | Rats | Receptors, Cytoplasmic and Nuclear - physiology | Hep G2 Cells | Microvessels - physiology | Animals | Endothelial Cells - cytology | Receptors, Steroid - physiology | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Ligands | Cell Line, Transformed | Proteins | Brain | Messenger RNA | Permeability | Endothelium | Neurochemistry | Glycoproteins | Cellular biology | Gene expression | Index Medicus | Drugs | Central nervous system | Membrane permeability | mRNA | siRNA | pregnane X receptors | Endothelial cells | HcaR protein | Nuclear transport | Blood-brain barrier | P-Glycoprotein | orphan nuclear receptors
Journal Article