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1. Full Text Toremifene interacts with and destabilizes the Ebola virus glycoprotein
by Zhao, Yuguang and Ren, Jingshan and Harlos, Karl and Jones, Daniel M and Zeltina, Antra and Bowden, Thomas A and Padilla-Parra, Sergi and Fry, Elizabeth E and Stuart, David I
Nature (London), ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 169 - 172
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Temperature | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antiviral Agents - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ebolavirus - drug effects | Ibuprofen - chemistry | Antiviral Agents - chemistry | Endosomes - drug effects | Viral Envelope Proteins - metabolism | Conserved Sequence | Marburgvirus - chemistry | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Membrane Fusion - drug effects | Toremifene - metabolism | Toremifene - pharmacology | Cell Line | Antiviral Agents - pharmacology | Ibuprofen - pharmacology | Models, Molecular | Protein Structure, Quaternary - drug effects | Ibuprofen - metabolism | Virus Attachment - drug effects | Ebolavirus - chemistry | Viral Envelope Proteins - antagonists & inhibitors | Protein Stability - drug effects | Viral Envelope Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Protein Subunits - chemistry | Toremifene - chemistry | Ebola virus | Glycoproteins | Host-virus relationships | Observations | Health aspects | Drug interactions | Drug therapy | Binding sites | Viral infections | Crystal structure | Index Medicus
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2. Ion channels
: from structure to function
by Kew, James N.C and Davies, Ceri H
2010, ISBN 9780199296750
Development of the Nervous System | Disease | Therapeutic treatments | Ligands | Biophysical characterization | Ion channels | Pharmacology | Physiology | Biophysics | Localization | Physiological functions
Book
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3. Clinical Implications of P-Glycoprotein Modulation in Drug–Drug Interactions
by Lund, Marie and Petersen, Tonny Studsgaard and Dalhoff, Kim Peder
Drugs (New York, N.Y.), ISSN 0012-6667, 05/2017, Volume 77, Issue 8, pp. 859 - 883
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Anti-Infective Agents - metabolism | Anti-Infective Agents - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gastrointestinal Agents - administration & dosage | Antineoplastic Agents - administration & dosage | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Central Nervous System Agents - adverse effects | Antineoplastic Agents - metabolism | Drug Interactions | Antineoplastic Agents - adverse effects | Antineoplastic Agents - pharmacology | Cell Line | Anti-Infective Agents - adverse effects | Immunologic Factors - administration & dosage | Gastrointestinal Agents - pharmacology | Anti-Infective Agents - administration & dosage | Cytochrome P-450 CYP3A Inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP3A - metabolism | Central Nervous System Agents - administration & dosage | Central Nervous System Agents - pharmacology | Central Nervous System Agents - metabolism | Gastrointestinal Agents - adverse effects | Immunologic Factors - adverse effects | Immunologic Factors - metabolism | Immunologic Factors - pharmacology | Gastrointestinal Agents - metabolism | Cytochrome | Health care | Drugs | Enzymes | Membranes | Excretion | Decision making | Organs | Substrate inhibition | Breast cancer | Glycoproteins | Metabolism | Substrates | Proteins | Side effects | Blood-brain barrier | Plasma membranes | Protein expression | Protein transport | P-Glycoprotein | Transporter | Inducers
Journal Article
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4. Full Text The P-Glycoprotein Transport System and Cardiovascular Drugs
by Wessler, Jeffrey D., MD, MPhil and Grip, Laura T., BS and Mendell, Jeanne, PhD, MPH and Giugliano, Robert P., MD, SM
Journal of the American College of Cardiology, ISSN 0735-1097, 2013, Volume 61, Issue 25, pp. 2495 - 2502
Cardiovascular | Internal Medicine | adverse drug event(s) | P-glycoprotein | drug-drug interaction | pharmacology | adverse drug event(s) drug-drug interaction P-glycoprotein pharmacology | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Protein Structure, Tertiary | Cardiovascular Agents - therapeutic use | Animals | Cardiovascular Diseases - metabolism | Cardiovascular Diseases - drug therapy | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cardiovascular Agents - metabolism | Protein Transport - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Protein Transport - drug effects | Cardiovascular Agents - pharmacology | Medical colleges | Anticoagulants (Medicine) | Permeability | Anti-arrhythmia drugs | Anticoagulants | Membranes | Blood-brain barrier | Human immunodeficiency virus--HIV | Rodents | Nervous system | Drug therapy | Binding sites | Cancer | Index Medicus | Abridged Index Medicus
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5. Full Text Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein
by Chufan, Eduardo E and Kapoor, Khyati and Ambudkar, Suresh V
Biochemical pharmacology, ISSN 0006-2952, 02/2016, Volume 101, pp. 40 - 53
Drug-binding site | ABC transporter | Multidrug resistance | Modulators | Structural motifs | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Dibenzocycloheptenes - chemistry | Membrane Transport Modulators - chemistry | Hydrolysis - drug effects | Humans | Molecular Conformation | ATP Binding Cassette Transporter, Sub-Family B - chemistry | Quinolines - pharmacology | Tetrahydroisoquinolines - chemistry | Biocatalysis - drug effects | Dibenzocycloheptenes - metabolism | Adenosine Triphosphate - metabolism | Membrane Transport Modulators - pharmacology | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Binding Sites | Mutant Proteins - antagonists & inhibitors | Acridines - chemistry | Recombinant Proteins - metabolism | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Amino Acid Motifs | Quinolines - metabolism | Membrane Transport Modulators - metabolism | Animals | Hydrogen Bonding | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Mutant Proteins - chemistry | Lepidoptera | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Ligands | Molecular Docking Simulation | HeLa Cells | Adenosine Triphosphate - chemistry | ATP Binding Cassette Transporter, Sub-Family B - genetics | Amino Acid Substitution | Hydrolysis | Hydrogen | Cells | Protein binding | Index Medicus | multidrug resistance | structural motifs | modulators | drug-binding site
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6. Full Text Ginsenoside‐Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation
by Endale, M and Lee, WM and Kamruzzaman, SM and Kim, SD and Park, JY and Park, MH and Park, TY and Park, HJ and Cho, JY and Rhee, MH
British journal of pharmacology, ISSN 0007-1188, 09/2012, Volume 167, Issue 1, pp. 109 - 127
platelet | PI3K | thrombus | ginsenoside‐Rp1 | tyrosine‐phosphorylation | GPVI | ginsenoside-Rp1 | tyrosine-phosphorylation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Calcium - metabolism | P-Selectin - metabolism | Male | Ginsenosides - pharmacology | Phosphoproteins - metabolism | Adenosine Triphosphate - metabolism | Platelet Membrane Glycoproteins - metabolism | Platelet Aggregation Inhibitors - pharmacology | Collagen - pharmacology | Microfilament Proteins - metabolism | Platelet Aggregation - drug effects | Phosphorylation - drug effects | Thrombosis - prevention & control | Cyclic AMP - metabolism | Mice, Inbred C57BL | Rats | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Thromboxane A2 - metabolism | Tyrosine - metabolism | Animals | Blood Coagulation - drug effects | Cyclic GMP - metabolism | Mice | Mitogen-Activated Protein Kinases - metabolism | Tyrosine | Medical examination | Vasodilators | Thrombin | Thrombosis | Blood | Blood clot | Collagen | Genetically modified organisms | Phenols | Genetic research | Universities and colleges | Integrins | Index Medicus | Research Papers
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7. Full Text Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
by Yuan, Yuan and Cao, Duanfang and Zhang, Yanfang and Ma, Jun and Qi, Jianxun and Wang, Qihui and Lu, Guangwen and Wu, Ying and Yan, Jinghua and Shi, Yi and Zhang, Xinzheng and Gao, George F
Nature communications, ISSN 2041-1723, 04/2017, Volume 8, Issue 1, pp. 15092 - 15092
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antibodies, Neutralizing | Antiviral Agents - pharmacology | Middle East Respiratory Syndrome Coronavirus - ultrastructure | Receptors, Virus - metabolism | Protein Multimerization | Models, Molecular | Glycosylation | Cryoelectron Microscopy | SARS Virus - ultrastructure | Protein Binding | Protein Domains | Glycoproteins - chemistry | Glycoproteins - ultrastructure | Spike Glycoprotein, Coronavirus - chemistry | Membrane Fusion - drug effects | Spike Glycoprotein, Coronavirus - ultrastructure | Index Medicus
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8. Full Text Communication between Multiple Drug Binding Sites on P-glycoprotein
by Catherine Martin and Georgina Berridge and Christopher F. Higgins and Prakash Mistry and Peter Charlton and Richard Callaghan
Molecular pharmacology, ISSN 0026-895X, 09/2000, Volume 58, Issue 3, pp. 624 - 632
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Binding, Competitive | Cricetinae | Paclitaxel - pharmacology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - drug effects | Allosteric Regulation | Tritium | Quinolines - pharmacology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Rhodamine 123 - pharmacology | Animals | Benzylidene Compounds - pharmacology | Drug Interactions | Isoquinolines - pharmacology | Acridines - pharmacology | Benzimidazoles - pharmacology | Cell Membrane - metabolism | Vinblastine - pharmacology | Kinetics | Nicardipine - pharmacology | Radioligand Assay | Radiopharmaceuticals - pharmacology | Tetrahydroisoquinolines | Cell Membrane - drug effects | CHO Cells | Index Medicus
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