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Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2012, Volume 53, Issue 2, pp. 260 - 270
Journal Article
Nature, ISSN 0028-0836, 11/2012, Volume 491, Issue 7423, pp. 269 - 273
Myocardial cell death is initiated by excessive mitochondrial Ca2+ entry causing Ca2+ overload, mitochondrial permeability transition pore (mPTP) opening and... 
OXIDATION | HYPERTROPHY | APOPTOSIS | INNER MEMBRANE | II INHIBITION PROTECTS | MULTIDISCIPLINARY SCIENCES | CALCIUM UNIPORTER | IN-VIVO | CALMODULIN KINASE | FAILURE | KINASE-II | Mitochondria, Heart - metabolism | Apoptosis - drug effects | Calcium - metabolism | Cyclosporine - pharmacology | Mitochondria, Heart - pathology | Membrane Potential, Mitochondrial - drug effects | Heart Failure - prevention & control | Myocardium - metabolism | Membrane Potential, Mitochondrial - physiology | Female | Stress, Physiological - drug effects | Reperfusion Injury - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Heart - physiopathology | Mitochondrial Membrane Transport Proteins - metabolism | Calcium - pharmacology | Reperfusion Injury - pathology | Reperfusion Injury - enzymology | Mice, Inbred C57BL | Mitochondria, Heart - enzymology | Mice, Transgenic | Myocardium - pathology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | Serine - metabolism | Heart Failure - drug therapy | Myocardium - enzymology | Animals | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry | Myocardial Infarction - drug therapy | Reperfusion Injury - prevention & control | Heart - drug effects | Mice | Myocardial Infarction - prevention & control | Heart failure | Cell death | Heart cells | Research | Mitochondrial myopathies | Properties | Observations | Protein kinases | Calmodulin | Proteins | Heart | Mitochondria | Heart attacks | Rodents | Homeostasis | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 769 - 780
Background Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress... 
Allergy and Immunology | airway hyperresponsiveness | antioxidant | proliferation | MitoQ | inflammation | mitochondria | airway smooth muscle | Ozone | oxidative stress | chronic obstructive pulmonary disease | ASTHMA FEATURES | CELLS | IMMUNITY | MECHANISMS | IMMUNOLOGY | BETA | MURINE MODEL | ALLERGY | ALLERGIC-ASTHMA | ENERGY-METABOLISM | COPD | Respiratory System - pathology | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | Bronchial Hyperreactivity - genetics | Ubiquinone - pharmacology | Muscle, Smooth - drug effects | Smoking - physiopathology | Organophosphorus Compounds - pharmacology | Myocytes, Smooth Muscle - drug effects | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Bronchial Hyperreactivity - chemically induced | Signal Transduction | Mitochondria - pathology | Smoking - metabolism | Bronchial Hyperreactivity - pathology | Reactive Oxygen Species - antagonists & inhibitors | Electron Transport Chain Complex Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - chemically induced | Respiratory System - drug effects | Airway Remodeling - genetics | Mice | Oxidative Stress - drug effects | Bronchial Hyperreactivity - drug therapy | Myocytes, Smooth Muscle - pathology | Pneumonia - pathology | Membrane Potential, Mitochondrial - drug effects | Pneumonia - chemically induced | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Myocytes, Smooth Muscle - metabolism | Ubiquinone - analogs & derivatives | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Muscle, Smooth - metabolism | Animals | Pneumonia - drug therapy | Respiratory System - metabolism | Aged | Muscle, Smooth - pathology | Oxidative stress | Care and treatment | Lung diseases, Obstructive | Inflammation | Pharmaceutical industry | Biomedical research | Disease | Laboratories | Mortality | Colleges & universities | Smooth muscle | Mitochondrial DNA | Metabolism | Defects | Antioxidants | Mitochondria | Hospitals | Biopsy | Chronic obstructive pulmonary disease | Apoptosis | Smoking | Index Medicus | Abridged Index Medicus | NO, Nitric oxide | ΔΨm, Mitochondrial membrane potential | ASM, Airway smooth muscle | NAC, N-acetylcysteine | RL, Lung resistance | BAL, Bronchoalveolar lavage | OCR, Oxygen consumption rate | dTPP, Decyltriphenylphosphonium bromide | AHR, Airway hyperresponsiveness | logPC100, Concentration of acetylcholine that increased lung resistance by 100 | GOLD, Global Initiative for Chronic Obstructive Lung Disease | ATP, Adenosine triphosphate | KC, Keratinocyte-derived cytokine | JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | COPD, Chronic obstructive pulmonary disease | ROS, Reactive oxygen species | Mechanisms of Allergy and Clinical Immunology
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 33, Issue 5, pp. 1477 - 1488
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0135083 - e0135083
The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by conducting different omics data analyses, we demonstrated that... 
APOPTOSIS | OXIDATIVE STRESS | P53 ACTIVATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | TUBULAR EPITHELIAL-CELLS | DOWN-REGULATION | AUDITORY CELLS | DEATH | CANCER | NEPHROTOXICITY | L-Lactate Dehydrogenase - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Male | Membrane Potential, Mitochondrial - drug effects | Glycolysis - drug effects | Reactive Oxygen Species - agonists | Tumor Suppressor Protein p53 - genetics | Antineoplastic Agents - toxicity | Dose-Response Relationship, Drug | Cisplatin - toxicity | Tumor Suppressor Protein p53 - agonists | Epithelial Cells - cytology | Kidney Tubules - metabolism | Cell Line | Kidney Tubules - drug effects | Citric Acid Cycle - drug effects | Gene Expression Regulation | Injections, Intraperitoneal | Tumor Suppressor Protein p53 - metabolism | Rats | Rats, Sprague-Dawley | Kidney Tubules - cytology | Animals | L-Lactate Dehydrogenase - genetics | Acetylcysteine - pharmacology | Cell Proliferation - drug effects | Physiological aspects | Reactive oxygen species | Genetic aspects | Research | Cisplatin | Bioengineering | Tricarboxylic acid cycle | Oxidative stress | Correlation | Toxicity | p53 Protein | Genes | Science | Cytotoxicity | Kinases | Ovarian cancer | Mitochondria | Cell growth | Pathways | Metabolites | Rodents | Cell cycle | Inhibition | Adenosine triphosphate | Urine | Abnormalities | Mortality | Data processing | Interdisciplinary aspects | Metabolism | Gene expression | Side effects | Cell death | Glycolysis | Apoptosis | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 12/2015, Volume 282, Issue 24, pp. 4714 - 4726
Mitochondrial trifunctional protein and long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiencies are fatty acid oxidation disorders biochemically characterized... 
mitochondrial permeability transition | long‐chain 3‐hydroxy fatty acid | calcium homeostasis | heart | mitochondrial bioenergetics | long-chain 3-hydroxy fatty acid | INNER MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MTP DEFICIENCIES | PYRIDINE-NUCLEOTIDES | LIVER MITOCHONDRIA | BRAIN MITOCHONDRIA | SKELETAL-MUSCLE | CALCIUM UNIPORTER | TRIFUNCTIONAL PROTEIN-DEFICIENCY | G1528C MUTATION | BETA-OXIDATION DISORDERS | Nervous System Diseases - enzymology | Mitochondrial Myopathies - metabolism | Rhabdomyolysis - enzymology | Mitochondria, Heart - metabolism | Mitochondrial Swelling - drug effects | Rats, Wistar | Humans | Mitochondria, Heart - drug effects | Membrane Potential, Mitochondrial - drug effects | Cardiomyopathies - enzymology | Lipid Metabolism, Inborn Errors - enzymology | Mitochondrial Membranes - drug effects | Oxidative Phosphorylation - drug effects | Adenosine Triphosphate - metabolism | Nervous System Diseases - metabolism | NADP - metabolism | Mitochondrial Membrane Transport Proteins - metabolism | Myristic Acids - metabolism | Lipid Metabolism, Inborn Errors - metabolism | Enzyme Inhibitors - pharmacology | Mitochondria, Heart - enzymology | Calcium Channel Blockers - pharmacology | Organ Specificity | Mitochondrial Membranes - metabolism | Rhabdomyolysis - metabolism | Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase - metabolism | Animals | Calcium Signaling - drug effects | Mitochondrial Trifunctional Protein - metabolism | Cardiomyopathies - metabolism | Cell Membrane Permeability - drug effects | Mitochondrial Myopathies - enzymology | Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase - deficiency | Palmitic Acids - metabolism | Mitochondrial Trifunctional Protein - deficiency | Deregulation | Mitochondrial DNA | Permeability | Fatty acids | Heart | Homeostasis | Dehydrogenases | Index Medicus
Journal Article
Journal Article