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Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, 04/2017, Volume 74, Issue 8, p. 1379
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00018-016-2405-9 Seven... 
Pharmacy | Atherosclerosis | Physiological aspects | Thrombin | G proteins | Health aspects | Cells | Membrane proteins
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 494, Issue 7436, pp. 201 - 206
The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly,... 
PATHOGENESIS | LOCALIZES | COMPLEX | PROTEIN | BECLIN-1 | PATHWAY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | DISEASE | INFECTION | BINDING | Apoptosis Regulatory Proteins - pharmacology | Recombinant Fusion Proteins - pharmacology | Humans | Cell Membrane Permeability | Molecular Sequence Data | Peptide Fragments - pharmacology | Membrane Proteins - pharmacology | Membrane Proteins - therapeutic use | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | HIV-1 - physiology | nef Gene Products, Human Immunodeficiency Virus - metabolism | Membrane Proteins - metabolism | Beclin-1 | Amino Acid Sequence | HIV-1 - metabolism | Virus Replication - drug effects | Peptide Fragments - metabolism | HIV-1 - drug effects | tat Gene Products, Human Immunodeficiency Virus - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | West Nile virus - drug effects | Macrophages - cytology | Recombinant Fusion Proteins - chemistry | Apoptosis Regulatory Proteins - metabolism | Chikungunya virus - drug effects | Peptide Fragments - chemistry | Animals | Membrane Proteins - chemistry | Mice | HeLa Cells | Apoptosis Regulatory Proteins - therapeutic use | tat Gene Products, Human Immunodeficiency Virus - metabolism | Proteins | Peptides | Microscopy | Rodents | Mortality | Amino acids | Infections | Autophagy | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 111 - 116
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 2011, Volume 7, Issue 1, pp. 521 - n/a
Synthetic biology aims to systematically design and construct novel biological systems that address energy, environment, and health issues. Herein, we describe... 
synthetic biology | Pseudomonas aeruginosa | pyocin | quorum sensing | genetic circuits | CELLS | BACTERIA | PROTEIN | SENSITIVE METHOD | SPECIFICITY | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMID | OTITIS | PERACETIC-ACID | BINDING | Recombinant Fusion Proteins - pharmacology | Humans | Pseudomonas aeruginosa - growth & development | Biofilms - growth & development | Escherichia coli - pathogenicity | Escherichia coli - metabolism | Homoserine - pharmacology | Homoserine - analogs & derivatives | Organisms, Genetically Modified - genetics | Genes, Reporter | Biofilms - drug effects | Recombinant Fusion Proteins - biosynthesis | Green Fluorescent Proteins - analysis | Quorum Sensing - drug effects | Pseudomonas Infections - drug therapy | 4-Butyrolactone - pharmacology | Pyocins - biosynthesis | Pseudomonas aeruginosa - drug effects | Escherichia coli - chemistry | Pseudomonas Infections - microbiology | Gene Expression Regulation, Bacterial - drug effects | Bacterial Proteins - pharmacology | Pyocins - pharmacology | Escherichia coli - genetics | Green Fluorescent Proteins - biosynthesis | Plasmids | Synthetic Biology - methods | Biosensing Techniques - methods | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Bacterial Proteins - biosynthesis | 4-Butyrolactone - analogs & derivatives | Antibiosis - genetics | Chassis | Water-borne diseases | Cell culture | Mixed culture | Escherichia coli | Fluorescence | Confocal microscopy | Infections | Biology | E7 protein | Devices | Matrix methods | Antiinfectives and antibacterials | Proteins | Engineering | Microorganisms | Microbiota | Biological weapons | E coli | Helicobacter pylori | Mathematical analysis | Bacteria | Synthetic biology | Inhibition | Public health | Killing | Pathogens | Escherichia | Damage assessment | Empirical equations | Transfer functions | Data processing | Membrane proteins | Biofilms | Infectious diseases | Antibiotics | Microscopy | Lysis | Green fluorescent protein | Strategy | Cholera | Detection | Index Medicus
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 04/2008, Volume 294, Issue 4, pp. G1060 - G1069
Probiotics promote intestinal epithelial integrity and reduce infection and diarrhea. We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble... 
Protein kinase C | Zonula occludens-1 | Intestine | Lactobacillus rhamnosus GG | Mucosal protection | Occludin | zonula occludens-1 | mucosal protection | OXIDATIVE STRESS | PHYSIOLOGY | intestine | DIARRHEA | PERMEABILITY | CYTOSKELETON | CACO-2 CELL MONOLAYER | LACTOBACILLUS GG | TIGHT JUNCTIONS | occludin | IN-VIVO | GROWTH | INTESTINAL BARRIER | GASTROENTEROLOGY & HEPATOLOGY | protein kinase C | Protein Kinase C beta | Intestinal Mucosa - metabolism | Cadherins - metabolism | Nitriles - pharmacology | Humans | Tight Junctions - enzymology | Phosphoproteins - metabolism | Intestinal Mucosa - drug effects | Dose-Response Relationship, Drug | Lactobacillus rhamnosus - chemistry | Time Factors | Protein Kinase C - metabolism | Intestinal Mucosa - enzymology | Indoles - pharmacology | Membrane Proteins - metabolism | Tight Junctions - drug effects | Caco-2 Cells | Hydrogen Peroxide - toxicity | Tight Junctions - metabolism | Butadienes - pharmacology | Protein Kinase C - antagonists & inhibitors | Electric Impedance | Permeability | Probiotics - pharmacology | beta Catenin - metabolism | Probiotics - isolation & purification | Protein Transport | HT29 Cells | Bacterial Proteins - pharmacology | Pyrroles - pharmacology | Zonula Occludens-1 Protein | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase C-epsilon - metabolism | Inulin - metabolism | Protein Kinase Inhibitors - pharmacology | Bacterial Proteins - isolation & purification | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Studies | Bacteria | Kinases | Bacterial proteins | Digestive system | Cells | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 28, pp. 24882 - 24895
BH3 mimetics are small molecules designed or discovered to mimic the binding of BH3-only proteins to the hydrophobic groove of antiapoptotic BCL2 proteins. The... 
CYTOCHROME-C | APOPTOSIS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | SENSITIVITY | BAX | BCL-2 PROTEINS | INHIBITORS | RELEASE | CELL-DEATH | Humans | Peptide Fragments - pharmacology | Endoplasmic Reticulum Stress - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | Activating Transcription Factor 3 - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | bcl-Associated Death Protein - genetics | Peptidomimetics - pharmacology | Endoplasmic Reticulum Stress - drug effects | Membrane Proteins - genetics | Activating Transcription Factor 4 - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Sulfonamides - pharmacology | Activating Transcription Factor 3 - metabolism | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Activating Transcription Factor 4 - metabolism | Signal Transduction - drug effects | Myeloid Cell Leukemia Sequence 1 Protein | K562 Cells | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus | BH3 Mimetics | Vinblastine | ER Stress | Leukemia | Microtubules | BCL2 | Anticancer Drug | Cell Biology | Apoptosis | MCL1
Journal Article
Blood, ISSN 0006-4971, 03/2011, Volume 117, Issue 12, pp. 3286 - 3293
We examined in vivo FLT3 inhibition in acute myeloid leukemia patients treated with chemotherapy followed by the FLT3 inhibitor lestaurtinib, comparing newly... 
AML | YOUNGER PATIENTS | INTENSIVE CHEMOTHERAPY | SERUM-LEVELS | TYROSINE KINASE INHIBITOR | ACUTE MYELOID-LEUKEMIA | MUTATIONS | HEMATOLOGY | CLINICAL-RESPONSE | APLASTIC-ANEMIA | STEM-CELL MOBILIZATION | Niacinamide - analogs & derivatives | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Humans | Staurosporine - analogs & derivatives | Antineoplastic Agents - therapeutic use | Benzenesulfonates - therapeutic use | Membrane Proteins - pharmacology | Phenylurea Compounds | Benzenesulfonates - pharmacology | Multicenter Studies as Topic | Protein Kinase Inhibitors - antagonists & inhibitors | Membrane Proteins - physiology | Inhibitory Concentration 50 | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Membrane Proteins - blood | Pyridines - therapeutic use | Antineoplastic Agents - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Treatment Outcome | Leukemia, Myeloid, Acute - blood | Piperazines - therapeutic use | Piperazines - pharmacology | Randomized Controlled Trials as Topic | Indazoles - pharmacology | Drug Antagonism | Protein Kinase Inhibitors - therapeutic use | Staurosporine - therapeutic use | Carbazoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Carbazoles - pharmacology | Indazoles - therapeutic use | Staurosporine - pharmacology | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
Journal Article
Immunity, ISSN 1074-7613, 2006, Volume 25, Issue 4, pp. 607 - 617
Journal Article
Biomaterials, ISSN 0142-9612, 2010, Volume 32, Issue 1, pp. 65 - 74
Abstract The treatment of challenging fractures and large osseous defects presents a formidable problem for orthopaedic surgeons. Tissue... 
Advanced Basic Science | Dentistry | Drug delivery | Alginate | Bone morphogenetic protein | Scaffold | Bone regeneration | Nanofiber mesh | POLYCAPROLACTONE SCAFFOLDS | POLY(L-LACTIDE) MEMBRANE | MICROCOMPUTED TOMOGRAPHY | HYDROGELS | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | RESORBABLE POLYMERIC MEMBRANES | TISSUE REGENERATION | BIODEGRADABLE CARRIER | CONTROLLED SCAFFOLD DEGRADATION | IN-VIVO | MORPHOGENETIC PROTEIN-2 | Femur - pathology | Angiography | Humans | Femur - diagnostic imaging | X-Ray Microtomography | Biomechanical Phenomena - drug effects | Bone Morphogenetic Proteins - pharmacology | Wound Healing - drug effects | Alginates - pharmacology | Bone Regeneration - drug effects | Nanofibers - ultrastructure | Bone Morphogenetic Proteins - administration & dosage | Implants, Experimental | Bone Morphogenetic Protein 2 | Rats | Recombinant Proteins - pharmacology | Femur - physiopathology | Recombinant Proteins - administration & dosage | Transforming Growth Factor beta - pharmacology | Glucuronic Acid - pharmacology | Animals | Transforming Growth Factor beta - administration & dosage | Kinetics | Drug Delivery Systems - methods | Hexuronic Acids - pharmacology | Finite element method | Biomedical materials | Nanocomposites | Nanomaterials | Bones | Nanostructure | Repair | Growth factors | Defects | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2012, Volume 122, Issue 6, pp. 2104 - 2113
Journal Article