Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (4299) 4299
Publication (596) 596
Book / eBook (159) 159
Book Review (64) 64
Book Chapter (32) 32
Newsletter (22) 22
Conference Proceeding (5) 5
Dissertation (2) 2
Newspaper Article (2) 2
Paper (2) 2
Data Set (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (2773) 2773
index medicus (2347) 2347
humans (2156) 2156
male (882) 882
rats (862) 862
mice (787) 787
pharmacology & pharmacy (783) 783
cell biology (768) 768
physiology (753) 753
proteins (753) 753
biochemistry & molecular biology (645) 645
research article (593) 593
research (589) 589
multidisciplinary sciences (583) 583
medicine (569) 569
membrane transport modulators - pharmacology (556) 556
neurosciences (548) 548
science (501) 501
female (500) 500
cells, cultured (458) 458
physiological aspects (452) 452
cell membrane - metabolism (446) 446
expression (425) 425
signal transduction (421) 421
apoptosis (417) 417
cell line (415) 415
biology (404) 404
biochemistry (396) 396
cells (386) 386
article (372) 372
rodents (371) 371
calcium - metabolism (360) 360
kinetics (359) 359
dose-response relationship, drug (356) 356
gene expression (353) 353
pharmacology (341) 341
kinases (310) 310
membrane transport proteins - metabolism (309) 309
phosphorylation (309) 309
cancer (306) 306
activation (302) 302
rats, sprague-dawley (300) 300
calcium (299) 299
biological transport (284) 284
analysis (282) 282
cell line, tumor (278) 278
membrane proteins (276) 276
metabolism (275) 275
membranes (272) 272
mutation (271) 271
mitochondria (270) 270
membrane potentials - drug effects (269) 269
oxidative stress (265) 265
transport (263) 263
membrane proteins - metabolism (260) 260
membrane transport modulators (258) 258
neurons (252) 252
p-glycoprotein (252) 252
plasma-membrane (252) 252
biological transport - drug effects (250) 250
ion channels (248) 248
inhibition (247) 247
in-vitro (245) 245
in vitro techniques (243) 243
cell membranes (241) 241
time factors (238) 238
membrane transport proteins - antagonists & inhibitors (235) 235
health aspects (228) 228
lipids (224) 224
genetic aspects (222) 222
protein binding (222) 222
rats, wistar (218) 218
signal transduction - drug effects (218) 218
brain (216) 216
protein transport (213) 213
patch-clamp techniques (212) 212
cell membrane - drug effects (211) 211
enzyme inhibitors - pharmacology (202) 202
mice, inbred c57bl (201) 201
ligands (200) 200
oncology (200) 200
mitochondria - metabolism (197) 197
binding sites (196) 196
protein (193) 193
membrane (190) 190
apoptosis - drug effects (188) 188
permeability (184) 184
homeostasis (178) 178
neuroscience (178) 178
molecular cell biology (177) 177
receptors (177) 177
binding (175) 175
amino acid sequence (174) 174
models, biological (173) 173
neurons - drug effects (172) 172
nervous system (171) 171
review (170) 170
transporter (170) 170
molecular sequence data (169) 169
life sciences (167) 167
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (109) 109
UofT at Mississauga - Stacks (12) 12
Online Resources - Online (9) 9
Collection Dvlpm't (Acquisitions) - Closed Orders (7) 7
UofT at Scarborough - Stacks (7) 7
UTL at Downsview - May be requested (6) 6
Collection Dvlpm't (Acquisitions) - Vendor file (4) 4
Earth Sciences (Noranda) - Stacks (3) 3
Engineering & Comp. Sci. - Reference (2) 2
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Dentistry (Harry R Abbott) - Stacks (1) 1
Dentistry (Harry R Abbott) - Withdrawn (1) 1
Humber River Regional Hospital - Finch Stacks (1) 1
Physics - Stacks (1) 1
Toronto East General Hospital - Stacks (1) 1
Trinity College (John W Graham) - Stacks (1) 1
Trinity College (John W Graham) - Storage (1) 1
UofT at Mississauga - Reference (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (4479) 4479
Russian (13) 13
Spanish (11) 11
French (5) 5
Ukrainian (3) 3
Chinese (2) 2
Japanese (2) 2
Norwegian (1) 1
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Transporters and drug-drug interactions: Important determinants of drug disposition and effects
by König, Jörg and Müller, Fabian and Fromm, Martin F
Pharmacological Reviews, ISSN 0031-6997, 07/2013, Volume 65, Issue 3, pp. 944 - 966
Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs. They are localized in organs such as small intestine,... 
H+/ORGANIC CATION ANTIPORTER | SALT EXPORT PUMP | QUINIDINE-DIGOXIN INTERACTION | PHARMACOLOGY & PHARMACY | ST-JOHNS-WORT | ORGANIC ANION TRANSPORTERS | BLOOD-BRAIN-BARRIER | TOXIN EXTRUSION 1 | INCREASED ORAL BIOAVAILABILITY | INTESTINAL P-GLYCOPROTEIN | CANCER RESISTANCE PROTEIN | Food-Drug Interactions | Humans | Membrane Transport Proteins - drug effects | Genotype | Permeability | Membrane Transport Modulators - metabolism | Phenotype | Absorption | Animals | Drug Interactions | Biological Transport | Membrane Transport Proteins - genetics | Membrane Transport Modulators - pharmacology | Membrane Transport Proteins - metabolism | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text New advances in NMDA receptor pharmacology
by Ogden, Kevin K and Traynelis, Stephen F
Trends in Pharmacological Sciences, ISSN 0165-6147, 2011, Volume 32, Issue 12, pp. 726 - 733
N -Methyl- d -aspartate (NMDA) receptors are tetrameric ion channels containing two of four possible GluN2 subunits. These receptors have been implicated for... 
Advanced Basic Science | GLUTAMATE RECEPTORS | ALLOSTERIC MODULATORS | SUBUNIT SELECTIVITY | ISOLATED SPINAL-CORD | SYNAPTIC-TRANSMISSION | POLYAMINE RECOGNITION SITE | PREGNENOLONE SULFATE | PHARMACOLOGY & PHARMACY | ACID-INDUCED RESPONSES | D-ASPARTATE RECEPTOR | PROTON SENSITIVITY | Allosteric Regulation - drug effects | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Membrane Transport Modulators - chemistry | Humans | Protein Subunits - agonists | Receptors, N-Methyl-D-Aspartate - metabolism | Protein Subunits - metabolism | Membrane Transport Modulators - metabolism | Animals | Protein Isoforms - metabolism | Protein Isoforms - agonists | Protein Isoforms - chemistry | Receptors, N-Methyl-D-Aspartate - chemistry | Membrane Transport Modulators - pharmacology | Receptors, N-Methyl-D-Aspartate - agonists | Membrane Transport Modulators - therapeutic use | Ligands | Protein Conformation | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Binding Sites | Protein Isoforms - antagonists & inhibitors | Methyl aspartate | Nervous system diseases | Pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Nonclassical pharmacology of the dopamine transporter: Atypical inhibitors, allosteric modulators, and partial substrates
by Schmitt, Kyle C and Rothman, Richard B and Reith, Maarten E.A
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2013, Volume 346, Issue 1, pp. 2 - 10
The dopamine transporter (DAT) is a sodium-coupled symporter protein responsible for modulating the concentration of extraneuronal dopamine in the brain. The... 
BIOGENIC-AMINE TRANSPORTERS | NEUROTRANSMITTER-SODIUM SYMPORTER | BACTERIAL HOMOLOG | CRYSTAL-STRUCTURE | PROTEIN-PROTEIN INTERACTIONS | COCAINE | PHARMACOLOGY & PHARMACY | MONOAMINE TRANSPORTERS | LEUT | BINDING-SITES | IDENTIFICATION | Dopamine Plasma Membrane Transport Proteins - metabolism | Allosteric Regulation | Humans | Dopamine Plasma Membrane Transport Proteins - chemistry | Brain - metabolism | Nerve Tissue Proteins - chemistry | Dopamine - secretion | Protein Isoforms - metabolism | Protein Isoforms - agonists | Protein Isoforms - chemistry | Membrane Transport Modulators - pharmacology | Neurons - secretion | Biological Transport - drug effects | Neurons - metabolism | Neurons - drug effects | Dopamine - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Dopamine Plasma Membrane Transport Proteins - agonists | Nerve Tissue Proteins - agonists | Brain - drug effects | Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Brain - secretion | Animals | Ligands | Protein Conformation | Protein Isoforms - antagonists & inhibitors
Journal Article
Details down arrow
4. ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development
by Choi, Young Hee and Yu, Ai-Ming
Current Pharmaceutical Design, ISSN 1381-6128, 2014, Volume 20, Issue 5, pp. 793 - 807
Multidrug resistance (MDR) is a serious problem that hampers the success of cancer pharmacotherapy. A common mechanism is the overexpression of ATP-binding... 
Drug development | Pharmacokinetics | ABC transporter | Cancer therapy | Multidrug resistance | multidrug resistance | CANALICULAR MEMBRANE-VESICLES | RAT SMALL-INTESTINE | ACUTE MYELOID-LEUKEMIA | BLOOD-BRAIN-BARRIER | INTESTINAL P-GLYCOPROTEIN | CELL LUNG-CANCER | BREAST-CANCER | SOUTHWEST-ONCOLOGY-GROUP | ACUTE LYMPHOBLASTIC-LEUKEMIA | pharmacokinetics | PHARMACOLOGY & PHARMACY | PROTEIN-KINASE INHIBITORS | Neoplasms - metabolism | Membrane Transport Modulators - chemistry | Drug Resistance, Multiple | Humans | Molecular Conformation | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - chemistry | Membrane Transport Modulators - pharmacology | Drug Design | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Modulators - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Biological Transport - drug effects | Drug Evaluation, Preclinical - methods | Neoplasm Proteins - chemistry | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Animals | Models, Biological | Membrane Transport Modulators - therapeutic use | ATP-Binding Cassette Transporters - antagonists & inhibitors
Journal Article
Details down arrow
5. Full Text Positive Modulators of the N-Methyl- d -aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters
by Krausova, Barbora and Slavikova, Barbora and Nekardova, Michaela and Hubalkova, Pavla and Vyklicky, Vojtech and Chodounska, Hana and Vyklicky, Ladislav and Kudova, Eva
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2018, Volume 61, Issue 10, pp. 4505 - 4516
Here, we report the synthesis of pregn-5-ene and androst-5-ene dicarboxylic acid esters and explore the structure activity relationship (SAR) for their... 
PHYSICOCHEMICAL PROPERTIES | MOLECULAR-MECHANISM | NMDA RECEPTOR | NEURODEVELOPMENTAL DISORDERS | CHEMISTRY, MEDICINAL | INHIBITION | NEUROSTEROIDS | PREGNENOLONE SULFATE | MUTATIONS | HIPPOCAMPAL-NEURONS | SYNAPTIC PLASTICITY | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Membrane Transport Modulators - chemistry | Allosteric Regulation | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Models, Molecular | Structure-Activity Relationship | Membrane Transport Modulators - pharmacology | HEK293 Cells | Pregnenolone - pharmacology | Protein Conformation | Steroids - pharmacology | Molecular Structure | Steroids - chemistry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Characterization of the effects of Cl− channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl− channels
by Liu, Yani and Zhang, Huiran and Huang, Dongyang and Qi, Jinlong and Xu, Jiaxi and Gao, Haixia and Du, Xiaona and Gamper, Nikita and Zhang, Hailin
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 7/2015, Volume 467, Issue 7, pp. 1417 - 1430
The Ca2+ activated Cl− channels (CaCCs) play a multitude of important physiological functions. A number of candidate proteins have been proposed to form CaCC,... 
Biomedicine | Ca 2+ activated Cl − channels (CaCCs) | Human Physiology | Bestrophin-1 | Patch clamp | Inhibitor | TMEM16A | CHO cells | PHYSIOLOGY | CHLORIDE CHANNELS | PROTEIN | BEST-DISEASE | MEMBRANE | CURRENTS | SENSORY NEURONS | Ca2+ activated Cl- channels (CaCCs) | SMOOTH-MUSCLE-CELLS | XENOPUS OOCYTES | K+ CHANNELS | RETINAL-PIGMENT EPITHELIUM | Anoctamin-1 | Cricetinae | Flufenamic Acid - pharmacology | Chloride Channels - antagonists & inhibitors | Cricetulus | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology | Humans | Nitrobenzoates - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Chloride Channels - metabolism | Animals | Bestrophins | Eye Proteins - metabolism | Tannins - pharmacology | Membrane Transport Modulators - pharmacology | Niflumic Acid - pharmacology | Eye Proteins - antagonists & inhibitors | CHO Cells | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
by Thorneloe, Kevin S and Cheung, Mui and Bao, Weike and Alsaid, Hasan and Lenhard, Stephen and Jian, Ming-Yuan and Costell, Melissa and Maniscalco-Hauk, Kristeen and Krawiec, John A and Olzinski, Alan and Gordon, Earl and Lozinskaya, Irina and Elefante, Lou and Qin, Pu and Matasic, Daniel S and James, Chris and Tunstead, James and Donovan, Brian and Kallal, Lorena and Waszkiewicz, Anna and Vaidya, Kalindi and Davenport, Elizabeth A and Larkin, Jonathan and Burgert, Mark and Casillas, Linda N and Marquis, Robert W and Ye, Guosen and Eidam, Hilary S and Goodman, Krista B and Toomey, John R and Roethke, Theresa J and Jucker, Beat M and Schnackenberg, Christine G and Townsley, Mary I and Lepore, John J and Willette, Robert N
Science Translational Medicine, ISSN 1946-6234, 11/2012, Volume 4, Issue 159, pp. 159ra148 - 159ra148
Pulmonary edema resulting from high pulmonary venous pressure (PVP) is a major cause of morbidity and mortality in heart failure (HF) patients, but current... 
MEDICINE, RESEARCH & EXPERIMENTAL | HIGH VASCULAR PRESSURE | ACTIVATION | PERMEABILITY | SHEAR-STRESS | INDUCED LUNG INJURY | RESISTANCE | RECEPTOR POTENTIAL VANILLOID-4 | MICE | EXPRESSION | INDUCED VASODILATATION | CELL BIOLOGY | Membrane Transport Modulators - chemistry | Calcium - metabolism | Humans | Heart Failure - physiopathology | Water-Electrolyte Balance - drug effects | Protein Transport - drug effects | Pulmonary Edema - etiology | Heart Rate - drug effects | TRPV Cation Channels - metabolism | TRPV Cation Channels - antagonists & inhibitors | Membrane Transport Modulators - pharmacology | Pulmonary Edema - prevention & control | Pulmonary Edema - pathology | Blood Pressure - drug effects | Lung - metabolism | Disease Models, Animal | Endothelium - pathology | Heart Failure - complications | Lung - pathology | Permeability - drug effects | Administration, Oral | Diuretics - pharmacology | Rats | Membrane Transport Modulators - administration & dosage | Heart Failure - pathology | Pulmonary Edema - drug therapy | Mice, Knockout | Endothelium - drug effects | Animals | Endothelium - metabolism | Lung - drug effects | Membrane Transport Modulators - therapeutic use | Mice | In Vitro Techniques | Ion Channel Gating - drug effects
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes
by Heise, T and Seewaldt‐Becker, E and Macha, S and Hantel, S and Pinnetti, S and Seman, L and Woerle, H. J
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 07/2013, Volume 15, Issue 7, pp. 613 - 621
ABSTRACT Aim To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of empagliflozin in patients with type 2 diabetes following oral... 
empagliflozin | pharmacokinetics | BI 10773 | SGLT2 inhibitor | pharmacodynamics | urinary glucose excretion | Empagliflozin | Pharmacodynamics | Pharmacokinetics | Urinary glucose excretion | DAPAGLIFLOZIN | MELLITUS | PREVALENCE | COTRANSPORTER-2 SGLT-2 INHIBITOR | CANAGLIFLOZIN | DISEASE | ENDOCRINOLOGY & METABOLISM | INTERVENTION | Glycosuria - chemically induced | Benzhydryl Compounds - administration & dosage | Humans | Middle Aged | Male | Incidence | Dose-Response Relationship, Drug | Polyuria - epidemiology | Benzhydryl Compounds - adverse effects | Hypoglycemic Agents - administration & dosage | Membrane Transport Modulators - pharmacology | Adult | Female | Glucosides - therapeutic use | Polyuria - etiology | Benzhydryl Compounds - therapeutic use | Glucosides - adverse effects | Glycosuria - physiopathology | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Glucosides - pharmacology | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Membrane Transport Modulators - administration & dosage | Diabetes Mellitus, Type 2 - urine | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Germany - epidemiology | Hypoglycemic Agents - pharmacology | Glycosuria - epidemiology | Diabetes Mellitus, Type 2 - blood | Glucosides - administration & dosage | Membrane Transport Modulators - therapeutic use | Aged | Benzhydryl Compounds - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Membrane Transport Modulators - adverse effects | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Care and treatment | Safety and security measures | Blood sugar | Diabetes therapy | Diabetes | Glucose
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Connexin channel modulators and their mechanisms of action
by Verselis, Vytas K and Srinivas, Miduturu
Neuropharmacology, ISSN 0028-3908, 12/2013, Volume 75, pp. 517 - 524
Gap junction channels and hemichannels formed by the connexin family of proteins play important roles in many aspects of tissue homeostasis in the brain and in... 
Connexin | Hemichannels | Pharmacology | Gap junctions | VOLTAGE | POTASSIUM CHANNELS | SYNAPTIC-TRANSMISSION | PERMEATION PATHWAY | PORE-LINING RESIDUES | NEUROSCIENCES | GAP-JUNCTION CHANNEL | CELL COMMUNICATION | INTERCELLULAR COMMUNICATION | MIMETIC PEPTIDES | PHARMACOLOGY & PHARMACY | ATP RELEASE | Connexins - antagonists & inhibitors | Animals | Gap Junctions - physiology | Humans | Membrane Transport Modulators - pharmacology | Ion Channels - drug effects | Ion Channels - physiology | Gap Junctions - drug effects | Connexins - chemistry | Connexins - metabolism | Ion Channel Gating - drug effects | Proteins
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein
by Chufan, Eduardo E and Kapoor, Khyati and Ambudkar, Suresh V
Biochemical Pharmacology, ISSN 0006-2952, 02/2016, Volume 101, pp. 40 - 53
P-glycoprotein (P-gp) is a member of the ATP-binding cassette transporter superfamily. This multidrug transporter utilizes energy from ATP hydrolysis for the... 
Drug-binding site | ABC transporter | Multidrug resistance | Modulators | Structural motifs | ABCB1 | TURNOVER | PHARMACOLOGY & PHARMACY | BINDING | TARIQUIDAR | RESIDUES | CATALYTIC CYCLE | Dibenzocycloheptenes - chemistry | Membrane Transport Modulators - chemistry | Hydrolysis - drug effects | Humans | Molecular Conformation | ATP Binding Cassette Transporter, Sub-Family B - chemistry | Quinolines - pharmacology | Tetrahydroisoquinolines - chemistry | Biocatalysis - drug effects | Dibenzocycloheptenes - metabolism | Adenosine Triphosphate - metabolism | Membrane Transport Modulators - pharmacology | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Binding Sites | Mutant Proteins - antagonists & inhibitors | Acridines - chemistry | Recombinant Proteins - metabolism | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Amino Acid Motifs | Quinolines - metabolism | Membrane Transport Modulators - metabolism | Animals | Hydrogen Bonding | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Mutant Proteins - chemistry | Lepidoptera | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Ligands | Molecular Docking Simulation | HeLa Cells | Adenosine Triphosphate - chemistry | ATP Binding Cassette Transporter, Sub-Family B - genetics | Amino Acid Substitution | Hydrolysis | Hydrogen | Cells | Protein binding | multidrug resistance | structural motifs | modulators | drug-binding site
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. BK channel modulators: A comprehensive overview
by Nardi, Antonio and Olesen, Søren-Peter
Current Medicinal Chemistry, ISSN 0929-8673, 05/2008, Volume 15, Issue 11, pp. 1126 - 1146
The large Ca2+-activated K+ channel (BK channel) reflects per excellence the dilemma of the molecular target driven drug discovery process. Significant... 
BK channel blockers | BK channel openers | KCa1.1 | BK channels | Maxi-K channels | BK channel modulators | SCORPION PEPTIDE BLOCKER | CHEMISTRY, MEDICINAL | PITUITARY GH CELLS | REGULATORY BETA-1 SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+-ACTIVATED K+ CHANNELS | HUMAN CORONARY-ARTERY | maxi-K channels | ACTIVATED POTASSIUM CHANNELS | HUMAN ENDOTHELIAL-CELLS | BREAST-CANCER CELLS | SALVIANOLIC ACID-B | BKCa | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | Membrane Transport Modulators - chemistry | Humans | Large-Conductance Calcium-Activated Potassium Channels - agonists | Potassium Channel Blockers - therapeutic use | Clinical Trials as Topic | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Animals | Large-Conductance Calcium-Activated Potassium Channels - physiology | Membrane Transport Modulators - pharmacology | Membrane Transport Modulators - therapeutic use | Molecular Structure | Drug Evaluation, Preclinical | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology
Journal Article
Details down arrow
12. Full Text Novel designer receptors to probe GPCR signaling and physiology
by Wess, Jürgen and Nakajima, Kenichiro and Jain, Shalini
Trends in Pharmacological Sciences, ISSN 0165-6147, 2013, Volume 34, Issue 7, pp. 385 - 392
Muscarinic receptor-based designer receptors have emerged as powerful novel tools to study G-protein-coupled receptor (GPCR) signaling and physiology. These... 
Advanced Basic Science | ACTIVATION | INHIBITION | PROTEIN-COUPLED RECEPTOR | REMOTE-CONTROL | IN-VIVO | PHARMACOLOGY & PHARMACY | SCANNING MUTAGENESIS | LIGAND | IDENTIFICATION | MUSCARINIC ACETYLCHOLINE-RECEPTOR | BETA-CELL FUNCTION | Membrane Transport Modulators - chemistry | Receptors, G-Protein-Coupled - metabolism | Humans | Models, Molecular | Structure-Activity Relationship | Receptors, G-Protein-Coupled - agonists | Membrane Transport Modulators - metabolism | Animals | Signal Transduction - drug effects | Membrane Transport Modulators - pharmacology | Ligands | Protein Conformation | Molecular Structure | Receptors, G-Protein-Coupled - chemistry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights