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1. Full Text Real‐time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action
by Cawston, Erin E and Redmond, William J and Breen, Courtney M and Grimsey, Natasha L and Connor, Mark and Glass, Michelle
British journal of pharmacology, ISSN 0007-1188, 10/2013, Volume 170, Issue 4, pp. 893 - 907
internalization | receptor signalling | cannabinoid receptor | desensitization | allosteric modulator | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Cannabinoid Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Cyclohexanols - metabolism | Transfection | Piperidines - pharmacology | HEK293 Cells | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Cyclohexanols - pharmacology | Cyclic AMP - metabolism | Potassium Channels, Inwardly Rectifying - drug effects | Rats | Protein Transport | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Membrane Potentials | Signal Transduction - drug effects | Receptor, Cannabinoid, CB1 - drug effects | Cell Line, Tumor | Ligands | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Kinetics | Potassium Channels, Inwardly Rectifying - metabolism | Cyclohexanol | Urea | Chemical properties | Studies | Binding sites | Index Medicus | Research Papers
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2. Nonclassical pharmacology of the dopamine transporter: Atypical inhibitors, allosteric modulators, and partial substrates
by Schmitt, Kyle C and Rothman, Richard B and Reith, Maarten E.A
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 07/2013, Volume 346, Issue 1, pp. 2 - 10
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Dopamine Plasma Membrane Transport Proteins - metabolism | Allosteric Regulation | Humans | Dopamine Plasma Membrane Transport Proteins - chemistry | Brain - metabolism | Nerve Tissue Proteins - chemistry | Dopamine - secretion | Protein Isoforms - metabolism | Protein Isoforms - agonists | Protein Isoforms - chemistry | Membrane Transport Modulators - pharmacology | Neurons - secretion | Biological Transport - drug effects | Neurons - metabolism | Neurons - drug effects | Dopamine - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Dopamine Plasma Membrane Transport Proteins - agonists | Nerve Tissue Proteins - agonists | Brain - drug effects | Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Brain - secretion | Animals | Ligands | Protein Conformation | Protein Isoforms - antagonists & inhibitors
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3. Full Text Pluronic ® block copolymers as modulators of drug efflux transporter activity in the blood–brain barrier
by Kabanov, Alexander V and Batrakova, Elena V and Miller, Donald W
Advanced drug delivery reviews, ISSN 0169-409X, 2003, Volume 55, Issue 1, pp. 151 - 164
P-glycoprotein | Multidrug resistance (MDR) | Multidrug resistant protein (MRP) | Block copolymer | Blood–brain barrier | Blood-brain barrier | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Blood-Brain Barrier - drug effects | Membrane Transport Modulators | Drug Carriers | Brain - blood supply | Poloxamer - toxicity | Biological Transport, Active | Pharmaceutical Preparations - metabolism | Animals | Poloxamer - pharmacology | Endothelium, Vascular - metabolism | Drug-Related Side Effects and Adverse Reactions | Membrane Transport Proteins - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Index Medicus
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4. Full Text New advances in NMDA receptor pharmacology
by Ogden, Kevin K and Traynelis, Stephen F
Trends in pharmacological sciences (Regular ed.), ISSN 0165-6147, 2011, Volume 32, Issue 12, pp. 726 - 733
Advanced Basic Science | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Allosteric Regulation - drug effects | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Membrane Transport Modulators - chemistry | Humans | Protein Subunits - agonists | Receptors, N-Methyl-D-Aspartate - metabolism | Protein Subunits - metabolism | Membrane Transport Modulators - metabolism | Animals | Protein Isoforms - metabolism | Protein Isoforms - agonists | Protein Isoforms - chemistry | Receptors, N-Methyl-D-Aspartate - chemistry | Membrane Transport Modulators - pharmacology | Receptors, N-Methyl-D-Aspartate - agonists | Membrane Transport Modulators - therapeutic use | Ligands | Protein Conformation | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Binding Sites | Protein Isoforms - antagonists & inhibitors | Methyl aspartate | Nervous system diseases | Pharmacology | Index Medicus
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5. BK channel modulators: A comprehensive overview
by Nardi, Antonio and Olesen, Søren-Peter
Current medicinal chemistry, ISSN 0929-8673, 05/2008, Volume 15, Issue 11, pp. 1126 - 1146
BK channel blockers | BK channel openers | KCa1.1 | BK channels | Maxi-K channels | BK channel modulators | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Membrane Transport Modulators - chemistry | Humans | Large-Conductance Calcium-Activated Potassium Channels - agonists | Potassium Channel Blockers - therapeutic use | Clinical Trials as Topic | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Animals | Large-Conductance Calcium-Activated Potassium Channels - physiology | Membrane Transport Modulators - pharmacology | Membrane Transport Modulators - therapeutic use | Molecular Structure | Drug Evaluation, Preclinical | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology
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6. Full Text Characterization of the effects of Cl− channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl− channels
by Liu, Yani and Liu, Yani and Zhang, Huiran and Zhang, Huiran and Huang, Dongyang and Huang, Dongyang and Qi, Jinlong and Qi, Jinlong and Xu, Jiaxi and Xu, Jiaxi and Gao, Haixia and Gao, Haixia and Du, Xiaona and Du, Xiaona and Gamper, Nikita and Gamper, Nikita and Zhang, Hailin and Zhang, Hailin
Pflügers Archiv, ISSN 0031-6768, 7/2015, Volume 467, Issue 7, pp. 1417 - 1430
Biomedicine | Ca 2+ activated Cl − channels (CaCCs) | Human Physiology | Bestrophin-1 | Patch clamp | Inhibitor | TMEM16A | CHO cells | Life Sciences & Biomedicine | Physiology | Science & Technology | Anoctamin-1 | Cricetinae | Flufenamic Acid - pharmacology | Chloride Channels - antagonists & inhibitors | Cricetulus | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology | Humans | Nitrobenzoates - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Chloride Channels - metabolism | Animals | Bestrophins | Eye Proteins - metabolism | Tannins - pharmacology | Membrane Transport Modulators - pharmacology | Niflumic Acid - pharmacology | Eye Proteins - antagonists & inhibitors | CHO Cells | Index Medicus
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7. Full Text Nonacidic Farnesoid X Receptor Modulators
by Flesch, Daniel and Cheung, Sun-Yee and Schmidt, Jurema and Gabler, Matthias and Heitel, Pascal and Kramer, Jan and Kaiser, Astrid and Hartmann, Markus and Lindner, Mara and Lüddens-Dämgen, Kerstin and Heering, Jan and Lamers, Christina and Lüddens, Hartmut and Wurglics, Mario and Proschak, Ewgenij and Schubert-Zsilavecz, Manfred and Merk, Daniel
Journal of medicinal chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 16, pp. 7199 - 7205
Pyridines - chemistry | Humans | Imidazoles - chemistry | Male | Structure-Activity Relationship | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | HEK293 Cells | Imidazoles - chemical synthesis | Imidazoles - metabolism | Drug Stability | Pyridines - chemical synthesis | PPAR alpha - genetics | Imidazoles - pharmacology | Receptors, Cytoplasmic and Nuclear - genetics | Rats, Sprague-Dawley | Hep G2 Cells | Cholesterol 7-alpha-Hydroxylase - genetics | Animals | Pyridines - metabolism | Sterol Regulatory Element Binding Protein 1 - genetics | Zolpidem | Molecular Docking Simulation | Pyridines - pharmacology | HeLa Cells | ATP Binding Cassette Transporter, Subfamily B, Member 11 | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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8. HCN channels modulators: The need for selectivity
by Romanelli, Maria Novella and Sartiani, Laura and Masi, Alessio and Mannaioni, Guido and Manetti, Dina and Mugelli, Alessandro and Cerbai, Elisabetta
Current topics in medicinal chemistry, ISSN 1568-0266, 07/2016, Volume 16, Issue 16, pp. 1764 - 1791
Atrial and Ventricular arrhythmia | Atrial fibrillation | Ivabradine | Drug design | Hyperpolarization-activated current | Selectivity | HCN channels | Parkinson’s disease | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Membrane Transport Modulators - chemistry | Animals | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Humans | Membrane Transport Modulators - pharmacology | Drug Design | Molecular Structure | Membrane Transport Modulators - chemical synthesis | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors
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