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Journal Article
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2014, Volume 20, Issue 5, pp. 793 - 807
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 11/2012, Volume 4, Issue 159, pp. 159ra148 - 159ra148
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 07/2013, Volume 15, Issue 7, pp. 613 - 621
ABSTRACT Aim To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of empagliflozin in patients with type 2 diabetes following oral... 
empagliflozin | pharmacokinetics | BI 10773 | SGLT2 inhibitor | pharmacodynamics | urinary glucose excretion | Empagliflozin | Pharmacodynamics | Pharmacokinetics | Urinary glucose excretion | DAPAGLIFLOZIN | MELLITUS | PREVALENCE | COTRANSPORTER-2 SGLT-2 INHIBITOR | CANAGLIFLOZIN | DISEASE | ENDOCRINOLOGY & METABOLISM | INTERVENTION | Glycosuria - chemically induced | Benzhydryl Compounds - administration & dosage | Humans | Middle Aged | Male | Incidence | Dose-Response Relationship, Drug | Polyuria - epidemiology | Benzhydryl Compounds - adverse effects | Hypoglycemic Agents - administration & dosage | Membrane Transport Modulators - pharmacology | Adult | Female | Glucosides - therapeutic use | Polyuria - etiology | Benzhydryl Compounds - therapeutic use | Glucosides - adverse effects | Glycosuria - physiopathology | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Glucosides - pharmacology | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Membrane Transport Modulators - administration & dosage | Diabetes Mellitus, Type 2 - urine | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Germany - epidemiology | Hypoglycemic Agents - pharmacology | Glycosuria - epidemiology | Diabetes Mellitus, Type 2 - blood | Glucosides - administration & dosage | Membrane Transport Modulators - therapeutic use | Aged | Benzhydryl Compounds - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Membrane Transport Modulators - adverse effects | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Care and treatment | Safety and security measures | Blood sugar | Diabetes therapy | Diabetes | Glucose
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2016, Volume 101, pp. 40 - 53
P-glycoprotein (P-gp) is a member of the ATP-binding cassette transporter superfamily. This multidrug transporter utilizes energy from ATP hydrolysis for the... 
Drug-binding site | ABC transporter | Multidrug resistance | Modulators | Structural motifs | ABCB1 | TURNOVER | PHARMACOLOGY & PHARMACY | BINDING | TARIQUIDAR | RESIDUES | CATALYTIC CYCLE | Dibenzocycloheptenes - chemistry | Membrane Transport Modulators - chemistry | Hydrolysis - drug effects | Humans | Molecular Conformation | ATP Binding Cassette Transporter, Sub-Family B - chemistry | Quinolines - pharmacology | Tetrahydroisoquinolines - chemistry | Biocatalysis - drug effects | Dibenzocycloheptenes - metabolism | Adenosine Triphosphate - metabolism | Membrane Transport Modulators - pharmacology | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Binding Sites | Mutant Proteins - antagonists & inhibitors | Acridines - chemistry | Recombinant Proteins - metabolism | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Amino Acid Motifs | Quinolines - metabolism | Membrane Transport Modulators - metabolism | Animals | Hydrogen Bonding | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Mutant Proteins - chemistry | Lepidoptera | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Ligands | Molecular Docking Simulation | HeLa Cells | Adenosine Triphosphate - chemistry | ATP Binding Cassette Transporter, Sub-Family B - genetics | Amino Acid Substitution | Hydrolysis | Hydrogen | Cells | Protein binding | multidrug resistance | structural motifs | modulators | drug-binding site
Journal Article