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1. Mendelian randomization
: methods for using genetic variants in causal estimation
by Burgess, Stephen and Thompson, Simon G., author
2015, Chapman & Hall/CRC interdisciplinary statics series, ISBN 1466573171, xiv, 210
Statistics as Topic | Statistical methods | Genetics, Medical | Genetic epidemiology | Epidemiologic Methods | Medical genetics | Statistical Theory & Methods | Statistics for the Biological Sciences | Epidemiology
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2. Full Text Best (but oft-forgotten) practices: The design, analysis, and interpretation of Mendelian randomization studies
by Haycock, Philip C and Burgess, Stephen and Wade, Kaitlin H and Bowden, Jack and Relton, Caroline and Smith, George Davey
The American journal of clinical nutrition, ISSN 0002-9165, 04/2016, Volume 103, Issue 4, pp. 965 - 978
Confounding | Mendelian randomization | Causality | Observational epidemiology | Evidence synthesis | Reverse causation | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Mendelian Randomization Analysis - methods | Reproducibility of Results | Genetic Association Studies | Interleukin-6 - genetics | Receptors, Interleukin-6 - genetics | Humans | Risk Factors | Databases, Genetic | Genotype | Coronary Artery Disease - diagnosis | Cost-Benefit Analysis | Coronary Artery Disease - genetics | Polymorphism, Single Nucleotide | Interleukin-6 - metabolism | Research Design | Receptors, Interleukin-6 - metabolism | Epidemiology | Analysis | Mendel's law | Intervention | Genotype & phenotype | Public health | Index Medicus | Abridged Index Medicus
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3. Full Text The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
by Swerdlow, Daniel I and Holmes, Michael V and Kuchenbaecker, Karoline B and Engmann, Jorgen E. L and Shah, Tina and Sofat, Reecha and Guo, Yiran and Chung, Christina and Peasey, Anne and Ster, Roman Pfi and Mooijaart, Simon P and Ireland, Helen A and Leusink, Maarten and Langenberg, Claudia and Li, KaWah and Palmen, Jutta and Howard, Philip and Cooper, Jackie A and nos, Fotios and Hardy, John and Nalls, Michael A and Li, Yun Rose and Lowe, Gordon and Stewart, Marlene and Bielinski, Suzette J and Peto, Julian and Timpson, Nicholas J and Gallacher, John and Dunlop, Malcolm and Houlston, Richard and Tomlinson, Ian and Tzoulaki, Ioanna and Luan, Jian'an and Boer, Jolanda M. A and Forouhi, Nita G and Onland-Moret, N. Charlotte and van der Schouw, Yvonne T and Schnabel, Renate B and Hubacek, Jaroslav A and Kubinova, Ruzena and Baceviciene, Migle and Tamosiunas, Abdonas and Pajak, Anzej and Navis, Gerjan and Mateo Leach, Irene and Bakker, Stephan J. L and Gansevoort, Ron T and Kumari, Meena and van der Harst, Pim and Asselbergs, Folkert W and The Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium and Interleukin-6 Receptor Mendelian R and Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium
The Lancet (British edition), ISSN 0140-6736, 03/2012, Volume 379, Issue 9822, pp. 1214 - 1224
Internal Medicine | C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | SOLUBLE IL-6 | INDIVIDUAL PARTICIPANTS DATA | JOINT ANALYSIS | IL-6 RECEPTOR | GENOME-WIDE ASSOCIATION | TOCILIZUMAB | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | General aspects | Medical sciences | Coronary heart disease | Antibodies, Monoclonal, Humanized - adverse effects | Gene Frequency - genetics | Antibodies, Monoclonal, Humanized - therapeutic use | Genetic Association Studies | Receptors, Interleukin-6 - genetics | Humans | Inflammation Mediators - blood | Genotype | Treatment Outcome | Receptors, Interleukin-6 - antagonists & inhibitors | Signal Transduction - genetics | Randomized Controlled Trials as Topic | Coronary Disease - prevention & control | Phenotype | Coronary Disease - genetics | Signal Transduction - drug effects | Mendelian Randomization Analysis | Polymorphism, Single Nucleotide - genetics | Genetic Variation - genetics | Prevention | Drug therapy | Health aspects | Risk factors | Interleukin-6 | Cytokine receptors | Physiological aspects | Genetic aspects | Research | Studies | Medical research | Cardiovascular disease | Cholesterol | Cancer | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
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4. Full Text Methodological Challenges in Mendelian Randomization
by Tyler J. VanderWeele and Eric J. Tchetgen Tchetgen and Marilyn Cornelis and Peter Kraft
Epidemiology (Cambridge, Mass.), ISSN 1044-3983, 5/2014, Volume 25, Issue 3, pp. 427 - 435
Genetic markers | Phenotypes | Sensitivity analysis | Medical genetics | Random allocation | Instrumental variables estimation | Instrumental variables | Cigarettes | Epidemiology | Methods | Lung neoplasms | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Public health. Hygiene-occupational medicine | Public health. Hygiene | General aspects | Miscellaneous | Biological and medical sciences | Medical sciences | Mendelian Randomization Analysis - methods | Bias | Humans | Sensitivity and Specificity | Genotype | Genetic Markers | Random Allocation | Gene-Environment Interaction | Index Medicus
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5. Full Text Genetically low vitamin D concentrations and increased mortality: mendelian randomisation analysis in three large cohorts
by Afzal, Shoaib and Brøndum-Jacobsen, Peter and Bojesen, Stig E and Nordestgaard, Børge G
BMJ : British Medical Journal, ISSN 0959-8138, 11/2014, Volume 349, Issue nov18 2, pp. g6330 - g6330
RESEARCH | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Vitamin D Deficiency - genetics | Calcifediol - blood | Gene Frequency | Humans | Neoplasms - mortality | Genotype | Vitamin D Deficiency - mortality | Calcifediol - deficiency | Confounding Factors (Epidemiology) | Mendelian Randomization Analysis | Cardiovascular Diseases - mortality | Causality | Cohort Studies | Index Medicus | Abridged Index Medicus
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6. Full Text Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
by Burgess, Stephen and Butterworth, Adam and Thompson, Simon G
Genetic epidemiology, ISSN 0741-0395, 11/2013, Volume 37, Issue 7, pp. 658 - 665
instrumental variables | Mendelian randomization | genome‐wide association study | weak instruments | causal inference | Causal inference | Weak instruments | Instrumental variables | Genome-wide association study | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Mathematical & Computational Biology | Mendelian Randomization Analysis - methods | Genome-Wide Association Study | Bias | Humans | Risk Factors | Genes - genetics | Linkage Disequilibrium - genetics | Coronary Disease - physiopathology | Linear Models | Cholesterol, LDL - genetics | Likelihood Functions | Phenotype | Coronary Disease - genetics | Coronary Disease - metabolism | Cholesterol, LDL - biosynthesis | Cholesterol, LDL - metabolism | Least-Squares Analysis | Genetic Variation - genetics | Models, Genetic | Odds Ratio | Genetic research | Coronary heart disease | Low density lipoproteins | Analysis | Genomics | Cholesterol | Index Medicus | genome-wide association study
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7. Full Text Adult height, coronary heart disease and stroke : A multi-locus Mendelian randomization meta-analysis
by Nüesch, Eveline and Dale, Caroline and Palmer, Tom M and White, Jon and Keating, Brendan J and van Iperen, Erik P A and Goel, Anuj and Padmanabhan, Sandosh and Asselbergs, F. W and Verschuren, W. M and Wijmenga, C and Van der Schouw, Y. T and Onland-Moret, N. C and Lange, Leslie A and Hovingh, G. K and Sivapalaratnam, Suthesh and Morris, Richard W and Whincup, Peter H and Wannamethe, Goya S and Gaunt, Tom R and Ebrahim, Shah and Steel, Laura and Nair, Nikhil and Reiner, Alexander P and Kooperberg, Charles and Wilson, James F and Bolton, Jennifer L and McLachlan, Stela and Price, Jacqueline F and Strachan, Mark W J and Robertson, Christine M and Kleber, Marcus E and Delgado, Graciela and März, Winfried and Melander, Olle and Dominiczak, Anna F and Farrall, Martin and Watkins, Hugh and Leusink, Maarten and Maitland-van der Zee, Anke H and de Groot, Mark C H and Dudbridge, Frank and Hingorani, Aroon and Ben-Shlomo, Yoav and Lawlor, Debbie A and Amuzu, A and Caufield, M and Cavadino, A and Cooper, J and Davies, T. L and Day, I. N and nos, F and Engmann, J and Finan, C and Giambartolomei, C and Hardy, R and Humphries, S. E and Hypponen, E and Kivimaki, M and Kuh, D and Kumari, M and Ong, K and Plagnol, V and Power, C and Richards, M and Shah, S and Shah, T and Sofat, R and Talmud, P. J and Wareham, N and Warren, H and Whittaker, J. C and Wong, A and Zabaneh, D and Smith, George Davey and Wells, Jonathan C and Leon, David A and Holmes, Michael V and Casas, Juan P and EPIC-Netherland Investigators and UCLEB Investigators and IN Day
International journal of epidemiology, ISSN 0300-5771, 12/2016, Volume 45, Issue 6, pp. 1927 - 1937
Medicine(all) | Epidemiology | Journal Article | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Blood Pressure | Body Mass Index | Coronary Disease - blood | Mendelian Randomization Analysis - methods | Genetic Predisposition to Disease | Cholesterol - blood | Humans | Risk Factors | Coronary Disease - epidemiology | Logistic Models | Body Height - genetics | Stroke - blood | Triglycerides - blood | Observational Studies as Topic | Stroke - epidemiology | Polymorphism, Single Nucleotide | Respiratory Function Tests | Index Medicus | Mendelian Randomisation and Instrumental Variable Analysis | Hälsovetenskap | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences
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8. Full Text The Role of Adiponectin in Coronary Heart Disease Risk: A Mendelian Randomization Study
by Borges, Maria Carolina and Lawlor, Debbie A and de Oliveira, Cesar and White, Jon and Horta, Bernardo Lessa and Barros, Aluísio JD
Circulation research, ISSN 0009-7330, 06/2016, Volume 119, Issue 3, pp. 491 - 499
Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Mendelian Randomization Analysis - methods | Coronary Disease - genetics | Humans | Risk Factors | Polymorphism, Single Nucleotide - genetics | Genetic Variation - genetics | Adiponectin - physiology | Genome-Wide Association Study - methods | Index Medicus | coronary artery disease | adiponectin | cardiovascular disease | Clinical Track | 10062 | 10084 | mendelian randomization analysis obesity | 10189 | 10015 | 10058
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9. Full Text A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization
by Bowden, Jack and Del Greco M, Fabiola and Minelli, Cosetta and Davey Smith, George and Sheehan, Nuala and Thompson, John
Statistics in medicine, ISSN 0277-6715, 05/2017, Volume 36, Issue 11, pp. 1783 - 1802
instrumental variables | Mendelian randomization | meta‐analysis | pleiotropy | MR‐Egger regression | meta-analysis | MR-Egger regression | Statistics & Probability | Physical Sciences | Life Sciences & Biomedicine | Medical Informatics | Public, Environmental & Occupational Health | Mathematics | Medicine, Research & Experimental | Science & Technology | Mathematical & Computational Biology | Research & Experimental Medicine | Data Interpretation, Statistical | Meta-Analysis as Topic | Genetic Pleiotropy | Models, Statistical | Humans | Mendelian Randomization Analysis | Genetics | Statistical methods | Medical statistics | Epidemiology | Index Medicus
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