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1. Full Text Lukas Hintermann
European Journal of Organic Chemistry, ISSN 1434-193X, 10/2017, Volume 2017, Issue 37, pp. 5423 - 5423
“Menthol is one of my favorite chemicals, with its beautiful large crystals, mint odor, and the cooling sensation it causes on skin…” Find out more about this... 
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2. Menthol - pharmacology of an important naturally medicinal "cool"
by Farco, Joseph A and Grundmann, Oliver
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2013, Volume 13, Issue 1, pp. 124 - 131
Menthol, a natural product of the peppermint plant Mentha x piperita (Lamiaceae), is a monoterpene which is widely used as a natural product in cosmetics, a... 
Menthol | TRPM8 | TRPA1 | CMR1 | Mentha x piperita | Nicotine | CELLS | nicotine | CHEMISTRY, MEDICINAL | ANESTHETIC ACTIVITY | RECEPTOR | PEPPERMINT OIL | TRPM8 AGONIST | IN-VIVO | INDUCED CA2+ RELEASE | CHANNELS | COLD | (-)-MENTHOL | Biological Products - chemistry | Animals | Menthol - pharmacology | Menthol - therapeutic use | Humans | Menthol - adverse effects | Biological Products - adverse effects | Biological Products - pharmacology | Menthol - chemistry | Transient Receptor Potential Channels - metabolism | Transient Receptor Potential Channels - agonists | Biological Products - therapeutic use
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3. Full Text Menthol: A simple monoterpene with remarkable biological properties
by Kamatou, Guy P.P and Vermaak, Ilze and Viljoen, Alvaro M and Lawrence, Brian M
Phytochemistry, ISSN 0031-9422, 12/2013, Volume 96, pp. 15 - 25
Menthol ranks with vanilla and citrus as one of the most important flavouring additives. The chemical and biological properties of menthol are reviewed.... 
Cooling effects | Mentha piperita | Menthol | Flavour | Mentha canadensis | Biological activity | ESSENTIAL OILS | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIFUNGAL ACTIVITY | STRATUM-CORNEUM | FUSARIUM-VERTICILLIOIDES | PLANT SCIENCES | INSECTICIDAL ACTIVITY | IN-VITRO | CHEMICAL-COMPOSITION | PERCUTANEOUS-ABSORPTION | SKIN-PENETRATION ENHANCERS | Monoterpenes - isolation & purification | Oils, Volatile - chemistry | Humans | Oils, Volatile - pharmacology | Menthol - chemistry | Oils, Volatile - isolation & purification | Body Temperature - physiology | Mentha - chemistry | Monoterpenes - pharmacology | Menthol - isolation & purification | Menthol - pharmacology | Monoterpenes - chemistry | Molecular Structure | Index Medicus
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4. Menthol and methol containing external remedies
: Use, mode of effect and tolerance in children. International Symposium, Paris, April, 1966. Proceedings, Comptes Rendus, Verhandlungen
by Dost, Friedrich Hartmut and Leiber, Bernfried
1967, 187
Pediatrics | Congresses | Menthol
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5. Full Text TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
by Liu, Boyi and Fan, Lu and Balakrishna, Shrilatha and Sui, Aiwei and Morris, John B and Jordt, Sven-Eric
Pain, ISSN 0304-3959, 10/2013, Volume 154, Issue 10, pp. 2169 - 2177
The analgesic mechanism of menthol remains controversial. In behavioral and imaging tests in mice, we identify TRPM8 as the major mediator of menthol... 
Analgesia | Acrolein | Heat | Visceral pain | TRPA1 | Capsaicin | Menthol | TRPM8 | TRPV1 | Acetic acid | Inflammatory pain | Menthol Analgesia TRPM8 TRPV1 TRPA1 Inflammatory pain Visceral pain Acetic acid Acrolein Capsaicin Heat | ANTAGONIST | ANESTHETIC ACTIVITY | NEUROSCIENCES | SENSORY NEURONS | CLINICAL NEUROLOGY | CELLULAR BASIS | GABA(A) RECEPTOR | PHARMACOLOGY | COLD SENSITIVITY | ANESTHESIOLOGY | CHANNELS | MODULATION | Acute Pain - drug therapy | Analgesia - methods | Mice, Inbred C57BL | Cells, Cultured | Male | Pain Measurement - drug effects | TRPM Cation Channels - physiology | Mice, Knockout | Pain Measurement - methods | Animals | Menthol - pharmacology | Menthol - therapeutic use | Acute Pain - physiopathology | Inflammation - drug therapy | Mice | Inflammation - physiopathology | Analgesics
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6. Preliminary scientific evaluation of the possible public health effects of menthol versus nonmenthol cigarettes
United States. Food and Drug Administration issuing body
2013
Menthol | Cigarettes | Health aspects | Smoking
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7. Reference addendum
: preliminary scientific evaluation of the possible public health effects of methol versus nonmenthol cigarettes
United States. Food and Drug Administration issuing body
2013
The "Preliminary Scientific Evaluation of the Possible Public Health Effects of Menthol versus Nonmenthol Cigarettes" was submitted for Peer Review in August... 
Menthol | Cigarettes | Health aspects | Smoking
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8. Menthol cigarettes
: no disproportionate impact on public health
United States. Food and Drug Administration issuing body
2011
Menthol | Cigarettes | Health aspects | Smoking
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9. Full Text Oral l-menthol reduces thermal sensation, increases work-rate and extends time to exhaustion, in the heat at a fixed rating of perceived exertion
by Flood, T.R and Waldron, M and Jeffries, O
European Journal of Applied Physiology, ISSN 1439-6319, 07/2017, Volume 117, Issue 7, pp. 1501 - 1512
Purpose The study investigated the effect of a non-thermal cooling agent, L-menthol, on exercise at a fixed subjective rating of perceived exertion (RPE) in a... 
Thermoregulation | Pacing | Perception | Heat | Menthol | Exercise | HYPERTHERMIA | SPORT SCIENCES | PHYSIOLOGY | PROLONGED EXERCISE | EXERCISE PERFORMANCE | FATIGUE | BODY-TEMPERATURE | WARM | RESPONSES | ANTICIPATORY REDUCTION | ENDURANCE EXERCISE | Mouthwashes | Menthol - pharmacology | Energy Metabolism | Humans | Adult | Male | Hot Temperature | Physical Exertion - drug effects | Menthol - administration & dosage | Perception - drug effects | Skin Temperature | Heart rate | Physical training | Cold | Temperature effects | L-Menthol | Human factors research | Skin
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10. Toxicity of L-Menthol and its derivative four storage insects
by Aggarwal, K. K and Tripathi, A. K and Ahmad, Ateeque and Prajapati, Veena and Verma, Neetu and Kumar, Sushil
Toxicity of L-Menthol and its derivative four storage insects, 01/2001
L-menthol isolated from the essential oil of Mentha arvensis and seven of its acyl derivatives were tested for contact and vapour toxicity, and ovicidal and... 
Zoology | L-menthol, acyl derivatives, toxicity, ovicidal activity, repellency, storage insects, Callosobruchus maculatus, Rhyzopertha dominica, Sitophilus oryzae, Tribolium castaneum L-menthol, dérivés acétylés, toxicité, activité ov
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11. Full Text Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice
by Ha, Michael A and Smith, Gregory J and Cichocki, Joseph A and Fan, Lu and Liu, Yi-Shiuan and Caceres, Ana I and Jordt, Sven Eric and Morris, John B
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0117128 - e0117128
Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known.... 
RESPONSES | IN-VITRO | IRRITANTS | PAIN | CAPSAICIN COUGH | MULTIDISCIPLINARY SCIENCES | MOUSE | TRP CHANNELS | SENSITIVITY | NICOTINE METABOLISM | COLD RECEPTOR | Smoking - adverse effects | Animals | Menthol - pharmacology | TRPM Cation Channels - antagonists & inhibitors | Acrolein - administration & dosage | Cotinine - blood | Respiration - drug effects | TRPM Cation Channels - agonists | Female | Mice | Menthol - administration & dosage | Irritants - administration & dosage | Cotinine | Smoking | L-Menthol | Smoke | Blood | Transient receptor potential proteins | Acrolein | Toxicology | Cyclohexanone | Metabolites | Sensory neurons | Menthol | Pharmaceutical sciences | Irritation | Tobacco smoke | Exposure | Cigarettes | Cigarette smoking | Metabolism | Blood levels | Medicine | Studies | Addiction | Pharmacy | Anesthesiology | Plethysmography | Cigarette smoke | Nicotine | Index Medicus
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12. Full Text (−)-menthol increases excitatory transmission by activating both TRPM8 and TRPA1 channels in mouse spinal lamina II layer
by Luo, Yuhui and Sun, Wuping and Feng, Xiaojin and Ba, Xiyuan and Liu, Tao and Guo, Jing and Xiao, Lizu and Jiang, Jin and Jiang, Changyu and Hao, Yue and Xiong, Donglin
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2019, Volume 516, Issue 3, pp. 825 - 830
(−)-menthol, a major form of menthol, is one of the most commonly used chemicals. Many studies have demonstrated that (−)-menthol produces analgesic action... 
(−)-menthol | Spinal cord | Synaptic transmission | TRP channels | BIOCHEMISTRY & MOLECULAR BIOLOGY | PIPERINE | SENSITIVITY | (-)-menthol | TRPV1 | SENSORY NEURONS | SUBSTANTIA-GELATINOSA NEURONS | RECEPTOR POTENTIAL CHANNELS | BIOPHYSICS | ZINGERONE | MENTHOL | ANALGESIA | Analgesics
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13. Full Text Metabolomic profiles of current cigarette smokers
by Hsu, Ping‐Ching and Lan, Renny S and Brasky, Theodore M and Marian, Catalin and Cheema, Amrita K and Ressom, Habtom W and Loffredo, Christopher A and Pickworth, Wallace B and Shields, Peter G
Molecular Carcinogenesis, ISSN 0899-1987, 02/2017, Volume 56, Issue 2, pp. 594 - 606
Smoking‐related biomarkers for lung cancer and other diseases are needed to enhance early detection strategies and to provide a science base for tobacco... 
menthol | smokers | plasma | metabolomics | UHPLC‐QTOF‐MS | UHPLC-QTOF-MS | CELLS | BIRTH-WEIGHT PUPS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLOBAL METABOLOME | SMOKING | CANCER | CYCLIC-AMP | ONCOLOGY | LYSOPHOSPHATIDYLCHOLINE | FATTY-ACID | DISEASE | Biomarkers - metabolism | Metabolomics | Smoking - blood | Humans | Middle Aged | Glucuronates - blood | Metabolome | Glucuronates - metabolism | Male | Biomarkers - blood | Young Adult | Smoking - metabolism | Menthol - analogs & derivatives | Menthol - blood | Adolescent | Adult | Female | Aged | Menthol - metabolism | Prevention | Smokers | Metabolites | Analysis | Lung cancer | Liquid chromatography | Cigarettes | Mass spectrometry | Smoking | Cancer | Biomarkers | Carcinogens | Metabolism | Index Medicus | Plasma | Menthol
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14. Full Text TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology
by Journigan, V. Blair and Zaveri, Nurulain T
Life Sciences, ISSN 0024-3205, 03/2013, Volume 92, Issue 8-9, pp. 425 - 437
Since the discovery of the TRPM8 gene in 2001, the TRPM8 ion channel, better known as the ‘cold receptor’ has been the target of a significant effort from the... 
Agonist | Menthol | TRPM8 | Antagonist | Addiction | Nicotine | MEDICINE, RESEARCH & EXPERIMENTAL | POTENTIAL CHANNELS | AFFERENT NEURONS | TRPA1 | COLD RECEPTOR TRPM8 | AFRICAN-AMERICAN | CIGARETTE-SMOKING | OVERACTIVE BLADDER | PROSTATE-CANCER CELLS | TOBACCO-SMOKE | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Smoking - adverse effects | Cold Temperature | Prostatic Hyperplasia - pathology | Thermosensing - physiology | Humans | TRPM Cation Channels - agonists | Male | Menthol - chemistry | Antineoplastic Agents - chemistry | Neuralgia - drug therapy | Menthol - analogs & derivatives | Animals | Menthol - pharmacology | TRPM Cation Channels - antagonists & inhibitors | Sensory Receptor Cells - physiology | Inflammation - drug therapy | Urologic Diseases | Female | Ligands | Antineoplastic Agents - pharmacology | TRPM Cation Channels - drug effects | Prostatic Hyperplasia - drug therapy | Prostatic Neoplasms - drug therapy | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Investigations | Smoking
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15. Full Text An efficient bioprocess for enzymatic production of l-menthol with high ratio of substrate to catalyst using whole cells of recombinant E. coli
by Zheng, Gao-Wei and Pan, Jiang and Yu, Hui-Lei and Ngo-Thi, Minh-Thu and Li, Chun-Xiu and Xu, Jian-He
Journal of Biotechnology, ISSN 0168-1656, 2010, Volume 150, Issue 1, pp. 108 - 114
A gene encoding an esterase of ECU0554 previously isolated from soil was cloned and overexpressed in BL21. The recombinant esterase (recBsE) showed the best... 
High ratio of substrate to catalyst | Esterase | High substrate loading | Whole-cell biocatalysis | l-Menthol | L-Menthol | RESOLUTION | ESTERIFICATION | BIOCATALYSIS | BACILLUS-SUBTILIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ORGANIC-SOLVENT | DL-MENTHOL | LIPASE | ACETATE | ENANTIOSELECTIVE HYDROLYSIS | Recombinant Proteins - metabolism | Ethanol - metabolism | Esterases - chemistry | Acetates - metabolism | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Esterases - metabolism | Recombinant Proteins - chemistry | Bacillus subtilis - enzymology | Menthol - chemistry | Recombinant Proteins - genetics | Esterases - genetics | Bacillus subtilis - genetics | Bioreactors | Escherichia coli - genetics | Escherichia coli - metabolism | Bacterial Proteins - metabolism | Kinetics | Menthol - metabolism | Menthol - analysis | Enzymes | Esters | Catalysis | Escherichia coli
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16. Full Text Ion channel drug potency assay with an artificial bilayer chip
by El-Arabi, Ahmad M and Salazar, Carl S and Schmidt, Jacob J
Lab on a Chip, ISSN 1473-0197, 07/2012, Volume 12, Issue 13, pp. 2409 - 2413
The potency of pharmaceutical compounds acting on ion channels can be determined through measurements of ion channel conductance as a function of compound... 
MICROFLUIDIC DEVICE | ARRAY | BIOCHEMICAL RESEARCH METHODS | MEMBRANES | MENTHOL RECEPTOR TRPM8 | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | MEASUREMENT PLATFORM | INTERFACE | PROSTATE-CANCER | COLD | RECONSTITUTION | PLANAR LIPID-BILAYERS | Boron Compounds - chemistry | Temperature | Boron Compounds - metabolism | Rats | Menthol - chemistry | Electrochemical Techniques - instrumentation | Electrodes | Animals | Ion Channels - metabolism | Electrochemical Techniques - methods | TRPM Cation Channels - metabolism | Electrophysiological Phenomena | Lipid Bilayers - chemistry | Ion Channels - chemistry | Menthol - metabolism | Platforms | Chips | Lipids | Conductance | Ion channels | Menthol | Mammals | Pharmaceuticals
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17. Full Text A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms
by Cash, Brooks D and Epstein, Michael S and Shah, Syed M
Digestive Diseases and Sciences, ISSN 0163-2116, 2/2016, Volume 61, Issue 2, pp. 560 - 571
Peppermint oil (PO) has shown promise as an IBS therapy, but previous trials have demonstrated variable efficacy and tolerability results.To evaluate the... 
Biochemistry, general | Medicine & Public Health | Hepatology | Peppermint oil | Gastroenterology | Irritable bowel syndrome | Abdominal pain | Diarrhea | Oncology | l -menthol | Transplant Surgery | Bloating | l-menthol | CAPSULES | RANDOMIZED-TRIAL | DISORDERS | L-menthol | MENTHOL | GASTROENTEROLOGY & HEPATOLOGY | SEVERITY | MOTILITY | Double-Blind Method | Humans | Middle Aged | Parasympatholytics - administration & dosage | Irritable Bowel Syndrome - drug therapy | Male | Plant Oils - therapeutic use | Plant Oils - adverse effects | Adult | Female | Parasympatholytics - adverse effects | Plant Oils - administration & dosage | Parasympatholytics - therapeutic use | Care and treatment | Gastrointestinal agents | Gastrointestinal diseases | Original
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