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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 10/2000, Volume 68, Issue 4, pp. 401 - 411
Background: The metabolism of drugs and other xenobiotics is mediated by enzymes whose activities can be modulated by different compounds. The activities of... 
BLADDER-CANCER | S-MEPHENYTOIN | IN-VITRO | ORAL MIDAZOLAM | PHARMACOLOGY & PHARMACY | INDUCTION | POLYMORPHISM | METABOLIZING-ENZYMES | DEBRISOQUINE | DRUG-METABOLISM | N-HYDROXYLATION | Steroid Hydroxylases - metabolism | Central Nervous System Stimulants - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Anti-Arrhythmia Agents - pharmacology | Humans | Cytochrome P-450 Enzyme System - metabolism | Male | Mixed Function Oxygenases - metabolism | Reference Values | Adrenergic alpha-Antagonists - pharmacology | Cytochrome P-450 CYP2E1 - metabolism | Steroid 16-alpha-Hydroxylase | Adrenergic alpha-Antagonists - administration & dosage | Anticonvulsants - pharmacology | Enzyme Inhibitors - administration & dosage | Caffeine - pharmacology | Adult | Rifampin - administration & dosage | Drug Administration Schedule | Administration, Oral | Enzyme Inhibitors - pharmacology | Quinidine - pharmacology | Antibiotics, Antitubercular - pharmacology | Quinidine - administration & dosage | Cytochrome P-450 CYP1A2 - metabolism | Mephenytoin - pharmacology | Acetylation - drug effects | Cytochrome P-450 CYP2C19 | Debrisoquin - pharmacology | Cytochrome P-450 CYP2D6 - metabolism | Theophylline - pharmacology | Dapsone - pharmacology | Rifampin - pharmacology | Aryl Hydrocarbon Hydroxylases | Index Medicus | Abridged Index Medicus
Journal Article
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 05/2016, Volume 43, Issue 10, pp. 1048 - 1059
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2008, Volume 36, Issue 12, pp. 2513 - 2522
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Journal Article
Journal Article
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 2008, Volume 58, Issue 3, pp. 206 - 214
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Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2006, Volume 80, Issue 3, pp. 257 - 263
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 03/2019, Volume 130, pp. 156 - 165
Journal Article
Biomedical Chromatography, ISSN 0269-3879, 03/2015, Volume 29, Issue 3, pp. 437 - 444
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