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Nature genetics, ISSN 1546-1718, 2016, Volume 48, Issue 4, pp. 367 - 373
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 1532-6535, 2011, Volume 89, Issue 3, pp. 387 - 391
Journal Article
Gut, ISSN 0017-5749, 01/2017, Volume 66, Issue 1, pp. 59 - 69
.... We examined the role of host metabolism, lymphocytes and microbiome for the amelioration of colitis by the related thioguanine (TG... 
6-MERCAPTOPURINE | INFLAMMATORY-BOWEL-DISEASE | THERAPY | ACUTE LYMPHOBLASTIC-LEUKEMIA | ULCERATIVE-COLITIS | AZATHIOPRINE | 6-THIOGUANINE | AUTOPHAGY | ACTIVE CROHNS-DISEASE | COMBINATION | GASTROENTEROLOGY & HEPATOLOGY | Mucin-2 - genetics | Dextran Sulfate | Mercaptopurine - pharmacology | Thioguanine - pharmacology | Colitis - genetics | Immunosuppressive Agents - therapeutic use | Administration, Rectal | Colitis - pathology | Male | Gastrointestinal Microbiome - physiology | Bacteroides thetaiotaomicron - metabolism | Macrophages | RNA, Messenger - metabolism | Autophagy - drug effects | Thioguanine - therapeutic use | Mercaptopurine - therapeutic use | Colitis - chemically induced | Escherichia coli - metabolism | Mercaptopurine - metabolism | Fibroblasts | Immunosuppressive Agents - metabolism | Female | Colitis - drug therapy | Cytokines - genetics | Immunosuppressive Agents - administration & dosage | Administration, Oral | Mice, Inbred C57BL | Cells, Cultured | Thioguanine - metabolism | Epithelial Cells | Intestinal Mucosa - microbiology | Mice, Knockout | Host-Pathogen Interactions | Animals | Enterococcus faecalis - metabolism | Hypoxanthine Phosphoribosyltransferase - genetics | T-Lymphocytes - immunology | Colon - microbiology | Mice | Inflammatory bowel diseases | Care and treatment | Dosage and administration | Diagnosis | Research | Thioguanine | T cells | Mercaptopurine | COLONIC BACTERIA | Inflammatory Bowel Disease | IBD MODELS | DRUG METABOLISM | 1506
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173825
.... This study aimed to investigate the largely unknown mechanism of AP on thiopurine metabolism in cells with an active thiopurine metabolic pathway using HepG2 and HEK293 cells... 
IN-VITRO | XANTHINE-OXIDASE | INFLAMMATORY-BOWEL-DISEASE | 6-THIOGUANINE NUCLEOTIDE | HEPATOMA HEPARG CELLS | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | MITOCHONDRIAL INJURY | LOW-DOSE AZATHIOPRINE | T-LYMPHOCYTES | BLOOD | Mercaptopurine - pharmacology | Liver Neoplasms - genetics | Purines - metabolism | Humans | Methyltransferases - metabolism | Liver Neoplasms - drug therapy | Gene Expression Profiling | Gene Regulatory Networks | Carcinoma, Hepatocellular - drug therapy | Carcinoma, Hepatocellular - genetics | HEK293 Cells | Liver Neoplasms - metabolism | Allopurinol - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Drug Therapy, Combination | Antimetabolites - pharmacology | Carcinoma, Hepatocellular - metabolism | Inflammatory bowel diseases | Care and treatment | Erythrocytes | Dosage and administration | Research | Gene expression | Azathioprine | Protein-protein interactions | Mercaptopurine | Biotechnology | Oxidative stress | Laboratories | Leukemia | Genes | Methylated metabolites | Blood | Toxicology | Cell activation | 6-Mercaptopurine | Red blood cells | Metabolites | Intestine | Rodents | Drug dosages | NF-κB protein | Enzymes | Allopurinol | Blood cells | Metabolism | Biological activity | Inflammatory bowel disease | Medicine | Signaling | Antibiotics | Plasmids | Cell lines | Combined treatment | Protein interaction | Transporter | Apoptosis
Journal Article
British Journal of Haematology, ISSN 0007-1048, 09/2000, Volume 110, Issue 4, pp. 813 - 818
The difference in the current cure rates between adult and childhood acute lymphoblastic leukaemia (ALL) may be caused by differences in drug resistance.... 
ALL | drug resistance | children | MTT assay | adults | Adults | Children | Drug resistance | APOPTOSIS | SENSITIVITY | P-GLYCOPROTEIN | MTT-ASSAY | IN-VITRO | LEUKEMIA | HEMATOLOGY | EXPRESSION | AGE | IMMUNOPHENOTYPE | Doxorubicin - therapeutic use | Cytarabine - therapeutic use | Humans | Middle Aged | Child, Preschool | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - therapeutic use | Vincristine - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Thioguanine - therapeutic use | Teniposide - therapeutic use | Mercaptopurine - therapeutic use | Leukemia, T-Cell - metabolism | Statistics, Nonparametric | Daunorubicin - metabolism | Asparaginase - therapeutic use | Child | Mitoxantrone - therapeutic use | Daunorubicin - therapeutic use | Asparaginase - metabolism | Dexamethasone - therapeutic use | Cytarabine - metabolism | Adolescent | Vincristine - therapeutic use | Prednisolone - metabolism | Leukemia, Prolymphocytic - metabolism | Prognosis | Age Factors | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Leukemia, Prolymphocytic - drug therapy | Leukemia, T-Cell - drug therapy | Infant | Antineoplastic Agents - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Mercaptopurine - metabolism | Adult | Bone Marrow Cells - drug effects | Female | Doxorubicin - metabolism | Prednisolone - therapeutic use | Idarubicin - therapeutic use | Idarubicin - metabolism | Ifosfamide - therapeutic use | Mitoxantrone - metabolism | Thioguanine - metabolism | Etoposide - metabolism | Etoposide - therapeutic use | Teniposide - metabolism | Dexamethasone - metabolism | Ifosfamide - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 7, p. e0133244
6-Mercaptopurine (6-MP) is one of the key drugs in the treatment of many pediatric cancers, auto immune diseases and inflammatory bowel disease. 6-MP is a... 
6-MERCAPTOPURINE | MERCAPTOPURINE METABOLISM | PHARMACOKINETICS | PREDICTIVE CONTROL | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | THIOPURINE METHYLTRANSFERASE | RISK | PHARMACOGENETICS | MEDICINE | MAINTENANCE THERAPY | Guanine Nucleotides - metabolism | Neoplasms - metabolism | Prodrugs - administration & dosage | Genetic Association Studies | Humans | Mercaptopurine - administration & dosage | Antineoplastic Agents - administration & dosage | Prodrugs - metabolism | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Thionucleotides - metabolism | Models, Biological | Bayes Theorem | Mercaptopurine - metabolism | Immunosuppressive Agents - metabolism | Immunosuppressive Agents - administration & dosage | Precision Medicine | Enzymes | Pharmacogenetics | Care and treatment | Metabolites | Analysis | Gastrointestinal diseases | Physiological aspects | Research | Political aspects | Drugs | Parameter estimation | Inflammatory bowel diseases | Chemical engineering | Leukemia | Methyltransferase | Parameter sensitivity | Drug development | Thioguanine | Optimization | Immunosuppressive agents | Genotype & phenotype | Windows (intervals) | 6-Mercaptopurine | Intestine | Physiology | Modelling | Thiopurine S-methyltransferase | Parameter robustness | Mathematical models | Drug therapy | Drug dosages | Predictive control | Biomedical engineering | Sensitivity analysis | Medical treatment | Pharmacology | Metabolism | Gene expression | Patients | Inflammatory bowel disease | Experimental design | Model reduction | Control theory | Variation | Bayesian analysis | Cancer | Optimality criteria
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 553, Issue 7689, pp. 511 - 514
Journal Article
Journal Article
Journal Article