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PloS one, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76836 - e76836
.... However, the mechanisms underlying this effect remain to be elucidated. In this study, the effect of fenofibrate on high-glucose induced cell proliferation... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Collagen Type IV - metabolism | Cell Line | Extracellular Matrix - drug effects | Extracellular Matrix - metabolism | Rats | Mesangial Cells - cytology | PPAR alpha - genetics | Glucose - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Mesangial Cells - metabolism | Enzyme Activation - drug effects | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Extracellular Matrix - enzymology | Up-Regulation - drug effects | Fenofibrate - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Cycle Checkpoints - drug effects | Cell Proliferation - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Glucose | Collagen | Dextrose | Fibric acids | Cell proliferation | Flow cytometry | Phosphorylation | Nephrology | Pathogenesis | Science | AKT protein | Activation | Kinases | Cell adhesion & migration | Proteins | Cell growth | Rodents | Cell cycle | Mesangial cells | Extracellular matrix | Inhibition | Diabetes mellitus | Cyclin-dependent kinases | Extracellular signal-regulated kinase | siRNA | 1-Phosphatidylinositol 3-kinase | Fenofibrate | Cytometry | Nephropathy | S phase | Stem cells | Diabetes | Kidney diseases | Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 07/2009, Volume 361, Issue 1, pp. 40 - 51
This study aimed to determine whether early administration of drugs that block the renin... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Retina - drug effects | Angiotensin II Type 1 Receptor Blockers - adverse effects | Follow-Up Studies | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Male | Albuminuria | Angiotensin II Type 1 Receptor Blockers - pharmacology | Enalapril - therapeutic use | Enalapril - adverse effects | Mesangial Cells - drug effects | Glomerular Filtration Rate - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Adult | Female | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Diabetic Nephropathies - prevention & control | Double-Blind Method | Diabetes Mellitus, Type 1 - physiopathology | Kidney Glomerulus - drug effects | Diabetes Mellitus, Type 1 - pathology | Kaplan-Meier Estimate | Losartan - pharmacology | Logistic Models | Kidney Glomerulus - pathology | Disease Progression | Diabetes Mellitus, Type 1 - drug therapy | Diabetic Retinopathy - prevention & control | Enalapril - pharmacology | Losartan - therapeutic use | Mesangial Cells - pathology | Losartan - adverse effects | Renin-Angiotensin System - drug effects | Retina - pathology | Diabetic retinopathy | Control | Usage | Enalapril | Type 1 diabetes | Patient outcomes | Losartan | Enalaprilat | Drug therapy | Kidneys | Diabetes | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2012, Volume 181, Issue 6, pp. 1991 - 2002
.... The mechanism of netrin-1-induced suppression of inflammation was studied in vitro using a proximal tubular epithelial cell line... 
Pathology | Life Sciences & Biomedicine | Science & Technology | Organ Specificity - drug effects | Albuminuria - complications | Inflammation - pathology | Leukocytes - pathology | Gene Expression - drug effects | Apoptosis - drug effects | Diabetes Mellitus, Experimental - enzymology | Dinoprostone - biosynthesis | Netrin-1 | Albuminuria - blood | Epithelial Cells - drug effects | Hyperglycemia - complications | NF-kappa B - metabolism | Nerve Growth Factors - metabolism | Inflammation - blood | Mesangial Cells - drug effects | Necrosis | Diabetes Mellitus, Experimental - blood | Inflammation - complications | Hyperglycemia - pathology | Diabetes Mellitus, Experimental - complications | Nerve Growth Factors - blood | Kidney Tubules, Proximal - enzymology | Albuminuria - pathology | Kidney Tubules, Proximal - pathology | Tumor Suppressor Proteins - metabolism | Transgenes - genetics | Cytokines - secretion | Epithelial Cells - pathology | Mice, Transgenic | Glucose - pharmacology | Mesangial Cells - metabolism | Albuminuria - enzymology | Cell Movement - drug effects | Animals | Tumor Suppressor Proteins - blood | Hyperglycemia - blood | Chickens | Cyclooxygenase 2 - metabolism | Epithelial Cells - enzymology | Mesangial Cells - pathology | Diabetes Mellitus, Experimental - pathology | Hyperglycemia - enzymology | Leukocytes - drug effects | Mice | Inflammation - enzymology | Kidney Tubules, Proximal - drug effects | Index Medicus | Abridged Index Medicus | Regular
Journal Article
Experimental cell research, ISSN 0014-4827, 08/2016, Volume 346, Issue 1, pp. 99 - 110
.... But if EGFR is involved in aldosterone-induced renal fibrosis is less investigated. In the present study, we examined the effect of erlotinib, an inhibitor of EGFR... 
ERK1/2 | Profibrotic response | Reactive oxidative stress | Aldosterone | Epidermal growth factor receptor | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Transcriptional Activation - genetics | Reactive Oxygen Species - metabolism | Kidney - pathology | Receptors, Mineralocorticoid - metabolism | Kidney - enzymology | Extracellular Matrix - metabolism | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Mesangial Cells - drug effects | Kidney - metabolism | Receptor, Epidermal Growth Factor - metabolism | Phosphorylation - drug effects | Cell Line | Kidney - drug effects | Extracellular Matrix - drug effects | Kidney Glomerulus - drug effects | Kidney Glomerulus - pathology | Rats, Sprague-Dawley | Cell Movement - drug effects | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Models, Biological | Erlotinib Hydrochloride - pharmacology | Fibrosis | Mesangial Cells - pathology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aldosterone - adverse effects | Cell Proliferation - drug effects | Mice | Hypertrophy | Tyrosine | Fibronectins | Corticosteroids | Chronic kidney failure | Collagen | Analysis | Development and progression | Growth factors | Steroids | Index Medicus | COLLAGEN | PHOSPHORYLATION | RATS | ANIMAL TISSUES | POTENTIALS | COMPARATIVE EVALUATIONS | 60 APPLIED LIFE SCIENCES | STRESSES | KIDNEYS | HYPERTROPHY | INHIBITION | TYROSINE | PLANT GROWTH | FIBROSIS | MIGRATION | OXIDATION | SIGNALS | CELL PROLIFERATION | PLANT TISSUES | GROWTH FACTORS | DISEASES | MATRICES | PHOSPHOTRANSFERASES | ALDOSTERONE | RECEPTORS | HAZARDS
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0153965 - e0153965
.... Here, we investigated the effects of sarpogrelate and rosuvastatin on CKD in mice that were subjected to a high fat diet (HFD... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Rosuvastatin Calcium - therapeutic use | Mice, Inbred C57BL | Rosuvastatin Calcium - pharmacology | Diet, High-Fat - adverse effects | Male | Mesangial Cells - metabolism | Renal Insufficiency, Chronic - physiopathology | Mesangial Cells - drug effects | Renal Insufficiency, Chronic - drug therapy | Renal Insufficiency, Chronic - pathology | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Animals | Succinates - therapeutic use | Fibrosis | Mesangial Cells - pathology | Cell Proliferation - drug effects | Mice | Plasminogen Activator Inhibitor 1 - genetics | Renal Insufficiency, Chronic - chemically induced | Endothelial Cells - pathology | Streptozocin - adverse effects | Succinates - pharmacology | Endothelial Cells - drug effects | Obesity | Complications and side effects | Chronic kidney failure | Rosuvastatin | Dosage and administration | Research | Diagnosis | Drug therapy | Risk factors | Cystatin | Nephrology | Syngeneic grafts | Streptozocin | Transforming growth factor | Disorders | High fat diet | Rodents | Cystatin C | Mesangial cells | Physiology | Damage accumulation | Vascular endothelial growth factor | Growth factors | Drug dosages | Statins | Hypertension | Peripheral circulation | Excretion | Immunoglobulins | Serotonin | Incubation | Comorbidity | Complications | Diabetes mellitus | Health risks | Risk reduction | Platelet aggregation | Patients | Vascular endothelial growth factor receptors | Nephropathy | Collagen | Pharmacy | Plasminogen activator inhibitors | Kidney diseases | Diabetes | Cardiovascular diseases | Combinatorial analysis | Metabolic disorders | Kidney transplantation | Index Medicus
Journal Article
Inflammation, ISSN 1573-2576, 06/2014, Volume 38, Issue 2, pp. 510 - 519
.... This study was conducted to investigate effects of alpha-lipoic acid (ALA) on septic AKI in vitro... 
Pathology | nuclear factor kappa B signaling pathway | alpha-lipoic acid | Medicine & Public Health | inflammation | Rheumatology | Internal Medicine | acute kidney injury | Pharmacology/Toxicology | sepsis | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Dinoprostone - secretion | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Nitric Oxide Synthase Type II - biosynthesis | Phosphorylation | I-kappa B Proteins - metabolism | Lipopolysaccharides | Mesangial Cells - drug effects | Cyclooxygenase 2 - biosynthesis | Sepsis - pathology | I-kappa B Kinase - metabolism | Inflammation - drug therapy | Interleukin-1beta - metabolism | Interleukin-6 - metabolism | Cell Line | Cell Survival - drug effects | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Sepsis - immunology | Signal Transduction | Acute Kidney Injury - drug therapy | Acute Kidney Injury - pathology | Anti-Inflammatory Agents - pharmacology | Mesangial Cells - immunology | Rats | Thioctic Acid - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Interleukin-6 - secretion | Acute Kidney Injury - prevention & control | Dinoprostone - metabolism | Animals | Transcription Factor RelA - metabolism | Acetylcysteine - pharmacology | Nitric Oxide - metabolism | Medicine, Experimental | Medical research | Research | Anti-inflammatory drugs | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e95588 - e95588
.... However, NVP-BEZ235 had no effect on cell death in human renal carcinoma Caki cells. We tested whether combined treatment with natural compounds and NVP-BEZ235 could induce cell death... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Survival - drug effects | Apoptosis - drug effects | Humans | Curcumin - pharmacology | Cell Survival - genetics | Imidazoles - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Quinolines - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Carcinoma, Renal Cell - metabolism | Flow Cytometry | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | RNA, Small Interfering | DNA Fragmentation - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | TOR protein | Post-transcription | Regulations | Bcl-2 protein | p53 Protein | Gene regulation | AKT protein | Kinases | Cancer therapies | Signal transduction | Rhizomes | Pathways | Bioactive compounds | Fibroblasts | Mesangial cells | Curcumin | Colon | Inhibition | Medical research | Chemopreventive agents | Cell survival | Mortality | Gene expression | Biological activity | Mcl-1 protein | 1-Phosphatidylinositol 3-kinase | Signaling | Inhibitors | Cell death | Skin | Combined treatment | Synergistic effect | Clear cell-type renal cell carcinoma | Cancer | Apoptosis | Kidney transplantation | Index Medicus
Journal Article