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Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 29, pp. 25586 - 25603
Hyperglycemia induces a wide array of signaling pathways in the kidney that lead to hypertrophy and matrix expansion, eventually culminating in progressive... 
MAMMALIAN TARGET | FIBRONECTIN EXPRESSION | MESSENGER-RNA TRANSLATION | GROWTH-FACTOR-BETA | EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED COLLAGEN EXPRESSION | MESANGIAL CELLS | SUPEROXIDE-DISMUTASE | PROTEIN-SYNTHESIS | TRANSGENIC MICE | Hypertrophy - chemically induced | Kidney Cortex - drug effects | Epithelial Cells - metabolism | Kidney - pathology | Kidney Cortex - metabolism | Epithelial Cells - drug effects | Humans | Diabetes Mellitus, Type 1 - metabolism | Hypertrophy - metabolism | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Kidney - metabolism | Base Sequence | Hypertrophy - genetics | Regulatory-Associated Protein of mTOR | PTEN Phosphohydrolase - genetics | Diabetic Nephropathies - pathology | Kidney Tubules, Proximal - pathology | Kidney - drug effects | Diabetic Nephropathies - metabolism | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Rats | Diabetic Nephropathies - genetics | Epithelial Cells - pathology | Kidney Cortex - pathology | Glucose - pharmacology | Mesangial Cells - metabolism | Down-Regulation - drug effects | Animals | Signal Transduction - drug effects | Mesangial Cells - pathology | Fibronectins - genetics | Mice | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | Kidney Tubules, Proximal - drug effects | mTOR | Molecular Bases of Disease | Diabetes | Akt PKB | Fibronectin | Kidney
Journal Article
Diabetologia, ISSN 0012-186X, 1/2013, Volume 56, Issue 1, pp. 204 - 217
Many of the effects of resveratrol are consistent with the activation of AMP-activated protein kinase (AMPK), silent information regulator T1 (SIRT1) and... 
Oxidative stress | Medicine & Public Health | Human Physiology | Metabolic Diseases | Resveratrol | Internal Medicine | Diabetic nephropathy | Apoptosis | TRANSCRIPTIONAL COACTIVATOR PGC-1 | PROTEIN-KINASE | MITOCHONDRIAL-FUNCTION | FATTY-ACID-METABOLISM | PROLIFERATOR-ACTIVATED RECEPTOR | DIABETIC-NEPHROPATHY | SIRT1 DEACETYLASE | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | ALPHA ERR-ALPHA | NF-KAPPA-B | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Kidney - pathology | Stilbenes - therapeutic use | Male | Diabetes Mellitus, Type 2 - metabolism | Protective Agents - therapeutic use | Stilbenes - pharmacology | Sirtuin 1 - genetics | Mesangial Cells - drug effects | Kidney - metabolism | Protein Processing, Post-Translational - drug effects | RNA Interference | Mice, Mutant Strains | Protective Agents - pharmacology | Sirtuin 1 - chemistry | Diabetic Nephropathies - prevention & control | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Kidney - drug effects | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mesangial Cells - metabolism | Enzyme Activation - drug effects | Sirtuin 1 - antagonists & inhibitors | AMP-Activated Protein Kinases - chemistry | Lipotropic Agents - therapeutic use | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Lipid Metabolism - drug effects | Mesangial Cells - pathology | Lipotropic Agents - pharmacology | Mice | Diabetes Mellitus, Type 2 - pathology | Oxidative Stress - drug effects | Transcription Factors - agonists | Diabetes Mellitus, Type 2 - drug therapy | AMP-Activated Protein Kinases - genetics
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2009, Volume 361, Issue 1, pp. 40 - 51
This study aimed to determine whether early administration of drugs that block the renin–angiotensin system slows the progression of change in glomerular... 
CONTROLLED-TRIAL | MEDICINE, GENERAL & INTERNAL | STRUCTURAL-FUNCTIONAL RELATIONSHIPS | CORTICAL INTERSTITIUM | BLOOD-PRESSURE CONTROL | EARLY NATURAL-HISTORY | RETINOPATHY | ANGIOTENSIN-CONVERTING ENZYME | NEPHROPATHY | PROGRESSION | ENDOTHELIAL GROWTH-FACTOR | Retina - drug effects | Angiotensin II Type 1 Receptor Blockers - adverse effects | Follow-Up Studies | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Male | Albuminuria | Angiotensin II Type 1 Receptor Blockers - pharmacology | Enalapril - therapeutic use | Enalapril - adverse effects | Mesangial Cells - drug effects | Glomerular Filtration Rate - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Adult | Female | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Diabetic Nephropathies - prevention & control | Double-Blind Method | Diabetes Mellitus, Type 1 - physiopathology | Kidney Glomerulus - drug effects | Diabetes Mellitus, Type 1 - pathology | Kaplan-Meier Estimate | Losartan - pharmacology | Logistic Models | Kidney Glomerulus - pathology | Disease Progression | Diabetes Mellitus, Type 1 - drug therapy | Diabetic Retinopathy - prevention & control | Enalapril - pharmacology | Losartan - therapeutic use | Mesangial Cells - pathology | Losartan - adverse effects | Renin-Angiotensin System - drug effects | Retina - pathology | Diabetic retinopathy | Control | Usage | Enalapril | Type 1 diabetes | Patient outcomes | Losartan | Enalaprilat | Drug therapy | Kidneys | Diabetes | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 12/2016, Volume 437, Issue C, pp. 268 - 279
Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial hypertrophy and extracellular matrix (ECM) accumulation. Our recent... 
Oxidative stress | NF-κB | Diabetic nephropathy | Inflammation | Akt | Andrographolide | ACTIVATION | ADP-RIBOSYL CYCLASE | INDUCED FIBRONECTIN EXPRESSION | ANGIOTENSIN-II | CELL BIOLOGY | PATHOGENETIC MECHANISMS | IN-VITRO | NF-kappa B | NOX FAMILY | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | MESANGIAL CELLS | HIGH GLUCOSE | Inflammation - pathology | Diabetes Mellitus, Experimental - drug therapy | Reactive Oxygen Species - metabolism | Kidney - pathology | Streptozocin | Humans | Diabetic Nephropathies - drug therapy | Extracellular Matrix - metabolism | Hyperglycemia - complications | Male | NF-kappa B - metabolism | Hyperglycemia - drug therapy | Mesangial Cells - drug effects | Inflammation - complications | Cell Nucleus - metabolism | Diet, High-Fat | Glucose - toxicity | Diabetes Mellitus, Experimental - complications | NADP - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Diterpenes - pharmacology | Diabetic Nephropathies - pathology | Diterpenes - therapeutic use | Diabetic Nephropathies - metabolism | Extracellular Matrix - drug effects | Kidney Glomerulus - drug effects | Mice, Inbred C57BL | DNA - metabolism | Kidney Glomerulus - pathology | Mesangial Cells - metabolism | Rats, Sprague-Dawley | Diabetic Nephropathies - complications | Animals | Signal Transduction - drug effects | Mesangial Cells - pathology | Diabetes Mellitus, Experimental - pathology | Cell Proliferation - drug effects | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Hypertrophy
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0117400
Objective To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B... 
PHYSIOLOGY | INDUCED APOPTOSIS | PATHWAY | MULTIDISCIPLINARY SCIENCES | DISEASE | 3-KINASE-AKT | I COLLAGEN | MICE | KIDNEY | NEPHROPATHY | EXPRESSION | Diabetes Mellitus - pathology | Triterpenes - pharmacology | TOR Serine-Threonine Kinases - metabolism | Extracellular Matrix - metabolism | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Autophagy - drug effects | Mesangial Cells - drug effects | Cytoprotection - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Phagosomes - drug effects | Cell Line | Collagen Type I - metabolism | Kidney - drug effects | Extracellular Matrix - drug effects | PTEN Phosphohydrolase - metabolism | Rats | Glucose - pharmacology | Down-Regulation - drug effects | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Mesangial Cells - pathology | Cell Proliferation - drug effects | Hypertrophy | MicroRNA | Diabetes | Glucose | Collagen | Dextrose | TOR protein | Cell proliferation | Collagen (type I) | Nephrology | Collagens | Phagosomes | Homology | AKT protein | Kinases | Autophagy | Western blotting | Proteins | Signal transduction | Cell growth | Rodents | Mesangial cells | Extracellular matrix | Tensin | Diabetes mellitus | MiRNA | Rapamycin | Electron microscopy | Mammals | Gene expression | 1-Phosphatidylinositol 3-kinase | Signaling | Cell injury | Hospitals | Acids | Cell number | MicroRNAs | Ursolic acid | PTEN protein | Phagocytosis
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 3055 - 3066
OBJECTIVE-To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | GROWTH-FACTOR-BETA | OXIDATIVE STRESS | TGF-BETA | GLOMERULAR HYPERTROPHY | CELLS IN-VITRO | BARDOXOLONE METHYL | KIDNEY-FUNCTION | ENDOCRINOLOGY & METABOLISM | SULFORAPHANE PROTECTS | HIGH-DOSE THIAMINE | Acrolein - analogs & derivatives | Reactive Oxygen Species - metabolism | Kidney - pathology | Humans | Transforming Growth Factor beta1 - metabolism | NF-E2-Related Factor 2 - agonists | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Diabetic Nephropathies - physiopathology | RNA Interference | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Thiocyanates - pharmacology | NF-E2-Related Factor 2 - genetics | Thiocyanates - administration & dosage | Diabetic Nephropathies - prevention & control | Isothiocyanates | Extracellular Matrix Proteins - metabolism | Kidney - physiopathology | Acrolein - pharmacology | Thiocyanates - therapeutic use | Diabetic Nephropathies - pathology | Kidney - drug effects | Acrolein - administration & dosage | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mesangial Cells - metabolism | Random Allocation | Mice, Knockout | Animals | NF-E2-Related Factor 2 - metabolism | Mesangial Cells - pathology | Acrolein - therapeutic use | Cell Proliferation - drug effects | Mice | RNA, Small Interfering | Oxidative Stress - drug effects | Care and treatment | Streptozocin | Diabetic nephropathies | Weight loss | Development and progression | Research | Health aspects | Risk factors | Pharmacology and Therapeutics
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1130 - 1145
The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while... 
sclerosis | endothelial cells | autophagy | podocytes | proteinuria | diabetic nephropathy | Podocytes | Diabetic nephropathy | Autophagy | Endothelial cells | Sclerosis | Proteinuria | apoptosis-related cysteine peptidase | LC3A | sequestosome 1 | caspase 3 | mechanistic target of rapamycin | CELL BIOLOGY | Cdh5 | MAP1LC3A | CASP3 | STZ | NITRIC-OXIDE | Nphs2 | transmission electron microscopy | GLYCEMIC CONTROL | OXIDATIVE STRESS | GEC | TUBA | cadherin 5 | end-stage renal disease | NEPHROPATHY | streptozotocin | Wilms tumor 1 | DISEASE | GROWTH-FACTOR | SQSTM1 | ESRD | GFB | diabetes mellitus | blood urea nitrogen | microtubule-associated protein 1 light chain 3 | GBM | GENE-EXPRESSION | BUN | glomerular endothelial cells | nephrosis 2 | glomerular filtration barrier | podocin | tubulin | RENAL BIOPSY SPECIMENS | KNOCKOUT MICE | MTOR | WT1 | glomerular basement membrane | TEM | TRANSGENIC MICE | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Autophagy - drug effects | Mesangial Cells - drug effects | Endothelial Cells - ultrastructure | Glomerular Filtration Rate - drug effects | Diabetic Nephropathies - physiopathology | Gene Deletion | Mesangial Cells - ultrastructure | Integrases - metabolism | Microtubule-Associated Proteins - deficiency | Diabetic Nephropathies - prevention & control | Diabetic Nephropathies - pathology | Mice, Inbred C57BL | Cells, Cultured | Glucose - pharmacology | Podocytes - pathology | Phenotype | Podocytes - ultrastructure | Animals | Autophagy-Related Protein 5 | Podocytes - drug effects | Mesangial Cells - pathology | Endothelial Cells - pathology | Endothelial Cells - drug effects | Life Sciences | Development Biology
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 04/2012, Volume 44, Issue 4, pp. 629 - 638
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2011, Volume 331, Issue 1, pp. 34 - 40
Journal Article
Journal Article