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Kidney international, ISSN 0085-2538, 08/2011, Volume 80, Issue 4, pp. 358 - 368
Enhanced transforming growth factor-β1 (TGF-β1) expression in renal cells promotes fibrosis and hypertrophy during the progression of diabetic nephropathy. The TGF... 
TGF-β | fibrosis | diabetic nephropathy | gene expression | cell signaling | Up-Regulation | Diabetes Mellitus, Type 2 - genetics | Homeodomain Proteins - metabolism | Transforming Growth Factor beta1 - metabolism | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Homeostasis | MicroRNAs - metabolism | Diabetes Mellitus, Type 2 - metabolism | Transfection | Time Factors | Kruppel-Like Transcription Factors - metabolism | Upstream Stimulatory Factors - metabolism | Diabetes Mellitus, Type 1 - chemically induced | Diabetes Mellitus, Experimental - chemically induced | 3' Untranslated Regions | Diabetes Mellitus, Experimental - metabolism | Binding Sites | Collagen Type IV - metabolism | Promoter Regions, Genetic | Diabetic Nephropathies - pathology | Collagen Type I - metabolism | Diabetic Nephropathies - metabolism | Cells, Cultured | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Diabetic Nephropathies - genetics | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Oligonucleotides - metabolism | Animals | Fibrosis | Diabetes Mellitus, Experimental - pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Mutation | Zinc Finger E-box-Binding Homeobox 1 | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77468 - e77468
Diabetic nephropathy is the most common cause of chronic kidney failure and end-stage renal disease in the Western World. One of the major characteristics of... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Extracellular Matrix - metabolism | MicroRNAs - metabolism | Mesangial Cells - drug effects | Plasminogen Activator Inhibitor 1 - metabolism | Plasminogen Activator Inhibitor 1 - genetics | Epithelial Cells - cytology | Transforming Growth Factor beta1 - pharmacology | Diabetic Nephropathies - pathology | Kidney Tubules, Proximal - pathology | Signal Transduction | Diabetic Nephropathies - metabolism | Cells, Cultured | Gene Expression Regulation | Diabetic Nephropathies - genetics | Mesangial Cells - cytology | Glucose - pharmacology | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Fibronectins - metabolism | Proteins - genetics | Proteins - metabolism | RNA, Long Noncoding | Kidney Tubules, Proximal - metabolism | Fibronectins - genetics | MicroRNAs - genetics | Extracellular Matrix - pathology | Type 2 diabetes | Fibronectins | Epigenetic inheritance | Genes | Development and progression | Glucose | Transforming growth factors | Dextrose | MicroRNA | Chronic kidney failure | Bone morphogenetic proteins | Lymphomas | Methylation | End-stage renal disease | Pathogenesis | Genomics | Kinases | Accumulation | Fibronectin | Proteins | Ultrasonic imaging | Rodents | DNA methylation | Mesangial cells | Extracellular matrix | miRNA | Plasmacytoma | Growth factors | Deoxyribonucleic acid--DNA | Translocation | Transforming growth factor-b1 | Diabetes mellitus | Polyamide-imides | Chromosome 5 | Gene expression | Ribonucleic acid--RNA | Studies | Nephropathy | MicroRNAs | Plasminogen activator inhibitors | Renal failure | Epigenetics | Regulation | Kidney diseases | Diabetes | Non-coding RNA | Binding sites | Metabolic disorders | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal Article
Cellular signalling, ISSN 0898-6568, 07/2015, Volume 27, Issue 7, pp. 1276 - 1285
Journal Article
PloS one, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0125176 - e0125176
.... Rat glomerular mesangial cells (RMCs) were incubated in normal or high glucose medium with or without the PGC-1 alpha-overexpressing plasmid (pcDNA3-PGC-1 alpha) for 48 h... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Dynamins - metabolism | Reactive Oxygen Species - metabolism | Mitochondrial Dynamics - genetics | Oxidative Stress | Humans | Male | Hyperglycemia - genetics | Mesangial Cells - drug effects | Transfection | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Hyperglycemia - pathology | Deoxyguanosine - analogs & derivatives | Biomarkers - metabolism | Diabetic Nephropathies - pathology | Signal Transduction | Diabetic Nephropathies - metabolism | Gene Expression Regulation | Dynamins - genetics | Rats | Diabetic Nephropathies - genetics | Glucose - pharmacology | Mitochondria - metabolism | Mesangial Cells - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Transcription Factors - genetics | Plasmids - metabolism | Rats, Sprague-Dawley | Hyperglycemia - metabolism | Transcription Factors - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Mitochondrial Dynamics - drug effects | Mesangial Cells - pathology | Plasmids - chemistry | Glucose - metabolism | Deoxyguanosine - metabolism | Primary Cell Culture | 8-Hydroxy-2'-Deoxyguanosine | Oxidative stress | Pathogenesis | Biosynthesis | Glucose | Remodeling | Proteins | Hyperglycemia | Mitochondria | Rodents | Mesangial cells | Bioindicators | Inhibition | Oxygen | Kidneys | Diabetes mellitus | Metabolism | Gene expression | Hospitals | Nephropathy | Morphology | Structural damage | Biomarkers | Diabetes | Laboratory animals | Renal cortex | Endocrinology | Hypertrophy | Proteinuria | Apoptosis | Kidney transplantation | Index Medicus
Journal Article
American journal of physiology. Renal physiology, ISSN 1522-1466, 02/2012, Volume 302, Issue 3, pp. F329 - F341
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2014, Volume 289, Issue 47, pp. 32703 - 32716
High glucose-induced Akt acts as a signaling hub for mesangial cell hypertrophy and matrix expansion, which are recognized as cardinal signatures for the development of diabetic nephropathy... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | TOR Serine-Threonine Kinases - metabolism | Kidney Cortex - metabolism | Diabetes Mellitus, Type 1 - metabolism | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Mechanistic Target of Rapamycin Complex 1 | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Multiprotein Complexes - metabolism | Plasminogen Activator Inhibitor 1 - metabolism | Forkhead Transcription Factors - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Catalase - genetics | Cell Size - drug effects | Cells, Cultured | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Rats | Kidney Cortex - pathology | Mice, Transgenic | Glucose - pharmacology | Mesangial Cells - metabolism | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Fibronectins - metabolism | Catalase - metabolism | Nerve Tissue Proteins - metabolism | Animals | Feedback, Physiological - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Cell Signaling | Molecular Bases of Disease | Diabetes | Glucose | Extracellular Matrix | Antioxidant
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 04/2009, Volume 296, Issue 4, pp. 867 - 874
Viral RNA or bacterial products can activate glomerular mesangial cells via a subset of Toll-like receptors (Tlr... 
Glomerulonephritis | Innate immunity | Kidney | Toll-like receptor | Apoptosis | Necrosis | Physiology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Immune Complex Diseases - immunology | Toll-Like Receptor 2 - genetics | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Nephrotic Syndrome - metabolism | Interferon-gamma - metabolism | Glomerulonephritis - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Toll-Like Receptor 2 - deficiency | Antigen-Antibody Complex - metabolism | Interleukin-6 - metabolism | RNA - metabolism | Rabbits | Signal Transduction | Mesangial Cells - immunology | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Nephrotic Syndrome - pathology | Glomerulonephritis - immunology | Mesangial Cells - metabolism | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 3 - metabolism | Immune Complex Diseases - pathology | Mice, Knockout | Animals | Myeloid Differentiation Factor 88 - deficiency | Chemokine CXCL9 - metabolism | Glomerulonephritis - pathology | Mesangial Cells - pathology | Antibody Formation | Mice | Mutation | Immune Complex Diseases - metabolism | Immunity, Cellular | Myeloid Differentiation Factor 88 - metabolism | Molecules | Signal transduction | Cell culture | Kidneys | Rodents | Index Medicus
Journal Article
Molecular medicine reports, ISSN 1791-2997, 11/2017, Volume 16, Issue 5, pp. 7855 - 7863
.... However, the underlying molecular mechanism has never been revealed. The present study aimed to investigate how PEDF protects mesangial cells from diabetes induced damage... 
Tetrahydrobiopterin | Inducible nitric oxide synthase | Human glomerular mesangial cells | Oncology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | RNA, Small Interfering - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics