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Journal Article
Kidney International, ISSN 0085-2538, 08/2011, Volume 80, Issue 4, pp. 358 - 368
Enhanced transforming growth factor-β1 (TGF-β1) expression in renal cells promotes fibrosis and hypertrophy during the progression of diabetic nephropathy. The... 
TGF-β | fibrosis | diabetic nephropathy | gene expression | cell signaling | Up-Regulation | Diabetes Mellitus, Type 2 - genetics | Homeodomain Proteins - metabolism | Transforming Growth Factor beta1 - metabolism | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Homeostasis | MicroRNAs - metabolism | Diabetes Mellitus, Type 2 - metabolism | Transfection | Time Factors | Kruppel-Like Transcription Factors - metabolism | Upstream Stimulatory Factors - metabolism | Diabetes Mellitus, Type 1 - chemically induced | Diabetes Mellitus, Experimental - chemically induced | 3' Untranslated Regions | Diabetes Mellitus, Experimental - metabolism | Binding Sites | Collagen Type IV - metabolism | Promoter Regions, Genetic | Diabetic Nephropathies - pathology | Collagen Type I - metabolism | Diabetic Nephropathies - metabolism | Cells, Cultured | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Diabetic Nephropathies - genetics | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Oligonucleotides - metabolism | Animals | Fibrosis | Diabetes Mellitus, Experimental - pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Mutation | Zinc Finger E-box-Binding Homeobox 1
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2015, Volume 26, Issue 2, pp. 339 - 348
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2009, Volume 20, Issue 2, pp. 333 - 343
Journal Article
Diabetologia, ISSN 0012-186X, 1/2013, Volume 56, Issue 1, pp. 204 - 217
Many of the effects of resveratrol are consistent with the activation of AMP-activated protein kinase (AMPK), silent information regulator T1 (SIRT1) and... 
Oxidative stress | Medicine & Public Health | Human Physiology | Metabolic Diseases | Resveratrol | Internal Medicine | Diabetic nephropathy | Apoptosis | TRANSCRIPTIONAL COACTIVATOR PGC-1 | PROTEIN-KINASE | MITOCHONDRIAL-FUNCTION | FATTY-ACID-METABOLISM | PROLIFERATOR-ACTIVATED RECEPTOR | DIABETIC-NEPHROPATHY | SIRT1 DEACETYLASE | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | ALPHA ERR-ALPHA | NF-KAPPA-B | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Kidney - pathology | Stilbenes - therapeutic use | Male | Diabetes Mellitus, Type 2 - metabolism | Protective Agents - therapeutic use | Stilbenes - pharmacology | Sirtuin 1 - genetics | Mesangial Cells - drug effects | Kidney - metabolism | Protein Processing, Post-Translational - drug effects | RNA Interference | Mice, Mutant Strains | Protective Agents - pharmacology | Sirtuin 1 - chemistry | Diabetic Nephropathies - prevention & control | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Kidney - drug effects | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mesangial Cells - metabolism | Enzyme Activation - drug effects | Sirtuin 1 - antagonists & inhibitors | AMP-Activated Protein Kinases - chemistry | Lipotropic Agents - therapeutic use | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Lipid Metabolism - drug effects | Mesangial Cells - pathology | Lipotropic Agents - pharmacology | Mice | Diabetes Mellitus, Type 2 - pathology | Oxidative Stress - drug effects | Transcription Factors - agonists | Diabetes Mellitus, Type 2 - drug therapy | AMP-Activated Protein Kinases - genetics
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e46453
The loss of glomerular podocytes is a key event in the progression of chronic kidney disease resulting in proteinuria and declining function. Podocytes are... 
PLURIPOTENT STEM-CELLS | SOMATIC-CELLS | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | PARIETAL | PROLIFERATION | GLOMERULAR PODOCYTES | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | EXPRESSION | FIBROBLASTS | BETA | Cell Proliferation | Coculture Techniques | Humans | Cell Membrane Permeability | Fluorescein-5-isothiocyanate - metabolism | Fluorescent Dyes - metabolism | Octamer Transcription Factor-3 - genetics | Induced Pluripotent Stem Cells - metabolism | Tretinoin - pharmacology | Gene Expression | Podocytes - metabolism | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Tissue Culture Techniques | Mice, Inbred C57BL | Cells, Cultured | Fluorescein-5-isothiocyanate - analogs & derivatives | Kidney - cytology | Mesangial Cells - metabolism | Animals | Activins - pharmacology | Podocytes - physiology | Cell Differentiation - drug effects | Octamer Transcription Factor-3 - metabolism | Cell Aggregation | Mice | Bone Morphogenetic Protein 7 - pharmacology | Serum Albumin - metabolism | Care and treatment | Chronic kidney failure | Stem cells | Angiotensin | Research | Permeability | Tumor proteins | Health aspects | Risk factors | Cell culture | Nephrology | Transplants & implants | Hemodialysis | Laboratories | Pathogenesis | Oct-4 protein | Fluorescence | Biology | mRNA | Regeneration (physiology) | Proteins | Immunology | Rodents | DNA methylation | Fibroblasts | Physiology | Localization | Angiotensin II | Explants | Contractility | Talin | Gene expression | Regeneration | Morphology | Kidney diseases | Differentiation | Pluripotency | Cytoplasm | Proteinuria | Tumors | Kidney transplantation
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e77468
Diabetic nephropathy is the most common cause of chronic kidney failure and end-stage renal disease in the Western World. One of the major characteristics of... 
MESSENGER-RNAS | SMAD PROTEINS | HB-EGF | INTRONIC MICRORNAS | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | KINASE | EXPRESSION | STAGE RENAL-DISEASE | PHYSICAL INTERACTION | BETA | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Extracellular Matrix - metabolism | MicroRNAs - metabolism | Mesangial Cells - drug effects | Plasminogen Activator Inhibitor 1 - metabolism | Plasminogen Activator Inhibitor 1 - genetics | Epithelial Cells - cytology | Transforming Growth Factor beta1 - pharmacology | Diabetic Nephropathies - pathology | Kidney Tubules, Proximal - pathology | Signal Transduction | Diabetic Nephropathies - metabolism | Cells, Cultured | Gene Expression Regulation | Diabetic Nephropathies - genetics | Mesangial Cells - cytology | Glucose - pharmacology | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Fibronectins - metabolism | Proteins - genetics | Proteins - metabolism | RNA, Long Noncoding | Kidney Tubules, Proximal - metabolism | Fibronectins - genetics | MicroRNAs - genetics | Extracellular Matrix - pathology | Type 2 diabetes | Fibronectins | Epigenetic inheritance | Genes | Development and progression | Glucose | Transforming growth factors | Dextrose | MicroRNA | Chronic kidney failure | Bone morphogenetic proteins | Lymphomas | Methylation | End-stage renal disease | Pathogenesis | Genomics | Kinases | Accumulation | Fibronectin | Proteins | Ultrasonic imaging | Rodents | DNA methylation | Mesangial cells | Extracellular matrix | Plasmacytoma | Growth factors | Deoxyribonucleic acid--DNA | Translocation | Transforming growth factor-b1 | Diabetes mellitus | Polyamide-imides | MiRNA | Chromosome 5 | Gene expression | Ribonucleic acid--RNA | Studies | Nephropathy | MicroRNAs | Plasminogen activator inhibitors | Renal failure | Epigenetics | Regulation | Kidney diseases | Diabetes | Non-coding RNA | Binding sites | Metabolic disorders | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 29, pp. 25586 - 25603
Hyperglycemia induces a wide array of signaling pathways in the kidney that lead to hypertrophy and matrix expansion, eventually culminating in progressive... 
MAMMALIAN TARGET | FIBRONECTIN EXPRESSION | MESSENGER-RNA TRANSLATION | GROWTH-FACTOR-BETA | EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED COLLAGEN EXPRESSION | MESANGIAL CELLS | SUPEROXIDE-DISMUTASE | PROTEIN-SYNTHESIS | TRANSGENIC MICE | Hypertrophy - chemically induced | Kidney Cortex - drug effects | Epithelial Cells - metabolism | Kidney - pathology | Kidney Cortex - metabolism | Epithelial Cells - drug effects | Humans | Diabetes Mellitus, Type 1 - metabolism | Hypertrophy - metabolism | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Kidney - metabolism | Base Sequence | Hypertrophy - genetics | Regulatory-Associated Protein of mTOR | PTEN Phosphohydrolase - genetics | Diabetic Nephropathies - pathology | Kidney Tubules, Proximal - pathology | Kidney - drug effects | Diabetic Nephropathies - metabolism | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Rats | Diabetic Nephropathies - genetics | Epithelial Cells - pathology | Kidney Cortex - pathology | Glucose - pharmacology | Mesangial Cells - metabolism | Down-Regulation - drug effects | Animals | Signal Transduction - drug effects | Mesangial Cells - pathology | Fibronectins - genetics | Mice | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | Kidney Tubules, Proximal - drug effects | mTOR | Molecular Bases of Disease | Diabetes | Akt PKB | Fibronectin | Kidney
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 3055 - 3066
OBJECTIVE-To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | GROWTH-FACTOR-BETA | OXIDATIVE STRESS | TGF-BETA | GLOMERULAR HYPERTROPHY | CELLS IN-VITRO | BARDOXOLONE METHYL | KIDNEY-FUNCTION | ENDOCRINOLOGY & METABOLISM | SULFORAPHANE PROTECTS | HIGH-DOSE THIAMINE | Acrolein - analogs & derivatives | Reactive Oxygen Species - metabolism | Kidney - pathology | Humans | Transforming Growth Factor beta1 - metabolism | NF-E2-Related Factor 2 - agonists | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Diabetic Nephropathies - physiopathology | RNA Interference | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Thiocyanates - pharmacology | NF-E2-Related Factor 2 - genetics | Thiocyanates - administration & dosage | Diabetic Nephropathies - prevention & control | Isothiocyanates | Extracellular Matrix Proteins - metabolism | Kidney - physiopathology | Acrolein - pharmacology | Thiocyanates - therapeutic use | Diabetic Nephropathies - pathology | Kidney - drug effects | Acrolein - administration & dosage | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mesangial Cells - metabolism | Random Allocation | Mice, Knockout | Animals | NF-E2-Related Factor 2 - metabolism | Mesangial Cells - pathology | Acrolein - therapeutic use | Cell Proliferation - drug effects | Mice | RNA, Small Interfering | Oxidative Stress - drug effects | Care and treatment | Streptozocin | Diabetic nephropathies | Weight loss | Development and progression | Research | Health aspects | Risk factors | Pharmacology and Therapeutics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14385 - 14390
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 91 - 102
Aberrant regulation in oxidative stress, fibrogenesis, and the epithelial–mesenchymal transition (EMT) in renal cells under hyperglycemic conditions... 
Epithelial–mesenchymal transition | Free radicals | Aldose reductase | miR-200a-3p/141-3p | Fibrogenesis | Antioxidant defense | Epithelial-mesenchymal transition | Aldehyde Reductase - genetics | Cytoskeletal Proteins - genetics | Kidney Cortex - metabolism | Transforming Growth Factor beta2 - metabolism | Homeodomain Proteins - metabolism | Transforming Growth Factor beta1 - metabolism | Diabetes Mellitus, Experimental - genetics | Male | MicroRNAs - metabolism | Zinc Finger E-box Binding Homeobox 2 | Kruppel-Like Transcription Factors - metabolism | Aldehyde Reductase - metabolism | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Diabetes Mellitus, Experimental - metabolism | Kelch-Like ECH-Associated Protein 1 | Repressor Proteins - metabolism | Cell Line | Diabetic Nephropathies - pathology | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Repressor Proteins - genetics | Diabetic Nephropathies - genetics | Kidney Cortex - pathology | Mice, Transgenic | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Homeodomain Proteins - genetics | Animals | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mesangial Cells - pathology | Diabetes Mellitus, Experimental - pathology | Mice | MicroRNAs - genetics | Transforming Growth Factor beta2 - genetics | Adaptor Proteins, Signal Transducing - metabolism | Kruppel-Like Transcription Factors - genetics | Zinc Finger E-box-Binding Homeobox 1
Journal Article
Hypertension, ISSN 0194-911X, 07/2016, Volume 68, Issue 1, pp. 185 - 194
Angiotensin (Ang)-(1–7) has cardiovascular protective effects and is the opponent of the often detrimental Ang II within the renin–angiotensin system. Although... 
angiotensin | mesangial cells | mice