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Nature neuroscience, ISSN 1546-1726, 2002, Volume 5, Issue 7, pp. 627 - 628
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal... 
DOPAMINE NEURONS | NEUROSCIENCES | Parkinson Disease - therapy | Postoperative Complications - etiology | Mesencephalon - cytology | Humans | Middle Aged | Hyperkinesis - diagnosis | Neurons - transplantation | Brain Tissue Transplantation - adverse effects | Time Factors | Mesencephalon - transplantation | Putamen - physiopathology | Retrospective Studies | Dystonia - etiology | Parkinson Disease - diagnostic imaging | Cells, Cultured | Putamen - diagnostic imaging | Dyskinesias - etiology | Disease Progression | Hyperkinesis - etiology | Postoperative Complications - diagnosis | Cell Division - physiology | Dystonia - diagnosis | Mesencephalon - embryology | Dyskinesias - diagnosis | Tomography, Emission-Computed | Complications and side effects | Care and treatment | Parkinson's disease | Transplantation | Diagnosis | Research | Movement disorders | Risk factors | Cells | Neurons : transplantation | Cell Division : physiology | Neurosciences | Middle Age | Support | Medical and Health Sciences | Medicin och hälsovetenskap | Putamen : physiopathology | Dystonia : diagnosis | Hyperkinesis : diagnosis | Postoperative Complications : diagnosis | Cultured | Neurovetenskaper | Human | Basic Medicine | Mesencephalon : embryology | Dystonia : etiology | Mesencephalon : transplantation | Mesencephalon : cytology | Postoperative Complications : etiology | Parkinson Disease : therapy | Dyskinesias : diagnosis | Putamen : radionuclide imaging | Parkinson Disease : radionuclide imaging | Dyskinesias : etiology | Medicinska och farmaceutiska grundvetenskaper | Brain Tissue Transplantation : adverse effects | Non-U.S. Gov't | Hyperkinesis : etiology
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 6, pp. e0157602 - e0157602
Backgound The purpose of this study was to assess the biological and clinical effects of n-acetyl-cysteine (NAC) in Parkinson's disease (PD). Methods The... 
OXIDATIVE STRESS | ANTIOXIDANTS | GLUTATHIONE | TRANSPORTER BINDING | MULTIDISCIPLINARY SCIENCES | HEALTHY CONTROLS | FOLLOW-UP | ACETYLCYSTEINE | ALPHA-SYNUCLEIN | BRAIN | SPECT | Neuroprotective Agents - therapeutic use | Dopamine Plasma Membrane Transport Proteins - metabolism | Putamen - pathology | Mesencephalon - metabolism | Human Embryonic Stem Cells - cytology | Humans | Middle Aged | Caudate Nucleus - pathology | Male | Parkinson Disease - drug therapy | Dopaminergic Neurons - cytology | Dopaminergic Neurons - metabolism | Rotenone - antagonists & inhibitors | Rotenone - toxicity | Dopaminergic Neurons - drug effects | Mesencephalon - drug effects | Female | Cell Differentiation | Parkinson Disease - metabolism | Acetylcysteine - therapeutic use | Dopamine - metabolism | Mesencephalon - pathology | Cell Survival - drug effects | Human Embryonic Stem Cells - metabolism | Parkinson Disease - pathology | Parkinson Disease - diagnostic imaging | Tissue Culture Techniques | Putamen - diagnostic imaging | Single Photon Emission Computed Tomography Computed Tomography | Neurotoxins - toxicity | Putamen - drug effects | Caudate Nucleus - metabolism | Mesencephalon - diagnostic imaging | Antioxidants - therapeutic use | Caudate Nucleus - diagnostic imaging | Pilot Projects | Aged | Caudate Nucleus - drug effects | Neurotoxins - antagonists & inhibitors | Putamen - metabolism | Cell culture | Oxidative stress | Cysteine | Neurosciences | Parkinson's disease | Mesencephalon | Parkinsons disease | Acetylcysteine | Tissue culture | Antioxidants | Biological effects | Rodents | Dopamine transporter | Movement disorders | Binding | Medical imaging | Dopamine | Neurodegenerative diseases | Neurons | Exposure | Patients | Putamen | Rotenone | Medicine | Studies | Brain research | Stem cells | In vivo methods and tests | Transporter | Integrative medicine | Index Medicus
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2016, Volume 167, Issue 2, pp. 566 - 580.e19
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2015, Volume 351, Issue 6268, pp. aac9698 - aac9698
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 357, Issue 6357, pp. 1255 - 1261
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson's disease (PD), but how these... 
GLUCOCEREBROSIDASE | PACEMAKING | DJ-1 | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | MULTIDISCIPLINARY SCIENCES | Mitochondria - enzymology | Mesencephalon - metabolism | Humans | Protein Deglycase DJ-1 - genetics | Substantia Nigra - metabolism | Melanins - metabolism | Glucosylceramidase - deficiency | Lysosomes - metabolism | Dopaminergic Neurons - metabolism | Tacrolimus - pharmacology | Parkinson Disease - metabolism | Dopamine - metabolism | Disease Models, Animal | Substantia Nigra - enzymology | Cell Line | Calcineurin Inhibitors - pharmacology | Oxidation-Reduction | Mesencephalon - enzymology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Parkinson Disease - genetics | Mice, Knockout | Animals | Parkinson Disease - enzymology | Mice | Oxidative Stress - drug effects | alpha-Synuclein - metabolism | Oxidation-reduction reaction | Development and progression | Mitochondria | Dopamine | Parkinson's disease | Health aspects | Brain | Energy metabolism | Animal models | Target recognition | Mesencephalon | Pathogenesis | Substantia nigra | Parkinsons disease | Lysosomes | Synuclein | Accumulation | Pathways | Enzymatic activity | Neurodegeneration | Rodents | Oxidation | Degeneration | Species | Movement disorders | Dopamine receptors | Neurodegenerative diseases | Neurons | Medical treatment | Metabolism | Patients | Glucosylceramidase | Index Medicus
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2017, Volume 95, Issue 1, pp. 123 - 137.e8
Journal Article
Lancet neurology, ISSN 1474-4422, 2008, Volume 7, Issue 11, pp. 1044 - 1055
Summary Over the past 15 years the use of transcranial B-mode sonography to assess brainstem and subcortical brain structures has become an important tool for... 
Neurology | REAL-TIME SONOGRAPHY | RESTLESS LEGS SYNDROME | SUBSTANTIA-NIGRA HYPERECHOGENICITY | ADULT-ONSET DYSTONIA | BASAL GANGLIA | IN-VIVO DETECTION | IDIOPATHIC PARKINSONS-DISEASE | ESSENTIAL TREMOR | CLINICAL NEUROLOGY | BRAIN PARENCHYMA SONOGRAPHY | PROGRESSIVE SUPRANUCLEAR PALSY | Predictive Value of Tests | Basal Ganglia - diagnostic imaging | Lateral Ventricles - pathology | Humans | Basal Ganglia Cerebrovascular Disease - diagnostic imaging | Ultrasonography, Doppler, Transcranial - methods | Lateral Ventricles - diagnostic imaging | Lateral Ventricles - physiopathology | Mesencephalon - physiopathology | Movement Disorders - diagnostic imaging | Mesencephalon - pathology | Diagnosis, Differential | Parkinson Disease - pathology | Parkinson Disease - diagnostic imaging | Basal Ganglia - physiopathology | Movement Disorders - pathology | Brain - physiopathology | Basal Ganglia - pathology | Parkinson Disease - physiopathology | Mesencephalon - diagnostic imaging | Ultrasonography, Doppler, Transcranial - trends | Basal Ganglia Cerebrovascular Disease - pathology | Movement Disorders - physiopathology | Basal Ganglia Cerebrovascular Disease - physiopathology | Brain - pathology | Neuroimaging | Parkinson's disease | Scanning | Mesencephalon | Neurodegenerative diseases | Brain stem | Lentiform nucleus | Substantia nigra | Differential diagnosis | Ultrasound | Movement disorders
Journal Article
Journal Article