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Cell Reports, ISSN 2211-1247, 06/2012, Volume 1, Issue 6, pp. 703 - 714
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors... 
HUMAN ES | IN-VITRO | VENTRAL MESENCEPHALON | FLOOR PLATE | MIDBRAIN DOPAMINE NEURONS | SUBSTANTIA-NIGRA | RAT MODEL | LINES | PARKINSONS-DISEASE | IPS CELLS | CELL BIOLOGY | Body Patterning - drug effects | Organ Specificity - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | Motor Activity - drug effects | Neurons - cytology | Neural Stem Cells - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Neural Tube - drug effects | Cell Differentiation - genetics | Organ Specificity - genetics | Dopamine - secretion | Dopaminergic Neurons - metabolism | Telencephalon - drug effects | Dopaminergic Neurons - drug effects | Neural Stem Cells - transplantation | Neurons - metabolism | Neurons - drug effects | Cell Lineage - genetics | Cell Survival - drug effects | Telencephalon - metabolism | Telencephalon - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Glycogen Synthase Kinase 3 - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Embryonic Stem Cells - drug effects | Wnt Signaling Pathway - genetics | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Neural Tube - embryology | Body Patterning - genetics | Neural Stem Cells - metabolism | Electrophysiological Phenomena - drug effects | Biological Sciences | Biologi | Naturvetenskap | Cellbiologi | Natural Sciences | Cell Biology
Journal Article
Psychological Medicine, ISSN 0033-2917, 11/2009, Volume 39, Issue 11, pp. 1763 - 1777
Journal Article
Cell Reports, ISSN 2211-1247, 03/2016, Volume 14, Issue 8, pp. 1930 - 1939
Dopamine release during reward-driven behaviors influences synaptic plasticity. However, dopamine innervation and release in the hippocampus and its role... 
passive avoidance | fear conditioning | memory | ventral tegmental area | inhibitory avoidance | LTP | in vivo recording | Memory | Passive avoidance | Inhibitory avoidance | In vivo recording | Ventral tegmental area | Fear conditioning | TRANSPORTER | MEMORY | PERSISTENCE | NEURONS | STIMULI | RECEPTOR | LONG-TERM POTENTIATION | REWARD | MODULATION | VENTRAL TEGMENTAL AREA | CELL BIOLOGY | CA1 Region, Hippocampal - cytology | Mesencephalon - cytology | Synaptic Transmission - physiology | CA1 Region, Hippocampal - drug effects | Electrodes | CA3 Region, Hippocampal - drug effects | Long-Term Potentiation - drug effects | Pyramidal Cells - physiology | Receptors, Dopamine D1 - agonists | Long-Term Potentiation - physiology | Mesencephalon - drug effects | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Mesencephalon - physiology | Action Potentials - drug effects | Dopamine - metabolism | Microtomy | Pyramidal Cells - cytology | Synapses - drug effects | CA1 Region, Hippocampal - physiology | CA3 Region, Hippocampal - cytology | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Synapses - physiology | Tissue Culture Techniques | CA3 Region, Hippocampal - physiology | Mice, Inbred C57BL | Memory, Long-Term - drug effects | Synapses - ultrastructure | Avoidance Learning - physiology | Benzazepines - pharmacology | Memory, Long-Term - physiology | Action Potentials - physiology | Learning - physiology | Animals | Receptors, Dopamine D1 - physiology | Avoidance Learning - drug effects | Mice
Journal Article
Addiction Biology, ISSN 1355-6215, 07/2010, Volume 15, Issue 3, pp. 304 - 311
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2011, Volume 8, Issue 3, pp. 267 - 280
Studies of Parkinson's disease (PD) have been hindered by lack of access to affected human dopaminergic (DA) neurons. Here, we report generation of induced... 
PLURIPOTENT STEM-CELLS | KINASE-ACTIVITY | ALZHEIMERS-DISEASE | ANIMAL-MODELS | HUMAN FIBROBLASTS | ALPHA-SYNUCLEIN | LEWY-BODY-DISEASE | SUBSTANTIA-NIGRA | MIDBRAIN DOPAMINERGIC-NEURONS | PARKINSONS-DISEASE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Neurons - pathology | Humans | Middle Aged | rho-Associated Kinases - antagonists & inhibitors | Amino Acid Substitution - drug effects | Oxidopamine - pharmacology | rho-Associated Kinases - metabolism | Female | Cell Death - drug effects | Neurons - drug effects | Dopamine - metabolism | Protein-Serine-Threonine Kinases - metabolism | Induced Pluripotent Stem Cells - metabolism | Mesencephalon - pathology | Amides - pharmacology | Induced Pluripotent Stem Cells - pathology | Parkinson Disease - pathology | Induced Pluripotent Stem Cells - drug effects | Hydrogen Peroxide - pharmacology | Protein-Serine-Threonine Kinases - genetics | Parkinson Disease - genetics | Mutation - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Leupeptins - pharmacology | Phenotype | Animals | Cell Differentiation - drug effects | Parkinson Disease - enzymology | Mice | Pyridines - pharmacology | Oxidative Stress - drug effects | α-synuclein(SNCA) | 6-hydroxydopamine | p.G2019S | hydrogen peroxide | Leucine Rich Repeat Kinase 2 (LRRK2) | human embryonic stem cells (hESCs) | induced pluripotent stem cells (iPSCs) | midbrain dopaminergic neurons (mDA) | Parkinson’s disease | MG-132
Journal Article
Journal Article
Journal Article
Drugs, ISSN 0012-6667, 09/2013, Volume 73, Issue 13, pp. 1405 - 1415
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2009, Volume 106, Issue 4, pp. 1285 - 1290
Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the gastrointestinal tract in response to food intake. It enhances... 
Dopaminergic neurons | Brain | Receptors | Neurons | Cell death | Rodents | Motor ability | Hypoxia | Strokes | Apoptosis | Neuroprotection | Stroke | Diabetes | Neurodegeneration | Exendin-4 | CEREBELLAR GRANULE NEURONS | APOPTOSIS | MULTIDISCIPLINARY SCIENCES | neurodegeneration | stroke | NERVE GROWTH-FACTOR | DIABETES-MELLITUS | CYCLIC-AMP | IN-VITRO | GLUCAGON-LIKE PEPTIDE-1 | neuroprotection | DISEASE | ANIMAL-MODEL | diabetes | exendin-4 | CEREBRAL-ISCHEMIA | Neurons - pathology | Mesencephalon - cytology | Humans | Brain Infarction - pathology | Parkinson Disease - drug therapy | Cerebral Cortex - cytology | Stroke - pathology | Cytoprotection - drug effects | Parkinson Disease - metabolism | Cell Death - drug effects | Neurons - drug effects | Brain Infarction - drug therapy | Dopamine - metabolism | Disease Models, Animal | Receptors, Glucagon - genetics | Cell Hypoxia - drug effects | Parkinson Disease - pathology | Cells, Cultured | Rats | Receptors, Glucagon - metabolism | Treatment Outcome | Stroke - drug therapy | Peptides - pharmacology | Gene Expression Regulation - drug effects | Stroke - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Embryo, Mammalian - cytology | Venoms - therapeutic use | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Mice | Venoms - pharmacology | Peptides - therapeutic use | Parkinsonism | Stroke (Disease) | Development and progression | Cell receptors | Properties | Index Medicus | Biological Sciences
Journal Article
International Journal of Neuropsychopharmacology, ISSN 1461-1457, 2016, Volume 19, Issue 12
Background: Multiple studies suggest a pivotal role of the endocannabinoid system in regulating the reinforcing effects of various substances of abuse.... 
Depression | Anxiety | Dopamine | antagonism | Nicotine reward | SMOKING-CESSATION | PSYCHIATRY | CUE-INDUCED REINSTATEMENT | RECEPTOR PARTIAL AGONIST | CARDIOMETABOLIC RISK-FACTORS | NEUROSCIENCES | CLINICAL NEUROLOGY | YOHIMBINE-INDUCED INCREASES | anxiety | BODY-WEIGHT | ALCOHOL-SEEKING | CB1 antagonism | FOOD-REINFORCED BEHAVIOR | SEEKING BEHAVIOR | PHARMACOLOGY & PHARMACY | nicotine reward | depression | SUSTAINED-RELEASE BUPROPION | dopamine | Behavior, Addictive - drug therapy | Rats, Wistar | Mesencephalon - metabolism | Rats, Long-Evans | Motor Activity - drug effects | Male | Cannabinoid Receptor Antagonists - toxicity | Weight Loss - drug effects | Behavior, Addictive - metabolism | Tobacco Use Disorder - metabolism | Dose-Response Relationship, Drug | Motivation - drug effects | Piperidines - pharmacology | Time Factors | Tobacco Use Cessation Products | Depression - chemically induced | Dopaminergic Neurons - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Dopaminergic Neurons - drug effects | Mesencephalon - drug effects | Tobacco Use Disorder - psychology | Behavior, Animal - drug effects | Swimming | Behavior, Addictive - physiopathology | Mesencephalon - physiopathology | Disease Models, Animal | Pyrazoles - pharmacology | Cues | Piperidines - toxicity | Anxiety - psychology | Tobacco Use Disorder - physiopathology | Tobacco Use Disorder - drug therapy | Maze Learning - drug effects | Drug-Seeking Behavior - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Animals | Signal Transduction - drug effects | Drug Inverse Agonism | Pyrazoles - toxicity | Depression - psychology | Anxiety - chemically induced | Behavior, Addictive - psychology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2006, Volume 116, Issue 12, pp. 3229 - 3239
Journal Article