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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2015, Volume 309, Issue 10, pp. H1679 - H1696
Normal pregnancy is associated with adaptive hemodynamic, hormonal, and vascular changes, and estrogen (E-2) may promote vasodilation during pregnancy;... 
Vascular smooth muscle | Calcium | Nitric oxide | Estrogen | Endothelium | endothelium | estrogen | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | vascular smooth muscle | calcium | CA2+ ENTRY MECHANISMS | EPICARDIAL CORONARY-ARTERIES | MESENTERIC MICROVESSELS | VASCULAR SMOOTH-MUSCLE | ENDOTHELIAL NITRIC-OXIDE | GENDER-SPECIFIC REDUCTION | IN-VITRO | FEMALE RAT | PULMONARY-ARTERY ENDOTHELIUM | PERIPHERAL VASCULAR DISEASE | SIGNAL-REGULATED KINASE | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Immunohistochemistry | Mesenteric Arteries - physiology | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Endothelium, Vascular - drug effects | Estrogen Receptor beta - metabolism | Estrogen Receptor alpha - agonists | Potassium Channel Blockers - pharmacology | Muscle, Smooth, Vascular - drug effects | Phenols - pharmacology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Arteries - drug effects | Mesenteric Arteries - metabolism | Vasoconstriction - drug effects | Blotting, Western | Endothelium, Vascular - metabolism | Carotid Arteries - physiology | Vasodilation - drug effects | Adaptation, Physiological | Blood Pressure | Tetraethylammonium - pharmacology | Muscle, Smooth, Vascular - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Mesenteric Arteries - drug effects | Receptors, G-Protein-Coupled - agonists | Arteries - metabolism | Endothelium, Vascular - physiology | Vasoconstriction - physiology | Estrogen Receptor beta - agonists | Pregnancy - metabolism | Arteries - physiology | Aorta, Thoracic - physiology | Estrogen Receptor alpha - metabolism | Female | Renal Artery - metabolism | Aorta, Thoracic - drug effects | Vasodilation - physiology | Estrogens - metabolism | Muscle, Smooth, Vascular - physiology | Pregnancy - physiology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Renal Artery - physiology | Animals | Renal Artery - drug effects | Pregnancy | Dilatation | Pregnant women | Vasodilators | Blood vessels | Phenols | G proteins | Membrane proteins | Research | Health aspects | Genomics | Protein expression | Physiology | Hormones | Index Medicus | Vascular Biology and Microcirculation
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 597 - 601
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 787 - 796
Background and purpose:  Pharmacological analysis of synergism or functional antagonism between different receptors commonly assumes that interacting receptors... 
fluorescent ligand binding | endothelium | adrenoceptor | vascular smooth muscle | adventitia | confocal microscopy | cannabinoid | angiotensin | α1B/D-adrenoceptor knockout | 1B/D | adrenoceptor knockout | Adventitia | Fluorescent ligand binding | Angiotensin | Confocal microscopy | Vascular smooth muscle | Cannabinoid | Adrenoceptor | Endothelium | MESENTERIC-ARTERIES | SUBTYPES | ANANDAMIDE | GPR55 | SURFACE EXPRESSION | ANGIOTENSIN-II | ALPHA(1D)-ADRENERGIC RECEPTORS | alpha(1B/D)-adrenoceptor knockout | PHARMACOLOGY | CARDIOVASCULAR-DISEASE | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | Receptors, Adrenergic, alpha-1 - metabolism | Molecular Probe Techniques | Propanolamines - metabolism | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Fluorescent Dyes - metabolism | Prazosin - metabolism | Male | Molecular Imaging | Prazosin - analogs & derivatives | Receptors, Cannabinoid - metabolism | Receptors, Adrenergic - genetics | Tail - blood supply | Receptors, Adrenergic, beta - metabolism | Mesenteric Arteries - cytology | Boron Compounds - metabolism | Angiotensin II - metabolism | Receptors, Adrenergic - metabolism | Mice, Inbred C57BL | Rats | Pyrazoles - metabolism | Mesenteric Arteries - metabolism | Connective Tissue - metabolism | Mice, Knockout | Receptors, Adrenergic - deficiency | Microscopy, Confocal | Animals | Endothelium, Vascular - metabolism | Ligands | Mice | Localization | Rodents | Veins & arteries | Index Medicus | Research Papers | Themed Section | D-adrenoceptor knockout | α1B
Journal Article
Circulation Research, ISSN 0009-7330, 11/2011, Volume 109, Issue 11, pp. 1259 - 1268
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2005, Volume 25, Issue 10, pp. 2106 - 2113
OBJECTIVE—Angiotensin (Ang) II-induced vascular damage may be partially mediated by reactive oxygen species generation and inflammation. Homozygous... 
Hypertension | Macrophages | Reactive oxygen species | KAPPA-B ACTIVATION | SPONTANEOUSLY HYPERTENSIVE-RATS | CHRONIC GRANULOMATOUS-DISEASE | CONVERTING-ENZYME-INHIBITION | BLOOD-PRESSURE | macrophages | NAD(P)H OXIDASE | reactive oxygen species | IN-VIVO | PERIPHERAL VASCULAR DISEASE | SUPEROXIDE PRODUCTION | GROWTH-FACTOR | HEMATOLOGY | hypertension | SMOOTH-MUSCLE CELLS | Vasculitis - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress - physiology | Vasculitis - pathology | NADPH Oxidases - metabolism | Mesenteric Arteries - immunology | Mesenteric Arteries - pathology | Aorta - metabolism | Vasculitis - immunology | Mice, Mutant Strains | Inflammation Mediators - metabolism | Macrophage Colony-Stimulating Factor - genetics | Macrophages - immunology | Endothelium, Vascular - immunology | Inflammation Mediators - immunology | Vasoconstrictor Agents - pharmacology | Angiotensin II - pharmacology | Osteopetrosis - pathology | Vascular Resistance | Macrophages - pathology | Aorta - immunology | Osteopetrosis - metabolism | Macrophage Colony-Stimulating Factor - metabolism | Mesenteric Arteries - metabolism | Mice, Inbred Strains | Osteopetrosis - immunology | Aorta - pathology | Phenotype | Animals | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Mice | Oxidative Stress - drug effects | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2017, Volume 174, Issue 8, pp. 657 - 671
BACKGROUND AND PURPOSE The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS-derived NO and ROS signalling in... 
DIABETES-MELLITUS | HYPERPOLARIZING FACTOR | CONCISE GUIDE | NITRIC-OXIDE SYNTHASE | IN-VIVO | PHARMACOLOGY & PHARMACY | INDUCED RELAXATION | HYDROGEN-PEROXIDE | GTP CYCLOHYDROLASE-1 | BLOOD-PRESSURE | VASCULAR SUPEROXIDE-PRODUCTION | Mesenteric Arteries - cytology | Nitric Oxide - biosynthesis | Reactive Oxygen Species - metabolism | Biopterin - deficiency | Endothelial Cells - metabolism | GTP Cyclohydrolase - deficiency | Cells, Cultured | Male | GTP Cyclohydrolase - metabolism | Mesenteric Arteries - metabolism | Biopterin - analogs & derivatives | Biopterin - metabolism | Mice, Knockout | Animals | Mice | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | GTP Cyclohydrolase - genetics | COX-2 inhibitors | Enzymes | Vasodilators | Analysis | Cardiac patients | Physiological aspects | Acetylcholine | Tubulins | High performance liquid chromatography | Arteries | Endothelium | GTP | Hydrogen peroxide | Homeostasis | Biosynthesis | Vasodilation | Western blotting | Prostaglandin endoperoxide synthase | Proteins | Clonal deletion | Tetrahydrobiopterin | Rodents | Phenylephrine | Deletion | Therapeutic applications | Vasoconstriction | Liquid chromatography | High-performance liquid chromatography | Nitric-oxide synthase | Endothelial cells | GTP cyclohydrolase | Nitric oxide | Microvasculature | Cardiovascular diseases | Veins & arteries | Index Medicus | Research Papers | Research Paper
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2016, Volume 36, Issue 12, pp. 2404 - 2411
OBJECTIVE—To establish the role of Kv7 channels in EPAC (exchange protein directly activated by cAMP)-dependent relaxations of the rat vasculature and to... 
K channel | signaling pathways | vascular smooth muscle | isoproterenol | cyclic nucleotide | SENSITIVE POTASSIUM CHANNELS | PROTEIN-KINASE | DOWN-REGULATION | K(V)7 CHANNELS | ADRENOCEPTOR-MEDIATED VASORELAXATION | ISOLATED MESENTERIC-ARTERY | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | HYPERTENSIVE-RATS | K+ CHANNELS | CAMP | Rats, Wistar | Humans | Male | Mesenteric Arteries - drug effects | KCNQ Potassium Channels - antagonists & inhibitors | Dose-Response Relationship, Drug | Transfection | Guanine Nucleotide Exchange Factors - metabolism | HEK293 Cells | Renal Artery - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | A Kinase Anchor Proteins - metabolism | Potassium Channel Blockers - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | rap1 GTP-Binding Proteins - metabolism | Vasodilator Agents - pharmacology | Signal Transduction | KCNQ Potassium Channels - agonists | Adrenergic beta-Agonists - pharmacology | Mesenteric Arteries - metabolism | Guanine Nucleotide Exchange Factors - agonists | Animals | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Membrane Potentials | KCNQ Potassium Channels - metabolism | Protein Kinase Inhibitors - pharmacology | Renal Artery - drug effects | Vasodilation - drug effects | In Vitro Techniques | KCNQ Potassium Channels - genetics | Index Medicus | Cell Signalling | Vascular Smooth Muscle | Ion Channels | Cyclic Nucleotide | Signalling Pathways | Vascular Biology | Membrane Transport | K Channel | Isoproterenol
Journal Article
Journal Article
Diabetologia, ISSN 0012-186X, 01/2010, Volume 53, Issue 5, pp. 989 - 1000
Journal Article
Circulation Research, ISSN 0009-7330, 04/2012, Volume 110, Issue 9, pp. 1211 - 1216
RATIONALE:Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates... 
Endothelial dysfunction | Vasodilatation | Oxidative stress | Uncoupling protein | Diabetes | OXYGEN SPECIES PRODUCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | RESISTANCE ARTERIES | DIABETIC-RATS | endothelial dysfunction | uncoupling protein | vasodilatation | SKELETAL-MUSCLE | NITRIC-OXIDE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HYDROGEN-PEROXIDE | MITOCHONDRIAL SUPEROXIDE | HEMATOLOGY | diabetes | UP-REGULATION | oxidative stress | Free Radical Scavengers - pharmacology | Myography | Mesenteric Arteries - physiopathology | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Oxidative Stress | Humans | Ion Channels - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Mesenteric Arteries - drug effects | Mitochondrial Proteins - genetics | Dose-Response Relationship, Drug | Transfection | Time Factors | Mitochondrial Proteins - metabolism | Diet, High-Fat | Obesity - etiology | Aorta, Thoracic - drug effects | Mitochondrial Proteins - deficiency | Organ Culture Techniques | Disease Models, Animal | Vasodilator Agents - pharmacology | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Obesity - physiopathology | Aorta, Thoracic - physiopathology | Mesenteric Arteries - metabolism | Regional Blood Flow | Mice, Knockout | Obesity - metabolism | Animals | Ion Channels - metabolism | Endothelium, Vascular - metabolism | Glucose - metabolism | Mice | Nitric Oxide Synthase - metabolism | Uncoupling Protein 2 | Vasodilation - drug effects | Nitric Oxide - metabolism | Ion Channels - deficiency | Index Medicus
Journal Article
Journal Article