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European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, 04/2017, Volume 53, Issue 4, pp. 460 - 510
Journal Article
Hypertension, ISSN 0194-911X, 02/2012, Volume 59, Issue 2, pp. 324 - 330
Journal Article
Circulation, ISSN 0009-7322, 07/2013, Volume 128, Issue 1, pp. 9 - 18
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2013, Volume 33, Issue 4, pp. 777 - 784
OBJECTIVE—To analyze the role of toll-like receptor 4 in modulating metabolism and endothelial function. APPROACH AND RESULTS—Type 2 diabetic mice with mutated... 
systolic arterial blood pressure | endothelium-derived contracting factor | nitric oxide | proinflammatory cytokines | obesity | OXIDATIVE STRESS | ACTIVATION | MACROPHAGES | VASCULAR SMOOTH-MUSCLE | SYNTHASE | INSULIN-RESISTANCE | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | NADH/NADPH OXIDASE | HYPERTENSION | HEMATOLOGY | INNATE IMMUNITY | Mesenteric Arteries - physiopathology | Oxidative Stress | Receptors, Leptin - genetics | NADPH Oxidases - metabolism | Endothelium, Vascular - drug effects | RNA, Messenger - metabolism | Toll-Like Receptor 4 - deficiency | Carotid Arteries - enzymology | NADPH Oxidases - genetics | Disease Models, Animal | NADH, NADPH Oxidoreductases - genetics | Down-Regulation | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Toll-Like Receptor 4 - genetics | Obesity - physiopathology | Toll-Like Receptor 4 - metabolism | Vasoconstriction - drug effects | Mice, Knockout | Receptors, Leptin - deficiency | 6-Ketoprostaglandin F1 alpha - metabolism | Lipopolysaccharides - pharmacology | Mice | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Mutation | Vasodilation - drug effects | Mesenteric Arteries - enzymology | Muscle, Smooth, Vascular - enzymology | Phosphorylation | Diabetes Mellitus, Type 2 - genetics | Endothelium, Vascular - enzymology | Muscle, Smooth, Vascular - physiopathology | Obesity - genetics | Dose-Response Relationship, Drug | Superoxides - metabolism | Membrane Proteins - metabolism | Aorta - physiopathology | Nitric Oxide Synthase Type III - metabolism | NADH, NADPH Oxidoreductases - metabolism | Aorta - enzymology | Vasodilator Agents - pharmacology | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - enzymology | Endothelium, Vascular - physiopathology | NADPH Oxidase 4 | Mice, Inbred C3H | NADPH Oxidase 1 | Animals | Diabetes Mellitus, Type 2 - physiopathology | Carotid Arteries - physiopathology | Obesity - enzymology | Cyclooxygenase 1 - metabolism | Nitric Oxide - metabolism
Journal Article
Journal Article
The Journal of Physiology, ISSN 0022-3751, 10/2011, Volume 589, Issue 19, pp. 4777 - 4786
Non‐Technical Summary  Adverse environments during early life are linked with an increased risk of cardiovascular disease. There is an alarming increase in the... 
SUPPLEMENTATION | IN-UTERO | CONTRIBUTE | PHYSIOLOGY | CALCIUM STATUS | D DEFICIENCY | CARDIOVASCULAR-DISEASE | NITRIC-OXIDE | 1,25-DIHYDROXYVITAMIN D-3 | NEUROSCIENCES | BLOOD-PRESSURE | PREGNANCY | Mesenteric Arteries - physiopathology | Muscle, Smooth, Vascular - metabolism | Body Weight - drug effects | Endothelium, Vascular - drug effects | Male | Mesenteric Arteries - drug effects | Nitroprusside - pharmacology | Vitamin D Deficiency - physiopathology | Muscle, Smooth, Vascular - physiopathology | Heart Rate - drug effects | Heart Rate - physiology | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Vasodilation - physiology | Biological Factors - metabolism | Muscle, Smooth, Vascular - drug effects | Endothelium, Vascular - physiopathology | Rats | Mesenteric Arteries - metabolism | Rats, Sprague-Dawley | Hypertension - physiopathology | Hypertension - metabolism | Vitamin D - blood | Animals | Endothelium, Vascular - metabolism | Muscle Contraction - physiology | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Vasodilation - drug effects | Vitamin D Deficiency - metabolism | Body Weight - physiology | Nitric Oxide - metabolism | Prostaglandins - metabolism | Pregnancy | Hypertension | Heart beat | Vitamin D | Vasodilators | Nitric oxide | Calcifediol | Alfacalcidol | Endothelium-derived relaxing factors | Endothelium | Blood pressure | Womens health | Rodents | Veins & arteries | Integrative
Journal Article
Diabetologia, ISSN 0012-186X, 01/2010, Volume 53, Issue 5, pp. 989 - 1000
Journal Article
Circulation Research, ISSN 0009-7330, 04/2012, Volume 110, Issue 9, pp. 1211 - 1216
RATIONALE:Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates... 
Endothelial dysfunction | Vasodilatation | Oxidative stress | Uncoupling protein | Diabetes | OXYGEN SPECIES PRODUCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | RESISTANCE ARTERIES | DIABETIC-RATS | endothelial dysfunction | uncoupling protein | vasodilatation | SKELETAL-MUSCLE | NITRIC-OXIDE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HYDROGEN-PEROXIDE | MITOCHONDRIAL SUPEROXIDE | HEMATOLOGY | diabetes | UP-REGULATION | oxidative stress | Free Radical Scavengers - pharmacology | Myography | Mesenteric Arteries - physiopathology | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Oxidative Stress | Humans | Ion Channels - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Mesenteric Arteries - drug effects | Mitochondrial Proteins - genetics | Dose-Response Relationship, Drug | Transfection | Time Factors | Mitochondrial Proteins - metabolism | Diet, High-Fat | Obesity - etiology | Aorta, Thoracic - drug effects | Mitochondrial Proteins - deficiency | Organ Culture Techniques | Disease Models, Animal | Vasodilator Agents - pharmacology | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Obesity - physiopathology | Aorta, Thoracic - physiopathology | Mesenteric Arteries - metabolism | Regional Blood Flow | Mice, Knockout | Obesity - metabolism | Animals | Ion Channels - metabolism | Endothelium, Vascular - metabolism | Glucose - metabolism | Mice | Nitric Oxide Synthase - metabolism | Uncoupling Protein 2 | Vasodilation - drug effects | Nitric Oxide - metabolism | Ion Channels - deficiency
Journal Article
Cardiovascular Research, ISSN 0008-6363, 2010, Volume 87, Issue 3, pp. 569 - 577
Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we investigated... 
Remodelling | Arginase | Spontaneously hypertensive rat | Endothelial function | Arteries | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | RESISTANCE ARTERIES | BLOOD-PRESSURE REDUCTION | GENE POLYMORPHISMS | HYPERTROPHY | SMOOTH-MUSCLE | STIFFNESS | VASCULAR FUNCTION | NITRIC-OXIDE | ANTIHYPERTENSIVE TREATMENT | Carotid Arteries - drug effects | Mesenteric Arteries - physiopathology | Compliance | Arginase - metabolism | Rats, Inbred WKY | Endothelium, Vascular - drug effects | Heart Diseases - prevention & control | Hypertension - drug therapy | Male | Mesenteric Arteries - drug effects | Endothelium, Vascular - enzymology | Arginine - analogs & derivatives | Dose-Response Relationship, Drug | Time Factors | Carotid Arteries - enzymology | Blood Pressure - drug effects | Membrane Proteins - metabolism | Aorta - physiopathology | Arginase - antagonists & inhibitors | Hypertension - enzymology | Hypertension - genetics | Aorta - enzymology | Disease Models, Animal | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Aorta - drug effects | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Rats | Myocardium - pathology | Heart Diseases - enzymology | Vasoconstriction - drug effects | Hypertension - pathology | Hypertension - physiopathology | Cardiovascular Agents - pharmacology | Collagen - metabolism | Animals | Carotid Arteries - physiopathology | Arginine - pharmacology | Cyclooxygenase 2 - metabolism | Fibrosis | Nitric Oxide Synthase - metabolism | Cyclooxygenase 1 - metabolism | Vasodilation - drug effects | Mesenteric Arteries - enzymology | Heart Diseases - pathology
Journal Article
Journal Article