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The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 12, pp. 3626 - 3636
The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates... 
MEDICINE, RESEARCH & EXPERIMENTAL | BREAST-CANCER CELLS | DEVELOPMENTAL REGULATORS | CELLULAR MEMORY | E-CADHERIN EXPRESSION | HEMATOPOIETIC STEM-CELLS | PROSTATE-CANCER | MYC TRANSGENIC MICE | SELF-RENEWAL | NF-KAPPA-B | TRANSCRIPTION FACTOR | Nasopharyngeal Neoplasms - genetics | Neoplasm Transplantation | Nasopharyngeal Neoplasms - metabolism | Epithelial Cells - metabolism | Cadherins - metabolism | Humans | Glycogen Synthase Kinase 3 beta | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Mesoderm - cytology | Repressor Proteins - antagonists & inhibitors | Nasopharyngeal Neoplasms - pathology | Cadherins - genetics | Epithelial Cells - cytology | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Nasopharyngeal Neoplasms - etiology | Snail Family Transcription Factors | Nasopharynx - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | PTEN Phosphohydrolase - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Neoplasm Invasiveness | Down-Regulation | Gene Silencing | PTEN Phosphohydrolase - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Glycogen Synthase Kinase 3 - metabolism | Transcription Factors - metabolism | Animals | Polycomb Repressive Complex 1 | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mesoderm - metabolism | Mice | Nasopharynx - cytology | Chromatin | Care and treatment | Lymphomas | Research | Analysis | Cancer
Journal Article
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 138, Issue 5, pp. 1810 - 1822.e2
Background & Aims The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown. Recognizing that Hedgehog signaling is... 
Gastroenterology and Hepatology | BMP4 | Hedgehog Signaling | SOX9 | Barrett's Esophagus | CELLS | SONIC HEDGEHOG | ESOPHAGEAL | MORPHOGENESIS | PYLORIC SPHINCTER EPITHELIUM | GROWTH | COLUMNAR | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Precancerous Conditions - etiology | Adenocarcinoma - pathology | Epithelial Cells - metabolism | Humans | Hedgehog Proteins - metabolism | Bile - metabolism | Precancerous Conditions - metabolism | Barrett Esophagus - etiology | Bone Morphogenetic Protein 4 - metabolism | Esophageal Neoplasms - pathology | Adenocarcinoma - metabolism | Barrett Esophagus - pathology | Keratins - metabolism | Transfection | Hedgehog Proteins - genetics | RNA Interference | Esophageal Neoplasms - metabolism | Precancerous Conditions - pathology | Cell Differentiation | Patched Receptors | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Barrett Esophagus - metabolism | Cell Line | Gastroesophageal Reflux - metabolism | Esophagus - metabolism | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Mice, Transgenic | Signal Transduction - genetics | Cell Communication - genetics | Metaplasia | Esophagus - pathology | Phenotype | Animals | Gastroesophageal Reflux - complications | Bile Reflux - complications | Bile Reflux - metabolism | Mesoderm - metabolism | Mice | Mesoderm - pathology | Patched-1 Receptor | Hydrogen-Ion Concentration | Receptors, Cell Surface - genetics | RNA | Oncology, Experimental | Brain tumors | Barrett's esophagus | Bone morphogenetic proteins | Research | Universities and colleges | Cancer | Hedgehog signaling
Journal Article
Journal Article
Nature cell biology, ISSN 1476-4679, 2008, Volume 10, Issue 5, pp. 593 - 601
Journal Article
Developmental cell, ISSN 1534-5807, 03/2017, Volume 40, Issue 6, pp. 595 - 607.e4
The interplay between transcription factors and chromatin dictates gene regulatory network activity. Germ layer specification is tightly coupled with zygotic... 
Smad2/3 | Foxa | Tle/Groucho | ChIP-seq | pioneer factor | histone modifications | Sox7 | germ layer specification | Xenopus tropicalis | epigenetics | CHIP-SEQ | MATERNAL VEGT | GROUCHO | STEM-CELLS | IN-VITRO | INTERACTION MOTIF | ASYMMETRIC EXPRESSION | ENDODERM | COMPACTED CHROMATIN | DEVELOPMENTAL BIOLOGY | EARLY XENOPUS DEVELOPMENT | CELL BIOLOGY | Protein Binding - genetics | Xenopus Proteins - genetics | Blastula - metabolism | Xenopus - genetics | Embryo, Nonmammalian - metabolism | Cleavage Stage, Ovum - metabolism | Co-Repressor Proteins - metabolism | Endoderm - embryology | Nodal Protein - metabolism | RNA Polymerase II - metabolism | RNA, Messenger - metabolism | Xenopus - embryology | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Transcription, Genetic | Lysine - metabolism | Mesoderm - embryology | RNA, Messenger - genetics | Signal Transduction - genetics | Forkhead Transcription Factors - genetics | Regulatory Sequences, Nucleic Acid - genetics | Endoderm - metabolism | Transcription Factors - metabolism | Animals | Sequence Analysis, RNA | Xenopus - metabolism | Xenopus Proteins - metabolism | Enhancer Elements, Genetic - genetics | Mesoderm - metabolism | Histones - metabolism | Genome | Methylation | Computer science | Chromatin | Genes | Genomics | Genetic aspects | DNA binding proteins | Gene expression | Epigenetic inheritance | Anopheles | endoderm | Ep300 | Tle | Groucho | mesoderm | Smad2 | Nodal | Foxh1 | TGFβ | zygotic gene activation | RNA Polymerase II
Journal Article
Cancer cell, ISSN 1535-6108, 2006, Volume 9, Issue 4, pp. 261 - 272
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 6, pp. 2324 - 2329
In many organs, myofibroblasts play a major role in the scarring process in response to injury. In liver fibrogenesis, hepatic stellate cells (HSCs) are... 
Phenotypes | Hepatocytes | Epithelial cells | Liver | Fibrosis | Cell lines | Antibodies | Hepatic stellate cells | Myofibroblasts | Liver cells | Epithelial-mesenchymal transition | Alpha-smooth muscle actin | Glisson's capsule | Podoplanin | alpha-smooth muscle actin | PATHWAYS | ACID | RAT | MULTIDISCIPLINARY SCIENCES | MOUSE | RECEPTOR | POPULATIONS | podoplanin | SMOOTH-MUSCLE | fibrosis | LINEAGE | Liver - pathology | WT1 Proteins - metabolism | Membrane Glycoproteins - metabolism | Hepatic Stellate Cells - metabolism | RNA, Messenger - metabolism | Liver - injuries | Myofibroblasts - metabolism | Biliary Tract - metabolism | Cell Transdifferentiation - drug effects | Liver Cirrhosis - metabolism | Chemical and Drug Induced Liver Injury - pathology | WT1 Proteins - genetics | Hepatic Stellate Cells - pathology | Liver Cirrhosis - etiology | Myofibroblasts - pathology | Epithelium - pathology | Gene Expression | Liver Regeneration | Epithelium - metabolism | Signal Transduction | Liver - metabolism | RNA, Messenger - genetics | Cells, Cultured | Mice, Transgenic | Chemical and Drug Induced Liver Injury - genetics | Carbon Tetrachloride - toxicity | Biliary Tract - pathology | Nerve Tissue Proteins - metabolism | Cell Lineage | Transforming Growth Factor beta - pharmacology | Animals | Chemical and Drug Induced Liver Injury - metabolism | Liver Cirrhosis - pathology | Mesoderm - metabolism | Mice | Mesoderm - pathology | Transforming Growth Factor beta - metabolism | Biological Sciences
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 547, Issue 7664, pp. 453 - 457
... of polyunsaturated lipids. These lipids are the substrates for lipid peroxidation by lipoxygenase enzymes8,9. This lipid metabolism creates a dependency on pathways convergin... 
EPITHELIAL-MESENCHYMAL TRANSITION | METABOLISM | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | HUMAN-MELANOMA CELLS | SENSITIVITY | DEATH | INHIBITOR | EXPRESSION | SIGNATURE | REVEALS | Prostatic Neoplasms - metabolism | Cadherins - metabolism | Humans | Mesoderm - drug effects | Melanoma - enzymology | Male | Lipid Peroxides - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Neoplasms - genetics | Mesoderm - enzymology | Cell Death | Epithelial-Mesenchymal Transition | Lipid Peroxidation - drug effects | Cell Transdifferentiation | Prostatic Neoplasms - drug therapy | Melanoma - metabolism | Glutathione Peroxidase - metabolism | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasms - enzymology | Melanoma - pathology | Iron - metabolism | Neoplasms - drug therapy | Cell Lineage | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mesoderm - metabolism | Neoplasms - pathology | Mesoderm - pathology | Peroxidase | Research | Chemical properties | Chemical synthesis | Analysis | Cancer cells | Therapy | Biotechnology | Carcinoma | Mesenchyme | Genes | Lipid peroxidation | Lipids | Iron | Genomes | Phospholipids | Kinases | Cancer therapies | Proteins | Organoids | Dissipation | Peroxides | Lipid metabolism | Glutathione | Transfer RNA | Peroxidation | Glutathione peroxidase | Enzymes | Mortality | Melanoma | Selenocysteine | Tumor cell lines | Metabolism | Substrates | Cell death | Lipoxygenase | Prostate cancer | Prostate | Tumors | Apoptosis | Cancer | Index Medicus
Journal Article