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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2018, Volume 366, Issue 1, pp. 205 - 219
In this study, we examined the effects of target expression, neonatal Fc receptor (FcRn) expression in tumors, and pH-dependent target binding on the... 
Metabolism, Transport, and Pharmacogenomics
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2011, Volume 336, Issue 1, pp. 87 - 94
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2013, Volume 347, Issue 3, pp. 746 - 754
Nicotine metabolism is believed to affect not only nicotine’s pharmacological effects but also nicotine addiction. As a key step toward testing this... 
Metabolism, Transport, and Pharmacogenomics
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 10/2018, Volume 367, Issue 1, pp. 168 - 183
Corticosteroids (CS) regulate the expression of numerous genes at the mRNA and protein levels. The time course of CS pharmacogenomics and proteomics were... 
MESSENGER-RNA DEGRADATION | GLUCOCORTICOID-RECEPTOR | QUANTITATIVE PROTEOMICS | PROTEIN EXPRESSION | GENE-EXPRESSION | NUCLEAR FACTOR-1 | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | METHYLPREDNISOLONE | TRANSCRIPTIONAL REGULATION | AMINOTRANSFERASE GENE | Metabolism, Transport, and Pharmacogenomics
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2018, Volume 364, Issue 2, pp. 238 - 245
Nicotine metabolism increases in pregnancy, which may contribute to the difficulties that pregnant women have in quitting smoking. We aimed to determine the... 
Index Medicus | Metabolism, Transport, and Pharmacogenomics
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 655 - 664
Brain metastases are a common cause of death in stage IV metastatic melanoma. Dabrafenib is a BRAF (gene encoding serine/threonine-protein kinase B-Raf)... 
BREAST-CANCER | SURVIVAL | EFFLUX | TRANSPORTERS | PHARMACOLOGY & PHARMACY | OPEN-LABEL | P-GLYCOPROTEIN ABCB1 | CANCER RESISTANCE PROTEIN | PHASE-2 TRIAL | VEMURAFENIB | ABCG2
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 05/2019, Volume 369, Issue 2, pp. 234 - 243
UDP-glucuronosyltransferase (UGT) 2A1 is an important enzyme in the detoxification of polycyclic aromatic hydrocarbons found in cigarette smoke. This enzyme is... 
LUNG-CANCER | UDP-GLUCURONOSYLTRANSFERASES | POLYCYCLIC AROMATIC-HYDROCARBONS | ENZYMES | GENES | VALIDATION | PHARMACOLOGY & PHARMACY | MICRORNAS | IDENTIFICATION | EXPRESSION | VARIANT
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2018, Volume 365, Issue 2, pp. 249 - 261
A compartmental blood-brain barrier (BBB) model describing drug transport across the BBB was implemented to evaluate the influence of efflux transporters on... 
TRANSPORT | GLIOBLASTOMA | PLASMA | EFFICACY | SLICE METHOD | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | STUDYING DRUG DISTRIBUTION | MODEL | P-GLYCOPROTEIN ABCB1 | CANCER RESISTANCE PROTEIN | Metabolism, Transport, and Pharmacogenomics
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2018, Volume 367, Issue 1, pp. 40 - 48
Efforts to prevent human immunodeficiency virus (HIV) infection via pre-exposure prophylaxis (PrEP) include the development of anti-HIV drugs as microbicides... 
HIV-INFECTION | ORAL TENOFOVIR | PHARMACOKINETICS | DISOPROXIL FUMARATE | SEX | MEN | DRUGS | ELIMINATION | PHARMACOLOGY & PHARMACY | AWARENESS | PREEXPOSURE PROPHYLAXIS PREP | Metabolism, Transport, and Pharmacogenomics
Journal Article
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2018, Volume 365, Issue 2, pp. 413 - 421
The farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in bile acid homeostasis. FXR agonists, obeticholic acid (OCA) and... 
SUBSTRATE-SPECIFICITY | ORGANIC SOLUTE TRANSPORTER | RAT HEPATOCYTES | OBSTRUCTIVE-CHOLESTASIS | SALT EXPORT PUMP | ALPHA-OST-BETA | PRIMARY BILIARY-CIRRHOSIS | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE PROTEIN-3 | INDUCED LIVER-INJURY | NUCLEAR RECEPTOR | Metabolism, Transport, and Pharmacogenomics
Journal Article
Journal Article
Journal Article