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Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Anaplastic Lymphoma Kinase | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | ErbB Receptors - antagonists & inhibitors | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2016, Volume 24, Issue 3, pp. 389 - 401
Journal Article
Plant, Cell & Environment, ISSN 0140-7791, 04/2016, Volume 39, Issue 4, pp. 745 - 767
The impact of transient carbon depletion on reproductive growth in Arabidopsis was investigated by transferring long‐photoperiod‐grown plants to continuous... 
starch | abortion | carbon starvation | seed | Starch | Abortion | Seed | Carbon starvation | LOW WATER POTENTIALS | DROUGHT STRESS | FRUIT-SET | HYPOCOTYL ELONGATION | DEPENDENT AUXIN GRADIENTS | PLANT SCIENCES | SEED ABORTION | GENE-EXPRESSION | GRAIN-YIELD | PLANT-GROWTH | POLLEN MATURATION | Seeds - radiation effects | Transcription, Genetic - drug effects | Arabidopsis - physiology | Meristem - radiation effects | Arabidopsis - growth & development | Meristem - physiology | Starch - metabolism | Transcription, Genetic - radiation effects | Flowers - radiation effects | Carbohydrates - deficiency | Arabidopsis Proteins - metabolism | Biological Transport - radiation effects | Light | Sucrose - metabolism | Membrane Transport Proteins - metabolism | Biological Transport - drug effects | Meristem - drug effects | Pollen - physiology | Reproduction - radiation effects | Carbon - pharmacology | Metabolome - radiation effects | Pollen - drug effects | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Indoleacetic Acids - metabolism | Subcellular Fractions - drug effects | Seeds - drug effects | Photoperiod | Pollen - radiation effects | Subcellular Fractions - metabolism | Arabidopsis - metabolism | Triglycerides - metabolism | Reproduction - drug effects | Gene Expression Regulation, Plant - drug effects | Phenotype | Metabolome - drug effects | Seeds - physiology | Subcellular Fractions - radiation effects | Flowers - drug effects | Flowers - physiology | Lipids - analysis | Carbon Dioxide - pharmacology | Arabidopsis thaliana | Growth | Analysis | Life Sciences | Vegetal Biology
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1327 - 1333
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7396, pp. 62 - 68
Journal Article
Plant Physiology, ISSN 0032-0889, 12/2009, Volume 151, Issue 4, pp. 1902 - 1917
Ectomycorrhizas (EMs) alleviate stress tolerance of host plants, but the underlying molecular mechanisms are unknown. To elucidate the basis of EM-induced... 
Fungi | Mycorrhizas | Cell walls | Genes | Stress tolerance | Plant roots | Auxins | Environmental Stress and Adaptation to Stress | Biosynthesis | Plants | Salinity | ARABIDOPSIS-THALIANA | PLANT XEROPHYTA-VISCOSA | ARBUSCULAR MYCORRHIZAL SYMBIOSIS | SALICYLIC-ACID | FUNGUS PAXILLUS-INVOLUTUS | GENE-EXPRESSION | SALT-STRESS | ABSCISIC-ACID | BETULA-PENDULA | PROTECTION MECHANISMS | PLANT SCIENCES | Solubility - drug effects | Carbohydrate Metabolism - drug effects | Genes, Plant | Salicylic Acid - metabolism | Sodium Chloride - pharmacology | Basidiomycota - physiology | Adaptation, Physiological - drug effects | Carbohydrate Metabolism - genetics | Plant Roots - genetics | Gene Expression Profiling | Mycorrhizae - physiology | Populus - genetics | Plant Roots - drug effects | Plant Roots - physiology | Adaptation, Physiological - genetics | Abscisic Acid - metabolism | Stress, Physiological - drug effects | Populus - microbiology | Stress, Physiological - genetics | Cell Size - drug effects | Signal Transduction - genetics | Populus - physiology | Plant Roots - microbiology | Metabolome - genetics | Mycorrhizae - drug effects | Gene Expression Regulation, Plant - drug effects | Mycorrhizae - genetics | Metabolome - drug effects | Signal Transduction - drug effects | Populus - drug effects | Physiological aspects | Roots (Botany) | Genetic aspects | Research
Journal Article
Autophagy, ISSN 1554-8627, 06/2016, Volume 12, Issue 6, pp. 936 - 948
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. 8173 - 8180
Journal Article
Science Translational Medicine, ISSN 1946-6234, 06/2015, Volume 7, Issue 292, pp. 292ra98 - 292ra98
Journal Article
New Phytologist, ISSN 0028-646X, 02/2017, Volume 213, Issue 3, pp. 1107 - 1123
... over a hundred TIAs, including the anticancer drugs, vinblastine and vincristine (Kellner et al ., ). TIAs are condensed products of tryptamine, derived from the shikimate... 
MAP kinase | terpenoid indole alkaloids (TIAs) | Catharanthus roseus (Madagascar periwinkle) | phosphorylation | transcriptional regulation | AP2/ERF gene cluster | ELICITOR | AP2 | ACTIVATED PROTEIN-KINASE | SECONDARY METABOLISM | TOBACCO | PLANT SCIENCES | SALT STRESS | PATHWAY | NICOTINE BIOSYNTHESIS | ERF gene cluster | ARABIDOPSIS | EXPRESSION | JASMONATE | Multigene Family | Transcriptional Activation - genetics | Transcription Factors - chemistry | Genes, Plant | Transcriptional Activation - drug effects | Plant Roots - genetics | Protein Transport - drug effects | Structure-Activity Relationship | Plant Roots - drug effects | Catharanthus - drug effects | Cell Nucleus - metabolism | MAP Kinase Signaling System - genetics | Plant Proteins - chemistry | Protein Binding - drug effects | Plant Proteins - metabolism | Phosphorylation - drug effects | Promoter Regions, Genetic | Plant Cells - metabolism | Catharanthus - enzymology | Secologanin Tryptamine Alkaloids - metabolism | Cyclopentanes - pharmacology | Transcription Factors - genetics | Metabolome - genetics | Amino Acid Motifs | Transcription Factors - metabolism | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | MAP Kinase Signaling System - drug effects | Models, Biological | Oxylipins - pharmacology | Plant Cells - drug effects | Acetates - pharmacology | Catharanthus - genetics | Cell Nucleus - drug effects | Genetic research | Physiological aspects | Alkaloids | Genetic aspects | Analysis | Genes
Journal Article
Journal Article