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Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2013, Volume 69, pp. 632 - 646
A new series of tacrine–flavonoid hybrids ( – ) had been designed, synthesized, and evaluated as multifunctional cholinesterase (ChE) inhibitors against... 
β-Amyloid aggregation | Alzheimer's disease | Flavonoid | Metal chelator | Tacrine | Cholinesterase | FIBRIL FORMATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | beta-Amylaid aggregation | CHOLINESTERASE-INHIBITORS | POTENT INHIBITORS | DESIGN STRATEGY | IN-VIVO | BIOLOGICAL EVALUATION | ACETYLCHOLINESTERASE INHIBITORS | DUAL INHIBITORS | AGGREGATION | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Dose-Response Relationship, Drug | Picrates - chemistry | Amyloid beta-Peptides - metabolism | Biphenyl Compounds - chemistry | Neuroblastoma - pathology | Tacrine - chemistry | Peptide Fragments - metabolism | Oxidation-Reduction | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Alzheimer Disease - enzymology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Organometallic Compounds - chemical synthesis | Peptide Fragments - antagonists & inhibitors | Neuroblastoma - drug therapy | Alzheimer Disease - metabolism | Cell Line, Tumor | Organometallic Compounds - chemistry | Cell Proliferation - drug effects | Mice | Cholinesterases - metabolism | Chelating Agents - chemical synthesis | Flavonoids - chemistry | Organometallic Compounds - pharmacology | Drug Screening Assays, Antitumor
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 174 - 186
A series of deferiprone-resveratrol hybrids have been designed and synthesized as multitarget-directed ligands (MTDLs) through merging the chelating moiety... 
Beta amyloid aggregation | Antioxidant | 3-hydroxypyridin-4-one | Metal chelator | Resveratrol derivatives
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2019, Volume 165, pp. 172 - 197
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2014, Volume 78, pp. 425 - 430
Journal Article