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American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 08/2009, Volume 297, Issue 2, pp. 461 - 470
Recently, kidney fibrosis following transplantation has become recognized as a main contributor of chronic allograft nephropathy. In transplantation, transient... 
Ischemia-reperfusion | α-smooth muscle actin | Superoxide | Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin | Interstitial fibrosis | alpha-smooth muscle actin | manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin | OXIDATIVE STRESS | ISCHEMIA/REPERFUSION INJURY | PHYSIOLOGY | REPERFUSION INJURY | ischemia-reperfusion | interstitial fibrosis | MAPK KINASE ACTIVATION | NITRIC-OXIDE | UROLOGY & NEPHROLOGY | INDUCED FUNCTIONAL INJURY | superoxide | SUPEROXIDE-DISMUTASE | URETERAL OBSTRUCTION | CHRONIC ALLOGRAFT NEPHROPATHY | IMMUNOSTIMULATED MACROPHAGES | Kidney - blood supply | Reactive Oxygen Species - metabolism | Kidney - pathology | Apoptosis - drug effects | S100 Calcium-Binding Protein A4 | Actins - metabolism | Male | Metalloporphyrins - pharmacology | Tyrosine - analogs & derivatives | Antigens, CD - metabolism | Kidney - metabolism | Time Factors | Lipid Peroxidation - drug effects | Reperfusion Injury - metabolism | Ischemia - pathology | Superoxide Dismutase - metabolism | Disease Models, Animal | Kidney - drug effects | Oxidation-Reduction | Reperfusion Injury - pathology | Ischemia - metabolism | S100 Proteins - metabolism | Antioxidants - pharmacology | Disease Progression | Hydrogen Peroxide - metabolism | Collagen - metabolism | Tyrosine - metabolism | Animals | Reperfusion Injury - prevention & control | Antigens, Differentiation, Myelomonocytic - metabolism | Fibrosis | Glucosephosphate Dehydrogenase - metabolism | HSP47 Heat-Shock Proteins - metabolism | Mice | Mice, Inbred BALB C | Oxidative Stress - drug effects | Proliferating Cell Nuclear Antigen - metabolism | Vitamin E - pharmacology | Proteins | Studies | Rodents | Oxidation | Kidney diseases | Gene expression | Cells | Index Medicus
Journal Article
American journal of physiology. Renal physiology, ISSN 1931-857X, 04/2018, Volume 314, Issue 4, pp. F658 - F666
Downregulation of aquaporins (AQPs) in obstructive kidney disease has been well demonstrated with elusive mechanisms. Our previous study indicated that... 
Free Radical Scavengers - pharmacology | Ureteral Obstruction - complications | Kidney - pathology | Receptors, Vasopressin - metabolism | Male | Ureteral Obstruction - metabolism | Metalloporphyrins - pharmacology | Aquaporin 1 - metabolism | Aquaporins - genetics | Kidney Diseases - genetics | Kidney - metabolism | Cyclooxygenase 2 - genetics | Aquaporin 4 - genetics | Ureteral Obstruction - genetics | Superoxide Dismutase - metabolism | Disease Models, Animal | Kidney Diseases - metabolism | Kidney - drug effects | Prostaglandin-E Synthases - metabolism | Signal Transduction | Kidney Diseases - pathology | Down-Regulation | Mice, Inbred C57BL | Aquaporins - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Aquaporin 3 - genetics | Aquaporin 1 - genetics | Aquaporin 2 - metabolism | Dinoprostone - metabolism | Aquaporin 3 - metabolism | Animals | Aquaporin 4 - metabolism | Ureteral Obstruction - pathology | Cyclooxygenase 2 - metabolism | Kidney Diseases - etiology | Oxidative Stress - drug effects | Aquaporin 2 - genetics | Oxidative stress | Mitochondria | Genetic aspects | Kidney diseases | Health aspects | Aquaporins | Aquaporin 4 | Benzoic acid | Prostaglandin E2 | Superoxide dismutase | Mitochondrial DNA | Tetrakis(4-benzoic acid)porphyrin | Western blotting | Prostaglandin endoperoxide synthase | Prostaglandin E | Thiobarbituric acid | Aquaporin 1 | Aquaporin 2 | Aquaporin 3 | Urine | Kidneys | Secretion | Prostaglandin-E synthase | Polymerase chain reaction | Cyclooxygenase-1 | Cyclooxygenase-2 | Manganese | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 12/2007, Volume 293, Issue 6, pp. 1645 - 1655
Evidence for important roles of the highly reactive oxidant peroxynitrite in diabetic complications is emerging. We evaluated the role of peroxynitrite in... 
OXIDATIVE STRESS | PHYSIOLOGY | POLY(ADP-RIBOSE) POLYMERASE ACTIVATION | ENDOTHELIAL DYSFUNCTION | EPINEURIAL ARTERIOLES | ENDOCRINOLOGY & METABOLISM | ALDOSE REDUCTASE INHIBITION | NERVE CONDUCTION-VELOCITY | ANTIOXIDANT TREATMENT | PERIPHERAL NEUROPATHY | PEROXYNITRITE DECOMPOSITION CATALYST | ENDONEURIAL BLOOD-FLOW | Mesenteric Arteries - physiopathology | Rats, Wistar | Coronary Vessels - physiopathology | Body Weight - drug effects | Male | Mesenteric Arteries - drug effects | Sciatic Nerve - physiopathology | Aorta - metabolism | Metalloporphyrins - pharmacology | Tyrosine - analogs & derivatives | Diabetic Angiopathies - physiopathology | Metalloporphyrins - therapeutic use | Sciatic Nerve - metabolism | Regional Blood Flow - drug effects | Arterioles - physiopathology | Superoxides - metabolism | Neural Conduction - drug effects | Peroxynitrous Acid - antagonists & inhibitors | Sciatic Nerve - drug effects | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Experimental - physiopathology | Diabetic Neuropathies - physiopathology | Hypoglycemic Agents - therapeutic use | Diabetic Angiopathies - metabolism | Coronary Vessels - drug effects | Vasodilator Agents - pharmacology | Hyperalgesia - metabolism | Rats | Diabetic Neuropathies - drug therapy | Diabetic Angiopathies - drug therapy | Hyperalgesia - physiopathology | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Poly Adenosine Diphosphate Ribose - metabolism | Tyrosine - metabolism | Animals | Arterioles - metabolism | Peroxynitrous Acid - metabolism | Diabetic Neuropathies - metabolism | Ganglia, Spinal - metabolism | Studies | Diabetic neuropathy | Models | Rodents | Stress | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 4, pp. 1344 - 1357
Journal Article
Kidney International, ISSN 0085-2538, 06/2013, Volume 83, Issue 6, pp. 1042 - 1051
Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is... 
apoptosis | autophagy | chronic renal failure | hyperphosphatemia | oxidative stress | Hyperphosphatemia | Oxidative stress | Chronic renal failure | Autophagy | Apoptosis | PRIMARY CULTURE | INORGANIC-PHOSPHATE | DEATH | CALCIUM | DISEASE | GROWTH | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | BETA-GLYCEROPHOSPHATE | SELF-DIGESTION | Caspase Inhibitors - pharmacology | Superoxide Dismutase - genetics | Muscle, Smooth, Vascular - metabolism | Alkaline Phosphatase - metabolism | Myocytes, Smooth Muscle - pathology | Secretory Vesicles - metabolism | Metalloporphyrins - pharmacology | Valproic Acid - pharmacology | Autophagy - drug effects | Sodium-Phosphate Cotransporter Proteins, Type III - genetics | Vascular Calcification - metabolism | Transfection | RNA Interference | Time Factors | Amino Acid Chloromethyl Ketones - pharmacology | Cattle | Kidney Failure, Chronic - pathology | Vascular Calcification - etiology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Superoxide Dismutase - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Adenine - analogs & derivatives | Cells, Cultured | Rats | Vascular Calcification - prevention & control | Adenine - pharmacology | Antioxidants - pharmacology | Vascular Calcification - pathology | Kidney Failure, Chronic - metabolism | Proteins - genetics | Muscle, Smooth, Vascular - pathology | Phosphates - metabolism | Animals | Proteins - metabolism | Autophagy-Related Protein 5 | Secretory Vesicles - drug effects | Kidney Failure, Chronic - complications | Secretory Vesicles - pathology | Sodium-Phosphate Cotransporter Proteins, Type III - metabolism | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2007, Volume 117, Issue 11, pp. 3530 - 3539
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2012, Volume 40, Issue 3, pp. 504 - 514
Heme oxygenase (HO-1), the rate-limiting enzyme in the physiological breakdown of heme, is ubiquitous, and its expression can be increased by arsenite [... 
CYTOCHROME-P450 | METABOLISM | MECHANISM | DOWN-REGULATION | GENE-EXPRESSION | AH RECEPTOR | PHARMACOLOGY & PHARMACY | HUMAN LIVER | INDUCTION | PRIMARY CULTURES | PREGNANE-X-RECEPTOR | Arsenites - pharmacology | Cytochrome P-450 CYP1A1 - genetics | Heme - metabolism | Receptors, Steroid - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Cytochromes - genetics | Metalloporphyrins - pharmacology | Cell Nucleus - metabolism | Cytochrome P-450 CYP3A - genetics | Protein Processing, Post-Translational - drug effects | Polychlorinated Dibenzodioxins - pharmacology | Cytochromes - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Cytochrome P-450 CYP1A2 | Membrane Proteins - metabolism | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Heme Oxygenase (Decyclizing) - metabolism | Hepatocytes - drug effects | Cell Survival - drug effects | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Cells, Cultured | Rats | Cytochrome P-450 CYP1A1 - metabolism | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Polychlorinated Dibenzodioxins - analogs & derivatives | Animals | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytosol - metabolism | Trans-Activators - metabolism | Rifampin - pharmacology | Index Medicus
Journal Article
British Journal of Nutrition, ISSN 0007-1145, 2014, Volume 111, Issue 7, pp. 1221 - 1230
Several reports have indicated that dietary intake of DHA is associated with lower prevalence of periodontitis. In the present study, we investigated the... 
Lipopolysaccharide | Proinflammatory mediators | Prevotella intermedia | DHA | INFLAMMATORY DISEASES | ACTIVE RHEUMATOID-ARTHRITIS | PORPHYROMONAS-GINGIVALIS | GINGIVAL CREVICULAR FLUID | ACTINOBACILLUS-ACTINOMYCETEMCOMITANS | NUTRITION & DIETETICS | NITRIC-OXIDE PRODUCTION | POLYUNSATURATED FATTY-ACIDS | STIMULATES RELEASE | DESTRUCTIVE PERIODONTAL-DISEASE | NF-KAPPA-B | Dietary Fats - metabolism | Heme Oxygenase-1 - metabolism | Interleukin-6 - antagonists & inhibitors | Periodontitis - microbiology | Protoporphyrins - pharmacology | NF-kappa B - metabolism | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Metalloporphyrins - pharmacology | Periodontitis - metabolism | Heme Oxygenase-1 - genetics | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Docosahexaenoic Acids - antagonists & inhibitors | Interleukin-1beta - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Inflammation Mediators - metabolism | Inflammation Mediators - antagonists & inhibitors | Membrane Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Interleukin-6 - metabolism | Macrophages - immunology | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - antagonists & inhibitors | Lipopolysaccharides - toxicity | Periodontitis - immunology | Interleukin-6 - genetics | Membrane Proteins - genetics | Nitric Oxide - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Dietary Fats - antagonists & inhibitors | Heme Oxygenase-1 - antagonists & inhibitors | Membrane Proteins - agonists | Periodontitis - prevention & control | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | MAP Kinase Signaling System - drug effects | Membrane Proteins - antagonists & inhibitors | Nitric Oxide Synthase Type II - genetics | Prevotella intermedia - metabolism | Macrophages - drug effects | Mice | Lipopolysaccharides - isolation & purification | Macrophage Activation - drug effects | Nitric Oxide - metabolism | Cell Line, Transformed | Docosahexaenoic Acids - metabolism | Nitric Oxide Synthase Type II - metabolism | Pathogens | Immunology | Nutrition | Gum disease | Fatty acids | Rodents | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 83, Issue 2, pp. 740 - 748
Purpose Apoptosis in irradiated normal lung tissue has been observed several weeks after radiation. However, the signaling pathway propagating cell death after... 
Radiology | Hematology, Oncology and Palliative Medicine | PTEN | Nox4 | Reactive oxygen species | Radiation | Apoptosis | AEOL-10150 | NADPH OXIDASE | ACTIVATION | TGF-BETA | PROTECTS LUNGS | KINASE | GROWTH-FACTOR-BETA | CATALYTIC METALLOPORPHYRIN ANTIOXIDANT | ONCOLOGY | COCAINE BEHAVIORAL SENSITIZATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Up-Regulation | Radiation Injuries - drug therapy | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Oxidative Stress - physiology | Transforming Growth Factor beta1 - metabolism | Caspase 3 - metabolism | NADPH Oxidases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Metalloporphyrins - pharmacology | Time Factors | Lung Injury - metabolism | Female | Lung - radiation effects | Models, Animal | Lung Injury - drug therapy | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Endothelium - radiation effects | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | PTEN Phosphohydrolase - metabolism | In Situ Nick-End Labeling - methods | Antioxidants - pharmacology | NADPH Oxidase 4 | Random Allocation | Alveolar Epithelial Cells - radiation effects | Endothelium - physiopathology | Lung Injury - physiopathology | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Radiation Injuries - physiopathology | Apoptosis - physiology | Oxidative Stress - drug effects | Radiation Injuries - metabolism | Alveolar Epithelial Cells - physiology | Index Medicus | 1-Phosphatidylinositol 3-kinase | CHEST | OXIDATION | APOPTOSIS | GROWTH FACTORS | ENDOTHELIUM | LUNGS | RADIOLOGY AND NUCLEAR MEDICINE | TOXICITY | RADIATION INJURIES | STRESSES | apoptosis | radiation | ROS
Journal Article
Journal Article
Journal Article
Biochimie, ISSN 0300-9084, 11/2014, Volume 106, pp. 157 - 166
Heme biosynthesis begins in the mitochondrion with the formation of delta-aminolevulinic acid (ALA). In acute intermittent porphyria, hereditary tyrosinemia... 
Energetic dysfunctions | 5-Aminolevulinic acid | Oxidative stress | Mitochondria | Respiratory chain | Oxidative phosphorylation | ACUTE INTERMITTENT PORPHYRIA | LIVER-TRANSPLANTATION | PHOTODYNAMIC THERAPY | DELTA-AMINOLEVULINIC-ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE HEPATIC PORPHYRIA | DEATH-ASSOCIATED PROTEIN-3 | HEPATOCELLULAR-CARCINOMA | HEREDITARY TYROSINEMIA | NITRIC-OXIDE | Oxidants - pharmacology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | Humans | Oxidants - metabolism | Ion Channels - genetics | Mitochondrial Proteins - genetics | Electron Transport Complex I - metabolism | Metalloporphyrins - pharmacology | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Mitochondria - genetics | Aminolevulinic Acid - metabolism | Electron Transport Complex I - genetics | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Superoxide Dismutase - metabolism | Liver Neoplasms - genetics | Aminolevulinic Acid - pharmacology | Protoporphyrins - metabolism | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Hep G2 Cells | Transcription Factors - metabolism | Microscopy, Confocal | Ion Channels - metabolism | Oxygen Consumption - drug effects | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Uncoupling Protein 2 | Carcinoma, Hepatocellular - metabolism | Proteins | Antioxidants | Liver diseases | Physiological aspects | Mitochondrial DNA | Hemoglobin synthesis | Poisoning | Porphyrins | Index Medicus | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 16, pp. 11332 - 11346
Heme oxygenase-1 (HO-1), the inducible enzyme responsible for the rate-limiting step in the heme catabolism, is expressed in AIDS-Kaposi sarcoma (KS) lesions.... 
PHOSPHATIDYLINOSITOL 3-KINASE/AKT | OXIDATIVE STRESS | TIN-PROTOPORPHYRIN | CARBON-MONOXIDE | NEONATAL HYPERBILIRUBINEMIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMOKINE RECEPTOR | ANTICANCER TREATMENT | VASCULAR-PERMEABILITY | ENDOTHELIAL GROWTH-FACTOR | BILIVERDIN REDUCTASE | Immunohistochemistry | Neoplasms - metabolism | NIH 3T3 Cells | Neoplasm Transplantation | Up-Regulation | Heme Oxygenase-1 - metabolism | Cell Proliferation | Luciferases - metabolism | Receptors, G-Protein-Coupled - metabolism | Annexin A5 - pharmacology | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Culture Media, Serum-Free - metabolism | Dose-Response Relationship, Drug | Transfection | Heme - chemistry | Herpesvirus 8, Human - metabolism | Time Factors | Protoporphyrins - chemistry | Heme Oxygenase (Decyclizing) - metabolism | Fluorescent Antibody Technique, Indirect | Genes, Reporter | Fibroblasts - metabolism | RNA - metabolism | Promoter Regions, Genetic | Metalloporphyrins - metabolism | Cell Survival | Endothelial Cells - metabolism | Enzyme Inhibitors - pharmacology | Protoporphyrins - metabolism | DNA - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Heme Oxygenase-1 - antagonists & inhibitors | Blotting, Western | Animals | Mice, Nude | Models, Biological | Mice | Apoptosis | Index Medicus
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 6/2012, Volume 32, Issue 6, pp. 1024 - 1034
Journal Article