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Free radical biology & medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 51 - 59
Microglia are the resident immune cells in the brain. Microglial activation is characteristic of several inflammatory and neurodegenerative diseases including... 
Peroxynitrite | Free radicals | Protein radical | Inducible nitric oxide synthase | Lipopolysaccharide | Nitrone adducts | Parkinson disease | Microglia | NADPH OXIDASE | OXIDATIVE STRESS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | KAPPA-B | LIPOPOLYSACCHARIDE-ACTIVATED MICROGLIA | REACTIVE OXYGEN | ENDOCRINOLOGY & METABOLISM | GENERATION | TYROSINE NITRATION | PARKINSONS-DISEASE | Microglia - metabolism | Metalloporphyrins - pharmacology | Lipopolysaccharides | Thiocarbamates - pharmacology | RNA Interference | Nitric Oxide Synthase Type II - antagonists & inhibitors | Spin Trapping | Acetophenones - pharmacology | Free Radicals - metabolism | Proline - pharmacology | Microglia - cytology | NG-Nitroarginine Methyl Ester - pharmacology | NF-kappa B - antagonists & inhibitors | Proline - analogs & derivatives | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antioxidants - pharmacology | Neurodegenerative Diseases - metabolism | Coumarins - pharmacology | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Peroxynitrous Acid - metabolism | Amidines - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Benzylamines - pharmacology | Cell Line, Transformed | Boronic Acids - pharmacology | Nitric Oxide Synthase Type II - metabolism | Nitration | Nervous system diseases | Multiple sclerosis | Analysis | Nitric oxide | Environmental health | Physiological aspects | Alzheimer's disease | Index Medicus | Inducible nitric | oxide synthase | LPS | Parkinson’s disease
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2001, Volume 276, Issue 27, pp. 25096 - 25100
Journal Article
Circulation research, ISSN 1524-4571, 2004, Volume 95, Issue 10, pp. 1019 - 1026
Angiotensin II (Ang II) exerts detrimental effects on cerebral circulation, the mechanisms of which have not been elucidated. In particular, Ang II impairs the... 
Hypertension | Laser-Doppler flowmetry | gp91-null mice | Somatosensory activation | Cerebral circulation | LOCALIZATION | OXIDATIVE STRESS | SUPEROXIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | laser-Doppler flowmetry | NAD(P)H OXIDASE | somatosensory activation | HUMAN RENIN | PERIPHERAL VASCULAR DISEASE | CEREBRAL-BLOOD-FLOW | HEMATOLOGY | cerebral circulation | hypertension | CONTRIBUTES | FUNCTIONAL HYPEREMIA | BRAIN | Free Radical Scavengers - pharmacology | Reactive Oxygen Species - metabolism | Receptor, Angiotensin, Type 1 - physiology | Muscle, Smooth, Vascular - metabolism | Molecular Sequence Data | Endothelium, Vascular - drug effects | Male | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology | Glycoproteins - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Metalloporphyrins - pharmacology | Cytochromes b - deficiency | Membrane Glycoproteins - physiology | Somatosensory Cortex - enzymology | Hypertension - chemically induced | Acetophenones - pharmacology | Nitric Oxide Donors - pharmacology | Receptor, Angiotensin, Type 1 - drug effects | Angiotensin II - toxicity | Muscle, Smooth, Vascular - drug effects | Polyethylene Glycols - pharmacology | Amino Acid Sequence | Hypercapnia - physiopathology | Superoxide Dismutase - pharmacology | Free Radicals | Cerebrovascular Circulation - drug effects | Mice, Inbred C57BL | Somatosensory Cortex - drug effects | Losartan - pharmacology | Rats | Laser-Doppler Flowmetry | Arterioles - drug effects | NADPH Oxidase 2 | Rats, Sprague-Dawley | Animals | Arterioles - metabolism | Vibrissae - physiology | Cytochromes b - genetics | Endothelium, Vascular - metabolism | Hyperemia - physiopathology | Somatosensory Cortex - blood supply | Mice | NADPH Oxidases - physiology | S-Nitroso-N-Acetylpenicillamine - pharmacology
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 2003, Volume 35, Issue 11, pp. 1500 - 1514
In this study, we investigated the involvement of reactive oxygen species (ROS) and calcium in staurosporine (STS)-induced apoptosis in cultured retinal... 
Antioxidants | Mitochondria | Reactive oxygen species | Free radicals | Calcium | Retinal cells | Staurosporine | Caspase-3 | Apoptosis | staurosporine | free radicals | OXIDATIVE STRESS | VITAMIN-E | ACTIVATION | SUPEROXIDE | calcium | antioxidants | retinal cells | mitochondria | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | apoptosis | H-3 GABA | NEURONAL DEATH | reactive oxygen species | ENDOCRINOLOGY & METABOLISM | 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE MTT | CYTOCHROME-C RELEASE | caspase-3 | Nitric Oxide Synthase - chemistry | Reactive Oxygen Species | Uncoupling Agents - pharmacology | Coloring Agents - pharmacology | Arachidonic Acids - chemistry | Adenine - chemistry | Calcium - chemistry | Metalloporphyrins - pharmacology | Carbon - chemistry | Glutathione - pharmacology | Caspases - metabolism | Chromans - pharmacology | Retina - cytology | Time Factors | DNA Fragmentation | Cell Death | Rotenone - pharmacology | Caspase 3 | Oligomycins - chemistry | Neurons - metabolism | Xanthine Oxidase - antagonists & inhibitors | In Situ Nick-End Labeling | Cell Survival | Ubiquinone - analogs & derivatives | Enzyme Inhibitors - pharmacology | Mitochondria - metabolism | Tetrazolium Salts - pharmacology | Antioxidants - pharmacology | Chick Embryo | Blotting, Western | Benzoquinones - pharmacology | Indazoles - pharmacology | Animals | Protein Isoforms | Allopurinol - pharmacology | Cytosol - metabolism | Nitric Oxide Synthase - metabolism | Thiazoles - pharmacology | Retina - pathology | Staurosporine - pharmacology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 14, pp. 9101 - 9112
Aldose reductase (AR) catalyzes the reduction of several aldehydes ranging from lipid peroxidation products to glucose. The activity of AR is increased in the... 
S-NITROSYLATION | MOUSE HEART | LATE-PHASE | PEROXYNITRITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | MYOCARDIAL-CONTRACTILITY | SMOOTH-MUSCLE-CELLS | RAT-HEART | AKT | PROTEIN-SULFENIC ACIDS | Imidazolidines - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Metalloporphyrins - pharmacology | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - pathology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Lipid Peroxidation - drug effects | Aldehyde Reductase - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Bradykinin - pharmacology | Dithiothreitol - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Aldehyde Reductase - antagonists & inhibitors | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Ferric Compounds - pharmacology | Myocardium - pathology | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Naphthalenes - pharmacology | Myocardium - enzymology | Animals | Signal Transduction - drug effects | Nitric Oxide Synthase Type I - metabolism | Peroxynitrous Acid - metabolism | Glucose - metabolism | Hesperidin - pharmacology | Nitric Oxide - metabolism | Sorbitol - pharmacology | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Enzyme Catalysis and Regulation
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2007, Volume 293, Issue 6, pp. 3246 - 3253
Acute intravenous Tempol reduces mean arterial pressure (MAP) and heart rate (HR) in spontaneously hypertensive rats. We investigated the hypothesis that the... 
Nitric oxide synthase | Superoxide dismutase | Adenosine 5′-triphosphate-activated potassium channels | Catalase | Sympathetic nervous system | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | POTASSIUM CHANNELS | sympathetic nervous system | SENSITIVE K+ CHANNELS | ANGIOTENSIN-II | MODEL | CROMAKALIM | BLOOD-PRESSURE | adenosine 5 '-triphosphate-activated potassium channels | CALCIUM INFLUX | superoxide dismutase | ENDOTHELIAL-CELLS | SYMPATHETIC-NERVE ACTIVITY | PERIPHERAL VASCULAR DISEASE | nitric oxide synthase | catalase | Amitrole - pharmacology | Buthionine Sulfoximine - pharmacology | Antihypertensive Agents - pharmacology | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Sympathetic Nervous System - drug effects | Catalase - antagonists & inhibitors | Glutathione Peroxidase - antagonists & inhibitors | Antihypertensive Agents - administration & dosage | Nitric Oxide Synthase - antagonists & inhibitors | Hypertension - drug therapy | Male | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Cyclic N-Oxides - administration & dosage | Ganglionic Blockers - pharmacology | Spin Labels | Sympathetic Nervous System - physiopathology | Metalloporphyrins - pharmacology | Sympathetic Nervous System - metabolism | Dose-Response Relationship, Drug | Heart Rate - drug effects | Hexamethonium - pharmacology | KATP Channels - drug effects | Glyburide - pharmacology | Time Factors | Cyclic N-Oxides - pharmacology | Blood Pressure - drug effects | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Heme Oxygenase (Decyclizing) - metabolism | Potassium Channel Blockers - pharmacology | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Rats, Inbred SHR | Glutathione Peroxidase - metabolism | Enzyme Inhibitors - pharmacology | Rats | Hypertension - physiopathology | Hypertension - metabolism | Peptides - pharmacology | Catalase - metabolism | KATP Channels - metabolism | Animals | Nitric Oxide Synthase - metabolism | Infusions, Intravenous | Cromakalim - pharmacology | Nitric Oxide - metabolism
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 02/2009, Volume 296, Issue 2, pp. 289 - 298
Mitochondria affect cerebrovascular tone by activation of mitochondrial ATP-sensitive K+ (KATP) channels and generation of reactive oxygen species (ROS).... 
Depolarization | Zucker obese rats | Mitochondrial ATP-sensitive potassium channels | Diazoxide | PROTEIN-KINASE-C | METABOLIC SYNDROME | ACTIVATION | PHYSIOLOGY | mitochondrial ATP-sensitive potassium channels | DILATION | CALCIUM INFLUX | diazoxide | depolarization | ENDOTHELIAL-CELLS | NITRIC-OXIDE | DYSFUNCTION | POTASSIUM | CA2+ SPARKS | Free Radical Scavengers - pharmacology | Propionates - pharmacology | Mitochondria - enzymology | Diazoxide - pharmacology | Reactive Oxygen Species - metabolism | Muscle, Smooth, Vascular - metabolism | Endothelium, Vascular - drug effects | Male | Metalloporphyrins - pharmacology | Muscle, Smooth, Vascular - physiopathology | Cerebral Arteries - drug effects | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Potassium Channels, Calcium-Activated - metabolism | Nitro Compounds - pharmacology | Nitric Oxide Synthase Type III - metabolism | Potassium Channel Blockers - pharmacology | Superoxide Dismutase - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Vasodilator Agents - pharmacology | Succinate Dehydrogenase - antagonists & inhibitors | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Insulin Resistance | Rats | Cerebral Arteries - physiopathology | Obesity - physiopathology | Mitochondria - metabolism | Mitochondria - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Obesity - metabolism | Peptides - pharmacology | Rats, Zucker | Animals | Cerebral Arteries - metabolism | Endothelium, Vascular - metabolism | Succinate Dehydrogenase - metabolism | Vasodilation - drug effects | Nitric Oxide - metabolism | Neurohumoral Control of Cardiovascular Function
Journal Article
Journal Article
Kidney international, ISSN 0085-2538, 06/2013, Volume 83, Issue 6, pp. 1042 - 1051
Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is... 
apoptosis | autophagy | chronic renal failure | hyperphosphatemia | oxidative stress | Hyperphosphatemia | Oxidative stress | Chronic renal failure | Autophagy | Apoptosis | PRIMARY CULTURE | INORGANIC-PHOSPHATE | DEATH | CALCIUM | DISEASE | GROWTH | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | BETA-GLYCEROPHOSPHATE | SELF-DIGESTION | Caspase Inhibitors - pharmacology | Superoxide Dismutase - genetics | Muscle, Smooth, Vascular - metabolism | Alkaline Phosphatase - metabolism | Myocytes, Smooth Muscle - pathology | Secretory Vesicles - metabolism | Metalloporphyrins - pharmacology | Valproic Acid - pharmacology | Autophagy - drug effects | Sodium-Phosphate Cotransporter Proteins, Type III - genetics | Vascular Calcification - metabolism | Transfection | RNA Interference | Time Factors | Amino Acid Chloromethyl Ketones - pharmacology | Cattle | Kidney Failure, Chronic - pathology | Vascular Calcification - etiology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Superoxide Dismutase - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Adenine - analogs & derivatives | Cells, Cultured | Rats | Vascular Calcification - prevention & control | Adenine - pharmacology | Antioxidants - pharmacology | Vascular Calcification - pathology | Kidney Failure, Chronic - metabolism | Proteins - genetics | Muscle, Smooth, Vascular - pathology | Phosphates - metabolism | Animals | Proteins - metabolism | Autophagy-Related Protein 5 | Secretory Vesicles - drug effects | Kidney Failure, Chronic - complications | Secretory Vesicles - pathology | Sodium-Phosphate Cotransporter Proteins, Type III - metabolism
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 04/2010, Volume 113, Issue 2, pp. 363 - 373
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2009, Volume 156, Issue 8, pp. 1256 - 1266
Background and purpose:  The pleiotropic effects of HMG-CoA inhibitors (statins), which include anti-inflammation, antioxidation and immunomodulation, are not... 
endothelium | nitric oxide | peroxynitrite | lipid peroxidation | atherosclerosis and haem oxygenase | Atherosclerosis and haem oxygenase | Lipid peroxidation | Peroxynitrite | Nitric oxide | Endothelium | OXIDATIVE STRESS | ACTIVATION | LIPID-PEROXIDATION | ENDOGENOUS-CARBON-MONOXIDE | LOW-DENSITY-LIPOPROTEIN | ENDOTHELIAL-CELLS | ATHEROSCLEROTIC LESION FORMATION | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | SIMVASTATIN | EXPRESSION | Heme Oxygenase-1 - metabolism | Protoporphyrins - pharmacology | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - enzymology | Simvastatin - pharmacology | Metalloporphyrins - pharmacology | Hemin - metabolism | Atherosclerosis - enzymology | Time Factors | Lipid Peroxidation - drug effects | Nitric Oxide Synthase Type III - metabolism | Aorta - enzymology | Heptanoic Acids - pharmacology | Disease Models, Animal | Malondialdehyde - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Rabbits | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Aorta - drug effects | Enzyme Inhibitors - pharmacology | Heme Oxygenase-1 - antagonists & inhibitors | Nitric Oxide Synthase Type III - antagonists & inhibitors | Aorta - pathology | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Endothelium, Vascular - pathology | Nitric Oxide - metabolism | Arginine - metabolism | Research Papers
Journal Article