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Free Radical Biology and Medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 51 - 59
Microglia are the resident immune cells in the brain. Microglial activation is characteristic of several inflammatory and neurodegenerative diseases including... 
Peroxynitrite | Free radicals | Protein radical | Inducible nitric oxide synthase | Lipopolysaccharide | Nitrone adducts | Parkinson disease | Microglia | NADPH OXIDASE | OXIDATIVE STRESS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | KAPPA-B | LIPOPOLYSACCHARIDE-ACTIVATED MICROGLIA | REACTIVE OXYGEN | ENDOCRINOLOGY & METABOLISM | GENERATION | TYROSINE NITRATION | PARKINSONS-DISEASE | Microglia - metabolism | Metalloporphyrins - pharmacology | Lipopolysaccharides | Thiocarbamates - pharmacology | RNA Interference | Nitric Oxide Synthase Type II - antagonists & inhibitors | Spin Trapping | Acetophenones - pharmacology | Free Radicals - metabolism | Proline - pharmacology | Microglia - cytology | NG-Nitroarginine Methyl Ester - pharmacology | NF-kappa B - antagonists & inhibitors | Proline - analogs & derivatives | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antioxidants - pharmacology | Neurodegenerative Diseases - metabolism | Coumarins - pharmacology | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Peroxynitrous Acid - metabolism | Amidines - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Benzylamines - pharmacology | Cell Line, Transformed | Boronic Acids - pharmacology | Nitric Oxide Synthase Type II - metabolism | Nitration | Nervous system diseases | Multiple sclerosis | Analysis | Nitric oxide | Environmental health | Physiological aspects | Alzheimer's disease | Index Medicus | Inducible nitric | oxide synthase | LPS | Parkinson’s disease
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2004, Volume 109, Issue 1, pp. 1 - 8
Heme oxygenase‐1 (HO‐1), an inducible enzyme that catalyzes oxidative degradation of heme to form biliverdin, carbon monoxide and free iron, may protect tumor... 
heme oxygenase‐1 | zinc protoporphyrin | macromolecular therapeutics | tumor targeting/EPR effect | D‐amino acid oxidase | Macromolecular therapeutics | D-amino acid oxidase | Tumor targeting/EPR effect | Heme oxygenase-1 | Zinc protoporphyrin | HUMAN BRAIN-TUMORS | CANCER-CHEMOTHERAPY | INDUCED APOPTOSIS | NITRIC-OXIDE SYNTHASE | heme oxygenase-1 | MACROMOLECULAR DRUGS | MESSENGER-RNA | ONCOLOGY | GENE-EXPRESSION | SOLID TUMOR | HYDROGEN-PEROXIDE PRODUCTION | TARGETED DELIVERY | Oxidants - pharmacology | Body Weight | Reactive Oxygen Species - metabolism | Oxidative Stress | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Male | Metalloporphyrins - pharmacology | Oxygen - metabolism | Dose-Response Relationship, Drug | Antineoplastic Agents - pharmacology | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Polyethylene Glycols - pharmacology | Oxidation-Reduction | Hydrogen Peroxide - pharmacology | Etoposide - pharmacology | Tetrazolium Salts - pharmacology | Cisplatin - pharmacology | Hydrogen Peroxide - metabolism | Mitomycin - pharmacology | Neoplasms - drug therapy | Proline - chemistry | Drug Synergism | Animals | Cell Line, Tumor | Mice | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Apoptosis | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2005, Volume 94, Issue 2, pp. 299 - 306
Previous studies have shown that N ‐methyl‐ d ‐aspartate (NMDA) receptor activation results in production of reactive oxygen species (ROS) and activation of... 
reactive | learning and memory | oxygen species | superoxide | long‐term potentiation | Learning and memory | Superoxide | Oxygen species | Reactive | Long-term potentiation | STIMULATION | PHOSPHORYLATION | CHRONIC GRANULOMATOUS-DISEASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASCADE | NEUROSCIENCES | NITRIC-OXIDE | SMOOTH-MUSCLE-CELLS | SUPEROXIDE PRODUCTION | long-term potentiation | Catalase - pharmacology | Free Radical Scavengers - pharmacology | Excitatory Postsynaptic Potentials - radiation effects | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Excitatory Postsynaptic Potentials - drug effects | Metalloporphyrins - pharmacology | Organoselenium Compounds - pharmacology | Patch-Clamp Techniques - methods | Dopamine Agonists | N-Methylaspartate - pharmacology | Excitatory Postsynaptic Potentials - physiology | Drug Interactions | Acetylcysteine - analogs & derivatives | Neurons - physiology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Hippocampus - enzymology | Phosphorylation - drug effects | Neurons - drug effects | Extracellular Signal-Regulated MAP Kinases - classification | NG-Nitroarginine Methyl Ester - pharmacology | Lysine - analogs & derivatives | Blotting, Western - methods | Superoxide Dismutase - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Imidazolines - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Azoles - pharmacology | Enzyme Activation - drug effects | Hippocampus - cytology | Receptors, N-Methyl-D-Aspartate - physiology | Animals | Lysine - pharmacology | Acetylcysteine - pharmacology | Mice | In Vitro Techniques | Enzyme Activation - physiology | Catecholamines - pharmacology | Brain | Neurology | Enzymes | Acids | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2001, Volume 276, Issue 27, pp. 25096 - 25100
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2003, Volume 35, Issue 11, pp. 1500 - 1514
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 14, pp. 9101 - 9112
Aldose reductase (AR) catalyzes the reduction of several aldehydes ranging from lipid peroxidation products to glucose. The activity of AR is increased in the... 
S-NITROSYLATION | MOUSE HEART | LATE-PHASE | PEROXYNITRITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | MYOCARDIAL-CONTRACTILITY | SMOOTH-MUSCLE-CELLS | RAT-HEART | AKT | PROTEIN-SULFENIC ACIDS | Imidazolidines - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Metalloporphyrins - pharmacology | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - pathology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Lipid Peroxidation - drug effects | Aldehyde Reductase - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Bradykinin - pharmacology | Dithiothreitol - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Aldehyde Reductase - antagonists & inhibitors | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Ferric Compounds - pharmacology | Myocardium - pathology | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Naphthalenes - pharmacology | Myocardium - enzymology | Animals | Signal Transduction - drug effects | Nitric Oxide Synthase Type I - metabolism | Peroxynitrous Acid - metabolism | Glucose - metabolism | Hesperidin - pharmacology | Nitric Oxide - metabolism | Sorbitol - pharmacology | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Enzyme Catalysis and Regulation
Journal Article
Circulation Research, ISSN 0009-7330, 11/2004, Volume 95, Issue 10, pp. 1019 - 1026
Angiotensin II (Ang II) exerts detrimental effects on cerebral circulation, the mechanisms of which have not been elucidated. In particular, Ang II impairs the... 
Hypertension | Laser-Doppler flowmetry | gp91-null mice | Somatosensory activation | Cerebral circulation | OXIDATIVE STRESS | SUPEROXIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | laser-Doppler flowmetry | MOUSE SOMATOSENSORY CORTEX | NAD(P)H OXIDASE | somatosensory activation | HUMAN RENIN | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CEREBRAL-BLOOD-FLOW | HEMATOLOGY | cerebral circulation | hypertension | FUNCTIONAL HYPEREMIA | BRAIN | Free Radical Scavengers - pharmacology | Reactive Oxygen Species - metabolism | Receptor, Angiotensin, Type 1 - physiology | Muscle, Smooth, Vascular - metabolism | Molecular Sequence Data | Endothelium, Vascular - drug effects | Male | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology | Glycoproteins - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Metalloporphyrins - pharmacology | Cytochromes b - deficiency | Membrane Glycoproteins - physiology | Somatosensory Cortex - enzymology | Hypertension - chemically induced | Acetophenones - pharmacology | Nitric Oxide Donors - pharmacology | Receptor, Angiotensin, Type 1 - drug effects | Angiotensin II - toxicity | Muscle, Smooth, Vascular - drug effects | Polyethylene Glycols - pharmacology | Amino Acid Sequence | Hypercapnia - physiopathology | Superoxide Dismutase - pharmacology | Free Radicals | Cerebrovascular Circulation - drug effects | Mice, Inbred C57BL | Somatosensory Cortex - drug effects | Losartan - pharmacology | Rats | Laser-Doppler Flowmetry | Arterioles - drug effects | NADPH Oxidase 2 | Rats, Sprague-Dawley | Animals | Arterioles - metabolism | Vibrissae - physiology | Cytochromes b - genetics | Endothelium, Vascular - metabolism | Hyperemia - physiopathology | Somatosensory Cortex - blood supply | Mice | NADPH Oxidases - physiology | S-Nitroso-N-Acetylpenicillamine - pharmacology | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2008, Volume 107, Issue 2, pp. 375 - 384
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2007, Volume 27, Issue 6, pp. 1276 - 1282
OBJECTIVE—Activation of peroxisome proliferator-activated receptors (PPARs) by lipid-lowering fibrates and insulin-sensitizing thiazolidinediones inhibits... 
Inflammation | PPAR | Atherosclerosis | Heme oxygenase | atherosclerosis | heme oxygenase | LIPID-METABOLISM | PPAR-ALPHA ACTIVATORS | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | DEPENDENT PATHWAY | RESPONSIVE ELEMENT | PLASMA-CHOLESTEROL | inflammation | INTIMAL HYPERPLASIA | ENDOTHELIAL-CELLS | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | MICROSATELLITE POLYMORPHISM | Tumor Necrosis Factor-alpha - metabolism | Transcription, Genetic - drug effects | Cell Proliferation | Humans | Protoporphyrins - pharmacology | PPAR gamma - metabolism | Metalloporphyrins - pharmacology | Cyclooxygenase 2 - biosynthesis | Dose-Response Relationship, Drug | Heme Oxygenase-1 - genetics | RNA, Messenger - biosynthesis | Fenofibrate - pharmacology | Transfection | Chromans - pharmacology | Time Factors | Myocytes, Smooth Muscle - drug effects | Thiazolidinediones - pharmacology | Muscle, Smooth, Vascular - drug effects | PPAR gamma - genetics | Promoter Regions, Genetic | Heme Oxygenase-1 - biosynthesis | Anti-Inflammatory Agents - pharmacology | Myocytes, Smooth Muscle - enzymology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Enzyme Induction | PPAR alpha - genetics | Pyrimidines - pharmacology | Muscle, Smooth, Vascular - cytology | Heme Oxygenase-1 - antagonists & inhibitors | Polymorphism, Genetic | Membrane Proteins - biosynthesis | PPAR gamma - agonists | PPAR alpha - agonists | Mutation | PPAR alpha - metabolism | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Endothelial Cells - drug effects | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2007, Volume 293, Issue 6, pp. 3246 - 3253
Acute intravenous Tempol reduces mean arterial pressure (MAP) and heart rate (HR) in spontaneously hypertensive rats. We investigated the hypothesis that the... 
Nitric oxide synthase | Superoxide dismutase | Adenosine 5′-triphosphate-activated potassium channels | Catalase | Sympathetic nervous system | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | POTASSIUM CHANNELS | sympathetic nervous system | SENSITIVE K+ CHANNELS | NITRIC-OXIDE SYNTHESIS | BLOOD-PRESSURE | adenosine 5 '-triphosphate-activated potassium channels | CALCIUM INFLUX | DOCA-SALT RATS | superoxide dismutase | ENDOTHELIAL-CELLS | SYMPATHETIC-NERVE ACTIVITY | PERIPHERAL VASCULAR DISEASE | HYDROGEN-PEROXIDE | nitric oxide synthase | catalase | Amitrole - pharmacology | Buthionine Sulfoximine - pharmacology | Antihypertensive Agents - pharmacology | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Sympathetic Nervous System - drug effects | Catalase - antagonists & inhibitors | Glutathione Peroxidase - antagonists & inhibitors | Antihypertensive Agents - administration & dosage | Nitric Oxide Synthase - antagonists & inhibitors | Hypertension - drug therapy | Male | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Cyclic N-Oxides - administration & dosage | Ganglionic Blockers - pharmacology | Spin Labels | Sympathetic Nervous System - physiopathology | Metalloporphyrins - pharmacology | Sympathetic Nervous System - metabolism | Dose-Response Relationship, Drug | Heart Rate - drug effects | Hexamethonium - pharmacology | KATP Channels - drug effects | Glyburide - pharmacology | Time Factors | Cyclic N-Oxides - pharmacology | Blood Pressure - drug effects | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Heme Oxygenase (Decyclizing) - metabolism | Potassium Channel Blockers - pharmacology | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Rats, Inbred SHR | Glutathione Peroxidase - metabolism | Enzyme Inhibitors - pharmacology | Rats | Hypertension - physiopathology | Hypertension - metabolism | Peptides - pharmacology | Catalase - metabolism | KATP Channels - metabolism | Animals | Nitric Oxide Synthase - metabolism | Infusions, Intravenous | Cromakalim - pharmacology | Nitric Oxide - metabolism | Hypertension | Cardiovascular system | Heart rate | Blood pressure | Cardiology | Rodents | Index Medicus
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 02/2009, Volume 296, Issue 2, pp. 289 - 298
Mitochondria affect cerebrovascular tone by activation of mitochondrial ATP-sensitive K+ (KATP) channels and generation of reactive oxygen species (ROS).... 
Depolarization | Zucker obese rats | Mitochondrial ATP-sensitive potassium channels | Diazoxide | PROTEIN-KINASE-C | METABOLIC SYNDROME | ACTIVATION | PHYSIOLOGY | mitochondrial ATP-sensitive potassium channels | DILATION | CALCIUM INFLUX | diazoxide | depolarization | ENDOTHELIAL-CELLS | NITRIC-OXIDE | DYSFUNCTION | POTASSIUM | CA2+ SPARKS | Free Radical Scavengers - pharmacology | Propionates - pharmacology | Mitochondria - enzymology | Diazoxide - pharmacology | Reactive Oxygen Species - metabolism | Muscle, Smooth, Vascular - metabolism | Endothelium, Vascular - drug effects | Male | Metalloporphyrins - pharmacology | Muscle, Smooth, Vascular - physiopathology | Cerebral Arteries - drug effects | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Potassium Channels, Calcium-Activated - metabolism | Nitro Compounds - pharmacology | Nitric Oxide Synthase Type III - metabolism | Potassium Channel Blockers - pharmacology | Superoxide Dismutase - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Vasodilator Agents - pharmacology | Succinate Dehydrogenase - antagonists & inhibitors | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Insulin Resistance | Rats | Cerebral Arteries - physiopathology | Obesity - physiopathology | Mitochondria - metabolism | Mitochondria - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Obesity - metabolism | Peptides - pharmacology | Rats, Zucker | Animals | Cerebral Arteries - metabolism | Endothelium, Vascular - metabolism | Succinate Dehydrogenase - metabolism | Vasodilation - drug effects | Nitric Oxide - metabolism | Proteins | Obesity | Mitochondria | Rodents | Physiology | Insulin | Cells | Veins & arteries | Index Medicus | Neurohumoral Control of Cardiovascular Function
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 2015, Volume 172, Issue 6, pp. 1607 - 1619
Journal Article