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Journal of Alzheimer's Disease, ISSN 1387-2877, 2012, Volume 31, Issue 1, pp. 207 - 223
Ginseng extracts show cognition-enhancing effects in Alzheimer's disease (AD) patients. However, little is known about the active components and molecular... 
amyloid-β protein precursor | memory | transgenic mice | Alzheimer's disease | ALPHA-SECRETASE | ACTIVATION | PHOSPHORYLATION | KINASE | COGNITIVE IMPAIRMENT | amyloid-beta protein precursor | NEUROSCIENCES | NEUROBLASTOMA SH-SY5Y | PATHWAY | MICE | PRECURSOR PROTEIN | BRAIN | Calcium - metabolism | Humans | Glycoproteins - pharmacology | Alzheimer Disease - pathology | Brain - metabolism | Piperidines - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Phytotherapy - methods | Disease Models, Animal | Cell Survival - drug effects | Glycoproteins - therapeutic use | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Mutation - genetics | Brain - drug effects | Analysis of Variance | Panax - chemistry | Signal Transduction - drug effects | Ligands | Mice | Nootropic Agents - pharmacology | Protein Binding - physiology | Propionates - pharmacology | Receptors, Lysophosphatidic Acid - metabolism | Amyloid beta-Peptides - pharmacology | Peptide Fragments - pharmacology | Metalloproteases - metabolism | Dose-Response Relationship, Drug | Transfection | Amyloid beta-Protein Precursor - metabolism | Egtazic Acid - analogs & derivatives | Microfilament Proteins - metabolism | Neuroblastoma - pathology | Calcium-Binding Proteins - metabolism | Plant Proteins - therapeutic use | Peptide Fragments - metabolism | Plant Proteins - pharmacology | Presenilin-1 - genetics | Maze Learning - drug effects | Isoxazoles - pharmacology | Amyloid beta-Protein Precursor - genetics | Animals | Egtazic Acid - pharmacology | Memory Disorders - drug therapy | Indans - pharmacology | Memory Disorders - chemically induced
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 07/2018, Volume 23, Issue 8, p. 1893
The Asian world is home to a multitude of venomous and dangerous snakes, which are used to induce various medical effects in the preparation of traditional... 
BPP | Habu pit viper | bottom-up | viperidae | Protobothrops flavoviridis | snake venomics | tripeptide metalloprotease inhibitor | cytotoxicity | top-down | BOTHROPS-JARARACA | ACCELERATED EVOLUTION | PLATELET-AGGREGATION | PROTEOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLAVOCETIN-A | CHEMISTRY, MULTIDISCIPLINARY | BRADYKININ-POTENTIATING PEPTIDES | TRIMERESURUS-FLAVOVIRIDIS | INHIBITORS | LECTIN-LIKE PROTEINS | INSIGHTS | Serine Proteases - pharmacology | Neurons - pathology | Metalloproteases - isolation & purification | Metalloproteases - pharmacology | L-Amino Acid Oxidase - isolation & purification | L-Amino Acid Oxidase - chemistry | Humans | Isoenzymes - chemistry | Chromatography, High Pressure Liquid | Crotalid Venoms - isolation & purification | L-Amino Acid Oxidase - pharmacology | Lectins, C-Type - chemistry | Isoenzymes - isolation & purification | Antineoplastic Agents - isolation & purification | Mass Spectrometry | Inhibitory Concentration 50 | Serine Proteases - chemistry | Antineoplastic Agents - pharmacology | Neurons - metabolism | Chemical Fractionation - methods | Disintegrins - chemistry | Neurons - drug effects | Oligopeptides - chemistry | 5'-Nucleotidase - isolation & purification | Metalloproteases - chemistry | 5'-Nucleotidase - pharmacology | Phospholipases A2 - chemistry | Cell Survival - drug effects | Lectins, C-Type - isolation & purification | Phospholipases A2 - pharmacology | Disintegrins - isolation & purification | Antineoplastic Agents - chemistry | Phosphoric Diester Hydrolases - chemistry | Oligopeptides - isolation & purification | Phosphoric Diester Hydrolases - isolation & purification | Animals | Serine Proteases - isolation & purification | Cell Line, Tumor | Isoenzymes - pharmacology | Crotalid Venoms - chemistry | Phosphoric Diester Hydrolases - pharmacology | 5'-Nucleotidase - chemistry | Oligopeptides - pharmacology | Phospholipases A2 - isolation & purification | Trimeresurus - physiology | Disintegrins - pharmacology | Nucleotidase | Wine | Spectroscopy | Phospholipase A2 | Peptides | Toxicity | Serine | Cytotoxicity | Amino acids | Mass spectroscopy | Lymphocytes T | Snakes | Proteins | Poisons | Venom | Bradykinin | Alcoholics | Scientific imaging | Mass spectrometry | Phosphodiesterase
Journal Article
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 11/2018, Volume 213, pp. 27 - 38
In this work, we examined the proteolytic and phospholipase A (PLA ) activities of venom from the opisthoglyphous colubrid . Proteolytic activity (3 and 10 μg... 
Phospholipase A2 | Snake venom metalloproteinase (SVMP) | Esterase | Caseinolytic | Fibrinogenase | Back-fanged colubrid | Proteolytic | Pseudoboa neuwiedii | Phospholipase A | EDEMA-FORMING ACTIVITIES | SNAKE-VENOM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DUVERNOYS GLAND SECRETION | MOLECULAR PHYLOGENY | COLUBRID SNAKE | HEMORRHAGIC ACTIVITY | PHILODRYAS-PATAGONIENSIS | ZOOLOGY | NORTHEAST REGION | ENDOCRINOLOGY & METABOLISM | TOXICOLOGY | MYOTOXIN-II | GREEN RACER | Reptilian Proteins - chemistry | Metalloproteases - pharmacology | Temperature | Molecular Weight | Rats, Wistar | Substrate Specificity | Male | Snake Venoms - enzymology | Metalloproteases - metabolism | Colubridae - growth & development | Peptide Hydrolases - pharmacology | Phospholipase A2 Inhibitors - pharmacology | Reptilian Proteins - pharmacology | Protease Inhibitors - pharmacology | Proteolysis - drug effects | Esterases - pharmacology | Snake Venoms - pharmacology | Snake Venoms - metabolism | Anticoagulants - chemistry | Brazil | Colubridae - physiology | Metalloproteases - chemistry | Peptide Hydrolases - metabolism | Phospholipases A2 - chemistry | Anticoagulants - metabolism | Esterases - chemistry | Esterases - metabolism | Phospholipases A2 - pharmacology | Phospholipases A2 - metabolism | Peptide Hydrolases - chemistry | Animals | Blood Coagulation - drug effects | Anticoagulants - pharmacology | Reptilian Proteins - antagonists & inhibitors | Hydrogen-Ion Concentration | Reptilian Proteins - metabolism | Fibrin | Cysteine | Proteases | Venom | Fibrinogen | Phospholipases | Snakes | Mass spectrometry
Journal Article
Toxicon, ISSN 0041-0101, 12/2015, Volume 107, Issue Pt B, pp. 163 - 174
This contribution reports on the first characterization of the venom proteome and the bioactivity screening of , the Anatolian Meadow Viper. The crude venom as... 
Vipera anatolica | Anatolian Meadow Viper | Cytotoxicity | Viperidae | Snake venomics | Top-down venomics | Bioactivity screening | GLIOMA-CELLS | SNAKE-VENOM | BREAST-CANCER PROGRESSION | TOXINS | DISINTEGRINS | EVOLUTION | PHARMACOLOGY & PHARMACY | CONTORTROSTATIN | TOXICOLOGY | INHIBITORS | PROTEINS | REVEALS | Serine Proteases - pharmacology | Reptilian Proteins - chemistry | Metalloproteases - isolation & purification | Metalloproteases - pharmacology | Humans | Protein Isoforms - isolation & purification | Lectins, C-Type - chemistry | Reptilian Proteins - pharmacology | Metalloproteases - antagonists & inhibitors | Protease Inhibitors - pharmacology | Protease Inhibitors - isolation & purification | MCF-7 Cells | Protein Isoforms - chemistry | HEK293 Cells | Serine Proteases - chemistry | Disintegrins - chemistry | Metalloproteases - chemistry | Phospholipases A2 - chemistry | Caco-2 Cells | Cells, Cultured | Lectins, C-Type - isolation & purification | Phospholipases A2 - pharmacology | Protease Inhibitors - chemistry | Disintegrins - isolation & purification | Reptilian Proteins - isolation & purification | Viper Venoms - chemistry | Protein Isoforms - pharmacology | Animals | Serine Proteases - isolation & purification | Cell Line, Tumor | HeLa Cells | Reptilian Proteins - antagonists & inhibitors | Mass Spectrometry - methods | Phospholipases A2 - isolation & purification | Disintegrins - pharmacology | Cysteine | Protease inhibitors | Gliomas | Proteases | Analysis | Venom | Lectins | Snakes | Mass spectrometry | Proteins | Screening | Phospholipase | Profiling | Protease | Biochemistry
Journal Article
Molecular Human Reproduction, ISSN 1360-9947, 02/2015, Volume 21, Issue 10, pp. 792 - 802
Despite evidence that leptin may play a role in the pathogenesis of endometriosis, the specific function of leptin in the migration and invasion of... 
Leptin receptor | Leptin | Migration | Endometriosis | JAK2/STAT3 | Matrix metalloprotease | Invasion | PERITONEAL-FLUID LEPTIN | FUNCTIONAL ACTIVATION | leptin receptor | PELVIC ENDOMETRIOSIS | endometriosis | EUTOPIC ENDOMETRIUM | DEVELOPMENTAL BIOLOGY | leptin | TRANSDUCTION PATHWAYS | OBSTETRICS & GYNECOLOGY | matrix metalloprotease | REPRODUCTIVE BIOLOGY | invasion | PROSTATE-CANCER CELLS | migration | MATRIX-METALLOPROTEINASE SYSTEM | TISSUE INHIBITOR | EXTRACELLULAR-MATRIX | REPRODUCTIVE-CYCLE | RNA, Small Interfering - genetics | Receptors, Leptin - antagonists & inhibitors | Receptors, Leptin - genetics | Epithelial Cells - drug effects | Humans | Endometrium - drug effects | Matrix Metalloproteinase 2 - physiology | Sulfones - pharmacology | Leptin - physiology | Stromal Cells - enzymology | Laminin | STAT3 Transcription Factor - physiology | RNA Interference | Heterocyclic Compounds, 1-Ring - pharmacology | Stromal Cells - drug effects | Enzyme Induction - drug effects | Female | Flavonoids - pharmacology | Leptin - pharmacology | Janus Kinase 2 - physiology | Endometrium - cytology | Epithelial Cells - cytology | Janus Kinase 2 - antagonists & inhibitors | Matrix Metalloproteinase 2 - biosynthesis | Cell Line | Proteoglycans | Dipeptides - pharmacology | Tyrphostins - pharmacology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase Inhibitors - pharmacology | Signal Transduction - drug effects | Receptors, Leptin - physiology | Collagen | Epithelial Cells - enzymology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Drug Combinations | Stromal Cells - cytology
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, ISSN 1079-5642, 05/2003, Volume 23, Issue 5, pp. 769 - 775
OBJECTIVE—Production of several metalloproteinases (MMPs) from smooth muscle cells (SMCs) and macrophages causes matrix destruction and atherosclerotic plaque... 
Metalloproteinases | Plaque instability | Statins | Atherosclerosis | Isoprenoids | atherosclerosis | ARTERIAL INJURY | isoprenoids | metalloproteinases | HMG-COA REDUCTASE | ATHEROSCLEROTIC PLAQUE STABILITY | MATRIX-DEGRADING METALLOPROTEINASES | FOAM CELLS | plaque instability | IN-VITRO | WHHL RABBITS | statins | CHOLESTEROL-FED RABBITS | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | TISSUE FACTOR | Cholesterol, Dietary - toxicity | Lovastatin - pharmacology | Humans | Depression, Chemical | Culture Media, Conditioned - pharmacology | Simvastatin - pharmacology | Foam Cells - drug effects | Protein Processing, Post-Translational - drug effects | Foam Cells - secretion | Matrix Metalloproteinase 9 - secretion | Saphenous Vein - cytology | Muscle, Smooth, Vascular - drug effects | Mevalonic Acid - pharmacology | Protein Prenylation - drug effects | Rabbits | Cells, Cultured - drug effects | Cells, Cultured - enzymology | Cells, Cultured - secretion | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Squalene - pharmacology | Tissue Inhibitor of Metalloproteinase-2 - secretion | Matrix Metalloproteinase 1 - secretion | Matrix Metalloproteinase 2 - secretion | Polyisoprenyl Phosphates - pharmacology | Pyridines - pharmacology | Tissue Inhibitor of Metalloproteinase-1 - secretion | Aorta - cytology | Metalloproteases - secretion | Muscle, Smooth, Vascular - secretion | Matrix Metalloproteinase 3 - secretion | Muscle, Smooth, Vascular - enzymology
Journal Article
Circulation, ISSN 0009-7322, 08/2004, Volume 110, Issue 5, pp. 571 - 578
Background - Oxidized LDLs (oxLDLs) and matrix metalloproteinases (MMPs) are present in atherosclerotic lesions. OxLDLs activate various signaling pathways... 
Metalloproteases | Ceramides | Lipoproteins | Sphingomyelins | Cells, muscle, smooth | MIGRATION | ATHEROGENESIS | CARDIAC & CARDIOVASCULAR SYSTEMS | TISSUE | ATHEROSCLEROSIS | sphingomyelins | cells, muscle, smooth | ceramides | BETA | GELATINASE | INHIBITION | LDL | GROWTH | PERIPHERAL VASCULAR DISEASE | metalloproteases | EXPRESSION | lipoproteins | Muscle, Smooth, Vascular - metabolism | Phenylalanine - analogs & derivatives | DNA Replication - drug effects | Phenylalanine - pharmacology | Humans | Matrix Metalloproteinase 2 - physiology | Receptor, Epidermal Growth Factor - drug effects | Protease Inhibitors - pharmacology | Matrix Metalloproteinases, Membrane-Associated | Sphingomyelin Phosphodiesterase - metabolism | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Matrix Metalloproteinase 2 - pharmacology | Fibroblasts - metabolism | Muscle, Smooth, Vascular - drug effects | Rabbits | Cells, Cultured - drug effects | Mitogen-Activated Protein Kinase 1 - physiology | Sphingosine - physiology | RNA, Small Interfering - pharmacology | Lipoproteins, LDL - pharmacology | Thiophenes - pharmacology | Pyrimidines - pharmacology | Recombinant Proteins - pharmacology | Enzyme Activation - drug effects | Muscle, Smooth, Vascular - cytology | Piperazines - pharmacology | Cell Division - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Sphingomyelins - physiology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Metalloendopeptidases - pharmacology | Fibroblasts - drug effects | Matrix Metalloproteinase Inhibitors | Cells, Cultured - metabolism | Metalloendopeptidases - physiology | Mice | Lysophospholipids - physiology | Receptors, Platelet-Derived Growth Factor - drug effects | Ceramides - physiology
Journal Article
FEBS JOURNAL, ISSN 1742-464X, 02/2014, Volume 281, Issue 3, pp. 657 - 672
Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a... 
Candida albicans | wound healing | HISTIDINE-RICH POLYPEPTIDES | FUNGICIDAL ACTIVITY | HUMAN WHOLE SALIVA | metallopeptides | BIOCHEMISTRY & MOLECULAR BIOLOGY | METAL-BINDING | GINGIVAL CREVICULAR FLUID | ACTUN motif | HUMAN ENDOTHELIAL-CELLS | saliva | histidine rich peptide | MATRIX METALLOPROTEINASES | CANDIDA-ALBICANS | metalloprotease inhibitor | reactive oxygen species | EPIDERMAL-GROWTH-FACTOR | antimicrobial peptides | Zinc - metabolism | Histatins - pharmacology | Humans | Cysteine Proteinase Inhibitors - metabolism | Antifungal Agents - chemistry | Antimicrobial Cationic Peptides - metabolism | Antifungal Agents - therapeutic use | Matrix Metalloproteinase Inhibitors - therapeutic use | Anti-Bacterial Agents - therapeutic use | Histatins - therapeutic use | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Anti-Bacterial Agents - chemistry | Antifungal Agents - metabolism | Copper - metabolism | Cysteine Proteinase Inhibitors - chemistry | Wound Healing - drug effects | Antifungal Agents - pharmacology | Cysteine Proteinase Inhibitors - therapeutic use | Histatins - metabolism | Antimicrobial Cationic Peptides - chemistry | Antimicrobial Cationic Peptides - pharmacology | Anti-Bacterial Agents - metabolism | Matrix Metalloproteinase Inhibitors - chemistry | Protein Isoforms - therapeutic use | Histatins - chemistry | Matrix Metalloproteinase Inhibitors - metabolism | Antimicrobial Cationic Peptides - therapeutic use | Protein Isoforms - pharmacology | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Cysteine Proteinase Inhibitors - pharmacology | Protein Conformation | Anti-Bacterial Agents - pharmacology | Peptides | Copper compounds | Proteases
Journal Article