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1. Full Text An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster
by Catalán, Ana and Glaser-Schmitt, Amanda and Argyridou, Eliza and Duchen, Pablo and Parsch, John
PLoS Genetics, ISSN 1553-7390, 04/2016, Volume 12, Issue 4, p. e1005987
Insertions and deletions (indels) are a major source of genetic variation within species and may result in functional changes to coding or regulatory... 
OXIDATIVE STRESS | MORPHOLOGICAL DIVERSITY | EVOLUTION | METALLOTHIONEIN GENE | NATURAL-POPULATIONS | EUROPEAN POPULATIONS | DNA POLYMORPHISM | GENETICS & HEREDITY | SELECTIVE SWEEPS | HEAVY-METAL HOMEOSTASIS | REVEALS | Base Sequence - genetics | Gene Frequency - genetics | Animals, Genetically Modified | Gene Expression Regulation - genetics | United States | Europe | Oxidative Stress - genetics | 3' Untranslated Regions - genetics | Africa South of the Sahara | INDEL Mutation - genetics | Drosophila melanogaster - genetics | Sequence Analysis, DNA | Selection, Genetic - genetics | Animals | Metallothionein - genetics | Adaptation, Physiological - genetics | Sequence Deletion - genetics | Genetic aspects | Observations | Gene expression | Drosophila | Genetic polymorphisms | Studies | Oxidative stress | Insects | Population | Females | Zinc | Adaptation | Polymorphism
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2. Full Text A Robust Inducible-Repressible Promoter Greatly Facilitates Gene Knockouts, Conditional Expression, and Overexpression of Homologous and Heterologous Genes in Tetrahymena thermophila
by Yuhua Shang and Xiaoyuan Song and Josephine Bowen and Robert Corstanje and Yan Gao and Jacek Gaertig and Martin A. Gorovsky
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2002, Volume 99, Issue 6, pp. 3734 - 3739
The Cd -inducible metallothionein (MTT1) gene was cloned from Tetrahymena thermophila. Northern blot analysis showed that MTT1 mRNA is not detectable in the... 
Cadmium | Biological Sciences | Cell growth | Phenotypes | Heterokaryon | Surface antigens | Plasmids | Genes | Genetic loci | Promoter regions | Cells | BETA-TUBULIN | TRANSFORMATION | REPLACEMENT | ELECTROPORATION | METALLOTHIONEIN GENE | CADMIUM | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ALPHA-TUBULIN | RIBOSOMAL-RNA GENES | MICROINJECTION | RNA, Protozoan - genetics | Gene Frequency - genetics | Genes, Protozoan - genetics | Antigens, Protozoan - biosynthesis | Molecular Sequence Data | Tubulin - genetics | Tetrahymena thermophila - drug effects | Germ-Line Mutation - genetics | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Gene Deletion | Antigens, Protozoan - genetics | Genes, Essential - genetics | Tetrahymena thermophila - genetics | RNA, Messenger - genetics | Transgenes - genetics | Cadmium - pharmacology | Genes, Reporter - genetics | Down-Regulation - drug effects | Mutagenesis, Insertional - genetics | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | RNA, Protozoan - metabolism | Animals | Histones - genetics | Metallothionein - genetics | Genes, Lethal - genetics | Neomycin | Genetic aspects | Ciliata | Promoters (Genetics) | Research | Genetic regulation | Metallothionein
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3. Full Text Converting nonsense codons into sense codons by targeted pseudouridylation
by Karijolich, John and Yu, Yi-Tao
Nature, ISSN 0028-0836, 06/2011, Volume 474, Issue 7351, pp. 395 - 399
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon(1-3). Here, we demonstrate that... 
SITE | TURNOVER | RNA | GENE | RECOGNITION | MULTIDISCIPLINARY SCIENCES | U2 SNRNA | TERMINATION | SACCHAROMYCES-CEREVISIAE | Gene Expression Regulation, Fungal | Amino Acid Sequence | Metallothionein - metabolism | Saccharomyces cerevisiae - genetics | RNA, Messenger - genetics | Peptide Chain Termination, Translational | Molecular Sequence Data | Ribosomes - metabolism | Saccharomyces cerevisiae Proteins - genetics | Amino Acids - genetics | RNA, Messenger - metabolism | Pseudouridine - metabolism | RNA, Fungal - metabolism | Amino Acids - metabolism | Metallothionein - genetics | tRNA Methyltransferases - genetics | Base Sequence | Genetic Code - genetics | Protein Biosynthesis - genetics | RNA, Fungal - genetics | Codon - genetics | Codon, Nonsense - genetics | Proteins | Amino acids | Mass spectrometry
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4. Full Text Genome-wide screen of promoter methylation identifies novel markers in melanoma
by Koga, Yasuo and Pelizzola, Mattia and Cheng, Elaine and Krauthammer, Michael and Sznol, Mario and Ariyan, Stephan and Narayan, Deepak and Molinaro, Annette M and Halaban, Ruth and Weissman, Sherman M
Genome Research, ISSN 1088-9051, 08/2009, Volume 19, Issue 8, pp. 1462 - 1470
DNA methylation is an important component of epigenetic modifications, which influences the transcriptional machinery aberrant in many human diseases. In this... 
HUMAN-DISEASE | HYPERMETHYLATION | DNA METHYLATION | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MALIGNANT-MELANOMA | CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EPIGENETIC INACTIVATION | CUTANEOUS MELANOMA | GENES | GENETICS & HEREDITY | EPIGENOMICS | Humans | Middle Aged | HSP20 Heat-Shock Proteins - genetics | Male | Gene Expression Profiling | Promoter Regions, Genetic - genetics | DNA Methylation | Melanoma - genetics | Adult | Female | Collagen - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Infant, Newborn | Reproducibility of Results | Oligonucleotide Array Sequence Analysis - methods | Cells, Cultured | Molecular Chaperones - genetics | Collagen Type I | Melanoma - pathology | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Genome, Human - genetics | Proteins - genetics | Nucleoplasmins | Metallothionein - genetics | Aged | Biomarkers, Tumor - genetics | Genome-Wide Association Study - methods | Cluster Analysis | Polymerase chain reaction | Usage | Analysis | Melanoma | Genetic aspects | Gene expression | Methylation | Methods
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5. Full Text Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies
by Váchová, Libuše and Štoví, Vratislav and Hlaváček, Otakar and Chernyavskiy, Oleksandr and Štěpánek, Luděk and Kubínová, Lucie and Palková, Zdena
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 679 - 687
Much like other microorganisms, wild yeasts preferentially form surface-associated communities, such as biofilms and colonies, that are well protected against... 
CELL ADHESION | PROTEIN | GENE | BUDDING YEAST | PDR1 | CANDIDA-ALBICANS BIOFILMS | ABC TRANSPORTERS | FLUCONAZOLE RESISTANCE | SACCHAROMYCES-CEREVISIAE | EXPRESSION | CELL BIOLOGY | Metallothionein - metabolism | Galactose - metabolism | Membrane Glycoproteins - metabolism | Biofilms - growth & development | Galactokinase - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Oxazines - metabolism | ATP-Binding Cassette Transporters - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Profilins - genetics | Extracellular Matrix - physiology | Gene Deletion | Copper - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Multidrug Resistance-Associated Proteins - genetics | Permeability | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Membrane Glycoproteins - genetics | Saccharomyces cerevisiae - cytology | Transcription Factors - metabolism | Metallothionein - genetics | Galactokinase - metabolism | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Multidrug Resistance-Associated Proteins - metabolism | Saccharomyces cerevisiae - growth & development | Yeast fungi | Physiological aspects | Microbial colonies
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6. Full Text Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations
by Chang, Shang-Lin and Lai, Huei-Yi and Tung, Shu-Yun and Leu, Jun-Yi
PLoS Genetics, ISSN 1553-7390, 01/2013, Volume 9, Issue 1, p. e1003232
Large-scale genome rearrangements have been observed in cells adapting to various selective conditions during laboratory evolution experiments. However, it... 
MOLECULAR CHARACTERIZATION | PHOSPHATE TRANSPORTER | CUP2 GENE-PRODUCT | CANDIDA-ALBICANS | BUDDING YEAST | GENOME EVOLUTION | GENETICS & HEREDITY | COPPER | DRUG-RESISTANCE | SACCHAROMYCES-CEREVISIAE | ADAPTIVE EVOLUTION | Genetics, Population | Metallothionein - metabolism | Saccharomyces cerevisiae - genetics | Segmental Duplications, Genomic | Gene Dosage | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Biological Evolution | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Transcription Factors - metabolism | Metallothionein - genetics | Proton-Phosphate Symporters - genetics | Genome, Fungal | Chromosomes - genetics | Chromosome Aberrations | Saccharomyces cerevisiae Proteins - metabolism | Genomic Instability - drug effects | Proton-Phosphate Symporters - metabolism | Israel | Copper - toxicity | Genomic Instability - genetics | Yeast fungi | Physiological aspects | Genetic aspects | Research | Genetic regulation | Chromosomes | Health aspects | Proteins | Genetics | Yeast | Mutation | Genomics
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7. Full Text MiR-545-3p/MT1M axis regulates cell proliferation, invasion and migration in hepatocellular carcinoma
by Changjun, Liu and Feizhou, Huang and Dezhen, Peng and Zhao, Lei and Xianhai, Mao
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 12/2018, Volume 108, pp. 347 - 354
Studies have shown that metallothionein 1 M (MT1M) is a tumor suppressor gene which is frequently down-regulated in human hepatocellular carcinoma (HCC). The... 
Hepatocellular carcinoma | Invasion and migration | miR-545-3p | MT1M | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | MAMMALIAN METALLOTHIONEINS | PROGNOSIS | MICRORNAS | BREAST-CANCER | BIOMARKERS | METALLOTHIONEIN EXPRESSION | LUNG-CANCER | GROWTH | PHARMACOLOGY & PHARMACY | MIR-24 PROMOTES | Humans | Middle Aged | 3' Untranslated Regions - genetics | Male | Promoter Regions, Genetic - genetics | Cell Movement - genetics | Neoplasm Invasiveness - pathology | Carcinoma, Hepatocellular - genetics | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - genetics | Cell Proliferation - genetics | Liver Neoplasms - genetics | Down-Regulation - genetics | Hep G2 Cells | Animals | Metallothionein - genetics | RNA Processing, Post-Transcriptional - genetics | Mice, Nude | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Aged | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Neoplasm Invasiveness - genetics | Methylation | Metallothionein | Hepatoma
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8. Full Text Type 4 metallothionein genes are involved in regulating Zn ion accumulation in late embryo and in controlling early seedling growth in Arabidopsis
by REN, YUJUN and LIU, YANG and CHEN, HONGYU and LI, GANG and ZHANG, XUELIAN and ZHAO, JIE
Plant, Cell & Environment, ISSN 0140-7791, 04/2012, Volume 35, Issue 4, pp. 770 - 789
ABSTRACT Type 4 metallothionein (MT) genes are recognized for their specific expression in higher plant seeds, but their functions are still unclear. In this... 
ABA | AtMT4b | AtMT4a | ESCHERICHIA-COLI | ABSCISIC-ACID BIOSYNTHESIS | PHYTOCHROME REGULATION | ABA BIOSYNTHESIS | DROUGHT TOLERANCE | PLANT SCIENCES | ORYZA-SATIVA L | TRANSGENIC ARABIDOPSIS | FUNCTIONAL-ANALYSIS | ALDEHYDE OXIDASE | ROOT DEVELOPMENT | Metallothionein - metabolism | Arabidopsis - growth & development | Gene Expression - genetics | Hypocotyl - genetics | Zinc - metabolism | Plant Roots - genetics | Seedlings - genetics | Arabidopsis - embryology | Biomass | Promoter Regions, Genetic - genetics | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Seedlings - embryology | Zinc - analysis | Seeds - growth & development | Gibberellins - metabolism | Plants, Genetically Modified | Copper - metabolism | Abscisic Acid - metabolism | Plant Roots - growth & development | Arabidopsis Proteins - genetics | Seeds - genetics | Cotyledon - embryology | Germination | Gene Expression Regulation, Plant - genetics | Hypocotyl - growth & development | Signal Transduction - genetics | Cotyledon - genetics | Arabidopsis - genetics | Seeds - embryology | Phenotype | Copper - analysis | Hypocotyl - embryology | Metallothionein - genetics | Plant Roots - embryology | Cotyledon - growth & development | Mutation | Plant Growth Regulators - metabolism | Arabidopsis thaliana | Embryonic development | Gibberellins | Growth | Arabidopsis | Analysis | Genes | Abscisic acid | Genetic research | Genetic transcription | Plant hormones | Metallothionein
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9. Full Text Environmental change drives accelerated adaptation through stimulated copy number variation
by Hull, Ryan M and Cruz, Cristina and Jack, Carmen V and Houseley, Jonathan
PLoS Biology, ISSN 1544-9173, 06/2017, Volume 15, Issue 6, pp. e2001333 - e2001333
Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in many human disorders, particularly cancer, in which CNV promotes both... 
MUTATION-RATES | REPLICATION FORK BLOCKING | HALF-CROSSOVERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | ACQUIRED-RESISTANCE | FRAGILE SITES | RIBOSOMAL DNA | GENE AMPLIFICATION | GENOME REARRANGEMENTS | SACCHAROMYCES-CEREVISIAE | S-PHASE CHECKPOINT | Gene Expression Regulation, Fungal | Saccharomyces cerevisiae - genetics | Copper - pharmacology | Gene Expression Profiling - methods | Saccharomyces cerevisiae - drug effects | Signal Transduction - genetics | Saccharomyces cerevisiae Proteins - genetics | Promoter Regions, Genetic - genetics | DNA Copy Number Variations | Drug Resistance - genetics | Metallothionein - genetics | Adaptation, Physiological - genetics | Gene Expression Regulation, Developmental | Lysine - metabolism | Models, Genetic | Histones - metabolism | Mutation | Methylation | Saccharomyces cerevisiae - growth & development | Chromatin | Yeast | Transcription | Funding | Copy number | Genomics | DNA damage | Ribosomal DNA | Disorders | Stimulation | Genomes | Selectivity | Mutation rates | Defects | Cell cycle | Tumorigenesis | Acetylation | Copper | Deoxyribonucleic acid--DNA | Adaptation | Cloning | Roles | Mammals | Gene expression | Loci | Promoters | Chemotherapy | Lysine | Alleles | Epigenetics | Data collection | Replication | Arrays | Histone H3 | Impact damage | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
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10. Full Text Properties of mitotic and meiotic recombination in the tandemly-repeated CUP1 gene cluster in the yeast Saccharomyces cerevisiae
by Zhao, Ying and Dominska, Margaret and Petrova, Aleksandra and Bagshaw, Halle and Kokoska, Robert J and Petes, Thomas D
Genetics, ISSN 0016-6731, 06/2017, Volume 206, Issue 2, pp. 785 - 800
In the yeast Saccharomyces cerevisiae, the genes encoding the metallothionein protein Cup1 are located in a tandem array on chromosome VIII. Using a diploid... 
Sister chromatid crossovers | Meiotic recombination | Repeated genes | Mitotic recombination | repeated genes | STRAND BREAK REPAIR | SEQUENCES | mitotic recombination | CONVERSION | TRANSCRIPTION | meiotic recombination | SISTER-CHROMATID EXCHANGE | PATHWAY | sister chromatid crossovers | GENETICS & HEREDITY | CROSSING-OVER | RIBOSOMAL DNA | HOMOLOGOUS RECOMBINATION | EXPRESSION | Multigene Family - genetics | Meiosis - genetics | Metallothionein - genetics | Rad51 Recombinase - genetics | Recombination, Genetic | Saccharomyces cerevisiae - genetics | Homologous Recombination - genetics | Sister Chromatid Exchange | Tandem Repeat Sequences | Saccharomyces cerevisiae Proteins - genetics | Mitosis - genetics | Rad52 DNA Repair and Recombination Protein - genetics | Genetic aspects | Research | Brewer's yeast | Chromosomes | Recombination | Yeast | Transcription | Genes | DNA damage | Sister chromatid exchange | Insertion | Meiosis | Saccharomyces | Proteins | Chromosome VIII | CUP1 gene | Genetic recombination | Saccharomyces cerevisiae | Metallothionein | Rad52 protein | Investigations
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11. Full Text Prognostic Value of a Nine‐Gene Signature in Glioma Patients Based on mRNA Expression Profiling
by Bao, Zhao‐Shi and Li, Ming‐Yang and Wang, Jia‐Yin and Zhang, Chuan‐Bao and Wang, Hong‐Jun and Yan, Wei and Liu, Yan‐Wei and Zhang, Wei and Chen, Ling and Jiang, Tao
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 02/2014, Volume 20, Issue 2, pp. 112 - 118
Summary Introduction Gliomas are the most common primary brain tumors in adults and a significant cause of cancer‐related mortality. A 9‐gene signature was... 
Risk score | Biomarker | mRNA | Prognosis | Gliomas | CELLS | MICROARRAY | ENHANCER | CLASSIFICATION | EMISSION-TOMOGRAPHY SCANS | NEUROSCIENCES | ANTIGEN SURVIVIN | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | ESOPHAGEAL CANCER | PRIMARY GLIOBLASTOMA | DISTANT METASTASES | Glioma - diagnosis | Microtubule-Associated Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Endosomal Sorting Complexes Required for Transport - genetics | Genomic Library | Tubulin - genetics | Gene Expression Profiling | RNA, Messenger - metabolism | Glioma - genetics | Microarray Analysis | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | DNA-Binding Proteins | Glioma - mortality | Histone Deacetylases - genetics | Inhibitor of Apoptosis Proteins | Membrane Proteins - genetics | Brain Neoplasms - diagnosis | Kaplan-Meier Estimate | Brain Neoplasms - genetics | Repressor Proteins - genetics | Survivin | rab1 GTP-Binding Proteins - genetics | Metallothionein - genetics | Genetic Variation - genetics | Transcription Factors | Messenger RNA | Analysis | Mortality | Genes | Genomics | Genetic aspects | Cancer | Medical prognosis | Genomes
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12. Full Text Orthologs of the Class A4 Heat Shock Transcription Factor HsfA4a Confer Cadmium Tolerance in Wheat and Rice
by Donghwan Shim and Jae-Ung Hwang and Joohyun Lee and Sichul Lee and Yunjung Choi and Gynheung An and Enrico Martinoia and Youngsook Lee
The Plant Cell, ISSN 1040-4651, 12/2009, Volume 21, Issue 12, pp. 4031 - 4043
Cadmium (Cd) is a widespread soil pollutant; thus, the underlying molecular controls of plant Cd tolerance are of substantial interest. A screen for wheat... 
Yeasts | Cadmium | Shock heating | Transcripti