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Molecular Pharmaceutics, ISSN 1543-8384, 08/2012, Volume 9, Issue 8, pp. 2358 - 2363
The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma and saliva samples in healthy human volunteers, and to introduce a... 
Salivary Excretion Classification System | effective permeability | pharmacokinetics | protein binding | bioequivalence | SimCYP | MEDICINE, RESEARCH & EXPERIMENTAL | RELATIVE BIOAVAILABILITY | PERMEABILITY | CLINICAL PHARMACOKINETICS | BIOLOGICAL FLUID | DRUGS | PHARMACOLOGY & PHARMACY | Quinolines - blood | Acetates - blood | Fluorobenzenes - pharmacokinetics | Hydrochlorothiazide - pharmacokinetics | Triazoles - blood | Piroxicam - blood | Azithromycin - blood | Humans | Losartan - blood | Saliva - secretion | Male | Naphthalenes - blood | Benzhydryl Compounds - blood | Fluorobenzenes - pharmacology | Quinolines - pharmacokinetics | Sulfonamides - blood | Azithromycin - pharmacokinetics | Tolterodine Tartrate | Female | Triazoles - pharmacokinetics | Naphthalenes - pharmacokinetics | Piroxicam - analogs & derivatives | Sitagliptin Phosphate | Hydrochlorothiazide - blood | Losartan - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Metformin - blood | Cresols - blood | Phenylpropanolamine - blood | Metformin - pharmacokinetics | Rosuvastatin Calcium | Cloxacillin - pharmacokinetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Cinacalcet Hydrochloride | Cloxacillin - blood | Saliva - metabolism | Pyrazines - pharmacokinetics | Piroxicam - pharmacokinetics | Pyrimidines - pharmacokinetics | Cresols - pharmacokinetics | Anthraquinones - blood | Anthraquinones - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Pyrazines - blood | Acetates - pharmacokinetics | Index Medicus
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2011, Volume 50, Issue 1, pp. 65 - 74
Background and Objectives: Exenatide is a glucagon-like peptide-1 receptor agonist, available in an immediate-release (IR), twice-daily formulation, which... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Exenatide, pharmacodynamics | Pharmacokinetic- pharmacodynamic-relationships | Population-pharmacokinetics | Antihyperglycaemics, pharmacokinetics | Glucagon-like-peptide-1-stimulants, pharmacokinetics | Diabetes-mellitus | Exenatide, pharmacokinetics | Antihyperglycaemics, pharmacodynamics | Glucagon-like-peptide-1-stimulants, pharmacodynamics | METFORMIN | GLYCEMIC CONTROL | SULFONYLUREA | LIQUID-CHROMATOGRAPHY | GLUCOSE | PHARMACOLOGY & PHARMACY | SYNTHETIC EXENDIN-4 | TREATED PATIENTS | WEIGHT | TYPE-2 | Humans | Middle Aged | Peptides - pharmacokinetics | Male | Dose-Response Relationship, Drug | Glucagon-Like Peptide 1 - agonists | Injections, Subcutaneous | Glucagon-Like Peptide 1 - pharmacokinetics | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Hypoglycemic Agents - pharmacokinetics | Drug Administration Schedule | Glucagon-Like Peptide 1 - pharmacology | Blood Glucose | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Diabetes Mellitus, Type 2 - blood | Glucagon-Like Peptide-1 Receptor | Gastric Emptying - drug effects | Venoms - therapeutic use | Venoms - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Delayed-Action Preparations | Peptides - therapeutic use | Venoms - pharmacokinetics | Type 2 diabetes | Drugs | Physiological aspects | Dosage and administration | Research | Pharmacokinetics | Drug therapy | Index Medicus
Journal Article
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 05/2018, Volume 84, Issue 5, pp. 987 - 996
AimsTo identify pharmacogenetic and demographic variables that influence the systemic exposure to metformin in an admixed Brazilian cohort. MethodsThe extreme... 
SLC47 | extreme discordant phenotype | SP1 | biogeographical ancestry | metformin pharmacokinetics | SLC22 | RENAL CLEARANCE | TRANSPORTERS | GENETIC-VARIANTS | TABLET | DISPOSITION | GENOTYPE DATA | OCT1 | PHARMACOLOGY & PHARMACY | ABSORPTION | DRUG-DRUG INTERACTIONS | FOOD | Hypoglycemic agents | Genetic aspects | Analysis | Genetic polymorphisms | Index Medicus | Pharmacogenetics
Journal Article
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 07/2018, Volume 20, Issue 7, pp. 1593 - 1601
Aims To assess potential causes of metformin intolerance, including altered metformin uptake from the intestine, increased anaerobic glucose utilization and... 
antidiabetic drug | pharmacokinetics | metformin | type 2 diabetes | DRUG-INTERACTIONS | TRANSPORTERS | PLASMA | METABOLISM | REDUCTION | ENDOCRINOLOGY & METABOLISM | SEROTONIN | ACCUMULATION | INHIBITOR | TYPE-2 | ASSOCIATION | Overweight - complications | Bile Acids and Salts - blood | Gastrointestinal Diseases - physiopathology | Lactic Acid - blood | Humans | Middle Aged | Half-Life | Male | Metabolic Clearance Rate | Metformin - adverse effects | Hypoglycemic Agents - blood | Serotonin - blood | Female | Diabetes Mellitus, Type 2 - complications | Metformin - blood | Body Mass Index | Hypoglycemic Agents - therapeutic use | Severity of Illness Index | Hypoglycemic Agents - pharmacokinetics | Abdominal Pain - etiology | Metformin - pharmacokinetics | Gastrointestinal Diseases - metabolism | Gastrointestinal Diseases - blood | Diarrhea - etiology | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Gastrointestinal Diseases - chemically induced | Cohort Studies | Type 2 diabetes | Lactates | Care and treatment | Medical examination | Hypoglycemic agents | Glucose | Blood | Dextrose | Deoxycholic acid | Glucose metabolism | Intolerance | Body mass index | Phenotypes | Bile acids | Serotonin | Intestine | Lactic acid | Metformin | Diabetes | Pharmacokinetics | Bile | Index Medicus | Original
Journal Article