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Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 12/2016, Volume 119, Issue 6, pp. 523 - 532
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6558 - 6567
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2017, Volume 18, Issue 9, p. 1959
Journal Article
Nature Reviews Endocrinology, ISSN 1759-5029, 10/2016, Volume 12, Issue 10, pp. 566 - 592
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e57289
The mTOR pathway is aberrantly stimulated in many cancer cells, including pancreatic ductal adenocarcinoma (PDAC), and thus it is a potential target for... 
PATHWAY ACTIVATION | DIABETIC-PATIENTS | INSULIN-RECEPTOR | PROTEIN-COUPLED RECEPTOR | COMPETITIVE MAMMALIAN TARGET | MULTIDISCIPLINARY SCIENCES | KINASE | TUMOR-SUPPRESSOR | RISK | GROWTH-FACTOR | SIGNALING SYSTEMS | Pancreatic Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Neurotensin - pharmacology | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Insulin - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Metformin - pharmacology | Pancreatic Neoplasms - pathology | Morpholines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Pancreatic Neoplasms - genetics | Pyrimidines - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Sirolimus - pharmacology | Hypoglycemic Agents - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Signal Transduction - drug effects | Cell Line, Tumor | Feedback, Physiological - drug effects | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Type 2 diabetes | Tyrosine | Pancreatic cancer | Cancer cells | Neuropeptides | Rapamycin | Metformin | Neurotensin | Drug therapy | TOR protein | Adenocarcinoma | Cell proliferation | Therapy | Phosphorylation | Thoracic surgery | G protein-coupled receptors | AKT protein | Insulin-like growth factors | Activation | Feedback loops | Kinases | Proteins | Receptors | Negative feedback | Cell growth | Allosteric properties | Pathways | Feedback | Inhibition | Protein-tyrosine kinase | Extracellular signal-regulated kinase | Insulin | Medicine | Signaling | Inhibitors | Protein synthesis | Diabetes | Aberration | Molecular biology | Cancer
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 07/2011, Volume 45, Issue 1, pp. 111 - 119
Airway smooth muscle (ASM) cells have been reported to contribute to the inflammation of asthma. Because the thiazolidinediones (TZDs) exert anti-inflammatory... 
TNF-α | IL-1β | shRNA | Anti-inflammatory | PPARγ | ACTIVATED PROTEIN-KINASE | 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE | TNF-alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR-GAMMA AGONISTS | IL-1 beta | NECROSIS-FACTOR-ALPHA | PPAR gamma | HUMAN ADIPOCYTES | CELL BIOLOGY | MURINE MODEL | RESPIRATORY SYSTEM | anti-inflammatory | GENE-EXPRESSION | PPAR-GAMMA | BINDING-SITES | NF-KAPPA-B | Enzyme Activators - pharmacology | Respiratory System - pathology | AMP-Activated Protein Kinases - metabolism | Asthma - metabolism | Humans | Myocytes, Smooth Muscle - pathology | PPAR gamma - metabolism | Aminoimidazole Carboxamide - pharmacology | Gene Knockdown Techniques | Ribonucleotides - pharmacology | Chromans - pharmacology | Inflammation Mediators - metabolism | Thiazolidinediones - pharmacology | Cytokines - genetics | Myocytes, Smooth Muscle - metabolism | Antimetabolites - pharmacology | PPAR gamma - genetics | Pyrazoles - pharmacology | Anti-Inflammatory Agents - pharmacology | AMP-Activated Protein Kinases - antagonists & inhibitors | Metformin - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Pyrimidines - pharmacology | Asthma - drug therapy | Asthma - genetics | Hypoglycemic Agents - pharmacology | Vidarabine - pharmacology | PPAR gamma - antagonists & inhibitors | Aminoimidazole Carboxamide - analogs & derivatives | Respiratory System - metabolism | Anilides - pharmacology | Rosiglitazone | Asthma - pathology | AMP-Activated Protein Kinases - genetics | Cytokines - biosynthesis | Troglitazone
Journal Article
Journal Article