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Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175486
We optically measured effects of orally available ivacaftor (Kalydeco (R)) on sweat rates of identified glands in 3 R117H subjects, each having a unique set of... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | GLANDS | GENE | MESSENGER-RNA TRANSCRIPTS | PARTIAL PENETRANCE | MULTIDISCIPLINARY SCIENCES | CODING SEQUENCES | MUTATION | DISEASE | CYSTIC-FIBROSIS | CFTR POTENTIATOR | Muscarinic Agonists - pharmacology | Sweat - secretion | Humans | Male | Quinolones - pharmacology | Aminophenols - pharmacology | Methacholine Chloride - administration & dosage | Gene Deletion | Methacholine Chloride - pharmacology | Adrenergic beta-Agonists - administration & dosage | Adult | Female | Injections, Intradermal | Muscarinic Agonists - administration & dosage | Administration, Oral | Chloride Channel Agonists - pharmacology | Adrenergic beta-Agonists - pharmacology | Sweating - genetics | Exons - genetics | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Sweating - drug effects | Quinolones - administration & dosage | Ion Channel Gating - genetics | Analysis of Variance | Chloride Channel Agonists - administration & dosage | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mutation | Aminophenols - administration & dosage | Ion Channel Gating - drug effects | Ivacaftor | Care and treatment | Gene mutations | Methacholine | Cystic fibrosis | Dosage and administration | Research | Wine | Pediatrics | Acetylcholine receptors (muscarinic) | Laboratories | Linkage disequilibrium | Glands | Biology | Iontophoresis | Adenylate cyclase | Membrane conductance | Chloride | Intestine | Anion channels | Genetics | Physiology | Children | Sweat | Digestive tract | Gating | Channel opening | Secretion | Channel gating | Bioassays | Organs | Chloride transport | Ion transport | Cultures | Medical screening | Medicine | Clear cells | Lungs | Alleles | In vivo methods and tests | Conductance | Cystic fibrosis transmembrane conductance regulator | Molecular biology
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 10/2011, Volume 301, Issue 4, pp. L402 - L414
Finkbeiner WE, Zlock LT, Morikawa M, Lao AY, Dasari V, Widdicombe JH. Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of... 
Ion transport | Mucus | Trachea | Bronchi | PHYSIOLOGY | trachea | ION-TRANSPORT | GLYCOPROTEINS | SEROUS ACINAR-CELLS | ion transport | bronchi | mucus | TRANSMEMBRANE CONDUCTANCE REGULATOR | GOBLET CELLS | FLUID SECRETION | RESPIRATORY SYSTEM | BRONCHIAL SUBMUCOSAL GLAND | GENE-EXPRESSION | TRACHEAL SURFACE EPITHELIUM | TRACHEOBRONCHIAL GLANDS | Respiratory Mucosa - drug effects | ortho-Aminobenzoates - pharmacology | Exocrine Glands - drug effects | Cystic Fibrosis - physiopathology | Humans | Cystic Fibrosis - pathology | Exocrine Glands - pathology | Trachea - drug effects | Adrenergic alpha-1 Receptor Agonists - pharmacology | Adenosine Triphosphate - pharmacology | Bronchi - drug effects | Respiratory Mucosa - pathology | Phenylephrine - pharmacology | Chlorides - metabolism | Methacholine Chloride - pharmacology | Adult | Ion Transport - drug effects | Bronchi - pathology | Cystic Fibrosis - metabolism | Adrenergic beta-Agonists - pharmacology | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Calcium Channel Blockers - pharmacology | Mucins - secretion | Trachea - pathology | Isoproterenol - pharmacology | Bronchoconstrictor Agents - pharmacology | Primary Cell Culture | Physiological aspects | Cystic fibrosis | Genetic aspects | Research | Mucins | Airway management | Correlation analysis | Cells | Adenosine triphosphatase
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 128, Issue 3, pp. 508 - 515.e2
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 03/2014, Volume 306, Issue 6, pp. L476 - L486
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 09/2017, Volume 313, Issue 3, pp. L507 - L515
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2003, Volume 17, Issue 13, pp. 1831 - 1841
The airways of mice deficient in the cAMP phosphodiesterase PDE4D gene are refractory to muscarinic cholinergic stimulation. This study was undertaken to... 
Second messengers | Cyclic AMP | Metabolism | Trachea | PROTEIN-KINASE-A | trachea | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHODIESTERASE ISOZYMES | IDENTIFICATION | SIGNALING COMPLEX | CELL BIOLOGY | AUTORADIOGRAPHIC LOCALIZATION | CYCLIC-AMP | second messengers | RYANODINE RECEPTOR | RECEPTOR KNOCKOUT MICE | BIOLOGY | cyclic AMP | metabolism | RAT-BRAIN | INHIBITORS | Carbachol - antagonists & inhibitors | Cyclic Nucleotide Phosphodiesterases, Type 4 | Culture Techniques | Dinoprostone - biosynthesis | Trachea - drug effects | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | Muscle, Smooth - drug effects | Methacholine Chloride - pharmacology | Potassium Chloride - pharmacology | Trachea - physiology | Muscle, Smooth - physiology | Rolipram - pharmacology | Cyclic AMP - metabolism | Cholinergic Agonists - pharmacology | Isoenzymes - physiology | Dinoprostone - pharmacology | Isoenzymes - genetics | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Arginine Vasopressin - pharmacology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Mice, Knockout | Animals | Muscle Contraction | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Bronchoconstrictor Agents - pharmacology | Mice | Trachea - enzymology | Muscle, Smooth - enzymology | Cyclooxygenase Inhibitors | Dinoprostone | Life Sciences | Methacholine Chloride | Phosphodiesterase Inhibitors | Cholinergic Agonists | Isoenzymes | Arginine Vasopressin | 3',5'-Cyclic-AMP Phosphodiesterases | Potassium Chloride | Muscle, Smooth | Human health and pathology | Rolipram | Carbachol | Indomethacin | Bronchoconstrictor Agents | Urology and Nephrology
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 01/2012, Volume 302, Issue 1, pp. 120 - 132
Expression and function of Kv7 (KCNQ) voltage-activated potassium channels in guinea pig and human airway smooth muscle cells (ASMCs) were investigated by... 
Kcnq voltage-activated potassium channel | Asthma therapy | Bronchoconstrictor signal transduction | Precision-cut lung slice | PROTEIN-KINASE-C | PHYSIOLOGY | RAT | bronchoconstrictor signal transduction | FUNCTIONAL-CHARACTERIZATION | GUINEA-PIG | KCNQ voltage-activated potassium channel | RESPIRATORY SYSTEM | asthma therapy | precision-cut lung slice | KCNQ | ASTHMA | IONIC MECHANISMS | ARTERY | EXPRESSION | CLINICAL-SIGNIFICANCE | Humans | Male | Bronchodilator Agents - metabolism | Bronchoconstriction - drug effects | Methacholine Chloride - pharmacology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Carbamates - pharmacology | Pyrazoles - pharmacology | Bronchoconstriction - physiology | Guinea Pigs | Histamine - pharmacology | Bronchodilator Agents - pharmacology | Celecoxib | Calcium Channel Blockers - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Verapamil - pharmacology | Anthracenes - pharmacology | KCNQ Potassium Channels - drug effects | Patch-Clamp Techniques | Animals | Signal Transduction - drug effects | KCNQ Potassium Channels - metabolism | Aminopyridines - pharmacology | Phenylenediamines - pharmacology | KCNQ Potassium Channels - genetics | Physiological aspects | Muscle cells | Cellular signal transduction | Potassium channels | Research | Health aspects | Bronchodilator agents | Signal transduction | Airway management | Physiology | Pharmacology | Gene expression | Rodents
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2017, Volume 312, Issue 6, pp. L873 - L881
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid alpha-glucosidase (GAA), an enzyme responsible for hydrolyzing lysosomal... 
Pompe disease | Airway smooth muscle | Pulmonary mechanics | Glycogen storing disease | HOMEOSTASIS | PHYSIOLOGY | ENTRY | glycogen storing disease | OPERATED CA2+ INFLUX | INVOLVEMENT | airway smooth muscle | PHENOTYPE | pulmonary mechanics | INFANTILE | ACID MALTASE DEFICIENCY | CONTRACTION | RESPIRATORY SYSTEM | DISEASE | ARTERIOPATHY | Lung - pathology | Muscle, Skeletal - enzymology | Albuterol - pharmacology | Bronchi - physiopathology | Trachea - drug effects | Lung - physiopathology | Glycogen Storage Disease Type II - pathology | Glycogen Storage Disease Type II - physiopathology | Lung - enzymology | Bronchi - drug effects | Glycogen Storage Disease Type II - enzymology | Extracellular Space - metabolism | Animals | Glycogen - metabolism | Calcium Signaling - drug effects | Muscle Contraction - drug effects | Lung - drug effects | Methacholine Chloride - pharmacology | Muscle, Skeletal - drug effects | Muscle, Skeletal - physiopathology | Potassium Chloride - pharmacology | Mice | Trachea - physiopathology | alpha-Glucosidases - metabolism | Enzymes | Motor neurons | Genetic disorders | Glycogen | Bronchus | Lysosomes | Smooth muscle | Muscular system | Muscle contraction | Potassium chloride | Skeletal muscle | Calcium influx | Hereditary diseases | Calcium signalling | Respiratory tract | Signal transduction | Rodents | Chlorides | Methacholine | Respiration | Trachea | Calcium (extracellular)
Journal Article