Neuropsychopharmacology, ISSN 0893-133X, 04/2012, Volume 37, Issue 5, pp. 1192 - 1203
The nonmedical use of 'designer' cathinone analogs, such as 4-methylmethcathinone (mephedrone) and 3,4-methylenedioxymethcathinone (methylone), is increasing...
serotonin (5-HT) | microdialysis | transporters | mesolimbic | dopamine | MDMA | NOREPINEPHRINE | PSYCHIATRY | CATHINONE | NEUROTOXICITY | NEUROSCIENCES | 4-METHYLMETHCATHINONE MEPHEDRONE | METABOLISM | DRUGS | 3,4-METHYLENEDIOXYMETHAMPHETAMINE | PHARMACOLOGY & PHARMACY | STIMULANT | Dopamine Plasma Membrane Transport Proteins - metabolism | Synaptosomes - drug effects | Microdialysis - methods | Nucleus Accumbens - metabolism | Male | Chromatography, High Pressure Liquid | Methamphetamine - chemistry | Dose-Response Relationship, Drug | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Time Factors | Serotonin - pharmacokinetics | Methamphetamine - analogs & derivatives | Dopamine - metabolism | Locomotion - drug effects | Methamphetamine - pharmacology | Hallucinogens - pharmacology | 1-Methyl-4-phenylpyridinium - pharmacokinetics | Rats | Rats, Sprague-Dawley | Animals | Analysis of Variance | Membrane Transport Proteins | Serotonin - metabolism | Electrochemistry | Norepinephrine Plasma Membrane Transport Proteins - metabolism | In Vitro Techniques | Nucleus Accumbens - drug effects | Tritium - pharmacokinetics | mephedrone | release | methylone | serotonin | monoamine | Original | addiction and substance abuse
serotonin (5-HT) | microdialysis | transporters | mesolimbic | dopamine | MDMA | NOREPINEPHRINE | PSYCHIATRY | CATHINONE | NEUROTOXICITY | NEUROSCIENCES | 4-METHYLMETHCATHINONE MEPHEDRONE | METABOLISM | DRUGS | 3,4-METHYLENEDIOXYMETHAMPHETAMINE | PHARMACOLOGY & PHARMACY | STIMULANT | Dopamine Plasma Membrane Transport Proteins - metabolism | Synaptosomes - drug effects | Microdialysis - methods | Nucleus Accumbens - metabolism | Male | Chromatography, High Pressure Liquid | Methamphetamine - chemistry | Dose-Response Relationship, Drug | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Time Factors | Serotonin - pharmacokinetics | Methamphetamine - analogs & derivatives | Dopamine - metabolism | Locomotion - drug effects | Methamphetamine - pharmacology | Hallucinogens - pharmacology | 1-Methyl-4-phenylpyridinium - pharmacokinetics | Rats | Rats, Sprague-Dawley | Animals | Analysis of Variance | Membrane Transport Proteins | Serotonin - metabolism | Electrochemistry | Norepinephrine Plasma Membrane Transport Proteins - metabolism | In Vitro Techniques | Nucleus Accumbens - drug effects | Tritium - pharmacokinetics | mephedrone | release | methylone | serotonin | monoamine | Original | addiction and substance abuse
Journal Article
Drug Testing and Analysis, ISSN 1942-7603, 07/2014, Volume 6, Issue 7-8, pp. 805 - 807
Pharmaceuticals and banned substances have been detected in hundreds of purportedly natural supplements. Recently, several athletes have been disqualified from...
dietary supplements | methamphetamine | adulteration | Adulteration | Dietary supplements | Methamphetamine | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | PHARMACOLOGY & PHARMACY | AMPHETAMINES | Central Nervous System Stimulants - analysis | Methamphetamine - analysis | Humans | Mass Spectrometry | Chromatography, High Pressure Liquid | Methamphetamine - analogs & derivatives | Dietary Supplements - analysis
dietary supplements | methamphetamine | adulteration | Adulteration | Dietary supplements | Methamphetamine | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | PHARMACOLOGY & PHARMACY | AMPHETAMINES | Central Nervous System Stimulants - analysis | Methamphetamine - analysis | Humans | Mass Spectrometry | Chromatography, High Pressure Liquid | Methamphetamine - analogs & derivatives | Dietary Supplements - analysis
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 08/2019, Volume 50, Issue 3, pp. 2045 - 2053
Psychostimulant use disorders remain an unabated public health concern worldwide, but no FDA approved medications are currently available for treatment....
fast‐scan cyclic voltammetry | cocaine use disorder | dopamine microdialysis | nucleus accumbens shell | addiction | fast-scan cyclic voltammetry | DAYTIME SLEEPINESS | COGNITIVE PERFORMANCE | RELEASE | NEUROSCIENCES | MODAFINIL | NUCLEUS-ACCUMBENS | COCAINE DEPENDENCE | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | OVERDOSE DEATHS | AMPHETAMINE | Subpopulations | Drug abuse | Dopamine | Mesolimbic system | Methamphetamine | Clinical trials | Voltammetry | Enantiomers | Drug development | Nucleus accumbens | Microdialysis | Modafinil | Extracellular levels | Dopamine transporter | Cocaine | Public health | Dopamine receptors
fast‐scan cyclic voltammetry | cocaine use disorder | dopamine microdialysis | nucleus accumbens shell | addiction | fast-scan cyclic voltammetry | DAYTIME SLEEPINESS | COGNITIVE PERFORMANCE | RELEASE | NEUROSCIENCES | MODAFINIL | NUCLEUS-ACCUMBENS | COCAINE DEPENDENCE | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | OVERDOSE DEATHS | AMPHETAMINE | Subpopulations | Drug abuse | Dopamine | Mesolimbic system | Methamphetamine | Clinical trials | Voltammetry | Enantiomers | Drug development | Nucleus accumbens | Microdialysis | Modafinil | Extracellular levels | Dopamine transporter | Cocaine | Public health | Dopamine receptors
Journal Article
Current Topics in Behavioral Neurosciences, ISSN 1866-3370, 10/2016, Volume 32, pp. 209 - 230
The present review briefly explores the neurotoxic properties of methcathinone, mephedrone, methylone, and methylenedioxypyrovalerone (MDPV), four synthetic...
Mephedrone | MDPV | Synthetic cathinones | Neurotoxicity | Methylone | Methcathinone | Inflammation - chemically induced | Dopamine Plasma Membrane Transport Proteins - metabolism | Central Nervous System Stimulants - pharmacology | Methamphetamine - adverse effects | Body Temperature - drug effects | Dopamine Plasma Membrane Transport Proteins - drug effects | Humans | Propiophenones - pharmacology | Pyrrolidines - adverse effects | Fever - chemically induced | Pyrrolidines - pharmacology | Serotonin Plasma Membrane Transport Proteins - drug effects | Central Nervous System Stimulants - adverse effects | Benzodioxoles - adverse effects | Body Temperature Regulation - drug effects | Methamphetamine - analogs & derivatives | Dopamine - metabolism | Methamphetamine - pharmacology | Alkaloids - pharmacology | Alkaloids - adverse effects | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Neurotoxicity Syndromes - etiology | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Propiophenones - adverse effects | Serotonin - metabolism | Oxidative Stress - drug effects | Benzodioxoles - pharmacology | Index Medicus
Mephedrone | MDPV | Synthetic cathinones | Neurotoxicity | Methylone | Methcathinone | Inflammation - chemically induced | Dopamine Plasma Membrane Transport Proteins - metabolism | Central Nervous System Stimulants - pharmacology | Methamphetamine - adverse effects | Body Temperature - drug effects | Dopamine Plasma Membrane Transport Proteins - drug effects | Humans | Propiophenones - pharmacology | Pyrrolidines - adverse effects | Fever - chemically induced | Pyrrolidines - pharmacology | Serotonin Plasma Membrane Transport Proteins - drug effects | Central Nervous System Stimulants - adverse effects | Benzodioxoles - adverse effects | Body Temperature Regulation - drug effects | Methamphetamine - analogs & derivatives | Dopamine - metabolism | Methamphetamine - pharmacology | Alkaloids - pharmacology | Alkaloids - adverse effects | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Neurotoxicity Syndromes - etiology | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Propiophenones - adverse effects | Serotonin - metabolism | Oxidative Stress - drug effects | Benzodioxoles - pharmacology | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2015, Volume 25, Issue 13, pp. 2613 - 2616
We have previously shown that quinolyl moieties are attractive structural replacements for the phenyl groups in lobelane. These quinolyl analogues had improved...
Vesicular [3H]dopamine uptake | Methamphetamine abuse | VMAT-2 | Quinolyl analogues of norlobelane | Vesicular | H]dopamine uptake | CHEMISTRY, MEDICINAL | Vesicular [H-3]dopamine uptake | GZ-793A | CHEMISTRY, ORGANIC | VMAT2 INHIBITOR | LOBELINE | Lobeline - chemistry | Synaptic Vesicles - metabolism | Tetrabenazine - analogs & derivatives | Tetrabenazine - metabolism | Vesicular Monoamine Transport Proteins - metabolism | Humans | Lobeline - pharmacology | Vesicular Monoamine Transport Proteins - antagonists & inhibitors | Rats | Amphetamine-Related Disorders - drug therapy | Structure-Activity Relationship | Methamphetamine - metabolism | Animals | Synaptic Vesicles - drug effects | Kinetics | In Vitro Techniques | Binding Sites | Lobeline - analogs & derivatives | Amphetamine-Related Disorders - metabolism | Dopamine - metabolism | methamphetamine abuse | vesicular [3H]dopamine uptake
Vesicular [3H]dopamine uptake | Methamphetamine abuse | VMAT-2 | Quinolyl analogues of norlobelane | Vesicular | H]dopamine uptake | CHEMISTRY, MEDICINAL | Vesicular [H-3]dopamine uptake | GZ-793A | CHEMISTRY, ORGANIC | VMAT2 INHIBITOR | LOBELINE | Lobeline - chemistry | Synaptic Vesicles - metabolism | Tetrabenazine - analogs & derivatives | Tetrabenazine - metabolism | Vesicular Monoamine Transport Proteins - metabolism | Humans | Lobeline - pharmacology | Vesicular Monoamine Transport Proteins - antagonists & inhibitors | Rats | Amphetamine-Related Disorders - drug therapy | Structure-Activity Relationship | Methamphetamine - metabolism | Animals | Synaptic Vesicles - drug effects | Kinetics | In Vitro Techniques | Binding Sites | Lobeline - analogs & derivatives | Amphetamine-Related Disorders - metabolism | Dopamine - metabolism | methamphetamine abuse | vesicular [3H]dopamine uptake
Journal Article
Journal of Separation Science, ISSN 1615-9306, 12/2018, Volume 41, Issue 23, pp. 4281 - 4285
A liquid chromatographic chiral stationary phase, which contains two N–CH3 amide connecting groups, based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid...
liquid chromatography | methoxyphenamine | enantiomer separation | chiral stationary phases | Molecular Structure | Chromatography, High Pressure Liquid | Methamphetamine - analogs & derivatives | Methamphetamine - chemistry | Crown Ethers - chemistry | Methamphetamine - isolation & purification | Liquid chromatography | Enantiomers | Crown ethers | Analysis | Silicas
liquid chromatography | methoxyphenamine | enantiomer separation | chiral stationary phases | Molecular Structure | Chromatography, High Pressure Liquid | Methamphetamine - analogs & derivatives | Methamphetamine - chemistry | Crown Ethers - chemistry | Methamphetamine - isolation & purification | Liquid chromatography | Enantiomers | Crown ethers | Analysis | Silicas
Journal Article
Addiction Biology, ISSN 1355-6215, 09/2017, Volume 22, Issue 5, pp. 1169 - 1178
Synthetic cathinones are beta‐ketone amphetamine analogs that have emerged as a heterogeneous class of abused compounds that function as either monoamine...
Alpha‐PVP | discrimination | non‐human primates | Alpha-PVP | non-human primates | Central Nervous System Stimulants | Reinforcement (Psychology) | Male | Macaca mulatta | Injections, Intramuscular | Discrimination Learning - physiology | Animals | Propiophenones | Pyrrolidines | Conditioning, Operant | Cocaine | Methamphetamine - analogs & derivatives | Dopamine Uptake Inhibitors | Primates | Drug abuse | Analysis | Resveratrol | Drug discrimination | Amphetamine | Monoamine transporter | Hydrophobicity | Structure-activity relationships | Food | Index Medicus
Alpha‐PVP | discrimination | non‐human primates | Alpha-PVP | non-human primates | Central Nervous System Stimulants | Reinforcement (Psychology) | Male | Macaca mulatta | Injections, Intramuscular | Discrimination Learning - physiology | Animals | Propiophenones | Pyrrolidines | Conditioning, Operant | Cocaine | Methamphetamine - analogs & derivatives | Dopamine Uptake Inhibitors | Primates | Drug abuse | Analysis | Resveratrol | Drug discrimination | Amphetamine | Monoamine transporter | Hydrophobicity | Structure-activity relationships | Food | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 01/2014, Volume 231, Issue 1, pp. 199 - 207
Abuse of synthetic cathinones, popularized as "bath salts," has increased dramatically in the USA since their debut in 2010. Preclinical behavioral studies may...
Drug abuse | Mephedrone | Rat | Methylone | Methcathinone | Intracranial self-stimulation | Methylenedioxypyrovalerone | PSYCHIATRY | BEHAVIOR | RELEASERS | MONOAMINE TRANSPORTERS | TIME | NEUROSCIENCES | 4-METHYLMETHCATHINONE | DRUGS | ASSAYS | PHARMACOLOGY & PHARMACY | AMPHETAMINE | Brain | Data Interpretation, Statistical | Designer Drugs - pharmacology | Electric Stimulation | Self Stimulation | Rats | Male | Rats, Sprague-Dawley | Dose-Response Relationship, Drug | Benzodioxoles | Injections | Self Administration | Animals | Conditioning, Operant - drug effects | Propiophenones | Pyrrolidines | Substance-Related Disorders - psychology | Methamphetamine - analogs & derivatives | Complications and side effects | Development and progression | Dosage and administration | Research | Risk factors | Psychotropic drugs | Amphetamines | Psychopharmacology | Index Medicus | Abuse
Drug abuse | Mephedrone | Rat | Methylone | Methcathinone | Intracranial self-stimulation | Methylenedioxypyrovalerone | PSYCHIATRY | BEHAVIOR | RELEASERS | MONOAMINE TRANSPORTERS | TIME | NEUROSCIENCES | 4-METHYLMETHCATHINONE | DRUGS | ASSAYS | PHARMACOLOGY & PHARMACY | AMPHETAMINE | Brain | Data Interpretation, Statistical | Designer Drugs - pharmacology | Electric Stimulation | Self Stimulation | Rats | Male | Rats, Sprague-Dawley | Dose-Response Relationship, Drug | Benzodioxoles | Injections | Self Administration | Animals | Conditioning, Operant - drug effects | Propiophenones | Pyrrolidines | Substance-Related Disorders - psychology | Methamphetamine - analogs & derivatives | Complications and side effects | Development and progression | Dosage and administration | Research | Risk factors | Psychotropic drugs | Amphetamines | Psychopharmacology | Index Medicus | Abuse
Journal Article
9.
Full Text
Pharmacological characterization of the aminorex analogs 4-MAR, 4,4′-DMAR, and 3,4-DMAR
Neurotoxicology, ISSN 0161-813X, 05/2019, Volume 72, pp. 95 - 100
4,4′-Dimethylaminorex (4,4′-DMAR) is a novel psychoactive substance (NPS) that appeared on the illicit drug market in addition to the psychostimulant...
Monoamine | 4,4′-dimethylaminorex | Aminorex | 3,4-dimethylaminorex | Novel psychoactive substance | 4-methylaminorex | Binding | Dopamine | Serotonin | Toxicity | Methamphetamine | Pharmacology | Derivatives | Substrates | MDMA | Receptors | Amphetamine | Monoamine transporter | Amphetamines | Dopamine transporter | Affinity | Norepinephrine | Inhibition | Transporter | Dopamine receptors
Monoamine | 4,4′-dimethylaminorex | Aminorex | 3,4-dimethylaminorex | Novel psychoactive substance | 4-methylaminorex | Binding | Dopamine | Serotonin | Toxicity | Methamphetamine | Pharmacology | Derivatives | Substrates | MDMA | Receptors | Amphetamine | Monoamine transporter | Amphetamines | Dopamine transporter | Affinity | Norepinephrine | Inhibition | Transporter | Dopamine receptors
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 1/2017, Volume 390, Issue 1, pp. 15 - 24
3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical...
Neurosciences | Biomedicine | Monoamine receptors | Neurochemical profile | MDMA analogues | Monoamine transporters | Pharmacology/Toxicology | 3,4-Methylenedioxy- N -methylamphetamine (MDMA) | 3,4-Methylenedioxy-N-methylamphetamine (MDMA) | POSTTRAUMATIC-STRESS-DISORDER | NICOTINIC RECEPTORS | NOREPINEPHRINE | ECSTASY | DRUGS | DOPAMINE | PHARMACOLOGY & PHARMACY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE-ASSISTED PSYCHOTHERAPY | SEROTONIN | INDUCED NEUROTOXICITY | UP-REGULATION | Tyrosine 3-Monooxygenase - metabolism | Vesicular Monoamine Transport Proteins - metabolism | Receptors, Serotonin, 5-HT2 - chemistry | Stress Disorders, Post-Traumatic - metabolism | Humans | Neurotransmitter Uptake Inhibitors - pharmacology | Benzofurans - pharmacology | Serotonin 5-HT2 Receptor Agonists - pharmacology | Receptors, Serotonin, 5-HT2 - drug effects | Structure-Activity Relationship | Receptors, Serotonin, 5-HT2 - metabolism | Neurotransmitter Uptake Inhibitors - metabolism | Benzofurans - chemistry | Catechol O-Methyltransferase - metabolism | Monoamine Oxidase - chemistry | Indoles - metabolism | Tyrosine 3-Monooxygenase - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Stress Disorders, Post-Traumatic - drug therapy | Indoles - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - chemistry | Radioligand Assay | Serotonin 5-HT2 Receptor Agonists - metabolism | Binding Sites | Monoamine Oxidase Inhibitors - pharmacology | Vesicular Monoamine Transport Proteins - chemistry | Vesicular Monoamine Transport Proteins - antagonists & inhibitors | Serotonin 5-HT2 Receptor Agonists - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - metabolism | Neurotransmitter Uptake Inhibitors - chemistry | Monoamine Oxidase Inhibitors - metabolism | Protein Binding | Protein Conformation | Monoamine Oxidase Inhibitors - chemistry | Catechol O-Methyltransferase - chemistry | Indoles - chemistry | Benzofurans - metabolism | Monoamine Oxidase - metabolism | Monoamine oxidase | Batteries | Methamphetamine | Ecstasy (Drug) | Resveratrol | Post-traumatic stress disorder
Neurosciences | Biomedicine | Monoamine receptors | Neurochemical profile | MDMA analogues | Monoamine transporters | Pharmacology/Toxicology | 3,4-Methylenedioxy- N -methylamphetamine (MDMA) | 3,4-Methylenedioxy-N-methylamphetamine (MDMA) | POSTTRAUMATIC-STRESS-DISORDER | NICOTINIC RECEPTORS | NOREPINEPHRINE | ECSTASY | DRUGS | DOPAMINE | PHARMACOLOGY & PHARMACY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE-ASSISTED PSYCHOTHERAPY | SEROTONIN | INDUCED NEUROTOXICITY | UP-REGULATION | Tyrosine 3-Monooxygenase - metabolism | Vesicular Monoamine Transport Proteins - metabolism | Receptors, Serotonin, 5-HT2 - chemistry | Stress Disorders, Post-Traumatic - metabolism | Humans | Neurotransmitter Uptake Inhibitors - pharmacology | Benzofurans - pharmacology | Serotonin 5-HT2 Receptor Agonists - pharmacology | Receptors, Serotonin, 5-HT2 - drug effects | Structure-Activity Relationship | Receptors, Serotonin, 5-HT2 - metabolism | Neurotransmitter Uptake Inhibitors - metabolism | Benzofurans - chemistry | Catechol O-Methyltransferase - metabolism | Monoamine Oxidase - chemistry | Indoles - metabolism | Tyrosine 3-Monooxygenase - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Stress Disorders, Post-Traumatic - drug therapy | Indoles - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - chemistry | Radioligand Assay | Serotonin 5-HT2 Receptor Agonists - metabolism | Binding Sites | Monoamine Oxidase Inhibitors - pharmacology | Vesicular Monoamine Transport Proteins - chemistry | Vesicular Monoamine Transport Proteins - antagonists & inhibitors | Serotonin 5-HT2 Receptor Agonists - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - metabolism | Neurotransmitter Uptake Inhibitors - chemistry | Monoamine Oxidase Inhibitors - metabolism | Protein Binding | Protein Conformation | Monoamine Oxidase Inhibitors - chemistry | Catechol O-Methyltransferase - chemistry | Indoles - chemistry | Benzofurans - metabolism | Monoamine Oxidase - metabolism | Monoamine oxidase | Batteries | Methamphetamine | Ecstasy (Drug) | Resveratrol | Post-traumatic stress disorder
Journal Article
Forensic Science International, ISSN 0379-0738, 08/2007, Volume 170, Issue 2-3, pp. 100 - 104
A rapid and sensitive method using LC-MS/MS triple stage quadrupole for the determination of traces of amphetamine (AP), methamphetamine (MA),...
Hair | Urine | Amphetamines | LC-MS/MS | DFSA | MDMA | METHAMPHETAMINE | METABOLITES | MEDICINE, LEGAL | urine | SEXUAL ASSAULT | TANDEM MASS-SPECTROMETRY | amphetamines | PERFORMANCE LIQUID-CHROMATOGRAPHY | hair | DRUG-FACILITATED CRIMES | USERS | Substance Abuse Detection - methods | Hallucinogens - analysis | Spectrometry, Mass, Electrospray Ionization | Humans | Adolescent | Hair - chemistry | 3,4-Methylenedioxyamphetamine - analysis | Amphetamines - analysis | Chromatography, Liquid | Female | Forensic Toxicology - methods | 3,4-Methylenedioxyamphetamine - analogs & derivatives | Ecstasy | Sex crimes | Drug dosages | Blood | Methods
Hair | Urine | Amphetamines | LC-MS/MS | DFSA | MDMA | METHAMPHETAMINE | METABOLITES | MEDICINE, LEGAL | urine | SEXUAL ASSAULT | TANDEM MASS-SPECTROMETRY | amphetamines | PERFORMANCE LIQUID-CHROMATOGRAPHY | hair | DRUG-FACILITATED CRIMES | USERS | Substance Abuse Detection - methods | Hallucinogens - analysis | Spectrometry, Mass, Electrospray Ionization | Humans | Adolescent | Hair - chemistry | 3,4-Methylenedioxyamphetamine - analysis | Amphetamines - analysis | Chromatography, Liquid | Female | Forensic Toxicology - methods | 3,4-Methylenedioxyamphetamine - analogs & derivatives | Ecstasy | Sex crimes | Drug dosages | Blood | Methods
Journal Article
NEUROPHARMACOLOGY, ISSN 0028-3908, 05/2018, Volume 133, pp. 171 - 180
This study aimed to address the mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA commonly reported in "Ecstasy" formulations:...
DESIGNER CATHINONES | Drug discrimination | Self-administration | MALE RATS | TRANSPORTER | SEROTONERGIC-DOPAMINERGIC MEDIATION | Patch clamp | 3,4-METHYLENEDIOXYPYROVALERONE MDPV | Synthetic cathinones | MEPHEDRONE | NEUROSCIENCES | BATH SALTS | MDMA | PSYCHOACTIVE SUBSTANCES | PHARMACOLOGY & PHARMACY | AMPHETAMINE | 3-CHOICE DISCRIMINATION | Dopamine Plasma Membrane Transport Proteins - metabolism | Central Nervous System Stimulants - pharmacology | Humans | Male | Serotonin - pharmacology | Self Administration | Conditioning, Operant - drug effects | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | HEK293 Cells | Methamphetamine - analogs & derivatives | Disease Models, Animal | Methamphetamine - pharmacology | Substance-Related Disorders - etiology | Hallucinogens - pharmacology | Reinforcement (Psychology) | Rats | Benzazepines - pharmacology | Dopamine Plasma Membrane Transport Proteins - genetics | Rats, Sprague-Dawley | Substance-Related Disorders - physiopathology | Patch-Clamp Techniques | Animals | Dopamine Antagonists - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - analogs & derivatives | Drug Combinations
DESIGNER CATHINONES | Drug discrimination | Self-administration | MALE RATS | TRANSPORTER | SEROTONERGIC-DOPAMINERGIC MEDIATION | Patch clamp | 3,4-METHYLENEDIOXYPYROVALERONE MDPV | Synthetic cathinones | MEPHEDRONE | NEUROSCIENCES | BATH SALTS | MDMA | PSYCHOACTIVE SUBSTANCES | PHARMACOLOGY & PHARMACY | AMPHETAMINE | 3-CHOICE DISCRIMINATION | Dopamine Plasma Membrane Transport Proteins - metabolism | Central Nervous System Stimulants - pharmacology | Humans | Male | Serotonin - pharmacology | Self Administration | Conditioning, Operant - drug effects | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | HEK293 Cells | Methamphetamine - analogs & derivatives | Disease Models, Animal | Methamphetamine - pharmacology | Substance-Related Disorders - etiology | Hallucinogens - pharmacology | Reinforcement (Psychology) | Rats | Benzazepines - pharmacology | Dopamine Plasma Membrane Transport Proteins - genetics | Rats, Sprague-Dawley | Substance-Related Disorders - physiopathology | Patch-Clamp Techniques | Animals | Dopamine Antagonists - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - analogs & derivatives | Drug Combinations
Journal Article
Drug and Alcohol Dependence, ISSN 0376-8716, 2015, Volume 150, pp. 1 - 13
Highlights • A systematic review of amphetamine and related derivative-induced toxicity treatment. • Benzodiazepines and antipsychotics are preferred treatment...
Psychiatry | Hypertension | Amphetamines | Agitation | Tachycardia | Beta-blockers | Sedation | MYOCARDIAL-INFARCTION | PSYCHIATRY | SUBSTANCE ABUSE | RANDOMIZED CONTROLLED-TRIAL | DELIRIUM FOLLOWING USE | ACUTE CORONARY SYNDROME | BATH SALTS | EMERGENCY-DEPARTMENT UTILIZATION | METHAMPHETAMINE ABUSE | CASE SERIES | PLACEBO-CONTROLLED TRIAL | Tachycardia - drug therapy | Dexmedetomidine - therapeutic use | Prospective Studies | Tachycardia - chemically induced | Humans | Hypertension - drug therapy | Hypnotics and Sedatives - therapeutic use | Antipsychotic Agents - therapeutic use | Adrenergic Antagonists - therapeutic use | Akathisia, Drug-Induced - drug therapy | Hypertension - chemically induced | Amphetamine-Related Disorders | Amphetamines - adverse effects | Psychoses, Substance-Induced - drug therapy | Benzodiazepines - therapeutic use | Care and treatment | Antipsychotic drugs | Emergency medicine | Pharmacy | Control systems | Antianxiety agents | Benzodiazepines | Index Medicus
Psychiatry | Hypertension | Amphetamines | Agitation | Tachycardia | Beta-blockers | Sedation | MYOCARDIAL-INFARCTION | PSYCHIATRY | SUBSTANCE ABUSE | RANDOMIZED CONTROLLED-TRIAL | DELIRIUM FOLLOWING USE | ACUTE CORONARY SYNDROME | BATH SALTS | EMERGENCY-DEPARTMENT UTILIZATION | METHAMPHETAMINE ABUSE | CASE SERIES | PLACEBO-CONTROLLED TRIAL | Tachycardia - drug therapy | Dexmedetomidine - therapeutic use | Prospective Studies | Tachycardia - chemically induced | Humans | Hypertension - drug therapy | Hypnotics and Sedatives - therapeutic use | Antipsychotic Agents - therapeutic use | Adrenergic Antagonists - therapeutic use | Akathisia, Drug-Induced - drug therapy | Hypertension - chemically induced | Amphetamine-Related Disorders | Amphetamines - adverse effects | Psychoses, Substance-Induced - drug therapy | Benzodiazepines - therapeutic use | Care and treatment | Antipsychotic drugs | Emergency medicine | Pharmacy | Control systems | Antianxiety agents | Benzodiazepines | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 21, pp. 6768 - 6781
A series of bupropion (1a) analogues (1b−1ff) were synthesized, and their in vitro and in vivo pharmacological properties evaluated with the goal of developing...
NONHUMAN-PRIMATES | SMOKING-CESSATION | CHEMISTRY, MEDICINAL | NOREPINEPHRINE | ABUSE | IN-VIVO | MEDICATION DEVELOPMENT | RATS | LOCOMOTOR-ACTIVITY | DOPAMINE TRANSPORTER | METHAMPHETAMINE DEPENDENCE | Dopamine Plasma Membrane Transport Proteins - metabolism | Humans | Bupropion - analogs & derivatives | Motor Activity - drug effects | Structure-Activity Relationship | Serotonin Uptake Inhibitors - chemical synthesis | Adrenergic Uptake Inhibitors - chemistry | Discrimination Learning - drug effects | Dopamine Uptake Inhibitors - chemical synthesis | Radioligand Assay | Adrenergic Uptake Inhibitors - chemical synthesis | Cell Line | Dopamine Uptake Inhibitors - pharmacology | Bupropion - chemical synthesis | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin Plasma Membrane Transport Proteins - metabolism | Cocaine - pharmacology | Animals | Dopamine Uptake Inhibitors - chemistry | Adrenergic Uptake Inhibitors - pharmacology | Bupropion - pharmacology | Cocaine-Related Disorders - drug therapy | Mice | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Serotonin Uptake Inhibitors - pharmacology | Index Medicus
NONHUMAN-PRIMATES | SMOKING-CESSATION | CHEMISTRY, MEDICINAL | NOREPINEPHRINE | ABUSE | IN-VIVO | MEDICATION DEVELOPMENT | RATS | LOCOMOTOR-ACTIVITY | DOPAMINE TRANSPORTER | METHAMPHETAMINE DEPENDENCE | Dopamine Plasma Membrane Transport Proteins - metabolism | Humans | Bupropion - analogs & derivatives | Motor Activity - drug effects | Structure-Activity Relationship | Serotonin Uptake Inhibitors - chemical synthesis | Adrenergic Uptake Inhibitors - chemistry | Discrimination Learning - drug effects | Dopamine Uptake Inhibitors - chemical synthesis | Radioligand Assay | Adrenergic Uptake Inhibitors - chemical synthesis | Cell Line | Dopamine Uptake Inhibitors - pharmacology | Bupropion - chemical synthesis | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin Plasma Membrane Transport Proteins - metabolism | Cocaine - pharmacology | Animals | Dopamine Uptake Inhibitors - chemistry | Adrenergic Uptake Inhibitors - pharmacology | Bupropion - pharmacology | Cocaine-Related Disorders - drug therapy | Mice | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Serotonin Uptake Inhibitors - pharmacology | Index Medicus
Journal Article