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Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7552, pp. 322 - 327
Na+/Cl--coupled biogenic amine transporters are the primary targets of therapeutic and abused drugs, ranging from antidepressants to the psychostimulants... 
BIOGENIC-AMINE TRANSPORTERS | COCAINE BINDING | SEROTONIN TRANSPORTER | SUBSTRATE TRANSPORT | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | RAT-BRAIN SYNAPTOSOMES | CONFORMATIONAL DYNAMICS | ALTERNATING-ACCESS | TRANSMITTER UPTAKE | MAMMALIAN-CELLS | Dopamine - chemistry | Dopamine Plasma Membrane Transport Proteins - metabolism | Cocaine - metabolism | Molecular Conformation | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Methamphetamine - chemistry | Sodium - metabolism | Antidepressive Agents - metabolism | Antidepressive Agents - chemistry | Chlorides - metabolism | Central Nervous System Stimulants - metabolism | Dextroamphetamine - chemistry | Protein Stability | Binding Sites | Dopamine - metabolism | Cocaine - chemistry | Dextroamphetamine - metabolism | Neurotransmitter Agents - metabolism | Models, Molecular | Phenethylamines - metabolism | Cocaine - analogs & derivatives | Methamphetamine - metabolism | Neurotransmitter Agents - chemistry | Animals | Dopamine - analogs & derivatives | Drosophila melanogaster - chemistry | Central Nervous System Stimulants - chemistry | Ligands | Physiological aspects | Neurotransmitters | Dopamine | Research | Neurological research | Biological transport | Methamphetamines | Mutagenesis | Antidepressants | Nervous system | Cocaine | Binding sites
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2013, Volume 85, Issue 12, pp. 1803 - 1815
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 3, pp. e1099 - e1099
Methamphetamine (METH) is a psychostimulant with high abuse potential and severe neurotoxicity. Recent studies in animal models have indicated that METH can... 
Cell death | Autophagy | Kappa opioid receptor | Methamphetamine | TRANSPORT | autophagy | PROTEIN-1 LAMP-1 | cell death | MELATONIN | methamphetamine | PATHWAY | CROSS | EXPRESSION | MODULATION | CELL BIOLOGY | Phosphorylation | Human Umbilical Vein Endothelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Methamphetamine - toxicity | Microtubule-Associated Proteins - metabolism | Humans | Microvessels - metabolism | Microvessels - pathology | Autophagy - drug effects | Dose-Response Relationship, Drug | Transfection | RNA Interference | Time Factors | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptors, Opioid, kappa - genetics | Beclin-1 | Cell Survival - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Lysosome-Associated Membrane Glycoproteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Cells, Cultured | Receptors, Opioid, kappa - metabolism | Microvessels - drug effects | Blood-Brain Barrier - drug effects | Central Nervous System Stimulants - toxicity | Apoptosis Regulatory Proteins - metabolism | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Receptors, Opioid, kappa - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Human Umbilical Vein Endothelial Cells - pathology | Enzyme Activation | Endothelial Cells - pathology | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Original
Journal Article
Journal Article
Neuroscience, ISSN 0306-4522, 2003, Volume 118, Issue 4, pp. 985 - 1002
In humans, mutations in the α-synuclein gene or exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produce Parkinson's disease with... 
synapse | methamphetamine | dopamine | neurotransmitter release | synaptic vesicle | Synaptic vesicle | Neurotransmitter release | Synapse | Dopamine | Methamphetamine | Mice, Knockout - genetics | Blotting, Southern - methods | Tyrosine 3-Monooxygenase - metabolism | Antibodies - metabolism | Humans | Nerve Tissue Proteins - deficiency | Substantia Nigra - metabolism | Stem Cells - metabolism | Corpus Striatum - metabolism | Mice, Knockout - metabolism | Immunoblotting - methods | Dose-Response Relationship, Drug | Parkinsonian Disorders - metabolism | Blastomeres - metabolism | Drug Interactions | DNA Primers - metabolism | Reserpine - pharmacology | Neurons - metabolism | Dopamine - metabolism | Disease Models, Animal | Methamphetamine - pharmacology | MPTP Poisoning | 3,4-Dihydroxyphenylacetic Acid - metabolism | Dopamine Uptake Inhibitors - pharmacology | Mice, Inbred C57BL | Rats | Mice, Transgenic | Parkinsonian Disorders - chemically induced | Synucleins | Nerve Tissue Proteins - genetics | Piperazines - pharmacology | Subcellular Fractions - metabolism | Immunohistochemistry - methods | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Animals | Homovanillic Acid - metabolism | Serotonin - metabolism | Adrenergic Uptake Inhibitors - pharmacology | Glutamic Acid - metabolism | Mice | alpha-Synuclein
Journal Article
Neuropharmacology, ISSN 0028-3908, 06/2016, Volume 105, pp. 520 - 532
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 07/2007, Volume 34, Issue 7, pp. 555 - 565
SUMMARY • The exact nature of oestrogen (positive, negative or no effect) in the dopaminergic neurodegenerative disorder Parkinson's disease is controversial.... 
oestrogen | neurodegeneration | Parkinson's disease | dopamine | Oestrogen | Dopamine | Neurodegeneration | SYSTEM | PHYSIOLOGY | METHAMPHETAMINE-INDUCED NEUROTOXICITY | FEMALE MICE | MALE-MICE | RISK | COFFEE CONSUMPTION | SUBSTANTIA-NIGRA | MPTP-INDUCED NEUROTOXICITY | POSTMENOPAUSAL ESTROGEN | IN-VIVO | PHARMACOLOGY & PHARMACY | Neuroprotective Agents - therapeutic use | Neurons - pathology | Estrogens - pharmacology | Substantia Nigra - pathology | Humans | Basal Ganglia - metabolism | Parkinson Disease - drug therapy | Substantia Nigra - metabolism | Nerve Degeneration - metabolism | Neuroprotective Agents - metabolism | Estrogens - therapeutic use | Parkinsonian Disorders - metabolism | Neuroprotective Agents - pharmacology | Parkinsonian Disorders - drug therapy | Neurons - metabolism | Parkinson Disease - metabolism | Estrogens - metabolism | Dopamine - metabolism | Disease Models, Animal | Parkinson Disease - pathology | Basal Ganglia - pathology | Nerve Degeneration - pathology | Substantia Nigra - drug effects | Animals | Parkinsonian Disorders - pathology | Nerve Degeneration - drug therapy | Basal Ganglia - drug effects | Parkinson Disease, pathology | Parkinsonian Disorders, pathology | Parkinsonian Disorders, metabolism | Neurons, metabolism | Nerve Degeneration, drug therapy | Substantia Nigra, metabolism | Nerve Degeneration, metabolism | Basal Ganglia, metabolism | Dopamine, metabolism | Estrogens, therapeutic use | Neurons, pathology | Substantia Nigra, pathology | Parkinson Disease, drug therapy | Nerve Degeneration, pathology | Neuroprotective Agents, metabolism | Neuroprotective Agents, therapeutic use | Parkinsonian Disorders, drug therapy | Basal Ganglia, pathology | Substantia Nigra, drug effects | Neuroprotective Agents, pharmacology | Parkinson Disease, metabolism | Estrogens, pharmacology | Estrogens, metabolism | Basal Ganglia, drug effects | Estrogen
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 01/2010, Volume 31, Issue 2, pp. 315 - 326
Methamphetamine (METH) causes irreversible damage to brain cells leading to neurological and psychiatric abnormalities. However, the mechanisms underlying... 
astrocytes | hippocampus | methamphetamine | TNF‐α | microglia | neurons | TNF-α | Astrocytes | Neurons | Hippocampus | Methamphetamine | Microglia | DRUG-DEPENDENCE | SUBSTITUTED AMPHETAMINES | MICROGLIAL ACTIVATION | TNF-alpha | ALZHEIMERS-DISEASE | DOPAMINERGIC NEUROTOXICITY | NEUROSCIENCES | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | INDUCED NEUROTOXICITY | ISCHEMIC-STROKE | Disks Large Homolog 4 Protein | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Central Nervous System Stimulants - pharmacology | Male | Neurons - cytology | Intracellular Signaling Peptides and Proteins - metabolism | Hippocampus - drug effects | Receptors, Tumor Necrosis Factor, Type I - metabolism | Glial Fibrillary Acidic Protein - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuroglia - drug effects | Neuroglia - cytology | Indomethacin - therapeutic use | Inflammation - drug therapy | Receptors, Tumor Necrosis Factor, Type II - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Synaptophysin - metabolism | Methamphetamine - pharmacology | Mice, Inbred C57BL | Hippocampus - pathology | Hippocampus - cytology | Indomethacin - pharmacology | Animals | Guanylate Kinases | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Qa-SNARE Proteins - metabolism | Neuroglia - metabolism | Mice | Synaptosomal-Associated Protein 25 - metabolism | CD11b Antigen - metabolism | Hippocampus - physiology | Inflammation - physiopathology | Brain | Neurosciences | Brain damage | Indomethacin | Universities and colleges | Tubulins | Intermediate filament proteins
Journal Article
Journal Article
Journal of Affective Disorders, ISSN 0165-0327, 02/2019, Volume 245, pp. 1106 - 1113
Bipolar disorder (BD) and substance use disorders share common symptoms, such as behavioral sensitization. Amphetamine-induced behavioral sensitization can... 
Amphetamine sensitization | Neurotrophic factor | Bipolar disorder | Depression-like behavior | Manic-like behavior | Anxious-like behavior | METHAMPHETAMINE | BDNF | PSYCHIATRY | SCHIZOPHRENIA | DOPAMINERGIC-NEURONS | PREFRONTAL CORTEX | CLINICAL NEUROLOGY | NUCLEUS-ACCUMBENS | MOOD | GDNF | ILLNESS PROGRESSION | BRAIN | Bipolar Disorder - chemically induced | Bipolar Disorder - metabolism | Frontal Lobe - metabolism | Rats, Wistar | Male | Nerve Growth Factors - metabolism | Hippocampus - drug effects | Glial Cell Line-Derived Neurotrophic Factor - drug effects | Corpus Striatum - metabolism | Brain - metabolism | Brain-Derived Neurotrophic Factor - drug effects | Depression - metabolism | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Depression - chemically induced | Nerve Growth Factors - drug effects | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Nerve Growth Factor - drug effects | Anxiety - metabolism | Disease Models, Animal | Locomotion - drug effects | Dextroamphetamine - pharmacology | Nerve Growth Factor - metabolism | Rats | Brain - drug effects | Hippocampus - metabolism | Animals | Neurotrophin 3 - metabolism | Frontal Lobe - drug effects | Neurotrophin 3 - drug effects | Corpus Striatum - drug effects | Anxiety - chemically induced | Brain | Nerve growth factor | Analysis | Central nervous system agents
Journal Article