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JAMA, ISSN 0098-7484, 07/2011, Volume 306, Issue 3, pp. 269 - 276
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 24, pp. 8608 - 8621
In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, 1) structure... 
Antitumor activity | DHFR inhibitors | 4(3 H)-Quinazolinone | Molecular modeling studies | 4(3H)-Quinazolinone | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | METHOTREXATE | CHEMISTRY, ORGANIC | NATIONAL-CANCER-INSTITUTE | 4(3H)-quinazolinone | TRIMETREXATE | PNEUMOCYSTIS-CARINII | antitumor activity | PHARMACOLOGY | molecular modeling studies | BIOLOGICAL EVALUATION | FORCE-FIELD | PART 2 | CYTOTOXICITY | Methotrexate - pharmacology | Folic Acid Antagonists - chemistry | Lung Neoplasms - drug therapy | Liver - enzymology | Tetrahydrofolate Dehydrogenase - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Lung Neoplasms - pathology | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Cattle | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Folic Acid Antagonists - chemical synthesis | Quinazolinones - pharmacology | Tumor Cells, Cultured - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Quinazolinones - chemical synthesis | Animals | Breast Neoplasms - pathology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Folic Acid Antagonists - pharmacology | Models | Dihydrofolate reductase | Analysis | Pharmacy
Journal Article
Journal Article
Sensors & Actuators: B. Chemical, ISSN 0925-4005, 10/2019, Volume 297, p. 126767
•Fe-Co-Co PBAs as a novel co-reaction accelerator of the C-g-C3N4/S2O82− ECL system to amplify the ECL signal.•The proposed method holds a new perspective of... 
Prussian blue analogues | C-g-C3N4 | Electrochemiluminescence | Methotrexate | Core-shell | Co-reaction | Accelerator | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | CARBON NITRIDE NANOSHEET | STRATEGY | PTCA | GRAPHENE | SENSOR | NANOCOMPOSITES | INSTRUMENTS & INSTRUMENTATION | ELECTRODE | IMMUNOSENSOR | G-C3N4 | Urine | Accelerators | Graphene | Pigments | Nanomaterials | Iron | Biosensors | Cobalt | Carbon nitride
Journal Article
Cancer, ISSN 0008-543X, 02/2006, Volume 106, Issue 3, pp. 514 - 523
BACKGROUND The objective of the current study was a retrospective evaluation of 100 consecutive premenopausal women with high‐risk, early breast carcinoma who... 
ovarian protection | adjuvant therapy | gonadotropin‐releasing hormone analogue | high‐risk early breast carcinoma | High-risk early breast carcinoma | Ovarian protection | Gonadotropin-releasing hormone analogue | Adjuvant therapy | AMENORRHEA | CYCLOPHOSPHAMIDE | TAMOXIFEN | METHOTREXATE | FLUOROURACIL | PREMENOPAUSAL PATIENTS | CANCER | gonadotropin-releasing hormone analogue | TRIAL | high-risk early breast carcinoma | THERAPY | ONCOLOGY | GOSERELIN | Cyclophosphamide - administration & dosage | Humans | Middle Aged | Estrogen Receptor Modulators | Gonadotropin-Releasing Hormone - analogs & derivatives | Fluorouracil - administration & dosage | Infertility, Female - chemically induced | Adult | Female | Ovary - drug effects | Gonadotropin-Releasing Hormone - therapeutic use | Retrospective Studies | Chemotherapy, Adjuvant | Carcinoma - pathology | Carcinoma - drug therapy | Premenopause | Ovary - physiology | Treatment Outcome | Breast Neoplasms - drug therapy | Pregnancy | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Age of Onset | Infertility, Female - prevention & control | Methotrexate - administration & dosage | Pregnancy Outcome | Care and treatment | Gonadotropin releasing hormone | Patient outcomes | Physiological aspects | Breast cancer | Research | Ovaries
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2015, Volume 80, Issue 17, pp. 8583 - 8596
Herein, we describe the synthesis and reactivity of enamines derived from ylidenemalononitriles and ylidenecyanoacetates. The enamine scope was expanded by (1)... 
CONVENIENT SYNTHESIS | BIOLOGICAL PROBES | ACID | DIMETHYLFORMAMIDE | METHOTREXATE | CHEMISTRY | CHEMISTRY, ORGANIC | INHIBITORS | ANTAGONISTS | DERIVATIVES | EFFICIENT | Nitriles | Pyridine | Research | Chemical properties | Chemical synthesis
Journal Article
Protein Expression and Purification, ISSN 1046-5928, 03/2016, Volume 119, pp. 102 - 109
Journal Article
Journal Article