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Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2013, Volume 66, pp. 135 - 145
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 24, pp. 8608 - 8621
In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, ) structure features... 
Antitumor activity | DHFR inhibitors | 4(3 H)-Quinazolinone | Molecular modeling studies | 4(3H)-Quinazolinone | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | METHOTREXATE | CHEMISTRY, ORGANIC | NATIONAL-CANCER-INSTITUTE | 4(3H)-quinazolinone | TRIMETREXATE | PNEUMOCYSTIS-CARINII | antitumor activity | PHARMACOLOGY | molecular modeling studies | BIOLOGICAL EVALUATION | FORCE-FIELD | PART 2 | CYTOTOXICITY | Methotrexate - pharmacology | Folic Acid Antagonists - chemistry | Lung Neoplasms - drug therapy | Liver - enzymology | Tetrahydrofolate Dehydrogenase - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Lung Neoplasms - pathology | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Cattle | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Folic Acid Antagonists - chemical synthesis | Quinazolinones - pharmacology | Tumor Cells, Cultured - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Quinazolinones - chemical synthesis | Animals | Breast Neoplasms - pathology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Folic Acid Antagonists - pharmacology | Models | Dihydrofolate reductase | Analysis | Pharmacy | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 2, pp. 767 - 786
By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP... 
PLACEBO | CHEMISTRY, MEDICINAL | CHRONIC PLAQUE PSORIASIS | EFFICACY | ACTIVE RHEUMATOID-ARTHRITIS | PHASE-III | METHOTREXATE | OPEN-LABEL | COMBINATION | TOFACITINIB CP-690,550 | DISCOVERY | Phosphorylation | Indazoles - chemical synthesis | Humans | Microsomes, Liver - metabolism | Crystallography, X-Ray | Administration, Cutaneous | Hepatocytes - metabolism | Indazoles - administration & dosage | Lung Diseases - drug therapy | Janus Kinase 3 - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - toxicity | Drug Design | Anti-Inflammatory Agents - administration & dosage | Binding Sites | Janus Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - pharmacology | Anti-Inflammatory Agents - toxicity | Heterocyclic Compounds, 2-Ring - administration & dosage | Solubility | Administration, Inhalation | Rats | Skin Diseases - drug therapy | Janus Kinase 1 - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - pharmacology | Indazoles - pharmacology | Janus Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Animals | Indazoles - toxicity | Dogs | Protein Kinase Inhibitors - toxicity | Anti-Inflammatory Agents - chemical synthesis | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, pp. 2674 - 2685
Bridge homologation of the previously reported nonclassical two-carbon-bridged antifolate, 2,4-diamino-6-phenethylpyrido[3,2- ]pyrimidine ( ), afforded the... 
DHFR | Molecular docking study | Nonclassical antifolates | Antitumor | ANTIFOLATE RESISTANCE | ANTIPROLIFERATIVE ACTIVITY | CHEMISTRY, MEDICINAL | MECHANISM | REDUCED FOLATE CARRIER | ANALOGS | THYMIDYLATE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | RECEPTOR | CANCER | POTENTIAL ANTICANCER AGENTS | THIOREDOXIN REDUCTASE | Methotrexate - pharmacology | Folic Acid Antagonists - chemistry | Up-Regulation | Tetrahydrofolate Dehydrogenase - chemistry | Apoptosis - drug effects | Pyridines - chemistry | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Pyrimidines - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Molecular Structure | Folic Acid Antagonists - chemical synthesis | Recombinant Proteins - metabolism | Catalytic Domain | Pyridines - chemical synthesis | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Blotting, Western | Tetrahydrofolate Dehydrogenase - metabolism | Hydrogen Bonding | Cell Line, Tumor | Molecular Docking Simulation | Pyridines - pharmacology | S Phase Cell Cycle Checkpoints - drug effects | Folic Acid Antagonists - pharmacology | Drug Screening Assays, Antitumor | Tetrahydrofolate Dehydrogenase - genetics | Antimitotic agents | Pyrimidines | Dihydrofolate reductase | Antineoplastic agents | Analysis | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 04/2019, Volume 56, Issue 4, pp. 1352 - 1361
Considering pteridine as a worthy structure for improving probes of magnificent therapeutic potentials, some new pteridine conjugates were synthesized by... 
AZOLE | DESIGN | DNA | BIOLOGICAL-ACTIVITY | METHOTREXATE | CHEMISTRY, ORGANIC | ANTITUMOR-ACTIVITY | FACILE | MICROWAVE-ASSISTED SYNTHESIS | DERIVATIVES | TNBS-INDUCED COLITIS | Pyrimidines | Aromatic amines | Analysis | Formaldehyde | Microorganisms | Amines | Nuclear magnetic resonance--NMR | Antimicrobial agents | Pharmacology | Chemical synthesis | Antiinfectives and antibacterials
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 125, pp. 1279 - 1288
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2006, Volume 41, Issue 11, pp. 1301 - 1309
The aim of this research was to examine chemical and biological properties of the products ( – / – , – , – ) of the reaction of methyl chromone-3-carboxylate (... 
Alkylating properties | Phosphorohydrazine | Chromone | Antitumor activity | Antibacterial activity | Tautomerism | Coumarin | antibacterial activity | CHEMISTRY, MEDICINAL | 3-AMINOFLAVONE | coumarin | CIS-DDP | chromone | HYDROGEN-BONDS | tautomerism | phosphorohydrazine | CHROMONE-3-CARBOXYLIC ESTERS | antitumor activity | alkylating properties | CIS-PT(II) COMPLEX | A549 CELLS | X-RAY | AGENTS | TRANSITION-METAL CHEMISTRY | MAIN-GROUP HYDRAZIDES | Antineoplastic Agents, Alkylating - chemical synthesis | Gram-Positive Bacteria - drug effects | Antineoplastic Agents, Alkylating - pharmacology | Coumarins - chemistry | Male | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Mice, Inbred DBA | Antineoplastic Agents, Alkylating - chemistry | Chromones - pharmacology | Leukemia L1210 - drug therapy | Magnetic Resonance Spectroscopy | Hydrazones - chemical synthesis | Hydrazones - chemistry | Leukemia P388 - drug therapy | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Chromones - chemistry | Coumarins - pharmacology | Gram-Negative Bacteria - drug effects | Animals | Coumarins - chemical synthesis | Anti-Bacterial Agents - pharmacology | Mice | Mice, Inbred BALB C | Chromones - chemical synthesis | Integrated logistic support | Pyridine | Analysis | Leukemia | Dimethyl sulfoxide | Nuclear magnetic resonance spectroscopy | Methotrexate | Enols | Antibacterial agents | Index Medicus
Journal Article