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Archives of Toxicology, ISSN 0340-5761, 7/2014, Volume 88, Issue 7, pp. 1451 - 1468
The superordinate principles governing the transcriptome response of differentiating cells exposed to drugs are still unclear. Often, it is assumed that... 
Histone deacetylase | Biomedicine | Environmental Health | Developmental toxicity | Occupational Medicine/Industrial Medicine | Embryonic stem cell | Histone modification | Pharmacology/Toxicology | Valproic acid | Biomedicine general | DESIGN PRINCIPLES | DEVELOPMENTAL NEUROTOXICITY | VALPROIC ACID | IN-VITRO | alproic acid | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | SYSTEMS | TOXICOLOGY | DIFFERENTIATION | INHIBITORS | EXPOSURE | Paired Box Transcription Factors - genetics | Hydroxamic Acids - toxicity | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Humans | Histone Deacetylase Inhibitors - administration & dosage | Transcriptome | Repressor Proteins - genetics | PAX6 Transcription Factor | Homeodomain Proteins - genetics | Valproic Acid - toxicity | Gene Expression Regulation - drug effects | Acetylation - drug effects | Valproic Acid - administration & dosage | Methylation - drug effects | Time Factors | Cell Differentiation - drug effects | Histone Deacetylase Inhibitors - toxicity | Hydroxamic Acids - administration & dosage | Eye Proteins - genetics | Histones - metabolism | Drugs | Divalproex | Analysis | Genomics | Resveratrol | Methylation | Gene expression | Embryonic stem cells | Epigenetics | Side effects | Pharmacology | Toxicity | Developmental biology | Stem cells | Index Medicus | Reproductive Toxicology
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7584, pp. 110 - 114
Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas(1,2). Mutant IDH protein produces a new... 
MAINTENANCE | METHYLATION | LANDSCAPE | DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | ARCHITECTURE | PHENOTYPE | EXPRESSION | 2-HYDROXYGLUTARATE | PRINCIPLES | Chromatin - metabolism | Up-Regulation | Humans | Glioma - genetics | Base Sequence | Glioma - pathology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Chromatin - drug effects | Repressor Proteins - metabolism | Oncogenes - genetics | Insulator Elements - genetics | Glioma - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Isocitrate Dehydrogenase - genetics | DNA Methylation - genetics | Down-Regulation - drug effects | Mutation - genetics | CRISPR-Cas Systems - genetics | Insulator Elements - drug effects | Phenotype | Isocitrate Dehydrogenase - chemistry | Receptor, Platelet-Derived Growth Factor alpha - genetics | CCCTC-Binding Factor | CpG Islands - genetics | Protein Binding | Isocitrate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Enhancer Elements, Genetic - genetics | Glutarates - metabolism | Cell Transformation, Neoplastic - drug effects | Chromatin - genetics | DNA Methylation - drug effects | Glioma - drug therapy | Complications and side effects | Care and treatment | Platelet-derived growth factor | Gliomas | Analysis | Influence | Genetic aspects | Research | Methylation | Oncogenes | DNA methylation | Epigenetics | Genomes | Mutation | Gene expression | Binding sites | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Cell Stem Cell, ISSN 1934-5909, 02/2017, Volume 20, Issue 2, pp. 233 - 246.e7
Journal Article
2010, DNA methylation
Web Resource
2010, DNA methylation
Web Resource
Nature Medicine, ISSN 1078-8956, 04/2017, Volume 23, Issue 4, pp. 493 - 500
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7668, pp. 471 - 475
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various... 
BREAST-CANCER | CELLS | METHYLATION | MULTIDISCIPLINARY SCIENCES | SENESCENCE | EXPRESSION | REQUIREMENT | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Viruses - genetics | Breast Neoplasms - immunology | Humans | Transcriptome | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - cytology | Female | Biological Mimicry - drug effects | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Disease Models, Animal | Viruses - drug effects | Viruses - immunology | Antigen Presentation - immunology | Breast Neoplasms - drug therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Breast Neoplasms - genetics | Repressor Proteins - biosynthesis | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | RNA, Double-Stranded - genetics | Cell Line, Tumor | Interferons - metabolism | Antigen Presentation - drug effects | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Cancer cells | Physiological aspects | Research | Protein kinases | Immunity | Cyclins | Cancer | Cell proliferation | Flow cytometry | Animal models | Phosphorylation | Senescence | Peptides | Genomics | Immune clearance | Cytotoxicity | Lymphocytes T | Genomes | Kinases | Cancer therapies | Cyclin-dependent kinase 4 | E2F protein | Breast carcinoma | Cell growth | Lymphocytes | New combinations | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Medical research | Immune response | Immunoregulation | Intracellular levels | Double-stranded RNA | Breast cancer | Pharmacology | Gene expression | Ribonucleic acid--RNA | Inhibitors | Immune checkpoint | Immunogenicity | Breast | DNA methyltransferase | Interferon | Retinoblastoma | Tumors | Apoptosis
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 474 - 478
Journal Article
Lancet, The, ISSN 0140-6736, 2013, Volume 381, Issue 9883, pp. 2109 - 2117
Journal Article