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Toxicology and Applied Pharmacology, ISSN 0041-008X, 2004, Volume 201, Issue 3, pp. 226 - 294
Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full... 
Mechanisms of toxicity | Dose response | Formaldehyde | Zinc | Progesterone/hydroxyflutamide | Propylene oxide | Dose-dependent transitions | Peroxisome proliferator-activated receptor | Acetaminophen | Vinylidene chloride | Butadiene, ethylene glycol | Methylene chloride | Vinyl acetate | Vinyl chloride | Manganese | Progesterone/ hydroxyflutamide | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | propylene oxide | ACTIVATED RECEPTOR-GAMMA | dose-dependent transitions | mechanisms of toxicity | vinylidene chloride | manganese | butadiene | INDUCED HEPATIC-NECROSIS | dose response | ethylene glycol | methylene chloride | PHARMACOLOGY & PHARMACY | TOXICOLOGY | peroxisome proliferator-activated receptor | vinyl acetate | zinc | SISTER-CHROMATID EXCHANGES | SPRAGUE-DAWLEY RATS | MANGANESE OXIDE AEROSOL | formaldehyde | CHRONIC INHALATION TOXICITY | PROTEIN CROSS-LINKS | acetaminophen | vinyl chloride | GLUTATHIONE-S-TRANSFERASE | PARA-BENZOQUINONE IMINE | progesterone/hydroxyflutamide | Analgesics, Non-Narcotic - pharmacokinetics | Progesterone - administration & dosage | Humans | Acetaminophen - administration & dosage | Epoxy Compounds - pharmacokinetics | Dichloroethylenes - toxicity | Manganese - pharmacokinetics | Methylene Chloride - administration & dosage | Analgesics, Non-Narcotic - toxicity | Manganese - administration & dosage | Dichloroethylenes - pharmacokinetics | Dichloroethylenes - administration & dosage | Formaldehyde - toxicity | Androgen Antagonists - toxicity | Ethylene Glycol - toxicity | Butadienes - toxicity | Androgen Antagonists - pharmacokinetics | Progesterone - pharmacokinetics | Oxidation-Reduction | Acetaminophen - toxicity | Vinyl Compounds - administration & dosage | Zinc - toxicity | Androgen Antagonists - administration & dosage | Flutamide - administration & dosage | Vinyl Compounds - toxicity | Zinc - administration & dosage | Peroxisome Proliferator-Activated Receptors - physiology | Drug-Related Side Effects and Adverse Reactions - chemically induced | Flutamide - toxicity | Drug-Related Side Effects and Adverse Reactions - metabolism | Vinyl Compounds - pharmacokinetics | Dose-Response Relationship, Drug | Methylene Chloride - toxicity | Zinc - pharmacokinetics | Epoxy Compounds - administration & dosage | Formaldehyde - administration & dosage | Ethylene Glycol - administration & dosage | Formaldehyde - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Butadienes - pharmacokinetics | Flutamide - analogs & derivatives | Analgesics, Non-Narcotic - administration & dosage | Epoxy Compounds - toxicity | Animals | Butadienes - administration & dosage | Progesterone - toxicity | Methylene Chloride - pharmacokinetics | Acetaminophen - pharmacokinetics | Flutamide - pharmacokinetics | Manganese Poisoning - metabolism
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2013, Volume 57, Issue 4, pp. 1763 - 1771
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
PBPK MODEL | MURINE MODEL | TUBERCULOSIS | KINETICS | CANCER-RISK | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | MONTE-CARLO-SIMULATION | RIFAPENTINE | RISK-ASSESSMENT | METHYLENE-CHLORIDE | Rifampin - pharmacokinetics | Animals | Antitubercular Agents - pharmacokinetics | Computer Simulation | Tuberculosis - drug therapy | Mice | Monte Carlo Method | Pharmacology
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 244, Issue 3, pp. 280 - 290
Dichloromethane (DCM, methylene chloride) is a lipophilic volatile compound readily absorbed and then metabolized to several metabolites that may lead to... 
Dichloromethane | Physiologically based pharmacokinetic (PBPK) model | Atypical CYP kinetics | Methylene chloride | Metabolism | DCM | VITRO | MOLECULAR-WEIGHT | REVISED ASSESSMENT | DIHALOMETHANES | RATS | ATYPICAL CYTOCHROME-P450 KINETICS | 2-YEAR DRINKING-WATER | METHYLENE-CHLORIDE | GLUTATHIONE | CANCER-RISK | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Models, Chemical | Glutathione - metabolism | Solvents - pharmacokinetics | Inhalation Exposure - analysis | Cytochrome P-450 CYP2E1 - metabolism | Solvents - toxicity | Methylene Chloride - toxicity | Animals | Metabolic Networks and Pathways | Methylene Chloride - pharmacokinetics | Female | Models, Animal | Mice | Binding Sites - drug effects | Physiological aspects | Metabolites | Analysis | Cytochrome P-450 | Index Medicus | Animal models | BIOLOGICAL PATHWAYS | LUNGS | RADIATION DOSES | 60 APPLIED LIFE SCIENCES | PRIMATES | DNA DAMAGES | ORGANIC HALOGEN COMPOUNDS | METABOLISM | KINETICS | HYPOTHESIS | DRUGS | VERTEBRATES | MICE | RADIOPROTECTIVE SUBSTANCES | MAMMALS | ANIMALS | METABOLITES | ORGANIC CHLORINE COMPOUNDS | RODENTS | RESPONSE MODIFYING FACTORS | METHYLENE CHLORIDE | ORGANIC COMPOUNDS | INHALATION | INTAKE | EVALUATION | TOXICITY | ADDUCTS | IN VIVO | SIMULATION | CONFORMATIONAL CHANGES | POLYPEPTIDES | DNA ADDUCTS | ORGANS | PEPTIDES | DOSES | RESPIRATORY SYSTEM | MEN | MAN | PROTEINS | BODY | MALES
Journal Article