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index medicus (164) 164
humans (139) 139
female (100) 100
methylenetetrahydrofolate dehydrogenase - genetics (94) 94
male (77) 77
folic acid (52) 52
animals (49) 49
adult (46) 46
methylenetetrahydrofolate reductase (44) 44
folate (43) 43
folic acid - metabolism (42) 42
polymorphism, genetic (41) 41
genetic aspects (38) 38
methylenetetrahydrofolate dehydrogenase - metabolism (37) 37
neural-tube defects (37) 37
genotype (36) 36
middle aged (34) 34
one-carbon metabolism (34) 34
risk factors (34) 34
homocysteine (32) 32
methylenetetrahydrofolate reductase - genetics (32) 32
physiological aspects (32) 32
mice (29) 29
methylenetetrahydrofolate dehydrogenase - deficiency (28) 28
mutation (28) 28
genetics & heredity (27) 27
polymorphism (27) 27
metabolism (26) 26
pregnancy (26) 26
research (26) 26
polymorphism, single nucleotide (25) 25
genetic predisposition to disease (24) 24
aged (23) 23
biochemistry & molecular biology (23) 23
case-control studies (23) 23
minor histocompatibility antigens (23) 23
oncology (23) 23
alleles (22) 22
abridged index medicus (21) 21
enzymes (21) 21
formate-tetrahydrofolate ligase - genetics (20) 20
risk (20) 20
gene frequency (19) 19
genes (19) 19
health aspects (19) 19
dna methylation (18) 18
mthfd1 (18) 18
aminohydrolases - genetics (17) 17
cancer (17) 17
ferredoxin-nadp reductase - genetics (17) 17
genetic polymorphisms (17) 17
methylation (17) 17
multienzyme complexes - genetics (17) 17
vitamin b (17) 17
folic-acid (16) 16
gene expression (16) 16
genetics (16) 16
homocysteine - metabolism (16) 16
mthfr (16) 16
nutrition & dietetics (16) 16
analysis (15) 15
dihydrouracil dehydrogenase - genetics (15) 15
formate-tetrahydrofolate ligase - metabolism (15) 15
homocysteine - blood (15) 15
polymorphisms (15) 15
vascular-disease (15) 15
adolescent (13) 13
child (13) 13
common mutation (13) 13
folic acid - blood (13) 13
plasma homocysteine (13) 13
population (13) 13
thymidylate synthase - genetics (13) 13
aminohydrolases - metabolism (12) 12
article (12) 12
carbon - metabolism (12) 12
folic acid - genetics (12) 12
genetic research (12) 12
infant (12) 12
aged, 80 and over (11) 11
chemotherapy (11) 11
gene (11) 11
genetic association studies (11) 11
methionine (11) 11
methylenetetrahydrofolate dehydrogenase (11) 11
mutations (11) 11
risk factor (11) 11
thymidylate synthase (11) 11
young adult (11) 11
5-methyltetrahydrofolate-homocysteine s-methyltransferase - genetics (10) 10
abnormalities (10) 10
cell biology (10) 10
dna (10) 10
homozygote (10) 10
internal medicine (10) 10
liver - enzymology (10) 10
methylenetetrahydrofolate reductase - metabolism (10) 10
multienzyme complexes - metabolism (10) 10
neural tube defects - genetics (10) 10
polymerase chain reaction (10) 10
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Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7504, pp. 298 - 302
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2015, Volume 112, Issue 2, pp. 400 - 405
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1140 - 1153
Journal Article
AMERICAN JOURNAL OF CLINICAL NUTRITION, ISSN 0002-9165, 11/2016, Volume 104, Issue 5, pp. 1459 - 1469
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in... 
high folate | NEURAL-TUBE DEFECTS | embryo | POLYMORPHISM | TANDEM MASS-SPECTROMETRY | birth defects | METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY | CHOLINE METABOLISM | methylenetetrahydrofolate reductase | PREGNANT CANADIAN WOMEN | NUTRITION & DIETETICS | developmental defects | MTHFD1 | S-ADENOSYLHOMOCYSTEINE | placenta | GENETIC RISK-FACTOR | LOW DIETARY-FOLATE | folic acid | CONGENITAL HEART-DEFECTS | S-Adenosylhomocysteine - metabolism | Folic Acid - pharmacology | Methylenetetrahydrofolate Dehydrogenase (NADP) - deficiency | Aminohydrolases - deficiency | Multienzyme Complexes - metabolism | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Aminohydrolases - genetics | Multienzyme Complexes - deficiency | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Female | Embryo, Mammalian - enzymology | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Formate-Tetrahydrofolate Ligase - deficiency | Logistic Models | Mice, Transgenic | Placenta - abnormalities | Placenta - enzymology | Multienzyme Complexes - genetics | Pregnancy | Formate-Tetrahydrofolate Ligase - metabolism | Animals | Choline - pharmacology | Formate-Tetrahydrofolate Ligase - genetics | Aminohydrolases - metabolism | Mice | Polymorphism, Single Nucleotide | Embryonic Development - drug effects | Dietary Supplements | S-Adenosylmethionine - metabolism | Ligases | Genetic variation | Pregnancy, Complications of | Development and progression | Genetic aspects | Health aspects | Folic acid | Vitamin B | Rodents | Dietary supplements | Prenatal development | Birth defects | Embryos | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 04/2018, Volume 148, Issue 4, pp. 501 - 509
Abstract Background Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in... 
Low folate | Embryo | Placenta | MTHFD1 | Developmental defects | Birth defects | Developmental delay | S-adenosylmethionine | Folic acid | low folate | NEURAL-TUBE DEFECTS | embryo | FOLIC-ACID SUPPLEMENTATION | POLYMORPHISM | birth defects | PREGNANCY | METHYLENETETRAHYDROFOLATE REDUCTASE | CHOLINE METABOLISM | BIOMARKERS | WOMEN | NUTRITION & DIETETICS | developmental defects | developmental delay | placenta | GENETIC RISK-FACTOR | folic acid | MTHFD1-SYNTHETASE DEFICIENCY | Multifunctional Enzymes - genetics | Pregnancy, Animal | S-Adenosylhomocysteine - metabolism | Folic Acid Deficiency - metabolism | Pregnancy Complications - blood | Methylenetetrahydrofolate Dehydrogenase (NADP) - deficiency | Congenital Abnormalities - etiology | Multifunctional Enzymes - deficiency | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Multifunctional Enzymes - metabolism | Folic Acid - administration & dosage | Methenyltetrahydrofolate Cyclohydrolase - genetics | DNA Methylation | Fetal Growth Retardation - etiology | Ligases | Female | Pregnancy Complications - metabolism | Folic Acid Deficiency - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Disease Models, Animal | Folic Acid Deficiency - blood | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Pregnancy Complications - etiology | Liver - metabolism | Formate-Tetrahydrofolate Ligase - deficiency | Fetal Development | Genotype | Polymorphism, Genetic | Pregnancy | Formate-Tetrahydrofolate Ligase - metabolism | Animals | Folic Acid Deficiency - complications | Diet | Folic Acid - blood | Methenyltetrahydrofolate Cyclohydrolase - deficiency | Pregnancy Complications - genetics | Formate-Tetrahydrofolate Ligase - genetics | Mice | Tetrahydrofolates - blood | Methenyltetrahydrofolate Cyclohydrolase - metabolism | S-Adenosylmethionine - metabolism | Physiological aspects | Oxidoreductases | Risk factors | Dehydrogenases | Adenosylmethionine | Congenital defects | Liver | Pregnancy complications | Methylenetetrahydrofolate reductase | Birth | Gene polymorphism | Methylenetetrahydrofolate dehydrogenase | Synthesis | Metabolites | Vitamin B | Food fortification | Nutrient deficiency | Developmental biology | Complications | Abnormalities | Risk analysis | Embryos | S-Adenosylmethionine | Methylation | Females | Homocysteine | Polymorphism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 2, pp. 549 - 554
Maternal supplementation with folic acid is known to reduce the incidence of neural tube defects (NTDs) by as much as 70%. Despite the strong clinical link... 
Enzymes | Phenotypes | Mitochondria | Dams | Sodium | Exons | Neural tube defects | Alleles | Formates | Embryos | CELLS | MESSENGER-RNA | MOUSE MUTANTS | RAT EMBRYOS | MULTIDISCIPLINARY SCIENCES | DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE | METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE | CLOSURE | MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE | FOLIC ACID METABOLISM | KNOCKOUT MICE | Methylenetetrahydrofolate Dehydrogenase (NADP) - deficiency | Aminohydrolases - deficiency | Embryonic Development - genetics | Formate-Tetrahydrofolate Ligase - deficiency | Neural Tube Defects - genetics | Genotype | Immunoblotting | DNA Primers - genetics | Multienzyme Complexes - genetics | Aminohydrolases - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Multienzyme Complexes - deficiency | Animals | Formates - pharmacology | Gene Deletion | Formate-Tetrahydrofolate Ligase - genetics | Metabolic Networks and Pathways - physiology | Mice | Embryonic Development - drug effects | Formates - administration & dosage | Abnormalities, Multiple - genetics | Craniofacial Abnormalities - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Embryonic development | Phenotype | Neural tube | Physiological aspects | Genetic aspects | Research | Gene expression | Health aspects | Biochemistry | Rodents | Index Medicus | Biological Sciences
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 09/2013, Volume 22, Issue 18, pp. 3705 - 3719
Genetic variants in one-carbon folate metabolism have been identified as risk factors for disease because they may impair the production or use of one-carbon... 
CONOTRUNCAL HEART-DEFECTS | NEURAL-TUBE DEFECTS | G-GREATER-THAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE | REDUCTASE DEFICIENCY | TANDEM MASS-SPECTROMETRY | FOLATE INTAKE | PLASMA HOMOCYSTEINE | ONE-CARBON METABOLISM | TRIFUNCTIONAL ENZYME | Choline - metabolism | Multifunctional Enzymes - genetics | Cell Proliferation | Methylenetetrahydrofolate Dehydrogenase (NADP) - deficiency | Humans | Aminohydrolases - deficiency | Multienzyme Complexes - metabolism | Male | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Aminohydrolases - genetics | Multifunctional Enzymes - metabolism | Genetic Variation | Multienzyme Complexes - deficiency | Congenital Abnormalities - genetics | Female | Models, Animal | Leukocyte Count | Pregnancy Complications - metabolism | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Mutagenesis, Site-Directed | Methionine - metabolism | Mice, Inbred C57BL | Cells, Cultured | Embryonic Development - genetics | Formate-Tetrahydrofolate Ligase - deficiency | Leucovorin - analogs & derivatives | Multienzyme Complexes - genetics | Gene Knock-In Techniques | Leucovorin - chemistry | Pregnancy | Embryo Loss | Formate-Tetrahydrofolate Ligase - metabolism | Animals | Pregnancy Complications - genetics | Folic Acid - metabolism | Formate-Tetrahydrofolate Ligase - genetics | Aminohydrolases - metabolism | Purines - biosynthesis | Mice | Polymorphism, Single Nucleotide | Index Medicus
Journal Article
American Journal of Clinical Nutrition, ISSN 0002-9165, 04/2012, Volume 95, Issue 4, pp. 882 - 891
Background: MTHFD1 encodes C1-tetrahydrofolate synthase, which is a folate-dependent enzyme that catalyzes the formation and interconversion of... 
METHYLENETETRAHYDROFOLATE REDUCTASE | FOLIC-ACID FORTIFICATION | NUTRITION & DIETETICS | MOUSE EMBRYOS | PREGNANCY COMPLICATIONS | GENETIC RISK-FACTOR | R653Q POLYMORPHISM | CONGENITAL HEART-DEFECTS | FOLATE STATUS | PLASMA HOMOCYSTEINE | ONE-CARBON METABOLISM | Choline - metabolism | Folic Acid Deficiency - metabolism | Maternal Nutritional Physiological Phenomena | Methylenetetrahydrofolate Dehydrogenase (NADP) - deficiency | Aminohydrolases - deficiency | Neural Tube Defects - genetics | Multienzyme Complexes - metabolism | Fetal Growth Retardation - genetics | Neural Tube Defects - metabolism | Homocysteine - metabolism | Aminohydrolases - genetics | Embryo Loss - metabolism | Genes, Lethal | Multienzyme Complexes - deficiency | Mice, Mutant Strains | Choline Deficiency - metabolism | Choline Deficiency - genetics | Female | Embryo Loss - genetics | Folic Acid Deficiency - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Disease Models, Animal | Hypoxanthine - metabolism | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Formate-Tetrahydrofolate Ligase - deficiency | Homocysteine - blood | Fetal Growth Retardation - metabolism | Multienzyme Complexes - genetics | Pregnancy | Formate-Tetrahydrofolate Ligase - metabolism | Animals | Folic Acid - blood | Folic Acid - metabolism | Formate-Tetrahydrofolate Ligase - genetics | Aminohydrolases - metabolism | Heterozygote | Mice | Mutagenesis, Insertional | Crosses, Genetic | Complications and side effects | Neural tube | Abnormalities | Fetus | Genetic aspects | Research | Genetic polymorphisms | Growth retardation | Risk factors | Enzymes | Genotype & phenotype | Nutrition | Gene expression | Metabolism | Rodents | Index Medicus | Abridged Index Medicus
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 03/2017, Volume 56, Issue 3, pp. 1030 - 1040
Journal Article
Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 2016, Volume 4, Issue 6, pp. 1160 - 1166.e10
Journal Article