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Journal Article
Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 106 - 118
Journal Article
Clinical & Experimental Allergy, ISSN 0954-7894, 04/2006, Volume 36, Issue 4, pp. 475 - 482
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 1, pp. 118 - 132
Journal Article
Nature Communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, p. 6332
Alveolar macrophages play a crucial role in the pathogenesis of emphysema, for which there is currently no effective treatment. Bisphosphonates are widely used... 
SMOKE-INDUCED EMPHYSEMA | BISPHOSPHONATES | INFLAMMATION | PRENYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DISEASE | TISSUE INHIBITOR | T-CELLS | OSTEOPOROSIS | ADIPOSE-TISSUE | Macrophages, Alveolar - pathology | Apoptosis - drug effects | NF-kappa B - immunology | Caspase 3 - immunology | Male | CD11c Antigen - immunology | Pulmonary Emphysema - chemically induced | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | CD11b Antigen - genetics | CD11c Antigen - genetics | Caspase 3 - genetics | Bronchoalveolar Lavage Fluid - cytology | Macrophages, Alveolar - immunology | Mevalonic Acid - immunology | Gene Expression | Lung - pathology | Phagocytosis - drug effects | CD11b Antigen - immunology | Signal Transduction | Mice, Inbred C57BL | Administration, Inhalation | Pulmonary Emphysema - pathology | Pulmonary Emphysema - drug therapy | Drug Repositioning | Mevalonic Acid - metabolism | Pulmonary Emphysema - immunology | Bone Density Conservation Agents - pharmacology | Cell Movement - drug effects | Animals | NF-kappa B - genetics | Macrophages, Alveolar - drug effects | Lung - drug effects | Alendronate - pharmacology | Aerosols | Contrast Media - metabolism | Pancreatic Elastase | Antigens, Differentiation - genetics | Mice | Bronchoalveolar Lavage Fluid - chemistry | Lung - immunology | Antigens, Differentiation - immunology
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2010, Volume 14, Issue 12, pp. 2803 - 2815
It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against tumours not located in bone. Mice transgenic for the activated ErbB‐2... 
tumour microenvironment | tumour‐associated macrophages | mevalonate pathway | zoledronic acid | angiogenesis | Zoledronic acid | Angiogenesis | Tumour-associated macrophages | Tumour microenvironment | Mevalonate pathway | MEDICINE, RESEARCH & EXPERIMENTAL | STIMULATION | tumour-associated macrophages | CELL-ADHESION | ANTITUMOR-ACTIVITY | CANCER | CELL BIOLOGY | BISPHOSPHONATES | NITRIC-OXIDE | AMERICAN-SOCIETY | T-CELLS | TRANSGENIC MICE | Neovascularization, Pathologic | Imidazoles - administration & dosage | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Antineoplastic Agents - administration & dosage | Interferon-gamma - metabolism | Nitric Oxide Synthase - genetics | Protein Prenylation | Interleukin-10 - metabolism | Female | Antineoplastic Agents - pharmacology | Macrophages - immunology | Nitric Oxide - biosynthesis | Mammary Neoplasms, Animal - immunology | Mammary Glands, Animal - pathology | Mice, Transgenic | Diphosphonates - administration & dosage | Imidazoles - pharmacology | Mevalonic Acid - metabolism | Macrophages - metabolism | Mammary Neoplasms, Animal - pathology | Animals | Metabolic Networks and Pathways | Genes, erbB-2 | Mammary Neoplasms, Animal - metabolism | Macrophages - drug effects | Mammary Neoplasms, Animal - drug therapy | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - drug effects | Nitric Oxide - metabolism | Diphosphonates - pharmacology | Interleukin | Bone tumors | Metastasis | Macrophages | Carcinogenesis | Vascularization | Carcinogens | Mevalonic acid | Lymphocytes | Vascular endothelial growth factor | Growth factors | Translocation | NF-κB protein | Phenotypes | Dendritic cells | ErbB protein | Transgenic mice | Breast cancer | Nuclear transport | Nitric-oxide synthase | Acids | Nitric oxide | Interferon | Laboratory animals | Tumors | Peritoneum | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157186
IL-5-induced chemotaxis of eosinophils is an important feature of allergic airway inflammatory diseases. Simvastatin, a lipid lowering agent, has been shown to... 
UPPER AIRWAY DISEASE | MURINE MODEL | PROTEIN | PROMYELOCYTIC LEUKEMIA-CELLS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | ALLERGIC-ASTHMA | HL-60 | DIFFERENTIATION | STATINS | EOTAXIN | Simvastatin - adverse effects | Receptors, CCR3 - immunology | Gene Expression Regulation - immunology | Rhinitis, Allergic - immunology | Humans | Rats | Male | Chemotaxis - drug effects | Rhinitis, Allergic - chemically induced | Simvastatin - pharmacology | Eosinophils - immunology | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Interleukin-5 - immunology | Animals | HL-60 Cells | Disease Models, Animal | Rhinitis, Allergic - pathology | Physiological aspects | Research | Chemokine receptors | Interleukin-5 | Eosinophils | Rhinitis | Leukocyte migration | Immunocytochemistry | Interleukin | Otolaryngology | mRNA | Kinases | Inflammatory diseases | Eotaxin | Butyric acid | Proteins | Respiratory tract | Receptors | Interleukin 5 | Mevalonic acid | Nose | Animal tissues | Allergic rhinitis | Peripheral blood | Fibroblasts | Respiratory tract diseases | CCR3 protein | Ovalbumin | Immunoglobulins | Cytokines | Leukocytes (eosinophilic) | Simvastatin | Inflammation | Gene expression | Chemotaxis | Allergies | Asthma | Medicine | Studies | Hospitals | Acids | Regulatory mechanisms (biology) | In vivo methods and tests | Infiltration | Cell migration | Chemokines
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2016, Volume 196, Issue 4, pp. 1461 - 1470
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e60975
Durable tumor cell eradication by chemotherapy is challenged by the development of multidrug-resistance (MDR) and the failure to induce immunogenic cell death.... 
ADAPTIVE IMMUNITY | BISPHOSPHONATES | ACTIVATION | MEDIATED DRUG-RESISTANCE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | ANTITUMOR-ACTIVITY | EXPRESSION | CHEMOTHERAPY | MODULATION | P-GLYCOPROTEIN | Prenylation - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cell Death - immunology | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Terpenes - metabolism | rho-Associated Kinases - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - drug effects | Cell Death - drug effects | Dendritic Cells - metabolism | Phagocytosis - drug effects | Imidazoles - pharmacology | Down-Regulation - drug effects | Mevalonic Acid - metabolism | Signal Transduction - drug effects | Models, Biological | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Protein Kinase Inhibitors - pharmacology | Cholesterol - biosynthesis | Diphosphonates - pharmacology | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Drug resistance in microorganisms | Anthracyclines | Immune response | Dendritic cells | Biochemistry | T cells | Investigations | Prevention | Chemotherapy | Cell death | Cancer cells | Health aspects | Cancer | Drugs | Toxicity | CD8 antigen | Lung cancer | Cytotoxicity | Oncology | Lymphocytes T | Drug resistance | Kinases | Doxorubicin | Recruitment | Proteins | Signal transduction | Mevalonic acid | Lymphocytes | Zoledronic acid | P-Glycoprotein | Medical research | Hematology | Mortality | Glycoprotein | RhoA protein | Breast cancer | Cholesterol | Studies | Signaling | Acids | Immunogenicity | Hypoxia | Apoptosis
Journal Article