X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (3758) 3758
Book Review (301) 301
Publication (176) 176
Book Chapter (24) 24
Conference Proceeding (10) 10
Dissertation (2) 2
Magazine Article (1) 1
Newspaper Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (3374) 3374
mevalonic acid - metabolism (2271) 2271
animals (1805) 1805
humans (1234) 1234
rats (858) 858
mevalonic acid (823) 823
male (785) 785
biochemistry & molecular biology (758) 758
cholesterol - biosynthesis (624) 624
mevalonic acid - pharmacology (618) 618
biosynthesis (501) 501
female (479) 479
liver - metabolism (472) 472
cholesterol (453) 453
carbon isotopes (435) 435
hydroxymethylglutaryl-coa reductase inhibitors - pharmacology (420) 420
cholesterol - metabolism (400) 400
acetates - metabolism (390) 390
cells, cultured (383) 383
mice (369) 369
hydroxymethylglutaryl coa reductases - metabolism (363) 363
lovastatin - pharmacology (355) 355
enzymes (339) 339
kinetics (337) 337
mevalonate pathway (328) 328
metabolism (320) 320
statins (290) 290
hmg-coa reductase (278) 278
proteins (266) 266
physiological aspects (264) 264
cell biology (263) 263
in vitro techniques (260) 260
cell line (259) 259
research (256) 256
terpenes - metabolism (246) 246
tritium (243) 243
mevalonate (242) 242
coenzyme-a reductase (233) 233
mevalonic acid - analogs & derivatives (231) 231
lipid metabolism (217) 217
sterols - biosynthesis (214) 214
expression (213) 213
gene expression (212) 212
time factors (209) 209
simvastatin (201) 201
isoprenoid biosynthesis (198) 198
molecular sequence data (195) 195
apoptosis (192) 192
cholesterol - blood (183) 183
analysis (180) 180
carbon radioisotopes (180) 180
biotechnology & applied microbiology (178) 178
chromatography, thin layer (178) 178
oncology (178) 178
lovastatin (174) 174
pharmacology & pharmacy (174) 174
multidisciplinary sciences (167) 167
amino acid sequence (166) 166
dose-response relationship, drug (165) 165
biophysics (163) 163
simvastatin - pharmacology (162) 162
genes (161) 161
inhibition (159) 159
escherichia-coli (155) 155
pathway (155) 155
plant sciences (155) 155
liver - drug effects (152) 152
liver - enzymology (152) 152
cells (151) 151
hydroxymethylglutaryl-coa reductase inhibitors (151) 151
adult (150) 150
lipids (150) 150
phosphates (146) 146
protein prenylation (146) 146
abridged index medicus (144) 144
enzyme inhibitors - pharmacology (143) 143
in-vitro (143) 143
cell line, tumor (142) 142
anticholesteremic agents - pharmacology (137) 137
cell division - drug effects (137) 137
lovastatin - analogs & derivatives (137) 137
polyisoprenyl phosphates - metabolism (137) 137
signal transduction (137) 137
sterols (135) 135
mutation (134) 134
terpenes (132) 132
identification (131) 131
biochemistry (128) 128
old medline (128) 128
phosphorylation (127) 127
life sciences (125) 125
signal transduction - drug effects (125) 125
middle aged (122) 122
tumor cells, cultured (122) 122
microbiology (120) 120
apoptosis - drug effects (118) 118
hydroxymethylglutaryl coa reductases - genetics (116) 116
isopentenyl diphosphate (116) 116
metabolites (116) 116
cancer (112) 112
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (3636) 3636
Japanese (33) 33
Russian (30) 30
German (24) 24
French (19) 19
Chinese (7) 7
Italian (7) 7
Polish (7) 7
Spanish (3) 3
Dutch (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Archives of Toxicology, ISSN 0340-5761, 1/2018, Volume 92, Issue 1, pp. 469 - 485
Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity... 
Biomedicine, general | Biomedicine | Environmental Health | TGFβ1 signaling | Occupational Medicine/Industrial Medicine | Renal fibrosis | Lipid accumulation | Pharmacology/Toxicology | Zoledronate | Fatty acid transporter | FIBROSIS | TGF beta 1 signaling | ALPHA | TOXICITY | MECHANISMS | MYOFIBROBLAST ACTIVATION | LIPID-ACCUMULATION | BISPHOSPHONATES | INHIBITION | LIVER | TOXICOLOGY | CHRONIC KIDNEY-DISEASE | Epithelial Cells - metabolism | Coenzyme A Ligases - genetics | Epithelial Cells - drug effects | Humans | Male | Coenzyme A Ligases - metabolism | Fenofibrate - pharmacology | Mice, Mutant Strains | Kidney Diseases - chemically induced | Oxidation-Reduction - drug effects | Dioxoles - pharmacology | Benzamides - pharmacology | Zoledronic Acid - adverse effects | Kidney Tubules - metabolism | Fatty Acids - metabolism | Kidney Diseases - metabolism | Cell Line | Fibrosis - chemically induced | Kidney Tubules - drug effects | Kidney Diseases - pathology | Mice, Inbred C57BL | Kidney Tubules - cytology | Animals | Lipid Metabolism - drug effects | Transforming Growth Factor beta - metabolism | Physiological aspects | Medical colleges | Kidney diseases | Transforming growth factors | Fatty acids | Animal models | Toxicity | Epithelial cells | Smad3 protein | Bone diseases | Accumulation | Necrosis | Proteins | Mevalonic acid | Zoledronic acid | Oxidation | Protein transport | Kidneys | Medical treatment | Pharmacology | Protein deficiency | Metabolism | Fenofibrate | Molecular modelling | Overexpression | Nephropathy | Fibrosis | Mice | Transporter | Guanosinetriphosphatase | Index Medicus | Organ Toxicity and Mechanisms
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 357 - 366
The YAP and TAZ mediators of the Hippo pathway ( hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2006, Volume 440, Issue 7086, pp. 940 - 943
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2010, Volume 14, Issue 12, pp. 2803 - 2815
It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against tumours not located in bone. Mice transgenic for the activated ErbB-2... 
Zoledronic acid | Angiogenesis | Tumour-associated macrophages | Tumour microenvironment | Mevalonate pathway | MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | angiogenesis | tumour-associated macrophages | DELTA T-CELLS | mevalonate pathway | ANTITUMOR-ACTIVITY | CELL BIOLOGY | BREAST-CANCER | NITRIC-OXIDE PRODUCTION | zoledronic acid | PROSTATE-CANCER | IN-VIVO | HER-2/NEU TRANSGENIC MICE | BONE METASTASIS | tumour microenvironment | AMERICAN-SOCIETY | Neovascularization, Pathologic | Imidazoles - administration & dosage | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Antineoplastic Agents - administration & dosage | Interferon-gamma - metabolism | Nitric Oxide Synthase - genetics | Protein Prenylation | Interleukin-10 - metabolism | Female | Antineoplastic Agents - pharmacology | Macrophages - immunology | Nitric Oxide - biosynthesis | Mammary Neoplasms, Animal - immunology | Mammary Glands, Animal - pathology | Mice, Transgenic | Diphosphonates - administration & dosage | Imidazoles - pharmacology | Mevalonic Acid - metabolism | Macrophages - metabolism | Mammary Neoplasms, Animal - pathology | Animals | Metabolic Networks and Pathways | Genes, erbB-2 | Mammary Neoplasms, Animal - metabolism | Macrophages - drug effects | Mammary Neoplasms, Animal - drug therapy | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - drug effects | Nitric Oxide - metabolism | Diphosphonates - pharmacology | Genotype & phenotype | Cytokines | Rodents | Nitric oxide | Interferon | Tumors | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 106 - 118
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2014, Volume 111, Issue 1, pp. E89 - E98
Journal Article
Cell, ISSN 0092-8674, 12/2015, Volume 163, Issue 7, pp. 1716 - 1729
Journal Article
Planta, ISSN 0032-0935, 11/2011, Volume 234, Issue 5, pp. 903 - 914
In plants, the mevalonic acid (MVA) pathway provides precursors for the formation of triterpenes, sesquiterpenes, phytosterols and primary metabolites... 
Proteins | Enzymes | Yeasts | Haploidy | Peroxisomes | Complementary DNA | Plasmids | Terpenoids | Alleles | Cytosol | Life Sciences | Arabidopsis | Mevalonic acid pathway | Forestry | Peroxisome | Ecology | Agriculture | Isoprenoid | Plant Sciences | Catharanthus | PHOSPHOMEVALONATE KINASE | SUBCELLULAR-LOCALIZATION | PLANT SCIENCES | HMG-COA SYNTHASE | ISOPRENOID BIOSYNTHESIS | PROTEOME ANALYSIS | THALIANA | GENES | REDUCTASE | TARGETING SIGNALS | ARABIDOPSIS LEAF PEROXISOMES | Transformation, Genetic | Amino Acid Sequence | Catharanthus - enzymology | Saccharomyces cerevisiae - genetics | Phosphotransferases (Phosphate Group Acceptor) - genetics | DNA, Complementary - genetics | Molecular Sequence Data | Phosphotransferases (Alcohol Group Acceptor) - genetics | RNA, Plant - genetics | Mevalonic Acid - metabolism | Genetic Complementation Test | Peroxisomes - metabolism | Arabidopsis - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Arabidopsis - genetics | Mevalonic Acid - analogs & derivatives | Saccharomyces cerevisiae - metabolism | Cloning, Molecular | Gene Expression Regulation, Plant | Cytosol - metabolism | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Catharanthus - genetics | DNA, Complementary - metabolism | Luminescent Proteins - metabolism | Arabidopsis thaliana | Saponins | Sesquiterpenes | Phytosterols | Fluorescence | Plant metabolites | Index Medicus
Journal Article