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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2004, Volume 24, Issue 8, pp. 1454 - 1459
OBJECTIVE—Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in the cleavage of a variety of... 
HepG2 | QPCR | Primary hepatocytes | Cholesterol | SRE | CELLS | ELEMENT-BINDING PROTEIN-2 | primary hepatocytes | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | LOW-DENSITY-LIPOPROTEIN | NUCLEAR RECEPTOR LXR | TARGET GENES | PATHWAY | LIVER | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Consensus Sequence | Lovastatin - pharmacology | Species Specificity | Humans | Regulatory Sequences, Nucleic Acid | Homeostasis | Lovastatin - analogs & derivatives | Hepatocytes - metabolism | Simvastatin - pharmacology | Promoter Regions, Genetic - genetics | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Cell Line - drug effects | Base Sequence | Liver X Receptors | Serine Endopeptidases - genetics | Orphan Nuclear Receptors | Proprotein Convertases | Sp1 Transcription Factor - physiology | Hepatocytes - drug effects | Heptanoic Acids - pharmacology | Tretinoin - pharmacology | Mevalonic Acid - pharmacology | Cell Line - metabolism | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Serine Endopeptidases - biosynthesis | Receptors, Cytoplasmic and Nuclear - drug effects | Rats | Hydroxymethylglutaryl CoA Reductases - physiology | Reverse Transcriptase Polymerase Chain Reaction | Hydroxycholesterols - pharmacology | Sequence Homology, Nucleic Acid | Gene Expression Regulation - drug effects | Mevalonic Acid - analogs & derivatives | Atorvastatin Calcium | Pyrroles - pharmacology | Sequence Alignment | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol - pharmacology | Mice | Pyridines - pharmacology | Cholesterol - biosynthesis | Sterol Regulatory Element Binding Protein 2 | Proprotein Convertase 9
Journal Article
Journal of Dental Research, ISSN 0022-0345, 4/2015, Volume 94, Issue 4, pp. 594 - 601
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2004, Volume 24, Issue 30, pp. 6715 - 6723
alpha-Synuclein contributes to the pathogenesis of Parkinson's disease (PD), but its precise role in the disorder and its normal function remain poorly... 
Nerve terminal | Synaptic localization | Lipid raft | Parkinson's disease | Synuclein | Neurodegeneration | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | neurodegeneration | FATTY-ACIDS | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | SIGNAL-TRANSDUCTION | nerve terminal | synuclein | lipid raft | LIVING CELL-MEMBRANES | CHOLESTEROL DEPLETION | synaptic localization | PRECURSOR PROTEIN | GPI-ANCHORED PROTEINS | LEWY BODY DEMENTIA | PARKINSONS-DISEASE | Sphingolipids - biosynthesis | Lovastatin - pharmacology | Cholesterol - physiology | Humans | Recombinant Fusion Proteins - analysis | HeLa Cells - metabolism | Lovastatin - analogs & derivatives | Mutation, Missense | Sphingolipids - physiology | Recombinant Fusion Proteins - metabolism | beta-Cyclodextrins - pharmacology | Kidney | Cell Compartmentation | Nerve Tissue Proteins - chemistry | Transfection | Cells, Cultured - ultrastructure | Protein Binding - drug effects | Nystatin - pharmacology | Fumonisins - pharmacology | Mevalonic Acid - pharmacology | Detergents - pharmacology | Mice, Inbred C57BL | Rats | Mice, Transgenic | Membrane Lipids - physiology | Hippocampus - cytology | Synucleins | Nerve Tissue Proteins - genetics | Mice, Inbred C3H | Nerve Tissue Proteins - metabolism | Animals | Membrane Microdomains - drug effects | Cell Membrane Permeability - drug effects | Brain Chemistry | Cells, Cultured - metabolism | HeLa Cells - ultrastructure | Membrane Microdomains - physiology | Mice | Cholesterol - biosynthesis | Digitonin - pharmacology | alpha-Synuclein | Amino Acid Substitution | Neurobiology of Disease
Journal Article
Journal Article
Cardiovascular Research, ISSN 0008-6363, 05/2010, Volume 86, Issue 2, pp. 311 - 320
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/1999, Volume 96, Issue 1, pp. 133 - 138
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2014, Volume 124, Issue 5, pp. 2059 - 2070
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e87594
The mevalonate pathway is essential in eukaryotes and responsible for a diversity of fundamental synthetic activities. 3-hydroxy- 3-methylglutaryl coenzyme A... 
IN-VITRO | ANTISCHISTOSOMAL ACTION | PLASMODIUM-FALCIPARUM | TRYPANOSOMA-CRUZI | MULTIDISCIPLINARY SCIENCES | HMG-COA REDUCTASE | FARNESYL PYROPHOSPHATE SYNTHASE | MEVALONATE PATHWAY | PROTEIN PRENYLATION | TRANSFERASE INHIBITORS | MOLECULAR-MECHANISMS | Mevalonic Acid - pharmacology | Pravastatin - pharmacology | Schistosoma mansoni - drug effects | Schistosoma mansoni - enzymology | Apoptosis - drug effects | Helminth Proteins - biosynthesis | Male | Helminth Proteins - genetics | Hydroxymethylglutaryl CoA Reductases - biosynthesis | Molecular Targeted Therapy | Schistosomiasis mansoni - drug therapy | Simvastatin - pharmacology | Schistosoma mansoni - genetics | Gene Knockdown Techniques | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Schistosomiasis mansoni - parasitology | RNA Interference | Anthelmintics - pharmacology | Inhibitory Concentration 50 | Female | Mice | Drug Evaluation, Preclinical | Hydroxymethylglutaryl CoA Reductases - genetics | Schistosomiasis | Enzymes | Hypercholesterolemia | Machine learning | Drug therapy | Health aspects | Statins | Killing | Drugs | RNA-mediated interference | Simvastatin | Caspase | Lethality | Parasites | Pravastatin | Drug development | Kinases | Gene expression | Learning algorithms | Eukaryotes | Mevalonic acid | Ribonucleic acids | Parasitic diseases | Hydroxymethylglutaryl-CoA reductase | Coenzyme A | Lipophilicity | Apoptosis
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2009, Volume 29, Issue 3, pp. 380 - 386
Objective-Activation of the endothelium by oxidized low-density lipoprotein (oxLDL) has been implicated in the development of atherosclerosis. Histone... 
Cytokines | Histone | Statins | Endothelium | HDAC | endothelium |