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Nature reviews. Cancer, ISSN 1474-1768, 2017, Volume 17, Issue 2, pp. 93 - 115
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2016, Volume 108, Issue 10, p. djw122
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 222 - 236
Acute myelogenous leukemia (AML) subtypes that result from oncogenic activation of homeobox (HOX) transcription factors are associated with poor prognosis. The... 
HEMATOPOIETIC-CELLS | PROGENITOR CELLS | HOX | MEDICINE, RESEARCH & EXPERIMENTAL | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | NPM1 MUTATIONS | ACUTE MYELOID-LEUKEMIA | GENE-EXPRESSION PROFILE | MLL | STEM | Phosphorothioate Oligonucleotides - genetics | Homeodomain Proteins - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Regulatory Sequences, Nucleic Acid | Transcriptome | Induction Chemotherapy | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Cell Transformation, Neoplastic - genetics | Base Sequence | Pre-B-Cell Leukemia Transcription Factor 1 | Binding Sites | Leukemia, Myeloid, Acute - therapy | Neoplastic Stem Cells - physiology | Doxorubicin - administration & dosage | Proto-Oncogene Proteins - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Combined Modality Therapy | Gene Expression Regulation, Leukemic | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Cytarabine - administration & dosage | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Binding | Mice, Inbred NOD | Mice | MicroRNAs - genetics | Myeloid Ecotropic Viral Integration Site 1 Protein | MicroRNA | Genetic transcription | Research | Flow cytometry | Insects | Leukemia | Cloning | MicroRNAs | Cell cycle | Software | Signatures | Gene expression | Deoxyribonucleic acid--DNA | Children & youth
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1064 - 1079
It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation. The... 
mTOR | translation | sensitivity | PI3K | therapy | resistance | TUMOR-SUPPRESSOR CANDIDATE | PROTEIN-KINASE | INITIATION-FACTOR 4E | ACUTE MYELOID-LEUKEMIA | GROWTH-FACTOR RECEPTOR | BONE-MARROW MICROENVIRONMENT | ONCOLOGY | AKT/PROTEIN-KINASE-B | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | CHRONIC LYMPHOCYTIC-LEUKEMIA | HEMATOLOGY | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | PTEN Phosphohydrolase - physiology | Apoptosis - genetics | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Gene Expression Regulation, Leukemic - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Transcription Factors - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | PTEN Phosphohydrolase - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Protein Processing, Post-Translational - drug effects | Drug Design | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Leukemia - genetics | Multiprotein Complexes - drug effects | PTEN Phosphohydrolase - genetics | Proteins - physiology | Transcription Factors - physiology | RNA, Messenger - genetics | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - physiology | Multiprotein Complexes - physiology | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Pseudogenes | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Proteins - drug effects | RNA, Neoplasm - genetics | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Genes | Leukemia | Physiological aspects | Development and progression | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 2136 - 2145.e7
Journal Article