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Hepatology, ISSN 0270-9139, 12/2012, Volume 56, Issue 6, pp. 2255 - 2267
Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the mechanism underlying the progression from cirrhosis to HCC... 
PROGENITOR CELLS | HEPATOCELLULAR-CARCINOMA | STEM-CELLS | HEPATOCYTES | TGF-BETA | EPIGENETIC REGULATION | PTEN | SELF-RENEWAL | TUMORIGENICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Rats, Wistar | TOR Serine-Threonine Kinases - metabolism | Humans | Glycoproteins - metabolism | Liver Neoplasms, Experimental - chemically induced | Male | MicroRNAs - metabolism | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Epithelial Cell Adhesion Molecule | Pluripotent Stem Cells - pathology | Liver Neoplasms, Experimental - metabolism | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Diethylnitrosamine | Liver Cirrhosis - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Antigens, Differentiation - metabolism | Liver Neoplasms, Experimental - pathology | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - metabolism | Liver - metabolism | Mice, Inbred C57BL | PTEN Phosphohydrolase - metabolism | Rats | Mice, SCID | AC133 Antigen | Cell Adhesion Molecules - metabolism | Cell Transformation, Neoplastic - metabolism | Pluripotent Stem Cells - metabolism | Thy-1 Antigens - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Pluripotent Stem Cells - drug effects | Liver Cirrhosis - pathology | Mice, Inbred NOD | Mice | Cell Transformation, Neoplastic - pathology | Transforming Growth Factor beta - metabolism | Proteins | Liver cancer | Liver cirrhosis | Hepatology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Neuron, ISSN 0896-6273, 08/2012, Volume 75, Issue 4, pp. 618 - 632
Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between... 
ALZHEIMERS-DISEASE BRAIN | DOMINANT OPTIC ATROPHY | MITOCHONDRIAL-FUNCTION | MOUSE MODEL | LIGHT-CHAIN | FRONTOTEMPORAL DEMENTIA | AXONAL-TRANSPORT | NEUROSCIENCES | DYNAMIN-RELATED PROTEIN | PHOSPHORYLATION SITES | TRANSGENIC MICE | Neurons - pathology | Microtubule-Associated Proteins - genetics | Tauopathies - genetics | Cytoskeletal Proteins - genetics | Gelsolin - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Tauopathies - pathology | Cytoplasm - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | GTP-Binding Proteins - genetics | Nerve Degeneration - metabolism | Neurons - ultrastructure | tau Proteins - genetics | Cell Death - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | ATP Synthetase Complexes - metabolism | Cell Cycle Proteins - genetics | Tauopathies - complications | Cytoskeletal Proteins - metabolism | Myosins - metabolism | Cytoplasm - genetics | RNA Interference - physiology | Disease Models, Animal | In Situ Nick-End Labeling | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | Cell Cycle Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Analysis of Variance | GTP Phosphohydrolases - genetics | Gelsolin - genetics | Mice | Drosophila Proteins - genetics | Nerve Degeneration - etiology | Voltage-Dependent Anion Channels - metabolism | GTP-Binding Proteins - metabolism | Nervous system diseases | Actin | Neurons | Utrophin | Myosin | Mitochondrial DNA | Alzheimer's disease | Proteins | Phosphorylation | Mitochondria | Neurotoxicity | Insects | Microscopy | Neurodegeneration | Pathogenesis | Morphology | Mutation | Defects | Index Medicus | Neurodegenerative diseases | Tau protein | Cell death | Elongation
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2018, Volume 13, Issue 7, pp. e0200847 - e0200847
To investigate the role of miR-122 in the development and regression of non-alcoholic fatty liver disease (NAFLD) in vitro, we used multicellular 3D human... 
OVEREXPRESSION | HOMEOSTASIS | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | DISEASE | SENSITIVITY | SYSTEMS | LIPOPROTEIN-LIPASE | Glucose Transporter Type 4 - metabolism | Signal Transduction | Humans | Liver - metabolism | Organoids - cytology | MicroRNAs - metabolism | Necrosis - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Hepatocytes - metabolism | Insulin Receptor Substrate Proteins - metabolism | Inflammation - metabolism | Insulin - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 8 - metabolism | Organoids - metabolism | Chemokine CCL3 - metabolism | Chemokine CCL2 - metabolism | Kupffer Cells - metabolism | Liver - cytology | Interleukin-6 - metabolism | Care and treatment | MicroRNA | Liver diseases | Development and progression | Insulin resistance | Inflammation | Research | Laboratories | Liver | Kupffer cells | Fluorescence | Reversing | Lipids | Necrosis | Interleukin 6 | Liver cancer | Fatty liver | Organoids | Rodents | Gastroenterology | Drug metabolism | Lipoprotein (low density) receptors | Inhibition | Lipid metabolism | Stellate cells | Cytokines | Incubation | Internal medicine | CCL3 protein | Regression analysis | Gene expression | Metabolism | Ribonucleic acid--RNA | Insulin | Patients | Fatty acids | Endothelial cells | Gelatinase B | Steatosis | Medicine | Urea | Signaling | Hepatocytes | Tumor necrosis factor | Pharmacy | Fibrosis | Neutrophil collagenase | Diabetes | Chemokines | Monocyte chemoattractant protein 1 | Metabolic disorders | Index Medicus | RNA | Ribonucleic acid
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2012, Volume 109, Issue 23, pp. 8983 - 8988
In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates glutamine catabolism to fuel growth and proliferation of cancer cells... 
T lymphocytes | Cell growth | Energy metabolism | Cellular metabolism | Small interfering RNA | Catabolism | Biosynthesis | Tumors | Cancer | Apoptosis | Amino acids | miRNA | Reactive oxygen species | Metabolic tumor suppressor | Redox signaling | APOPTOSIS | MULTIDISCIPLINARY SCIENCES | amino acids | CELL-GROWTH | HYPOXIA | CANCER | B-CELLS | PYRROLINE-5-CARBOXYLIC ACID | redox signaling | OXIDASE | GENE | reactive oxygen species | TUMOR-SUPPRESSOR | CARBOXYLATION | metabolic tumor suppressor | Gas Chromatography-Mass Spectrometry | Reactive Oxygen Species - metabolism | Nitrogen Isotopes - metabolism | Oxidation-Reduction | Proline - metabolism | Pyrroline Carboxylate Reductases - metabolism | Humans | Glutamine - metabolism | MicroRNAs - metabolism | Carbon Isotopes - metabolism | Gene Expression Regulation, Enzymologic - physiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Chromatin Immunoprecipitation | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Nuclear Magnetic Resonance, Biomolecular | Proline Oxidase - metabolism | Real-Time Polymerase Chain Reaction | Cell proliferation | Transcription factors | Proline | Cell metabolism | Genetic aspects | Properties | Glutamine | Metabolism | Prostate cancer | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e34653 - e34653
Background: Shedding microvesicles are membrane released vesicles derived directly from the plasma membrane. Exosomes are released membrane vesicles of late... 
CA2&-STIMULATED ADENOSINE-TRIPHOSPHATASE | HUMAN PROSTATIC FLUID | EPITHELIAL-CELLS | MEMBRANE-VESICLES | BIOLOGY | HUMAN SEMEN | SPERMATOZOA | EXTRACELLULAR ORGANELLES PROSTASOMES | SECRETION | TUMOR-DERIVED EXOSOMES | HUMAN SPERM | Exosomes - metabolism | Cell Line | NIH 3T3 Cells | Microscopy, Electron, Transmission - methods | Secretory Vesicles - metabolism | DNA - metabolism | RNA, Messenger - metabolism | Clathrin - metabolism | Animals | Cell Nucleus - metabolism | Biological Transport | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Mice | Annexin A2 - metabolism | Caveolin 3 - metabolism | Fibroblasts - metabolism | RNA - metabolism | Clathrin | RNA | Genes | Hostages | Nucleotide sequencing | Gene expression | DNA sequencing | Heart | Flow cytometry | Sperm | Centrifugation | Lung cancer | Ultracentrifugation | Biochemistry | Exosomes | Cytosol | Nuclei | Muscular dystrophy | Gene sequencing | Vesicles | Rodents | Penicillin | Fibroblasts | Public health | Deoxyribonucleic acid--DNA | Messages | Nucleotide sequence | Caveolin | Membrane vesicles | Cardiomyocytes | Electron microscopy | Metabolism | Medicine | Polymerase | DNA nucleotidylexotransferase | Cytometry | Hospitals | Transmission electron microscopy | Ribonucleic acids | MicroRNAs | Media (differential) | Biochemical characteristics | Clinical medicine | Mutation | Prostate | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper | Deoxyribonucleic acid | DNA
Journal Article
Diabetes, ISSN 0012-1797, 02/2017, Volume 66, Issue 2, pp. 347 - 357
MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is... 
MIR-122 | LIPID-METABOLISM | PLASMA | INSULIN-RESISTANCE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | DENSITY-LIPOPROTEINS | OUTCOMES | PRIMATES | BRUNECK | Multivariate Analysis | Prevalence | Prospective Studies | Atorvastatin Calcium - pharmacology | Humans | Middle Aged | Glycoproteins - metabolism | Male | Metabolic Syndrome - metabolism | MicroRNAs - metabolism | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Serum Albumin, Human | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Oligonucleotides - pharmacology | Mass Spectrometry | Adult | Female | Real-Time Polymerase Chain Reaction | Atorvastatin Calcium - therapeutic use | Hepatocytes - drug effects | Metabolic Syndrome - epidemiology | Dyslipidemias - drug therapy | Insulin Resistance | Lipid Metabolism | Reverse Transcriptase Polymerase Chain Reaction | Obesity - metabolism | Blotting, Northern | Animals | Carrier Proteins - metabolism | Complement Factor H - metabolism | Dyslipidemias - epidemiology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Lipoproteins, VLDL - metabolism | Obesity - epidemiology | MicroRNAs - drug effects | Dyslipidemias - metabolism | Aged | Mice | Serum Albumin - metabolism | Type 2 diabetes | MicroRNA | Analysis | Research | Metabolic syndrome X | Risk factors | Public health | Proteins | Proteomics | Lipids | Insulin resistance | Diabetes | Mass spectrometry | Fatty acids | Index Medicus | Abridged Index Medicus | Metabolism
Journal Article
Journal of Dairy Science, ISSN 0022-0302, 01/2016, Volume 99, Issue 1, pp. 758 - 770
Recent studies demonstrating a higher incidence of metabolic disorders after calving have challenged the management practice of increasing dietary energy... 
nutrition | transition cow | inflammation | immune response | Transition cow | Inflammation | Immune response | Nutrition | GENE NETWORKS | LEPTIN | AGRICULTURE, DAIRY & ANIMAL SCIENCE | ADIPOCYTES | FOOD SCIENCE & TECHNOLOGY | ENERGY-INTAKE | HOLSTEIN COWS | INSULIN-RESISTANCE | LIVER | FAT | HUMAN OBESITY | MICRORNA EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Fatty Acid Synthases - metabolism | Leptin - metabolism | Tumor Necrosis Factor-alpha - genetics | Transcriptome | MicroRNAs - metabolism | Overnutrition - metabolism | Interleukin-1beta - genetics | PPAR gamma - metabolism | RNA, Messenger - metabolism | Peripartum Period - physiology | Adipose Tissue - metabolism | Inflammation - metabolism | Subcutaneous Fat - metabolism | Interleukin-1beta - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Female | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | Nutritional Status | Lipogenesis | Fatty Acid Synthases - genetics | Interleukin-6 - metabolism | Diet - veterinary | PPAR gamma - genetics | Interleukin-6 - genetics | Breeding | RNA, Messenger - genetics | Chemokine CCL2 - genetics | Lipid Metabolism | Leptin - genetics | Energy Intake | Lipolysis | Animals | Energy Metabolism | Chemokine CCL5 - genetics | Overnutrition - veterinary | MicroRNAs - genetics | Cattle - physiology | Animal Feed | Nutritional aspects | Research | Metabolism | Health aspects | Analysis | Dairy cattle | Index Medicus
Journal Article