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Cell reports (Cambridge), ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Index Medicus | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Trends in molecular medicine, ISSN 1471-4914, 07/2016, Volume 22, Issue 7, pp. 615 - 628
... to degradation of key RNAs and pathologies due to RNP loss in ‘RNP hypo-assembly diseases’. Examples of these diseases include spinal muscular atrophy ( SMA... 
Pathology | stress granules | dyskeratosis congenita | spinal muscular atrophy | RNA quality control | RNP assembly | therapy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Immunologic Deficiency Syndromes - pathology | Microcephaly - genetics | Scoliosis - genetics | Hair - abnormalities | Humans | Walker-Warburg Syndrome - genetics | Muscular Dystrophies - genetics | Ribonucleoproteins - analysis | Dwarfism - metabolism | Osteochondrodysplasias - genetics | Walker-Warburg Syndrome - metabolism | Hair - pathology | Muscular Atrophy, Spinal - metabolism | Parkinson Disease - pathology | Muscular Dystrophies - metabolism | Hirschsprung Disease - pathology | Fetal Growth Retardation - metabolism | Ribonucleoproteins - metabolism | RNA Stability | Muscular Atrophy, Spinal - pathology | Fetal Growth Retardation - pathology | Osteochondrodysplasias - congenital | Mutation | Osteochondrodysplasias - metabolism | Osteochondrodysplasias - pathology | Hirschsprung Disease - genetics | Hair - metabolism | Fetal Growth Retardation - genetics | Dyskeratosis Congenita - genetics | Scoliosis - pathology | Muscular Atrophy, Spinal - genetics | Microcephaly - pathology | Ribonucleoproteins - genetics | Dyskeratosis Congenita - metabolism | Parkinson Disease - metabolism | Dwarfism - pathology | Walker-Warburg Syndrome - pathology | Mallory Bodies - genetics | Mallory Bodies - pathology | Microcephaly - metabolism | Scoliosis - metabolism | Parkinson Disease - genetics | Muscular Dystrophies - pathology | Dwarfism - genetics | Mallory Bodies - metabolism | Animals | Dyskeratosis Congenita - pathology | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Hirschsprung Disease - metabolism | RNA | Index Medicus | Therapy | Spinal Muscular Atrophy | Stress granules | Dyskeratosis Congenita
Journal Article
The Lancet (British edition), ISSN 0140-6736, 08/2016, Volume 388, Issue 10047, pp. 898 - 904
Summary Background Zika virus is an arthropod-borne virus that is a member of the family Flaviviridae transmitted mainly by mosquitoes of the genus Aedes .... 
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Pregnancy Trimester, Second | Limb Deformities, Congenital - virology | Pregnancy Complications, Infectious - virology | Neuroglia - pathology | Zika Virus Infection - congenital | Humans | Abortion, Spontaneous - virology | Brain - virology | Infant | Male | Microcephaly - virology | Pregnancy Trimester, First | Pregnancy Trimester, Third | Antigens, Viral - isolation & purification | Autopsy | Microcephaly - pathology | Fatal Outcome | Brazil | Adult | Female | RNA, Viral - isolation & purification | Zika Virus - immunology | Zika Virus Infection - pathology | Zika Virus - isolation & purification | Reverse Transcriptase Polymerase Chain Reaction | Pregnancy Complications, Infectious - pathology | Syndrome | Immunohistochemistry - methods | Pregnancy | Ultrasonography, Prenatal | Limb Deformities, Congenital - diagnostic imaging | Placenta - pathology | Brain - pathology | Neuroglia - virology | Placenta - virology | Virus diseases | Mosquitoes | Lung diseases | Birth defects | Conjunctivitis | Health aspects | Hyperthermia | Abortion | Fever | Zoonoses | Diseases | Disease transmission | Genetic disorders | Analysis | Pathology | Zika virus | Congenital diseases | Maternal & child health | Newborn babies | Health risk assessment | Index Medicus | Abridged Index Medicus
Journal Article
PLoS genetics, ISSN 1553-7390, 05/2016, Volume 12, Issue 5, pp. e1006037 - e1006037
One to two percent of all children are born with a developmental disorder requiring pediatric hospital admissions. For many such syndromes, the molecular... 
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Usage | Molecular diagnostic techniques | Dogs | Genetic aspects | Bone diseases | Gene expression | Health aspects | Diseases | Pathology | Mortality | Genes | Index Medicus
Journal Article
Acta neuropathologica, ISSN 1432-0533, 03/2017, Volume 133, Issue 6, pp. 983 - 999
Journal Article
PLoS pathogens, ISSN 1553-7374, 02/2018, Volume 14, Issue 2, pp. e1006854 - e1006854
Despite the low case fatality, Zika virus (ZIKV) infection has been associated with microcephaly in infants and Guillain-Barre A syndrome. Antiviral and... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Leukocytes - pathology | Sexually Transmitted Diseases, Viral - drug therapy | Zika Virus Infection - drug therapy | Cell Nucleus Size - drug effects | Cell Nucleus Shape - drug effects | Male | Azoles - therapeutic use | Spermatozoa - metabolism | Testis - drug effects | Leukocytes - immunology | Zika Virus Infection - virology | Testis - immunology | Receptors, Interferon - genetics | Organoselenium Compounds - therapeutic use | Zika Virus - pathogenicity | Spermatozoa - virology | Zika Virus - immunology | Spermatogenesis - drug effects | Spermatozoa - pathology | Cytokines - metabolism | Zika Virus Infection - pathology | Cell Size - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Zika Virus - drug effects | Spermatozoa - immunology | Mice, Knockout | Receptors, Interferon - metabolism | Cell Shape - drug effects | Sexually Transmitted Diseases, Viral - transmission | Zika Virus Infection - transmission | Antioxidants - therapeutic use | Animals | Testis - pathology | Sexually Transmitted Diseases, Viral - virology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Leukocytes - drug effects | Sexually Transmitted Diseases, Viral - pathology | Oxidative Stress - drug effects | Leukocytes - metabolism | Testis - virology | Prevention | Sexually transmitted diseases | Oxidative stress | Reactive oxygen species | Disease | Guillain-Barre syndrome | Spermatogenesis | Sperm | Pathogenesis | β-Interferon | Clinical trials | Inflammatory response | Homology | Viruses | Sexual transmission | Zika virus | Infants | Infections | Microcephaly | Aquatic insects | Interleukin 6 | Antioxidants | α-Interferon | Receptors | Granulocyte colony-stimulating factor | Rodents | Interleukin 1 | Peroxidase | Glutathione | Vector-borne diseases | Glutathione peroxidase | Enzymes | Medical research | Cytokines | Inflammation | Studies | Pathology | Mosquitoes | Disease transmission | Microencephaly | Nitric oxide | γ-Interferon | Fatalities | Interferon | Mice | Infiltration | Testes | Index Medicus
Journal Article