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Genes and Development, ISSN 0890-9369, 08/2003, Volume 17, Issue 15, pp. 1835 - 1840
Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer... 
Pericyte | Cell retention | Retina | Mesangial cell | PDGF | Heparan sulphate proteoglycan | DIABETIC-RETINOPATHY | VEGF ISOFORMS | pericyte | ANGIOGENESIS | A-CHAIN | DEVELOPMENTAL BIOLOGY | mesangial cell | CELL BIOLOGY | cell retention | retina | IN-VIVO | GENETICS & HEREDITY | MICE | heparan sulphate proteoglycan | HEPARAN-SULFATE PROTEOGLYCANS | GROWTH-FACTOR | BINDING | SMOOTH-MUSCLE CELLS | Kidney - physiology | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Microcirculation - metabolism | Retina - metabolism | Vascular Endothelial Growth Factors | Glomerulosclerosis, Focal Segmental - genetics | Molecular Sequence Data | Intercellular Signaling Peptides and Proteins - metabolism | Lymphokines - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Retinal Degeneration - genetics | Pericytes - metabolism | Proteinuria - genetics | Amino Acid Motifs | Retina - physiology | Phenotype | Platelet-Derived Growth Factor - metabolism | Animals | Endothelium, Vascular - metabolism | Alleles | Mice | Models, Genetic | Mutation | Microscopy, Fluorescence | Cell Movement | Proteins | Blood platelets | Secretion | Analysis | Genetic research | Genetic aspects | Growth factors | Endothelium | Index Medicus | Research Communications | Glomerulosclerosis; Focal Segmental/genetics | Intercellular Signaling Peptides and Proteins/metabolism | Platelet-Derived Growth Factor/metabolism | Proto-Oncogene Proteins c-sis/genetics/metabolism | Proteinuria/genetics | Models; Genetic | Microcirculation/metabolism | Lymphokines/metabolism | Microscopy; Fluorescence | Pericytes/metabolism | Kidney/physiology | Protein Structure; Tertiary | Retinal Degeneration/genetics | Endothelial Growth Factors/metabolism | Endothelium; Vascular/metabolism | Retina/metabolism/physiology
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2011, Volume 301, Issue 2, pp. H363 - H372
Ungvari Z, Bailey-Downs L, Sosnowska D, Gautam T, Koncz P, Losonczy G, Ballabh P, de Cabo R, Sonntag WE, Csiszar A. Vascular oxidative stress in aging: a... 
Senescence | Vascular injury | Oxidative stress resistance | Apoptosis | LIFE-SPAN | KAPPA-B ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | apoptosis | NECROSIS-FACTOR-ALPHA | NAKED MOLE-RAT | ARTERIAL ENDOTHELIAL-CELLS | LONGEST-LIVING RODENT | senescence | vascular injury | TRANSCRIPTION FACTOR NRF2 | oxidative stress resistance | MN SUPEROXIDE-DISMUTASE | NF-E2-RELATED FACTOR-2 | PERIPHERAL VASCULAR DISEASE | OXIDIZED PHOSPHOLIPIDS | Carotid Arteries - metabolism | Age Factors | Oxidative Stress | Rats, Inbred F344 | Homeostasis | Male | NF-kappa B - metabolism | Aorta - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | RNA, Messenger - metabolism | Rats, Inbred BN | Aging - genetics | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Heme Oxygenase (Decyclizing) - metabolism | Heme Oxygenase (Decyclizing) - genetics | Interleukin-6 - metabolism | Tissue Culture Techniques | Rats | Aging - pathology | Hydrogen Peroxide - metabolism | Aorta - pathology | Gene Expression Regulation, Enzymologic | Hyperglycemia - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Analysis of Variance | NF-E2-Related Factor 2 - metabolism | Glucose - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Aging - metabolism | Antioxidants | Oxidative stress | Transcription factors | Physiological aspects | Aging | Research | Health aspects | Cardiovascular disease | Genes | Rodents | Medical treatment | Index Medicus | Vascular Biology and Microcirculation
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer's disease(2,3) and is associated with... 
OXIDATIVE STRESS | DEMENTIA | PROTEIN | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | COGNITIVE IMPAIRMENT | NEURODEGENERATION | MICE | APOE | BLOOD-BRAIN-BARRIER | EXPRESSION | Neurons - pathology | Apolipoprotein E4 - genetics | Apolipoproteins E - deficiency | Cerebrovascular Circulation - physiology | Humans | Blood-Brain Barrier - physiopathology | NF-kappa B - metabolism | Apolipoproteins E - metabolism | Microcirculation | Matrix Metalloproteinase 9 - metabolism | Apolipoprotein E2 - deficiency | Apolipoprotein E4 - deficiency | Apolipoprotein E3 - deficiency | Blood-Brain Barrier - physiology | Neurons - metabolism | Cyclophilin A - metabolism | Apolipoprotein E4 - metabolism | Neurodegenerative Diseases - pathology | Apolipoprotein E2 - genetics | Pericytes - metabolism | Mice, Transgenic | Hippocampus - pathology | Neurodegenerative Diseases - metabolism | Apolipoprotein E3 - metabolism | Apolipoprotein E2 - metabolism | Blood-Brain Barrier - drug effects | Cyclophilin A - antagonists & inhibitors | Hippocampus - metabolism | Apolipoprotein E3 - genetics | Animals | Apolipoproteins E - genetics | Mice | Cyclophilin A - deficiency | Cyclophilin | Brain cells | Physiological aspects | Development and progression | Apolipoproteins | Properties | Alzheimer's disease | Proteins | Studies | Rodents | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2013, Volume 305, Issue 3, pp. H344 - H353
A contributing factor to increased peripheral resistance seen during hypertension is an increased production of endothelium-derived contractile factors... 
Cyclooxygenase | EDCF | ERK1/2 | cPLA | Endoplasmic reticulum stress | CYTOSOLIC PHOSPHOLIPASE A | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MESENTERIC-ARTERIES | ER STRESS | OLETF RATS | cyclooxygenase | endoplasmic reticulum stress | PROSTANOID RECEPTORS | UNFOLDED PROTEIN RESPONSE | GENE-EXPRESSION | RENAL-ARTERIES | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | Antihypertensive Agents - pharmacology | Epoprostenol - metabolism | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Rats, Inbred WKY | Endothelium, Vascular - drug effects | Hypertension - drug therapy | Male | Aorta - metabolism | Dinoprost - metabolism | Muscle, Smooth, Vascular - physiopathology | Dose-Response Relationship, Drug | Taurochenodeoxycholic Acid - pharmacology | Phenylbutyrates - pharmacology | tert-Butylhydroperoxide - pharmacology | Blood Pressure - drug effects | Membrane Proteins - metabolism | Aorta - physiopathology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Endoplasmic Reticulum Stress - drug effects | Acetylcholine - pharmacology | Aorta - drug effects | Cells, Cultured | Endothelium, Vascular - physiopathology | bcl-2-Associated X Protein - metabolism | Rats | Vasoconstriction - drug effects | Hypertension - physiopathology | Phospholipases A2, Cytosolic - metabolism | Hydrogen Peroxide - metabolism | Hypertension - metabolism | Thromboxane A2 - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Arachidonic Acid - pharmacology | Cyclooxygenase 1 - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Hypertension | Physiological aspects | Stress (Physiology) | Endoplasmic reticulum | Health aspects | Muscle contraction | Cardiovascular disease | Rodents | Medical treatment | Index Medicus | cPLA2 | Vascular Biology and Microcirculation | ERK1
Journal Article
Neurochemistry International, ISSN 0197-0186, 2009, Volume 54, Issue 3, pp. 253 - 263
Blood–brain barrier (BBB) characteristics are induced and maintained by cross-talk between brain microvessel endothelial cells and neighbouring elements of the... 
Astrocytes | Pericytes | In vitro BBB model (rat) | Tight junction | Transendothelial electrical resistance | Co-culture | P-Glycoprotein | Drug permeability | Blood–brain barrier | Brain endothelial cells | Blood-brain barrier | DRUG | PERMEABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGIOPOIETIN-1 | INDUCTION | GLIAL-CELLS | NEUROSCIENCES | MESSENGER-RNA | IN-VITRO MODEL | CULTURES | EXPRESSION | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pericytes - ultrastructure | Phosphoproteins - metabolism | Blood-Brain Barrier - ultrastructure | Occludin | Microcirculation - physiology | Endothelial Cells - ultrastructure | Membrane Proteins - metabolism | Capillaries - metabolism | Rhodamine 123 - pharmacokinetics | Tight Junctions - metabolism | Microscopy, Electron, Transmission | Capillaries - ultrastructure | Endothelial Cells - metabolism | Pericytes - metabolism | Cells, Cultured | Rats | Claudin-5 | Cerebral Arteries - ultrastructure | Membrane Potentials - physiology | Blood-Brain Barrier - metabolism | Astrocytes - ultrastructure | Tight Junctions - ultrastructure | Animals | Carrier Proteins - metabolism | Zonula Occludens-1 Protein | Cell Membrane Permeability - physiology | Cerebral Arteries - metabolism | Models, Biological | Cell Membrane Permeability - drug effects | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Astrocytes - metabolism | Proteins | Drug resistance in microorganisms | Brain | Fluorescein | Physiological aspects | Glucose | Universities and colleges | Permeability | Dextrose | Endothelium | Index Medicus
Journal Article
Journal Article
Journal of Chemical Neuroanatomy, ISSN 0891-0618, 2008, Volume 36, Issue 2, pp. 107 - 121
The blood–brain barrier (BBB) plays an important role in controlling the access of substances to the brain. Of the circumventricular organs (CVO), i.e. areas... 
EBA | Ghrelin | Arcuate nucleus | Leptin | Median eminence | Tight junction | AgRP | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | median eminence | MONOCLONAL-ANTIBODY | leptin | NEUROSCIENCES | NERVOUS-SYSTEM CONTROL | ghrelin | IMMUNOCYTOCHEMICAL LOCALIZATION | CIRCUMVENTRICULAR ORGANS | arcuate nucleus | TRANSFERRIN RECEPTOR | ENDOTHELIAL-CELLS | TISSUE BARRIERS | HEPG2-TYPE GLUCOSE TRANSPORTER | tight junction | Immunohistochemistry | Microcirculation - metabolism | Neuroglia - ultrastructure | Median Eminence - ultrastructure | Male | Pericytes - ultrastructure | Phosphoproteins - metabolism | Blood-Brain Barrier - ultrastructure | Endothelial Cells - ultrastructure | Hypothalamus - blood supply | Neurons - ultrastructure | Median Eminence - blood supply | Arcuate Nucleus of Hypothalamus - blood supply | Membrane Proteins - metabolism | Neurons - metabolism | Median Eminence - metabolism | Myocytes, Smooth Muscle - metabolism | Biomarkers - metabolism | Tight Junctions - metabolism | Arcuate Nucleus of Hypothalamus - ultrastructure | Endothelial Cells - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Pericytes - metabolism | Rats | Claudin-5 | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Hypothalamus - ultrastructure | Nerve Tissue Proteins - metabolism | Tight Junctions - ultrastructure | Animals | Hypothalamus - metabolism | Zonula Occludens-1 Protein | Neuroglia - metabolism | Microcirculation - ultrastructure | Myocytes, Smooth Muscle - ultrastructure | Neuropeptide Y | Brain | Neurosciences | Glucose | Sulfates | Muscle proteins | Dextrose | Glucose metabolism | Analysis | Intermedin | Intermediate filament proteins | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, pp. e36893 - e36893
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 15, pp. 2757 - 2764
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 11/2012, Volume 132, Issue 11, pp. 2642 - 2651
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2008, Volume 295, Issue 2, pp. 491 - 498
We hypothesized that impaired nitric oxide (NO)-dependent dilation (endothelial dysfunction) in Type 2 diabetes results, in part, from elevated production of... 
Coronary microcirculation | Reactive oxygen species | Nitric oxide | nitric oxide | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | OXIDANT STRESS | ATHEROSCLEROSIS | RECEPTOR | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | RAGE | coronary microcirculation | reactive oxygen species | VASCULAR INFLAMMATION | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | GLYCATION END-PRODUCTS | Body Weight | Coronary Vessels - physiopathology | Glycated Hemoglobin A - metabolism | NADPH Oxidases - metabolism | Male | NF-kappa B - metabolism | Lymphotoxin-alpha - metabolism | Diabetes Mellitus, Type 2 - metabolism | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Coronary Vessels - metabolism | Diabetic Angiopathies - physiopathology | Fasting - blood | Arterioles - physiopathology | Lipids - blood | Superoxides - metabolism | Female | Receptor for Advanced Glycation End Products | Disease Models, Animal | Diabetic Angiopathies - metabolism | Coronary Vessels - drug effects | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Arterioles - drug effects | Animals | Arterioles - metabolism | Diabetes Mellitus, Type 2 - physiopathology | Signal Transduction - drug effects | Glycation End Products, Advanced - metabolism | Mice | Coronary Circulation - drug effects | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Signal transduction | Rodents | Coronary vessels | Oxidation | Diabetes | Cells | Index Medicus | Translational Physiology
Journal Article