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ACS Nano, ISSN 1936-0851, 11/2013, Volume 7, Issue 11, pp. 9881 - 9895
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2018, Volume 293, Issue 32, pp. 12634 - 12646
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 35, pp. 14425 - 14437
The misfolding of proteins and their accumulation in extracellular tissue compartments as insoluble amyloid or amorphous protein aggregates are a hallmark... 
HUMAN-PLASMA | AMYLOID FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-BETA | CLUSTERIN | DEGRADATION | DENATURED PROTEINS | TOXICITY | FIBRINOLYTIC SYSTEM | MISFOLDING DISEASES | MOLECULAR-MECHANISMS | Protein Aggregates | Microglia - metabolism | Tissue Plasminogen Activator - metabolism | Peptide Fragments - toxicity | Humans | Plasminogen Activators - metabolism | Endothelium, Vascular - drug effects | Plasminogen - metabolism | Plasminogen Activators - toxicity | Tissue Plasminogen Activator - chemistry | Endothelium, Vascular - ultrastructure | Clusterin - metabolism | Superoxide Dismutase-1 - metabolism | Microglia - pathology | Fibrinolysin - metabolism | Peptide Fragments - genetics | Plasminogen Activators - genetics | alpha-2-Antiplasmin - metabolism | Clusterin - chemistry | Conalbumin - metabolism | Recombinant Proteins - metabolism | Cell Line | Cell Survival - drug effects | Peptide Fragments - metabolism | Microglia - drug effects | Fibrinolysin - antagonists & inhibitors | Plasminogen Activators - chemistry | Solubility | Recombinant Proteins - chemistry | Superoxide Dismutase-1 - chemistry | Conalbumin - chemistry | Fibrinolysin - chemistry | Peptide Fragments - chemistry | Animals | Endothelium, Vascular - metabolism | Microglia - ultrastructure | Plasminogen - chemistry | Superoxide Dismutase-1 - genetics | Hydrophobic and Hydrophilic Interactions | Endothelium, Vascular - pathology | Mice | Mutation | Amino Acid Substitution | Index Medicus | protease | toxicity | Protein Structure and Folding | chaperone | protein folding | extracellular chaperones | amorphous protein aggregate | protein degradation | plasminogen activation system
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2017, Volume 292, Issue 32, pp. 13415 - 13427
Recently, a single study revealed a new complex composed of Toll-like receptor 4 (TLR4), TLR6, and CD36 induced by fibrillary A beta peptides, the hallmark of... 
ACTIVATION | HUMAN PROSTATE | ALZHEIMERS-DISEASE | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TOLL-LIKE RECEPTORS | TRANSMEMBRANE DOMAIN | TUMOR-GROWTH | CELL-LINE | PEPTIDE | Microglia - metabolism | Coculture Techniques | CD36 Antigens - chemistry | Alzheimer Disease - pathology | Microglia - pathology | Neurons - metabolism | Toll-Like Receptor 4 - antagonists & inhibitors | Alzheimer Disease - immunology | Peptide Fragments - genetics | Toll-Like Receptor 6 - metabolism | Cell Survival - drug effects | Alzheimer Disease - drug therapy | Recombinant Proteins - chemistry | Toll-Like Receptor 4 - genetics | Recombinant Fusion Proteins - chemistry | Toll-Like Receptor 4 - metabolism | Peptide Fragments - chemistry | Ligands | Mice | Nootropic Agents - pharmacology | Protein Multimerization - drug effects | Neurons - pathology | CD36 Antigens - genetics | Immunoprecipitation | Nootropic Agents - metabolism | Peptide Fragments - pharmacology | Recombinant Fusion Proteins - metabolism | Nerve Tissue Proteins - chemistry | Microglia - immunology | CD36 Antigens - metabolism | Toll-Like Receptor 6 - genetics | Fluorescence Resonance Energy Transfer | Neurons - drug effects | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Peptide Fragments - metabolism | Toll-Like Receptor 6 - chemistry | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Cells, Cultured | Neurons - immunology | Toll-Like Receptor 4 - chemistry | Recombinant Proteins - pharmacology | Nootropic Agents - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Alzheimer Disease - metabolism | Toll-Like Receptor 6 - antagonists & inhibitors | Index Medicus | Immunology | neurodegenerative disease | Alzheimer disease | inflammation | neuroinflammation | amyloid-β | toll-like receptor | CD36 | TLR6 | microglia | TLR4
Journal Article
Molecules, ISSN 1420-3049, 01/2017, Volume 22, Issue 1, pp. 27 - 27
Activated microglia are known to be a major source of cellular neuroinflammation which causes various neurodegenerative diseases, including Alzheimer's... 
BV-2 microglia | Ent-kaurane diterpenoids | Pteris multifida | Anti-neuroinflammation | Nitric oxide (NO) | nitric oxide (NO) | ACTIVATION | ent-kaurane diterpenoids | NITRIC-OXIDE PRODUCTION | MICROGLIA | MACROPHAGES | CHEMISTRY, ORGANIC | anti-neuroinflammation | CONSTITUENTS | Plant Extracts - chemistry | Interleukin-6 - antagonists & inhibitors | Diterpenes, Kaurane - isolation & purification | Dinoprostone - biosynthesis | Solvents - chemistry | Tumor Necrosis Factor-alpha - genetics | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Microglia - immunology | Neuroprotective Agents - pharmacology | Cyclooxygenase 2 - genetics | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - isolation & purification | Methanol - chemistry | Cyclooxygenase 2 - immunology | Diterpenes, Kaurane - chemistry | Interleukin-1beta - antagonists & inhibitors | Diterpenes, Kaurane - pharmacology | Microglia - cytology | Cell Line | Nitric Oxide - biosynthesis | Neuroprotective Agents - chemistry | Interleukin-6 - genetics | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Nitric Oxide - antagonists & inhibitors | Gene Expression Regulation | Interleukin-1beta - immunology | Inflammation | Animals | Anti-Inflammatory Agents - chemistry | Pteris - chemistry | Neuroprotective Agents - isolation & purification | Plant Roots - chemistry | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Mice | Dinoprostone - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Nuclear magnetic resonance--NMR | Neurodegenerative diseases | Roots | Prostaglandin E2 | Data processing | Microglia | Lipopolysaccharides | Prostaglandin endoperoxide synthase | Interleukin 6 | Methyl alcohol | Tumor necrosis factor | Diterpenes | Tumor necrosis factor-TNF | Cyclooxygenase-2 | Index Medicus
Journal Article
Journal Article
by Zheng, J and Fan, R and Wu, HQ and Yao, HH and Yan, YJ and Liu, JM and Ran, L and Sun, ZF and Yi, LZ and Dang, L and Gan, PP and Zheng, P and Yang, TL and Zhang, Y and Tang, T and Wang, Y
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1604 - 12
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack... 
RESPONSES | ACTIVATION | NATURAL-PRODUCTS | STRATEGY | MULTIDISCIPLINARY SCIENCES | PHENYLALANINE | MICE | CHIRALITY | SUPRAMOLECULAR HYDROGELS | AGGREGATION | DISCOVERY | Inflammation - pathology | Rheum - chemistry | Anthraquinones - administration & dosage | Drug Carriers - administration & dosage | Delayed-Action Preparations - chemistry | Hydrogels - pharmacokinetics | Lipopolysaccharides - immunology | Drug Carriers - chemistry | Delayed-Action Preparations - administration & dosage | Phytochemicals - pharmacokinetics | Signal Transduction - immunology | Microglia - immunology | Nanofibers - administration & dosage | Inflammation - drug therapy | Hydrogels - administration & dosage | Delayed-Action Preparations - pharmacokinetics | Microglia - pathology | Transcription Factor RelA - immunology | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Phosphorylation - immunology | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Nanofibers - chemistry | Phytochemicals - chemistry | Cell Line | Nanofibers - ultrastructure | Phytochemicals - administration & dosage | Microscopy, Electron, Scanning | Microglia - drug effects | Inflammation - immunology | NF-KappaB Inhibitor alpha - immunology | Toll-Like Receptor 4 - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | NF-KappaB Inhibitor alpha - metabolism | Drug Liberation | Drug Carriers - pharmacokinetics | Mice | Anthraquinones - chemistry | Anthraquinones - pharmacokinetics | Hydrogels - chemistry | Translocation | Self assembly | Hydrogels | Gels | Toxicity | Cytotoxicity | Inflammation | TLR4 protein | Nuclear transport | Microglia | Lipopolysaccharides | Signal transduction | Biomedical materials | Self-assembly | Natural products | Assembling | Toll-like receptors | Sustained release | Biocompatibility | Nanofibers | Controlled release
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1 - 7
A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic... 
Cyclooxygenase | neuroinflammation | NSAID | (aza)indazoles | boronic ester | radiolabeling | PET | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 COX-2 | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLUORINATION | CANCER | MICROGLIA | INFLAMMATION | DISEASE | EXPRESSION | Index Medicus
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 11/2017, Volume 28, Issue 11, pp. 2874 - 2886
Brain-related disorders have outmatched cancer and cardiovascular diseases worldwide as the leading cause of morbidity and mortality. The lack of effective... 
CELLS | DRUG-DELIVERY | BRAIN-INJURY | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PAMAM DENDRIMERS | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | RELEASE | MODEL | CHEMISTRY, MULTIDISCIPLINARY | NEUROPROTECTION | DISEASE | BIOMEDICAL APPLICATIONS | Rabbits | Microglia - drug effects | Minocycline - chemistry | Inflammation - immunology | Drug Carriers - chemistry | Drug Delivery Systems | Inflammation - complications | Animals | Anti-Inflammatory Agents - chemistry | Cerebral Palsy - complications | Microglia - immunology | Cerebral Palsy - drug therapy | Inflammation - drug therapy | Minocycline - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Dendrimers - chemistry | Anti-Inflammatory Agents - administration & dosage | Minocycline - administration & dosage | Cerebral Palsy - immunology | Neuroimaging | Drugs | Oxidative stress | Animal models | Drug delivery systems | Intravenous administration | Central nervous system | Disorders | Ventricles (cerebral) | Drug delivery | Lipopolysaccharides | Antioxidants | Dendrimers | Blood-brain barrier | Microglial cells | Minocycline | Paralysis | Heart diseases | Neurological disorders | Kits | Brain diseases | Alkynes | Stability | Medical treatment | Chemical reactions | Inflammation | Substantia alba | Corpus callosum | Morbidity | Microglia | Neurological diseases | Side effects | Blood circulation | Tumor necrosis factor | Nitric oxide | In vivo methods and tests | Ventricle | Cardiovascular diseases | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e87030 - e87030
Microglial activation plays a pivotal role in the development and progression of neurodegenerative diseases. Thus, anti-inflammatory agents that control... 
SYSTEMIC INFLAMMATION | NKT CELLS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DISEASES | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | T-CELL-ACTIVATION | SPHINGOSINE BACKBONE | LIPOPOLYSACCHARIDE | NEURODEGENERATION | NF-KAPPA-B | Cell Line | Microglia - metabolism | Phosphorylation | Cell Survival | Pyridines - chemistry | Cells, Cultured | Imidazoles - chemistry | NF-kappa B - metabolism | Galactosylceramides - chemistry | Transcription Factor AP-1 - metabolism | MAP Kinase Signaling System | Gene Expression Regulation, Enzymologic | DNA - chemistry | Protein Kinase Inhibitors - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Interleukin-1beta - metabolism | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - chemistry | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Nitric Oxide Synthase Type II - metabolism | Post-transcription | Cell culture | Transcription factors | Nervous system | Activation | Kinases | Inflammatory diseases | Lipopolysaccharides | Interleukin 6 | Analogs | Signal transduction | Biological effects | Microglial cells | Tumor necrosis factor-TNF | Deoxyribonucleic acid--DNA | Binding | NF-κB protein | Antiinflammatory agents | Cytokines | Neurodegenerative diseases | MAP kinase | Pharmacology | Inflammation | Tumor necrosis factor-α | Gene expression | Chemical compounds | Nitric-oxide synthase | Microglia | Neurological diseases | Polymerase chain reaction | Signaling | Chemistry | Brain research | Cyclooxygenase-2 | Alzheimers disease | Galactosylceramide | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
ACS Nano, ISSN 1936-0851, 03/2016, Volume 10, Issue 3, pp. 3674 - 3684
MXenes are a family of "atomically thin, two-dimensional (2D) transition metal carbides and carbonitrides with many attractive properties. Two-dimensional... 
B. subtilis | antibacterial | membrane | E. coli | oxidati