X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (17037) 17037
Book Chapter (43) 43
Dissertation (18) 18
Magazine Article (6) 6
Book / eBook (5) 5
Reference (4) 4
Conference Proceeding (2) 2
Publication (2) 2
Newspaper Article (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (12855) 12855
microglia (11200) 11200
neurosciences (8815) 8815
mice (6653) 6653
microglia - drug effects (6606) 6606
inflammation (5583) 5583
microglia - metabolism (5507) 5507
male (5150) 5150
rats (5074) 5074
humans (4521) 4521
brain (4243) 4243
cells, cultured (3319) 3319
disease models, animal (2928) 2928
activation (2865) 2865
expression (2698) 2698
mice, inbred c57bl (2673) 2673
neuroinflammation (2632) 2632
immunology (2593) 2593
cytokines (2524) 2524
neurology (2513) 2513
neurons (2403) 2403
rats, sprague-dawley (2349) 2349
female (2317) 2317
astrocytes (2205) 2205
microglia - pathology (2178) 2178
central-nervous-system (2155) 2155
biochemistry & molecular biology (1964) 1964
rodents (1942) 1942
neurodegeneration (1850) 1850
pharmacology & pharmacy (1840) 1840
alzheimers-disease (1831) 1831
analysis (1805) 1805
cell biology (1793) 1793
cells (1783) 1783
lipopolysaccharides - pharmacology (1734) 1734
research (1721) 1721
oxidative stress (1711) 1711
macrophages (1709) 1709
alzheimer's disease (1671) 1671
cell line (1642) 1642
apoptosis (1635) 1635
neurons - drug effects (1604) 1604
immunohistochemistry (1591) 1591
proteins (1587) 1587
neuroprotection (1579) 1579
nervous system (1549) 1549
microglia - physiology (1459) 1459
cytokines - metabolism (1411) 1411
microglia - cytology (1407) 1407
gene expression (1349) 1349
neurons - metabolism (1320) 1320
microglia - immunology (1305) 1305
neurodegenerative diseases (1302) 1302
brain - metabolism (1284) 1284
animals, newborn (1272) 1272
rats, wistar (1259) 1259
dose-response relationship, drug (1234) 1234
nitric oxide (1233) 1233
astrocytes - drug effects (1225) 1225
astrocytes - metabolism (1199) 1199
clinical neurology (1199) 1199
time factors (1174) 1174
neuroprotective agents - pharmacology (1164) 1164
neurotoxicity (1143) 1143
nitric-oxide synthase (1117) 1117
brain - pathology (1114) 1114
nf-kappa-b (1103) 1103
signal transduction - drug effects (1095) 1095
brain - drug effects (1088) 1088
disease (1077) 1077
mouse model (1037) 1037
biomedicine (1021) 1021
multidisciplinary sciences (1013) 1013
central nervous system (1012) 1012
mice, transgenic (1009) 1009
lipopolysaccharides (998) 998
pathology (993) 993
tumor necrosis factor-alpha - metabolism (992) 992
signal transduction (984) 984
lipopolysaccharide (971) 971
in-vivo (958) 958
health aspects (953) 953
inflammation - metabolism (951) 951
microglial activation (948) 948
ischemia (941) 941
in-vitro (934) 934
research article (929) 929
parkinson's disease (926) 926
inhibition (914) 914
hippocampus (913) 913
physiological aspects (910) 910
neurons - pathology (908) 908
cell survival - drug effects (901) 901
nitric-oxide (891) 891
medicine (878) 878
gene expression regulation - drug effects (876) 876
microglial cells (871) 871
parkinsons-disease (863) 863
rna, messenger - metabolism (855) 855
nf-kappa b - metabolism (852) 852
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (17064) 17064
Japanese (78) 78
Chinese (57) 57
German (7) 7
Spanish (6) 6
French (4) 4
Korean (4) 4
Portuguese (3) 3
Polish (2) 2
Russian (2) 2
Dutch (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature neuroscience, ISSN 1546-1726, 2013, Volume 16, Issue 2, pp. 183 - 192
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that... 
LAMINA-I NEURONS | NEUROTROPHIC FACTOR | P2X RECEPTORS | DOWN-REGULATION | OPIOID-RECEPTOR GENE | SPINAL-CORD-INJURY | UNDERLYING NEUROPATHIC PAIN | ALTERED CHLORIDE HOMEOSTASIS | NERVE INJURY | NEUROSCIENCES | INDUCED ABNORMAL PAIN | Brain-Derived Neurotrophic Factor - genetics | Biophysical Phenomena - drug effects | Motor Activity - drug effects | Male | Ribosome Inactivating Proteins, Type 1 - pharmacology | Touch | CD11b Antigen - genetics | Microglia - physiology | Time Factors | Chlorides - metabolism | Pain Threshold - drug effects | Biophysical Phenomena - genetics | Vocalization, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Homeostasis - drug effects | Protein Synthesis Inhibitors - pharmacology | Spinal Cord - cytology | Neurons - drug effects | Membrane Potentials - drug effects | Hot Temperature - adverse effects | Microglia - drug effects | Mice, Inbred C57BL | Rats | Mice, Transgenic | Signal Transduction - genetics | Down-Regulation - drug effects | Rats, Sprague-Dawley | Symporters - metabolism | Gene Expression Regulation - drug effects | Narcotics - administration & dosage | Patch-Clamp Techniques | Rotarod Performance Test | Animals | Hyperalgesia - drug therapy | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | CD11b Antigen - metabolism | Receptors, Purinergic P2X4 - metabolism | Morphine - administration & dosage | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2017, Volume 66, Issue 4, pp. 908 - 919
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 11, pp. e0142340 - e0142340
.... Here, we used an adeno-associated viral vector-based mouse model of early-stage AD-type tauopathy to investigate effects of the mTOR inhibitor and autophagy stimulator rapamycin on the tau-driven... 
MAMMALIAN TARGET | IN-VITRO | STIMULATION | MULTIDISCIPLINARY SCIENCES | MEMORY IMPAIRMENT | DISEASE | TAU | ENTORHINAL CORTEX NEURONS | TOXICITY | AUTOPHAGY | PATHOLOGY | Microglia - metabolism | Entorhinal Cortex - metabolism | Humans | tau Proteins - metabolism | Male | Hippocampus - drug effects | Neurodegenerative Diseases - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | Synapses - metabolism | Dentate Gyrus - drug effects | Perforant Pathway - metabolism | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Disease Models, Animal | Synapses - drug effects | Dentate Gyrus - metabolism | Microglia - drug effects | Alzheimer Disease - drug therapy | Axons - drug effects | Axons - metabolism | Memory, Long-Term - drug effects | Entorhinal Cortex - drug effects | Neurodegenerative Diseases - metabolism | Sirolimus - pharmacology | Hippocampus - metabolism | Tauopathies - metabolism | Animals | Perforant Pathway - drug effects | Alzheimer Disease - metabolism | Mice | Tauopathies - drug therapy | TOR protein | Brain | Phosphorylation | Toxicity | Activation | mRNA | Kinases | Autophagy | Neurotoxicity | Neurodegeneration | Rodents | Long term memory | Degeneration | Inhibition | Alzheimer's disease | Neurodegenerative diseases | Neurons | Astrocytes | Rapamycin | Inflammation | Substrates | Microglia | Pathology | Cortex (entorhinal) | Dentate gyrus | Gliosis | Inhibitors | Tau protein | Hippocampus | Phagocytosis | Synapses | Index Medicus
Journal Article
Cell metabolism, ISSN 1550-4131, 2016, Volume 23, Issue 5, pp. 797 - 810
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and offer a cost-effective approach... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | HUMAN NEOCORTEX | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | FATTY-ACIDS | machine learning | CANCER | organoid | IN-VITRO | HUMAN CEREBRAL-CORTEX | MICROGLIA | GENE-EXPRESSION | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Biological Sciences
Journal Article
Neuropsychopharmacology (New York, N.Y.), ISSN 1740-634X, 2013, Volume 38, Issue 9, pp. 1609 - 1616
We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al,... 
AMPA receptor | depression | lipopolysaccharide | NMDA receptor | inflammation | ketamine | PSYCHIATRY | MACROPHAGES | INDOLEAMINE 2,3-DIOXYGENASE | INDUCTION | CALMETTE-GUERIN | NEUROSCIENCES | HIPPOCAMPUS | MICROGLIA | IMMUNE ACTIVATION | PHARMACOLOGY & PHARMACY | EXPRESSION | BRAIN | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Body Weight - drug effects | Motor Activity - drug effects | Male | Ketamine - antagonists & inhibitors | Lipopolysaccharides - antagonists & inhibitors | Brain - metabolism | Quinoxalines - pharmacology | Depression - drug therapy | Drug Interactions | Liver - drug effects | Depression - chemically induced | Immobility Response, Tonic - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - biosynthesis | Ketamine - therapeutic use | Cytokines - metabolism | Drug Administration Schedule | Food Preferences - drug effects | Liver - metabolism | Mice, Inbred C57BL | Excitatory Amino Acid Antagonists - pharmacology | Antidepressive Agents - therapeutic use | Brain - drug effects | Eating - drug effects | Animals | Signal Transduction - drug effects | Mice | Ketamine - pharmacology | Receptors, AMPA - antagonists & inhibitors | Antidepressants | biological psychiatry | animal models | behavioral science | bipolar | unipolar | Original
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 02/2018, Volume 22, Issue 2, pp. 1148 - 1166
Spinal cord injury (SCI) is a severe neurological disease; however, few drugs have been proved to treat SCI effectively... 
spinal cord injury | autophagic flux | salidroside | AMPK | M2 polarization | microglia | M1 polarization | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | OXIDATIVE STRESS | M2 MACROPHAGES | ACTIVATION | PROMOTES LOCOMOTOR RECOVERY | CELL BIOLOGY | RESPONSES | ADOPTIVE TRANSFER | INDUCED AUTOPHAGY | MACROPHAGE POLARIZATION | MEDIATED NEUROTOXICITY | Neurons - pathology | Spinal Cord Injuries - drug therapy | Recovery of Function - drug effects | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Spinal Cord Injuries - complications | Motor Activity - drug effects | Autophagy - drug effects | Lipopolysaccharides | Spinal Cord Injuries - pathology | Inflammation - complications | Inflammation - drug therapy | Adenylate Kinase - metabolism | Inflammation Mediators - metabolism | Microglia - pathology | Female | Glucosides - therapeutic use | Cell Polarity - drug effects | Neurons - metabolism | Neurons - drug effects | Phenols - pharmacology | Cell Line | Glucosides - pharmacology | Macrophages - pathology | Microglia - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Rats, Sprague-Dawley | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Models, Biological | Phenols - therapeutic use | Macrophages - drug effects | Mice | Spinal Cord Injuries - physiopathology | Nervous system diseases | Neurons | Analysis | Therapeutics | Spinal cord injuries | Homeopathy | Materia medica and therapeutics | TOR protein | Drugs | Polarization | Spinal cord | Pathogenesis | Recovery of function | Rats | Inflammation | Spinal cord injury | Drug development | Autophagy | Polarization modulation | Microglia | Respiratory tract | Salidroside | Blood-brain barrier | Rodents | Pheochromocytoma cells | Immunofluorescence | Injuries | Apoptosis | Original
Journal Article
Aging cell, ISSN 1474-9718, 2018, Volume 17, Issue 6, pp. e12832 - n/a
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 2, p. e87915
Neuroimmune gene induction is involved in many brain pathologies including addiction. Although increased expression of proinflammatory cytokines has been found... 
INDUCED NEUROINFLAMMATION | SLICE CULTURES | CELLS | CHROMATIN PROTEIN HMGB1 | MULTIDISCIPLINARY SCIENCES | MOBILITY GROUP BOX-1 | SPINAL-CORD | INDUCTION | ALCOHOL-DRINKING | NF-KAPPA-B | RECEPTOR 4 | Microglia - metabolism | Entorhinal Cortex - metabolism | Humans | Cytosol - drug effects | Hippocampus - drug effects | Brain - metabolism | Naltrexone - pharmacology | Cell Nucleus - metabolism | HMGB1 Protein - metabolism | Inflammation Mediators - metabolism | Benzamides - pharmacology | Neurons - metabolism | Toll-Like Receptor 4 - antagonists & inhibitors | Neurons - drug effects | Hydroxamic Acids - pharmacology | Cytokines - metabolism | Microglia - drug effects | Rats | Histone Deacetylases - metabolism | Entorhinal Cortex - drug effects | Toll-Like Receptor 4 - metabolism | Blotting, Western | Brain - drug effects | Gene Expression Regulation - drug effects | Hippocampus - metabolism | Acetylation - drug effects | Ethanol - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Cytosol - metabolism | Histone Deacetylase Inhibitors - pharmacology | Mice | Pyridines - pharmacology | Cell Nucleus - drug effects | Brain - immunology | Brain research | Alcohol, Denatured | Chromosomal proteins | Cytokines | RNA | Neurons | Analysis | Alcohol | Brain | Drug abuse | Histone deacetylase | Neurosciences | Spinal cord | Brain slice preparation | Neurobiology | Biology | Activation | Kinases | Experiments | HMGB1 protein | Proteins | Neurodegeneration | Toll-like receptors | Immune system | Translocation | Glycyrrhizin | Ethanol | Alcoholism | Hazards | Inflammation | TLR4 protein | Tumor necrosis factor-α | IL-1β | Gene expression | Addictions | Studies | Cortex (entorhinal) | Signaling | Hypotheses | Inhibitors | Addiction | Ligands | Laboratory animals | Hippocampus | Apoptosis
Journal Article