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Nature Neuroscience, ISSN 1097-6256, 02/2013, Volume 16, Issue 2, pp. 183 - 192
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that... 
LAMINA-I NEURONS | NEUROTROPHIC FACTOR | P2X RECEPTORS | DOWN-REGULATION | OPIOID-RECEPTOR GENE | SPINAL-CORD-INJURY | UNDERLYING NEUROPATHIC PAIN | ALTERED CHLORIDE HOMEOSTASIS | NERVE INJURY | NEUROSCIENCES | INDUCED ABNORMAL PAIN | Brain-Derived Neurotrophic Factor - genetics | Biophysical Phenomena - drug effects | Motor Activity - drug effects | Male | Ribosome Inactivating Proteins, Type 1 - pharmacology | Touch | CD11b Antigen - genetics | Microglia - physiology | Time Factors | Chlorides - metabolism | Pain Threshold - drug effects | Biophysical Phenomena - genetics | Vocalization, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Homeostasis - drug effects | Protein Synthesis Inhibitors - pharmacology | Spinal Cord - cytology | Neurons - drug effects | Membrane Potentials - drug effects | Hot Temperature - adverse effects | Microglia - drug effects | Mice, Inbred C57BL | Rats | Mice, Transgenic | Signal Transduction - genetics | Down-Regulation - drug effects | Rats, Sprague-Dawley | Symporters - metabolism | Gene Expression Regulation - drug effects | Narcotics - administration & dosage | Patch-Clamp Techniques | Rotarod Performance Test | Animals | Hyperalgesia - drug therapy | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | CD11b Antigen - metabolism | Receptors, Purinergic P2X4 - metabolism | Morphine - administration & dosage | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects | Index Medicus
Journal Article
Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Journal Article
Diabetes, ISSN 0012-1797, 04/2017, Volume 66, Issue 4, pp. 908 - 919
Cell proliferation and neuroinflammation in the adult hypothalamus may contribute to the pathogenesis of obesity. We tested whether the intertwining of these... 
ENERGY-BALANCE | DEPRESSIVE-LIKE BEHAVIOR | RESIDENT MICROGLIA | INSULIN-RESISTANCE | INDOLEAMINE 2,3-DIOXYGENASE | ENDOCRINOLOGY & METABOLISM | CELL-PROLIFERATION | SATURATED FAT | NF-KAPPA-B | INDUCED OBESITY | MELANOCORTIN SYSTEM | Adiposity - immunology | Interleukin-1beta - drug effects | Cytarabine - pharmacology | Weight Gain - immunology | Obesity - immunology | NF-kappa B - immunology | Body Weight - drug effects | Cytidine - pharmacology | Male | Body Weight - immunology | Microglia - immunology | Arcuate Nucleus of Hypothalamus - drug effects | Diet, High-Fat | Tumor Necrosis Factor-alpha - immunology | Weight Gain - drug effects | Leptin - immunology | Hypothalamus - drug effects | Macrophages, Peritoneal - drug effects | Eating - immunology | Hypothalamus - immunology | Adiposity - drug effects | Microglia - drug effects | Interleukin-1beta - immunology | Macrophages, Peritoneal - immunology | Arabinonucleosides - pharmacology | Inflammation | Eating - drug effects | Animals | Tumor Necrosis Factor-alpha - drug effects | Antimitotic Agents - pharmacology | Arcuate Nucleus of Hypothalamus - immunology | Cell Proliferation - drug effects | Mice | NF-kappa B - drug effects | Insulin resistance | Research | Brain | Obesity | Diet | Cytokines | Rodents | Index Medicus | Abridged Index Medicus | Life Sciences
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 2014, Volume 19, Issue 6, pp. 699 - 709
The limited success in understanding the pathophysiology of major depression may result from excessive focus on the dysfunctioning of neurons, as compared with... 
neurogenesis | interleukin-1 | chronic stress | depression | microglia | minocycline | BRAIN-REGIONS | COLONY-STIMULATING FACTORS | PRONEUROGENIC PHENOTYPE | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HIPPOCAMPAL NEUROGENESIS | CHRONIC MILD STRESS | RANDOMIZED CONTROLLED-TRIAL | MAJOR DEPRESSION | NEUROSCIENCES | PREFRONTAL CORTEX | SEROTONIN REUPTAKE INHIBITORS | RAT HIPPOCAMPUS | Uncertainty | Apoptosis - drug effects | Depressive Disorder - pathology | Depressive Disorder - drug therapy | Male | Hippocampus - drug effects | Depressive Disorder - etiology | Microglia - physiology | Microglia - pathology | Behavior, Animal - drug effects | Neurogenesis - drug effects | Microglia - drug effects | Stress, Psychological - drug therapy | Brain - physiopathology | Cell Proliferation - physiology | Rats | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Brain - drug effects | Stress, Psychological - pathology | Animals | Neurogenesis - physiology | Depressive Disorder - physiopathology | Brain - pathology | Cell Proliferation - drug effects | Mice | Apoptosis - physiology | Chronic Disease | Hippocampus - physiopathology | Stress, Psychological - complications | Stress, Psychological - physiopathology | Development and progression | Brain research | Research | Neurogenesis | Depression, Mental | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | HUMAN NEOCORTEX | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | FATTY-ACIDS | machine learning | CANCER | organoid | IN-VITRO | HUMAN CEREBRAL-CORTEX | MICROGLIA | GENE-EXPRESSION | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Neurotoxicity | Stem cells | Gene expression | Biological assays | Bioinformatics | Artificial intelligence | Index Medicus | Biological Sciences
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
FIBRIL FORMATION | PROTEIN | MULTIVESICULAR BODIES | HUMAN PLASMA | ACTIVATES MICROGLIA | CONGO RED | ENDOPLASMIC-RETICULUM | FAMILIAL PARKINSONS-DISEASE | RELEASE | BODY FORMATION | NEUROSCIENCES | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 04/2014, Volume 82, Issue 2, pp. 380 - 397
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142340 - e0142340
The perforant pathway projection from layer II of the entorhinal cortex to the hippocampal dentate gyrus is especially important for long-term memory... 
MAMMALIAN TARGET | IN-VITRO | STIMULATION | MULTIDISCIPLINARY SCIENCES | MEMORY IMPAIRMENT | DISEASE | TAU | ENTORHINAL CORTEX NEURONS | TOXICITY | AUTOPHAGY | PATHOLOGY | Microglia - metabolism | Entorhinal Cortex - metabolism | Humans | tau Proteins - metabolism | Male | Hippocampus - drug effects | Neurodegenerative Diseases - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | Synapses - metabolism | Dentate Gyrus - drug effects | Perforant Pathway - metabolism | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Disease Models, Animal | Synapses - drug effects | Dentate Gyrus - metabolism | Microglia - drug effects | Alzheimer Disease - drug therapy | Axons - drug effects | Axons - metabolism | Memory, Long-Term - drug effects | Entorhinal Cortex - drug effects | Neurodegenerative Diseases - metabolism | Sirolimus - pharmacology | Hippocampus - metabolism | Tauopathies - metabolism | Animals | Perforant Pathway - drug effects | Alzheimer Disease - metabolism | Mice | Tauopathies - drug therapy | TOR protein | Brain | Phosphorylation | Toxicity | Medical services | Activation | mRNA | Kinases | Autophagy | Neurotoxicity | Neurodegeneration | Rodents | Long term memory | Degeneration | Inhibition | Alzheimer's disease | Neurodegenerative diseases | Neurons | Astrocytes | Rapamycin | Inflammation | Substrates | Microglia | Pathology | Cortex (entorhinal) | Dentate gyrus | Gliosis | Inhibitors | Tau protein | Hippocampus | Phagocytosis | Synapses | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2016, Volume 23, Issue 5, pp. 797 - 810
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e87915 - e87915
Neuroimmune gene induction is involved in many brain pathologies including addiction. Although increased expression of proinflammatory cytokines has been found... 
INDUCED NEUROINFLAMMATION | SLICE CULTURES | CELLS | CHROMATIN PROTEIN HMGB1 | MULTIDISCIPLINARY SCIENCES | MOBILITY GROUP BOX-1 | SPINAL-CORD | INDUCTION | ALCOHOL-DRINKING | NF-KAPPA-B | RECEPTOR 4 | Microglia - metabolism | Entorhinal Cortex - metabolism | Humans | Cytosol - drug effects | Hippocampus - drug effects | Brain - metabolism | Naltrexone - pharmacology | Cell Nucleus - metabolism | HMGB1 Protein - metabolism | Inflammation Mediators - metabolism | Benzamides - pharmacology | Neurons - metabolism | Toll-Like Receptor 4 - antagonists & inhibitors | Neurons - drug effects | Hydroxamic Acids - pharmacology | Cytokines - metabolism | Microglia - drug effects | Rats | Histone Deacetylases - metabolism | Entorhinal Cortex - drug effects | Toll-Like Receptor 4 - metabolism | Blotting, Western | Brain - drug effects | Gene Expression Regulation - drug effects | Hippocampus - metabolism | Acetylation - drug effects | Ethanol - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Cytosol - metabolism | Histone Deacetylase Inhibitors - pharmacology | Mice | Pyridines - pharmacology | Cell Nucleus - drug effects | Brain - immunology | Brain research | Alcohol, Denatured | Chromosomal proteins | Cytokines | RNA | Neurons | Analysis | Alcohol | Brain | Drug abuse | Histone deacetylase | Neurosciences | Spinal cord | Brain slice preparation | Neurobiology | Biology | Activation | Kinases | Experiments | HMGB1 protein | Proteins | Neurodegeneration | Toll-like receptors | Translocation | Glycyrrhizin | Ethanol | Alcoholism | Cultures | Hazards | Inflammation | TLR4 protein | Tumor necrosis factor-α | IL-1β | Gene expression | Addictions | Immune systems | Studies | Cortex (entorhinal) | Signaling | Hypotheses | Inhibitors | Addiction | Ligands | Laboratory animals | Hippocampus | Apoptosis | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged | Index Medicus
Journal Article