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1. Full Text In vivo erythrocyte micronucleus assay. III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test
by Hayashi, Makoto and MacGregor, James T and Gatehouse, David G and Blakey, David H and Dertinger, Stephen D and Abramsson-Zetterberg, Lilianne and Krishna, Gopala and Morita, Takeshi and Russo, Antonella and Asano, Norihide and Suzuki, Hiroshi and Ohyama, Wakako and Gibson, Dave
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 02/2007, Volume 627, Issue 1, pp. 10 - 30
The in vivo micronucleus assay working group of the International Workshop on Genotoxicity Testing (IWGT) discussed new aspects in the in vivo micronucleus... 
Liver micronucleus assay | Validation | Flow cytometry | Automation | Micronucleus assay | Rat blood micronucleus assay | Germ cell micronucleus assay | Skin micronucleus assay | Colon micronucleus assay | colon micronucleus assay | ACRIDINE-ORANGE | rat blood micronucleus assay | COVALENT DNA MODIFICATIONS | SISTER CHROMATID EXCHANGES | MOUSE BONE-MARROW | SHORT-TERM TESTS | micronucleus assay | skin micronucleus assay | automation | TRANSPLACENTALLY ACTIVE CARCINOGENS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | liver micronucleus assay | GENETICS & HEREDITY | flow cytometry | TOXICOLOGY | germ cell micronucleus assay | FLOW-CYTOMETRIC ANALYSIS | COLLABORATIVE STUDY-GROUP | FETAL LIVER | validation | STUDY-GROUP MMS
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2. Anti-Clastogenic Effects of Citral
by Rabbani, Syed Iman and Devi, Kshama and Zahra, Noor
Anti-Clastogenic Effects of Citral, 12/2005
Citral is a major constituent of Cymbopogon citratus   or lemongrass oil. The anti-clastogenic effect of citral (20 mg/kg) was tested against the known... 
Citral, Antimutagenicity, Micronucleus test, Clastogens
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3. The effect of aging on micronuclei frequency and proliferation in human peripheral blood lymphocytes
by Orta, Tuncay and Günebakan, Süreyya
08/2012
Introduction: Increase in the instability of cellular genome with an increasing age is the result of an accumulation of cellular damage and mutations. This... 
micronucleus | lymphocytes | cell kinetics | Aging
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4. Full Text Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
by Bartsch, Kareen and Knittler, Katharina and Borowski, Christopher and Rudnik, Sönke and Damme, Markus and Aden, Konrad and Spehlmann, Martina E and Frey, Norbert and Saftig, Paul and Chalaris, Athena and Rabe, Björn
Human Molecular Genetics, ISSN 0964-6906, 10/2017, Volume 26, Issue 20, pp. 3960 - 3972
Hypomorphic mutations in the DNA repair enzyme RNase H2 cause the neuroinflammatory autoimmune disorder AicardiGoutie` res syndrome (AGS). Endogenous nucleic... 
TUBERCULOSIS DNA | AICARDI-GOUTIERES-SYNDROME | SENSING PATHWAY | RIBONUCLEASE H2 | RNADNA HYBRIDS | TREX1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | GENETICS & HEREDITY | MUTATIONS | SAMHD1 | AUTOIMMUNE-DISEASE | Autoimmune Diseases of the Nervous System - enzymology | Nervous System Malformations - pathology | Ribonuclease H - deficiency | DNA Replication | Micronucleus, Germline - genetics | Autoimmune Diseases of the Nervous System - pathology | Micronucleus, Germline - immunology | Mice, Knockout | DNA - genetics | Animals | Nervous System Malformations - enzymology | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | Mice | Autophagy - genetics | DNA Damage | Mutation | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | Micronucleus, Germline - enzymology | Ribonuclease H - genetics | Ribonuclease H - metabolism
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5. Full Text Zinc oxide nanoparticles: Genotoxicity, interactions with UV-light and cell-transforming potential
by Demir, Eşref and Akça, Hakan and Kaya, Bülent and Burgucu, Durmuş and Tokgün, Onur and Turna, Fatma and Aksakal, Sezgin and Vales, Gerard and Creus, Amadeu and Marcos, Ricard
Journal of Hazardous Materials, ISSN 0304-3894, 01/2014, Volume 264, pp. 420 - 429
The genotoxic and the soft agar anchorage independent cell transformation ability of zinc oxide nanoparticles (NPs) and its bulky forms have been evaluated in... 
Soft-agar assay | ZnO nanoparticles | Micronucleus assay | Comet assay | Genotoxicity | UV-light interaction | NIH 3T3 Cells | Humans | Zinc Oxide - toxicity | Cell Transformation, Neoplastic - chemically induced | Comet Assay | Nanoparticles - toxicity | Micronucleus Tests | Nanoparticles - radiation effects | Zinc Oxide - radiation effects | Animals | Ultraviolet Rays | HEK293 Cells | Mice | Zinc oxide | Cells | Index Medicus
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6. Full Text Contribution of ionic silver to genotoxic potential of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by the cytokinesis‐block micronucleus assay
by Sahu, Saura C and Roy, Shambhu and Zheng, Jiwen and Ihrie, John
Journal of Applied Toxicology, ISSN 0260-437X, 04/2016, Volume 36, Issue 4, pp. 532 - 542
Extensive human exposure to food‐ and cosmetics‐related consumer products containing nanosilver is of public concern because of the lack of information about... 
genotoxicity | micronucleus | nanoparticles | silver nanoparticles | Caco2 | nanosilver | HepG2 | cytokinesis‐block micronucleus | in vitro micronucleus | Nanoparticles | Genotoxicity | Micronucleus | Nanosilver | Cytokinesis-block micronucleus | Silver nanoparticles | ABERRATIONS IN-VITRO | cytokinesis-block micronucleus | PARTICLES | SIZE | TOXICITY | MODEL | FOOD-INDUSTRY | IMPACT | NANOPARTICLE-PROTEIN CORONA | DISSOLUTION | TOXICOLOGY | CYTOTOXICITY | Caco-2 Cells | Colon - cytology | DNA Damage - drug effects | Mutagens - toxicity | Micronucleus Tests - methods | Humans | Liver - metabolism | Metal Nanoparticles - chemistry | Colon - drug effects | Silver - chemistry | Linear Models | Colon - metabolism | Hep G2 Cells | Metal Nanoparticles - toxicity | Liver - drug effects | Endpoint Determination | Silver - toxicity | Liver - cytology | Cytokinesis - drug effects | Liver | Silver | Cytokines | Toxicity | Index Medicus | Human | Concentration (composition) | In vitro testing | Nanostructure | Assaying | Acetates
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7. Full Text Interlaboratory evaluation of the genotoxic properties of pencycuron, a commonly used phenylurea fungicide
by Nagy, Károly and Zheng, Congying and Bolognesi, Claudia and Ádám, Balázs
Science of the Total Environment, ISSN 0048-9697, 01/2019, Volume 647, pp. 1052 - 1057
Pencycuron, a phenylurea-type antifungal agent, is used in agriculture worldwide for inhibiting the growth of various fungal pathogens of crops. Pencycuron... 
Pencycuron | Micronucleus test | Pesticide | DNA damage | Genotoxicity | Comet assay | Fungicide | ENVIRONMENTAL SCIENCES | BLOCK MICRONUCLEUS ASSAY | DNA-DAMAGE | LYMPHOCYTES | Micronucleus Tests | Fungicides, Industrial - toxicity | DNA Damage | Phenylurea Compounds - toxicity | Comet Assay | Humans | Medicine, Preventive | Analysis | Astronomy | Preventive health services | Index Medicus
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8. Full Text Correlation of in vivo versus in vitro Benchmark doses (BMDs) derived from micronucleus test data: A proof of concept study
by Soeteman-Hernández, Lya G and Fellows, Mick D and Johnson, George E and Slob, Wout
Toxicological Sciences, ISSN 1096-6080, 12/2015, Volume 148, Issue 2, pp. 355 - 367
In this study, we explored the applicability of using in vitro micronucleus (MN) data from human lymphoblastoid TK6 cells to derive in vivo genotoxicity... 
Genotoxic potenc | In vitro micronucleus | TK6 cells, benchmark dose approach | 2-ACETYLAMINOFLUORENE | RESPONSE RELATIONSHIPS | ASSAY | MOUSE | TK6 cells | benchmark dose approach | TOXICITY | genotoxic potency | MUTAGENICITY | 1,2-DIMETHYLHYDRAZINE | in vitro micronucleus | GENOTOXICITY | TOXICOLOGY | PERIPHERAL-BLOOD LYMPHOCYTES | CELL | Cell Line | Reproducibility of Results | Micronucleus Tests - standards | Risk Assessment | Humans | Animal Testing Alternatives - standards | Benchmarking - standards | Dose-Response Relationship, Drug | Lymphocytes - pathology | Animals | Micronuclei, Chromosome-Defective - chemically induced | Models, Biological | Lymphocytes - drug effects | Index Medicus | in vitro micronucleus | Benchmark Doses and Micronucleus Test Data
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9. Full Text Assessing genotoxic effects in fish from a marine protected area influenced by former mining activities and other stressors
by Gusso-Choueri, Paloma Kachel and Choueri, Rodrigo Brasil and Santos, Gustavo Souza and de Araújo, Giuliana Seraphim and Cruz, Ana Carolina Feitosa and Stremel, Tatiana and de Campos, Sandro Xavier and Cestari, Marta Margarete and Ribeiro, Ciro Alberto Oliveira and de Sousa Abessa, Denis Moledo
Marine Pollution Bulletin, ISSN 0025-326X, 03/2016, Volume 104, Issue 1-2, pp. 229 - 239
The goal of the current study was to evaluate different genotoxicity tools in order to assess a marine protected area (MPA) affected by former mining... 
Biomarkers | Estuary | Environmental quality assessment | Weight of evidence | Genotoxicity | Multivariate approach | DETECTING DNA-DAMAGE | OREOCHROMIS-NILOTICUS | BIOCHEMICAL RESPONSES | COMET ASSAY | PISCINE MICRONUCLEUS | CELL GEL-ELECTROPHORESIS | ENVIRONMENTAL SCIENCES | MARINE & FRESHWATER BIOLOGY | IN-VIVO | NUCLEAR ABNORMALITIES | ECOTOXICOLOGICAL ASSESSMENT | MICRONUCLEUS TEST | Environmental Monitoring | Comet Assay - veterinary | Catfishes | Comet Assay - methods | Micronucleus Tests - methods | Environmental Exposure | Mutagenicity Tests - methods | Mining | Mutagenicity Tests - veterinary | Animals | Water Pollutants, Chemical - toxicity | Micronucleus Tests - veterinary | Brazil | DNA Damage | Protection and preservation | Mineral industry | Mining industry | Analysis
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10. Protective effect of vitamin C and or vitamin E on micronuclei induction by rifampicin in mice
by Awodele, O and Olayemi, S.O and Alimba, C.G and Egbejiogu, C and Akintonwa, A
04/2011
Rifampicin which is a known antituberculous agent has been reported to induce both chromosomal breakage and numerical chromosomal abnormalities. This study was... 
mutagenicity | rifampicin | micronucleus | deoxyribonucleic acid | mice | vitamin
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11. Full Text Evaluation of Duloxetine as Micronuclei Inducer in an Acute and a Subchronic Assay in Mouse
by Eduardo Madrigal-Bujaidara and Isela Alvarez-Gonzaleza and Eduardo Osiris Madrigal-Santillanb and Jose A Morales-Gonzalezb and Escuela Nacional de Ciencias Biologicas and Institute Politecnico Nacional and aLaboratorio de Genetica and Escuela Superior de Medicina and bLaboratorio Medicina de Conservacion
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 8, pp. 1245 - 1249
Duloxetine is a widely used antidepressant worldwide. In the present report, we evaluated its capacity to induce micronucleated polychromatic erythrocytes... 
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12. Full Text Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation
by Baert, Annelot and Depuydt, Julie and Van Maerken, Tom and Poppe, Bruce and Malfait, Fransiska and Storm, Katrien and van den Ende, Jenneke and Van Damme, Tim and De Nobele, Sylvia and Perletti, Gianpaolo and De Leeneer, Kim and Claes, Kathleen B.M and Vral, Anne
Breast Cancer Research, ISSN 1465-5411, 05/2016, Volume 18, Issue 1, pp. 52 - 52
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or... 
M cell-cycle checkpoint | DNA damage repair | Nonsense-mediated decay | BRCA1 mutations | micronucleus assay | Ionizing radiation | Homologous recombination | Radiosensitivity indicator | Haploinsufficiency | INSTABILITY | SPLICE SITES | HUMAN-CELLS | DNA-DAMAGE | G micronucleus assay | G/M cell-cycle checkpoint | HUMAN LYMPHOCYTES | WOMEN | REPAIR | ONCOLOGY | BREAST-CANCER RISK | MAMMOGRAPHY X-RAYS | IONIZING-RADIATION | Micronucleus Tests | Cell Cycle - genetics | Chromosomes, Human - radiation effects | Cell Cycle - radiation effects | Humans | Alleles | Radiation Tolerance - genetics | Heterozygote | Genes, BRCA1 | Mutation | Chromosomal Instability | Micronuclei, Chromosome-Defective - radiation effects | Complications and side effects | Gene mutations | DNA damage | Analysis | Breast cancer | Genetic aspects | Research | Index Medicus | G2 micronucleus assay
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13. Full Text "Normal values" for the lymphocyte cytokinesis-block micronucleus cytome parameters: Repeatability and reproducibility in a healthy reference population
by Bolognesi, C and Bonelli, L and Compalati, A and Ferla, V and Stagnaro, L and Ubezio, G and Bruzzi, P
SCIENCE OF THE TOTAL ENVIRONMENT, ISSN 0048-9697, 02/2019, Volume 652, pp. 513 - 522
The micronucleus test in peripheral blood lymphocytes is the most widely validated technique to evaluate the DNA damage and chromosomal instability in human... 
Biomonitoring | ASSAY | BIOMARKER | Cytome assay | SEX | RISK | Chromosomal instability | Occupational exposure | CANCER | ENVIRONMENTAL SCIENCES | GENERAL-POPULATION | Micronucleus | FREQUENCY | Healthy subjects | PERIPHERAL-BLOOD LYMPHOCYTES | ASSOCIATION | AGE | Environmental Monitoring | Reproducibility of Results | Micronucleus Tests - standards | Lymphocytes | Micronucleus Tests - methods | Humans | Biomarkers | Female | Male | Reference Values | DNA Damage | Cytokinesis | Occupational health and safety | Epidemiology | Analysis | Biological monitoring | Index Medicus
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14. Full Text Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro
by Vevers, William F and Jha, Awadhesh N
Ecotoxicology, ISSN 0963-9292, 7/2008, Volume 17, Issue 5, pp. 410 - 420
Intrinsic genotoxic and cytotoxic potential of titanium dioxide (TiO2) engineered nanoparticles (ENPs) were evaluated in a metabolically competent, established... 
Ecotoxicology | RTG-2 cells | Genotoxicity | Cytotoxicity | Ecology | Photo-genotoxicity | Comet assay | Neutral red retention assay | Environment, general | Nanoparticles | Micronucleus assay | Environment | Environmental Management | RISKS | OXIDATIVE DAMAGE | PARTICLES | DNA-DAMAGE | photo-genotoxicity | TOXICITY | neutral red retention assay | INDUCTION | MICRONUCLEUS TECHNIQUE | genotoxicity | ENVIRONMENTAL SCIENCES | micronucleus assay | nanoparticles | comet assay | DEGRADATION | SUNSCREENS | ECOLOGY | TOXICOLOGY | cytotoxicity | Micronucleus Tests | Titanium - toxicity | Cell Line | Animals | DNA Breaks | Oncorhynchus mykiss | Comet Assay | Nanoparticles - toxicity | Neutral Red | Titanium dioxide | Nanotechnology | Index Medicus
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15. Full Text Evaluation of genotoxic potential throughout the upper and middle stretches of Adige river basin
by Kračun-Kolarević, Margareta and Kolarević, Stoimir and Jovanović, Jovana and Marković, Vanja and Ilić, Marija and Simonović, Predrag and Simić, Vladica and Gačić, Zoran and Diamantini, Elena and Stella, Elisa and Petrović, Mira and Majone, Bruno and Bellin, Alberto and Paunović, Momir and Vuković-Gačić, Branka
Science of the Total Environment, ISSN 0048-9697, 11/2016, Volume 571, pp. 1383 - 1391
In this study a comprehensive genotoxicological survey throughout the upper and middle stretches of Adige river basin is presented. The study was carried out... 
Adige River | Ecogenotoxicology | Trout | Comet assay | Micronucleus | AQUATIC ORGANISMS | DETECTING DNA-DAMAGE | OXIDATIVE STRESS | BROWN TROUT | ENVIRONMENTAL SCIENCES | WASTE-WATER | Trout Adige River | TROUT SALMO-TRUTTA | ORGANIC POLLUTANTS POPS | UNIO-PICTORUM | MICRONUCLEUS TEST | Index Medicus
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16. Full Text Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by fluorescent microscopy of cytochalasin B‐blocked micronucleus formation
by Sahu, Saura C and Roy, Shambhu and Zheng, Jiwen and Yourick, Jeffrey J and Sprando, Robert L
Journal of Applied Toxicology, ISSN 0260-437X, 11/2014, Volume 34, Issue 11, pp. 1200 - 1208
ABSTRACT As a consequence of the increased use of silver nanoparticles in food, food contact materials, dietary supplements and cosmetics to prevent fungal and... 
genotoxicity | cytochalasin B‐blocked micronucleus assay | nanoparticles | silver nanoparticles | Caco2 cells | in vitro micronucleus assay | nanosilver | HepG2 cells | Nanoparticles | Genotoxicity | Nanosilver | Cytochalasin B-blocked micronucleus assay | Silver nanoparticles | OXIDATIVE STRESS | DNA-DAMAGE | CHO-CELLS | MECHANISTIC ASSAYS | IN-VITRO | COBALT NANOPARTICLES | cytochalasin B-blocked micronucleus assay | GENE-EXPRESSION | HUMAN HEPATOMA HEPG2 | TOXICOLOGY | DRUG-METABOLISM | Caco-2 Cells | Colon - cytology | DNA Damage - drug effects | Microscopy, Electron, Transmission | Humans | Colon - drug effects | Cytochalasin B - chemistry | Hep G2 Cells | Micronucleus Tests | Particle Size | Metal Nanoparticles - toxicity | Liver - drug effects | Silver - toxicity | Liver - cytology | Microscopy, Fluorescence | Comparative analysis | Microscope and microscopy | Liver | Silver | Cell culture | Colon | Toxicity | Index Medicus | Human | Bacteria | In vitro testing | Nanostructure | Assaying
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