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index medicus (383) 383
animals (341) 341
humans (316) 316
microphthalmia-associated transcription factor - metabolism (297) 297
mice (282) 282
microphthalmia-associated transcription factor (259) 259
melanoma (235) 235
cell line, tumor (219) 219
microphthalmia-associated transcription factor - genetics (201) 201
tyrosinase (187) 187
melanogenesis (178) 178
mitf (174) 174
monophenol monooxygenase - metabolism (169) 169
melanins - biosynthesis (164) 164
cell biology (141) 141
melanocytes - drug effects (136) 136
expression (134) 134
melanocytes - metabolism (134) 134
biochemistry & molecular biology (131) 131
melanocytes (126) 126
transcription factor (125) 125
dermatology (122) 122
pigmentation (113) 113
skin (99) 99
melanoma - metabolism (95) 95
proteins (95) 95
melanins - metabolism (94) 94
melanin (93) 93
gene expression (92) 92
melanoma - pathology (92) 92
transcription factors (92) 92
signal transduction - drug effects (89) 89
cells, cultured (88) 88
oncology (87) 87
signal transduction (87) 87
monophenol monooxygenase - genetics (86) 86
activation (85) 85
cells (83) 83
inhibition (80) 80
phosphorylation (80) 80
melanoma - genetics (75) 75
cell survival - drug effects (71) 71
integumentary system (68) 68
pharmacology & pharmacy (67) 67
article (66) 66
cell line (65) 65
down-regulation (65) 65
cancer (63) 63
differentiation (63) 63
melanocytes - cytology (63) 63
analysis (62) 62
in-vitro (62) 62
skin pigmentation (62) 62
melanoma, experimental - metabolism (61) 61
microphthalmia (61) 61
melanoma - drug therapy (60) 60
kinases (59) 59
apoptosis (58) 58
human melanocytes (56) 56
monophenol monooxygenase - antagonists & inhibitors (56) 56
dose-response relationship, drug (53) 53
research (53) 53
plant extracts - pharmacology (52) 52
skin cancer (52) 52
male (51) 51
malignant-melanoma (51) 51
oxidoreductases - metabolism (51) 51
research article (51) 51
gene (49) 49
multidisciplinary sciences (49) 49
medicine (48) 48
cell differentiation - drug effects (47) 47
down-regulation - drug effects (47) 47
molecular biology (47) 47
biology (46) 46
cell proliferation - drug effects (45) 45
extracellular signal-regulated map kinases - metabolism (45) 45
gene-expression (44) 44
genetic aspects (44) 44
mutation (44) 44
female (43) 43
melanoma, experimental - pathology (43) 43
blotting, western (42) 42
cyclic amp - metabolism (42) 42
intramolecular oxidoreductases - metabolism (41) 41
mice, inbred c57bl (41) 41
transcription factors - metabolism (41) 41
melanins - antagonists & inhibitors (40) 40
gene expression regulation, neoplastic (39) 39
proto-oncogene proteins c-akt - metabolism (39) 39
rna, messenger - metabolism (39) 39
biochemistry (38) 38
cell proliferation (38) 38
gene expression regulation - drug effects (38) 38
transcription factors - genetics (38) 38
dna-binding proteins - genetics (37) 37
gene expression regulation, neoplastic - drug effects (37) 37
medicine, research & experimental (37) 37
phosphorylation - drug effects (37) 37
cell differentiation (36) 36
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Journal of Investigative Dermatology, ISSN 0022-202X, 07/2015, Volume 135, Issue 7, pp. 1863 - 1872
Journal Article
Steroids, ISSN 0039-128X, 2011, Volume 76, Issue 12, pp. 1297 - 1304
► Diethylstilbestrol increase B16 melanoma cell proliferation, melanin synthesis and tyrosinase’s activity. ► Diethylstilbestrol increased the expressions of... 
Microphthalmia related transcription factor (MITF) | Melanogenesis | Protein kinase A (PKA) | Diethylstilbestrol (DES) | Tyrosinase | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | P38 MAPK | HUMAN MELANOCYTES | SIGNAL-TRANSDUCTION | MELASMA | ENDOCRINOLOGY & METABOLISM | ESTROGEN | MICROPHTHALMIA | SKIN | PIGMENTATION | HORMONES | Humans | Melanocytes - metabolism | Melanoma, Experimental - metabolism | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Diethylstilbestrol - pharmacology | Isoquinolines - pharmacology | Melanocytes - drug effects | Estrogen Receptor alpha - metabolism | Estrogens - metabolism | Cyclic AMP-Dependent Protein Kinases - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Survival - drug effects | Microphthalmia-Associated Transcription Factor - metabolism | Monophenol Monooxygenase - drug effects | Microphthalmia-Associated Transcription Factor - drug effects | Cyclic AMP | Estrogen Receptor alpha - antagonists & inhibitors | Sulfonamides - pharmacology | Animals | Estrogen Receptor alpha - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Proteins | Messenger RNA | Medical genetics | Melanoma | Phenols | Diethylstilbestrol | Universities and colleges | Protein kinases
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2005, Volume 28, Issue 12, pp. 2216 - 2219
Journal Article
Journal Article
Journal of Biomedical Science, ISSN 1021-7770, 2011, Volume 18, Issue 1, pp. 74 - 74
Background: Pigmentation is one of the essential defense mechanisms against oxidative stress or UV irradiation; however, abnormal hyperpigmentation in human... 
antimelanogenesis | MITF | CREB | C-phycocyanin | MAPK/ERK | p38 MAPK | MEDICINE, RESEARCH & EXPERIMENTAL | ANTIINFLAMMATORY ACTIVITY | ACTIVATED PROTEIN-KINASE | MECHANISM | VIVO | INDUCED APOPTOSIS | LIPID INDUCES MELANOGENESIS | MOUSE MELANOMA | C phycocyanin | IN-VITRO | HELA-CELLS | SPIRULINA-PLATENSIS | Melanoma, Experimental - enzymology | Phosphorylation | Melanins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - drug effects | Signal Transduction | Humans | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Transcription Factors - genetics | Proto-Oncogene Proteins c-akt - genetics | Melanins - biosynthesis | Transcription Factors - drug effects | Transcription Factors - metabolism | p38 Mitogen-Activated Protein Kinases - drug effects | MAP Kinase Signaling System - drug effects | MAP Kinase Signaling System - genetics | Monophenol Monooxygenase - biosynthesis | Spirulina - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Hyperpigmentation - prevention & control | Phycocyanin - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - drug effects | Antioxidants | Prevention | Analysis | Genes | Melanoma | Dosage and administration | Skin | Research | Gene expression | Free radicals (Chemistry) | Cancer | Proteins | Enzymes | Infections | Kinases | Apoptosis
Journal Article
BMC Complementary and Alternative Medicine, ISSN 1472-6882, 08/2013, Volume 13, Issue 1, pp. 214 - 214
Journal Article
Oncogene, ISSN 0950-9232, 05/2007, Volume 26, Issue 24, pp. 3521 - 3531
Journal Article
Oncogene, ISSN 0950-9232, 05/2003, Volume 22, Issue 20, pp. 3076 - 3080
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2006, Volume 116, Issue 10, pp. 2673 - 2681
High levels of microphthalmia transcription factor (MITF) expression have been described in several cell types, including melanocytes, mast cells, and... 
MEDICINE, RESEARCH & EXPERIMENTAL | FACTOR FAMILY | MICROPHTHALMIA GENE | NATRIURETIC PEPTIDES | CATHEPSIN-K | MOUSE | GENE-EXPRESSION | MICE | NEURAL CREST | WAARDENBURG SYNDROME TYPE-2 | CULTURED MAST-CELLS | Paired Box Transcription Factors - genetics | NIH 3T3 Cells | RNA, Small Interfering - genetics | Gene Expression - drug effects | Gene Expression - genetics | Natriuretic Peptide, Brain - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Body Weight - genetics | Microphthalmia-Associated Transcription Factor - physiology | Cell Enlargement - drug effects | Mice, Mutant Strains | Myocardium - metabolism | Organ Size - genetics | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Line | Natriuretic Peptide, Brain - genetics | PAX3 Transcription Factor | Heart - growth & development | Mice, Inbred C57BL | Cardiomegaly - physiopathology | Myocardium - pathology | Mutation - genetics | Mice, Knockout | Animals | Myocytes, Cardiac - drug effects | Models, Biological | Isoproterenol - pharmacology | Cardiomegaly - chemically induced | Myocytes, Cardiac - metabolism | Mice | Microphthalmia-Associated Transcription Factor - genetics | Paired Box Transcription Factors - metabolism | Cardiomegaly - metabolism | Genetic aspects | Microphthalmos | Research | Heart enlargement | Heart cells
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, pp. 270 - 274
Observations from cultured cells(1-3), animal models(4) and patients(5-7) raise the possibility that the dependency of tumours on the therapeutic drugs to... 
CELLS | ACTIVATION | INHIBITION | EFFICACY | MULTIDISCIPLINARY SCIENCES | RESISTANCE | BRAF V600E-MUTANT MELANOMA | PATIENT | MALIGNANT-MELANOMA | VEMURAFENIB | XENOGRAFTS | Lung Neoplasms - drug therapy | Humans | Melanoma - enzymology | Lung Neoplasms - pathology | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Epithelial-Mesenchymal Transition | Female | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Lung Neoplasms - enzymology | Microphthalmia-Associated Transcription Factor - metabolism | Melanoma - pathology | CRISPR-Cas Systems - genetics | Gene Editing | Mice, Knockout | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Transcription Factors - metabolism | Phenotype | Animals | MAP Kinase Signaling System - drug effects | Melanoma - drug therapy | Cell Line, Tumor | Mice | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Antimitotic agents | Complications and side effects | Drug abuse | Genetic aspects | Antineoplastic agents | Phosphotransferases | Health aspects | Drugs | Transcription factors | Bcl-2 protein | Mesenchyme | Lung cancer | Genes | DNA damage | Genomes | Lethality | Drug resistance | Kinases | Cancer therapies | Axl protein | Skin cancer | Genotype & phenotype | Dacarbazine | Signal transduction | Protein-tyrosine kinase receptors | Protein-tyrosine kinase | Drug dosages | Deoxyribonucleic acid--DNA | Tyrosine | Microphthalmia-associated transcription factor | Drug addiction | CRISPR | Withdrawal | Melanoma | Extracellular signal-regulated kinase | Vulnerability | Fra1 protein | Patients | Lymphoma | JunB protein | Signaling | Lymphocytes B | Mutation | Tumors | Cancer | Apoptosis | B-cell lymphoma
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 21, pp. 14667 - 14675
Journal Article