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PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e111432
Microphthalmia is a severe ocular disorder, and this condition is typically caused by mutations in transcription factors that are involved in eye development.... 
ANOPHTHALMIA | FAMILIES | MULTIDISCIPLINARY SCIENCES | MOUSE | CRYSTALLIN | MUTATIONS | ALPHA-A | PROMOTER | HOMEOBOX GENE | DELETION | REGION | Crystallins - metabolism | Microphthalmos - genetics | Aphakia - metabolism | Homeodomain Proteins - metabolism | Microphthalmos - metabolism | RNA, Messenger - metabolism | Aquaporins - genetics | Forkhead Transcription Factors - metabolism | Tumor Suppressor Proteins - genetics | Eye Proteins - genetics | Tumor Suppressor Proteins - metabolism | Aphakia - genetics | Lens, Crystalline - growth & development | Mice, Inbred C57BL | RNA, Messenger - genetics | Lens, Crystalline - metabolism | Aquaporins - metabolism | Crystallins - genetics | Codon, Nonsense | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Eye Proteins - metabolism | Mice | Proteins | Eye diseases | RNA | Analysis | Cataracts | Transcription factors | Nonsense mutation | Downstream effects | Genomics | Defects | Homeobox | Vesicles | Developmental stages | Genetics | Inbreeding | Crystal structure | Congenital diseases | Cloning | Aquaporins | C-Terminus | Crystallinity | Gene expression | Embryos | Mutants | Polymerase chain reaction | Environmental science | Overexpression | Crystallin | Eye disorders | Mutation | Short term memory | Microphthalmia | Lenses | Eye lens
Journal Article
Developmental Biology, ISSN 0012-1606, 03/2014, Volume 387, Issue 1, pp. 28 - 36
Pitx2 is the last effector of the left–right (LR) cascade known to date and plays a crucial role in the patterning of LR asymmetry. In embryos, the expression... 
Xenopus | OFCD syndrome | Left–right patterning | Notch signaling | Pitx2 | Left-right patterning | DEVELOPMENTAL BIOLOGY | LEFT-RIGHT ASYMMETRY | WRPW MOTIF | CONGENITAL CATARACTS | LENZ MICROPHTHALMIA SYNDROMES | TARGET GENES | CRANIOFACIAL DEVELOPMENT | TOOTH MORPHOGENESIS | HOMEOBOX GENE PITX2 | BCL-6 COREPRESSOR | XENOPUS EMBRYO | Transcriptional Activation - genetics | Heterotaxy Syndrome - genetics | Xenopus Proteins - genetics | Microphthalmos - genetics | Receptors, Notch - metabolism | Heart - embryology | Homeodomain Proteins - metabolism | Cataract - pathology | Molecular Sequence Data | Receptors, Notch - genetics | Microphthalmos - pathology | DNA-Binding Proteins - metabolism | Heart Defects, Congenital - genetics | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Base Sequence | Heart Septal Defects - pathology | Xenopus laevis - genetics | Binding Sites | Heart Septal Defects - genetics | Repressor Proteins - metabolism | Xenopus laevis - embryology | Heart - growth & development | Repressor Proteins - genetics | Signal Transduction - genetics | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Animals | Cataract - congenital | Xenopus laevis - metabolism | Protein Binding | Cataract - genetics | Xenopus Proteins - metabolism | Enhancer Elements, Genetic - genetics | Mesoderm - metabolism | Body Patterning - genetics | Smad Proteins - metabolism | Histone Deacetylase 1 - metabolism | Histones | Genetic transcription | Amphibians | Genes | left-right patterning
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 05/2015, Volume 427, Issue 10, pp. 1887 - 1902
Ultradian oscillators are cyclically expressed genes with a period of less than 24 h, found in the major signalling pathways. The Notch effector genes are... 
ultradian clock | human genetic mitochondrial diseases | hairy and enhancer of split (Hes) | somitogenesis | reactive oxygen species | ltradian clock | omitogenesis | CIRCADIAN CLOCK | SEGMENTATION CLOCK | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | VERTEBRATE SOMITOGENESIS | SOMITE SEGMENTATION | DYNAMIC EXPRESSION | PRESOMITIC MESODERM CELLS | SKIN DEFECTS MLS | LUNATIC-FRINGE | MEDAKA ORYZIAS-LATIPES | Electron Transport Complex III - metabolism | Transcription Factor HES-1 | Reactive Oxygen Species - metabolism | Calcium - metabolism | Humans | Embryo, Nonmammalian - metabolism | NADPH Oxidases - metabolism | Microphthalmos - pathology | Microphthalmos - metabolism | Myoblasts - metabolism | Somites - embryology | In Situ Hybridization | Gene Expression Regulation, Developmental | Myoblasts - cytology | Oryzias - genetics | Skin Abnormalities - pathology | Disease Models, Animal | Somites - metabolism | Basic Helix-Loop-Helix Transcription Factors - physiology | Signal Transduction | Cells, Cultured | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Syndrome | Animals | Biological Clocks - physiology | Skin Abnormalities - metabolism | Somites - pathology | Mice | Homeodomain Proteins - physiology | Oryzias - embryology | Oxidases | Antioxidants | Embryonic development | Deregulation | Mitochondrial DNA | Analysis
Journal Article
Oncogene, ISSN 0950-9232, 01/2017, Volume 36, Issue 1, pp. 84 - 96
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2016, Volume 34, Issue 11, pp. 2625 - 2634
Few gene targets of Visual System Homeobox 2 (VSX2) have been identified despite its broad and critical role in the maintenance of neural retina (NR) fate... 
Human induced pluripotent stem cells (hiPSCs) | WNT | optic vesicles | VSX2 | TRANSCRIPTION FACTORS | PROGENITOR PROLIFERATION | NON-SYNDROMIC MICROPHTHALMIA/ANOPHTHALMIA | EFFICIENT GENERATION | LARGE GENE LISTS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | CHICK EYE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NEURAL RETINA | HEMATOLOGY | EYE DEVELOPMENT | HOMEOBOX GENE | RETINAL-PIGMENT EPITHELIUM | Retinal Pigment Epithelium - metabolism | Wnt1 Protein - agonists | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Microphthalmos - genetics | Homeodomain Proteins - metabolism | Humans | Gene Expression Profiling | Microphthalmos - pathology | Wnt1 Protein - metabolism | Microphthalmos - metabolism | Embryoid Bodies - metabolism | Retinal Pigment Epithelium - pathology | Cell Differentiation | Induced Pluripotent Stem Cells - metabolism | Retinal Pigment Epithelium - drug effects | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Microphthalmia-Associated Transcription Factor - metabolism | Induced Pluripotent Stem Cells - drug effects | Benzothiazoles - pharmacology | Gene Expression Regulation | Embryoid Bodies - pathology | Pyrimidines - pharmacology | Transcription Factors - genetics | Homeodomain Proteins - genetics | Embryoid Bodies - drug effects | Transcription Factors - metabolism | Phenotype | Wnt Signaling Pathway - drug effects | Pyridines - pharmacology | Mutation | Primary Cell Culture | Body Patterning - genetics | Microphthalmia-Associated Transcription Factor - genetics | Amino Acid Substitution | Analysis | Stem cells | Heparan sulfate | Embryos | Wnt protein | Retina | Pharmacology | Epithelium | Retinogenesis | Retinal pigment epithelium | Augmentation | Homeobox | Polymerase chain reaction | Visual system | Signal transduction | Pluripotency
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e52915
Background: Matrix metalloproteinases (MMPs) are members of the metzincin superfamily of proteinases that cleave structural elements of the extracellular... 
DANIO-RERIO | OPTIC TECTUM | EMBRYONIC-DEVELOPMENT | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | CRANIOFACIAL DEVELOPMENT | NEUROGENESIS | VISUAL-SYSTEM | VERTEBRATE RETINA | HOMEOBOX GENE | EXPRESSION | Immunohistochemistry | Embryo, Nonmammalian - cytology | Retina - metabolism | Microphthalmos - genetics | Optic Lobe, Nonmammalian - embryology | Embryo, Nonmammalian - metabolism | Optic Lobe, Nonmammalian - cytology | Embryo, Nonmammalian - embryology | Green Fluorescent Proteins - genetics | Microphthalmos - metabolism | Optic Lobe, Nonmammalian - metabolism | Retina - embryology | Retinal Ganglion Cells - metabolism | Zebrafish - embryology | Gene Knockdown Techniques | Neurogenesis - genetics | In Situ Hybridization | Gene Expression Regulation, Developmental | Isoenzymes - metabolism | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Isoenzymes - genetics | Matrix Metalloproteinase 2 - metabolism | Zebrafish Proteins - metabolism | Matrix Metalloproteinase 14 - metabolism | Zebrafish - genetics | Gene Expression Regulation, Enzymologic | Matrix Metalloproteinase 2 - genetics | Microscopy, Confocal | Animals | Matrix Metalloproteinase 14 - genetics | Protein Binding | Microphthalmos - embryology | Zebrafish Proteins - genetics | Embryonic development | Proteases | Cellular signal transduction | Matrix metalloproteinases | Laboratories | Innervation | Retina | Biology | Matrix metalloproteinase | Neurogenesis | Tectum | Defects | Eye | Visual system | Cell cycle | Extracellular matrix | Metalloproteinase | Ganglion cells | Structural members | Optic nerve | Zebrafish | Superior colliculus | Embryos | Gelatinase A | Vertebrates | Retinal ganglion cells | Axons | Brain research | Lamination | Transduction | Kinetics | Microphthalmia
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0159639
Microphthalmia is characterized by abnormally small eyes and usually retinal dysplasia, accounting for up to 11% of the blindness in children. Right now there... 
WNT PATHWAY | MULTIDISCIPLINARY SCIENCES | GANGLION-CELLS | LENS DEVELOPMENT | NEURAL RETINA | MOUSE RETINA | DIFFERENTIATION | BETA-CATENIN | EXPRESSION | ZEBRAFISH RETINA | SONIC-HEDGEHOG | Retina - metabolism | Retina - growth & development | Retinal Dysplasia - metabolism | Zinc Finger Protein Gli2 | Retinal Dysplasia - veterinary | Zinc Finger Protein Gli3 | Male | Microphthalmos - pathology | Microphthalmos - metabolism | Wnt Proteins - metabolism | Embryo, Mammalian - metabolism | Ectoderm - metabolism | In Situ Hybridization | Retinal Dysplasia - pathology | Smad4 Protein - genetics | Kruppel-Like Transcription Factors - metabolism | Female | Cell Differentiation | Microphthalmos - veterinary | Real-Time Polymerase Chain Reaction | Wnt Signaling Pathway | Mice, Transgenic | Smad4 Protein - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Mice | Smad4 Protein - deficiency | Retina - pathology | Apoptosis | Care and treatment | Microphthalmos | Gene mutations | Retina | Genetic aspects | Research | Risk factors | Cataracts | Ectoderm | Wnt protein | Laboratories | Smad4 protein | Proteins | Eye (anatomy) | Physiology | Children | Growth factors | Dysplasia | Retinal cells | Developmental biology | Medical treatment | Signaling | Hospitals | Hedgehog protein | Blindness | Mutation | Molecular biology | Binding sites | Cancer | Microphthalmia | Eye lens
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153463
Arylsulfatase B (B-acetylgalactosamine 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from the non-reducing end of the glycosaminoglycans... 
BREAST-CANCER | CHONDROITIN SULFATE | FORMYLGLYCINE-GENERATING ENZYME | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TARGET | ARYLSULFATASE-B | MELANOMA PROTEIN-B | HEPARAN-SULFATE | PROGNOSTIC INDICATOR | GLYCOPROTEIN NONMETASTATIC B | P38 MAP KINASE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Phosphorylation | Chondroitin Sulfates - metabolism | Membrane Glycoproteins - metabolism | Humans | Galectin 3 - metabolism | RNA, Messenger - metabolism | N-Acetylgalactosamine-4-Sulfatase - genetics | RNA Interference | p38 Mitogen-Activated Protein Kinases - metabolism | N-Acetylgalactosamine-4-Sulfatase - antagonists & inhibitors | Promoter Regions, Genetic | Microphthalmia-Associated Transcription Factor - metabolism | Mice, Inbred C57BL | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Chondroitin Sulfates - chemistry | Galectin 3 - genetics | Hep G2 Cells | Membrane Glycoproteins - genetics | Mice, Knockout | src Homology Domains | Animals | Galectin 3 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Binding | Mice | N-Acetylgalactosamine-4-Sulfatase - metabolism | RNA, Small Interfering - metabolism | Enzymes | Phosphatases | Glycosaminoglycans | Microphthalmos | RNA | Genetic aspects | Research | Sulfates | Transcription factors | Laboratories | Veterans | Liver | Homeostasis | Homology | Biosynthesis | Activation | Galectin-3 | Kinases | Phosphatase | Experiments | Proteins | Liver cancer | Transcription activation | Animal tissues | Phosphate esters | Inhibition | Tyrosine | Heparan sulfate | Microphthalmia-associated transcription factor | Activator protein 1 | Glycoprotein | Melanoma | MAP kinase | Breast cancer | Gene expression | Sp1 protein | Sulfation | Medicine | Signaling | Arylsulfatase | Sulfate | Prostate | Protein-tyrosine-phosphatase
Journal Article
Journal Article
Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, 09/2011, Volume 35, Issue 9, pp. 1644 - 1661
Background:  Microphthalmia (reduced eye size), generally accompanied by vision defects, is a hallmark of fetal alcohol spectrum disorder (FASD) in humans. In... 
Zebrafish | Retinoic Acid | Ethanol | Sonic Hedgehog | Photoreceptor | Microphthalmia | Sonic hedgehog | Retinoic acid | ZEBRAFISH DANIO-RERIO | FETAL ALCOHOL SYNDROME | CHOLESTEROL MODIFICATION | SUBSTANCE ABUSE | PHOTORECEPTOR DEVELOPMENT | POTENTIAL MECHANISM | VITAMIN-A | VISUAL FUNCTION | POSTMITOTIC CELLS | GENE-EXPRESSION | CHICK-EMBRYO | Acridine Orange - metabolism | Retina - metabolism | Ethanol - toxicity | Embryo, Nonmammalian - metabolism | Hedgehog Proteins - metabolism | Vitamins - metabolism | Microphthalmos - pathology | Microphthalmos - metabolism | Retina - embryology | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | Neurogenesis | Vitamins - pharmacology | Dose-Response Relationship, Drug | Abnormalities, Drug-Induced - metabolism | Tretinoin - metabolism | Tretinoin - toxicity | Female | Transgenes | Central Nervous System Depressants - toxicity | Tretinoin - pharmacology | Abnormalities, Drug-Induced - pathology | Zebrafish - genetics | Animals | Signal Transduction - drug effects | Zebrafish - metabolism | Vitamins - toxicity | Microphthalmos - chemically induced | Retina - pathology | Fetal alcohol syndrome | Effect of alcohol on | Evaluation | Fetus | Tretinoin | Retina | Drug abuse | Alcoholism | Embryos | Cholesterol | Eye | Signal transduction | Microinjection | Hedgehog protein | Vision | Photoreceptors | Differentiation
Journal Article