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1. Full Text Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose
by Obach, R. Scott and Kalgutkar, Amit S and Soglia, John R and Zhao, Sabrina X
Chemical research in toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
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2. Full Text Enzyme kinetics and molecular docking studies on cytochrome 2B6, 2C19, 2E1, and 3A4 activities by sauchinone
by Gong, Eun Chae and Chea, Satya and Balupuri, Anand and Kang, Nam Sook and Chin, Young-Won and Choi, Young Hee
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 555
Saururus chinensis | Herb-drug interaction | CYP450 | Metabolic inhibition | Sauchinone | Human liver microsome | Docking | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Extracts - pharmacology | Humans | Chlorzoxazone - chemistry | Benzopyrans - chemistry | Cytochrome P-450 CYP3A - chemistry | Dioxoles - pharmacology | Anti-Inflammatory Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Binding Sites | Anti-Inflammatory Agents - pharmacology | Plant Extracts - isolation & purification | Saururaceae - chemistry | Benzopyrans - isolation & purification | Microsomes, Liver - chemistry | Dioxoles - chemistry | Ticlopidine - analogs & derivatives | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Anti-Obesity Agents - chemistry | Cytochrome P-450 CYP3A - metabolism | Mice | Molecular Docking Simulation | Kinetics | Anti-Obesity Agents - pharmacology | Cytochrome P-450 CYP2B6 - chemistry | Cytochrome P-450 Enzyme Inhibitors - isolation & purification | Plant Extracts - chemistry | Ticlopidine - pharmacology | Ticlopidine - chemistry | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Microsomes, Liver - drug effects | Cyclobutanes - pharmacology | Protein Interaction Domains and Motifs | Benzopyrans - pharmacology | Cytochrome P-450 CYP2E1 - chemistry | Catalytic Domain | Dioxoles - isolation & purification | Protein Structure, Secondary | Plant Components, Aerial - chemistry | Cytochrome P-450 CYP2C19 - chemistry | Hypoglycemic Agents - chemistry | Anti-Obesity Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Chlorzoxazone - pharmacology | Herb-Drug Interactions | Protein Binding | Clopidogrel | Cytochrome P-450 CYP2C19 - metabolism | Cyclobutanes - chemistry | Cytochrome | Herbs | Drugs | Liver | Drug interactions | Amino acids | Inflammation | Sibutramine | Metabolism | Microsomes | Molecular docking | Steatosis | Chlorzoxazone | Fatty liver | Mouse devices | Computer applications | Cytochromes | In vivo methods and tests | Drug interaction | Inhibition | Enzyme kinetics | Index Medicus | docking | sauchinone | herb-drug interaction | human liver microsome | metabolic inhibition
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3. Full Text New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine
by Richter, Lilian H.J and Maurer, Hans H and Meyer, Markus R
Toxicology letters, ISSN 0378-4274, 10/2017, Volume 280, pp. 142 - 150
New psychoactive substances (NPS) | Drugs of abuse | LC-HR-MS/MS | Metabolism | Primary human hepatocytes | Human liver preparations | Life Sciences & Biomedicine | Toxicology | Science & Technology | Benzodiazepinones - metabolism | Liver - enzymology | Humans | Microsomes, Liver - metabolism | Hepatocytes - metabolism | Valine - chemistry | Butyrophenones - metabolism | Indoles - metabolism | Pyrrolidines - metabolism | Molecular Structure | Psychotropic Drugs - metabolism | Butyrophenones - chemistry | Cannabinoids - metabolism | Indazoles - chemistry | Liver - metabolism | Quinolines - chemistry | Valine - analogs & derivatives | Cannabinoids - chemistry | Phenethylamines - chemistry | Phenethylamines - metabolism | Indazoles - metabolism | Psychotropic Drugs - chemistry | Pyrrolidines - chemistry | Benzodiazepinones - chemistry | Quinolines - metabolism | Valine - metabolism | Indoles - chemistry | Index Medicus
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4. Full Text In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol
by Negreira, Noelia and Erratico, Claudio and Kosjek, Tina and van Nuijs, Alexander L. N and Heath, Ester and Neels, Hugo and Covaci, Adrian
Analytical and bioanalytical chemistry, ISSN 1618-2642, 7/2015, Volume 407, Issue 19, pp. 5803 - 5816
Biochemistry, general | Cathinones | In vitro metabolism | Food Science | Methedrone | Laboratory Medicine | Chemistry | Analytical Chemistry | α-PVP | Quadrupole time-of-flight mass spectrometry | Characterization and Evaluation of Materials | MDPV | New psychoactive substances | Environmental Monitoring/Analysis | Biochemistry & Molecular Biology | Physical Sciences | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Cytosol - enzymology | Tandem Mass Spectrometry | Liver - enzymology | Humans | Liver - metabolism | Microsomes, Liver - metabolism | Cytochromes - metabolism | Pyrrolidines - metabolism | Benzodioxoles - metabolism | Cytosol - metabolism | Microsomes, Liver - enzymology | Propiophenones - metabolism | Index Medicus | Human | Enzymes | Reduction | Phase transformations | Metabolites | Hydroxylation | Liver | In vitro testing
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5. Full Text Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring
by Fallon, John K and Neubert, Hendrik and Hyland, Ruth and Goosen, Theunis C and Smith, Philip C
Journal of proteome research, ISSN 1535-3893, 10/2013, Volume 12, Issue 10, pp. 4402 - 4413
targeted quantitative proteomics | nanoUPLC-MS/MS | SIL | UGT1As | UGT2Bs | S9s | microsomes | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Amino Acid Sequence | Limit of Detection | Reproducibility of Results | Liver - enzymology | Humans | Molecular Sequence Data | Male | Isoenzymes - chemistry | Chromatography, High Pressure Liquid | Peptide Fragments - chemistry | Glucuronosyltransferase - chemistry | Glucuronosyltransferase - metabolism | Isoenzymes - metabolism | Proteomics | Female | Microsomes, Liver - enzymology | Indicator Dilution Techniques | Tandem Mass Spectrometry - methods | Trypsin - chemistry | Index Medicus
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6. Full Text Generation of metabolites by an automated online metabolism method using human liver microsomes with subsequent identification by LC-MS(n), and metabolism of 11 cathinones
by Mueller, Daniel M and Rentsch, Katharina M
Analytical and bioanalytical chemistry, ISSN 1618-2642, 2/2012, Volume 402, Issue 6, pp. 2141 - 2151
Biochemistry, general | Chemistry | Analytical Chemistry | LC-MS | Cathinones | Online extraction | Food Science | Characterization and Evaluation of Materials | Human liver microsomes | Laboratory Medicine | Human metabolism | Environmental Monitoring/Analysis | Biochemistry & Molecular Biology | Physical Sciences | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Humans | Microsomes, Liver - metabolism | Sensitivity and Specificity | Central Nervous System Stimulants - chemistry | Central Nervous System Stimulants - metabolism | Alkaloids - metabolism | Chromatography, Liquid - methods | Mass Spectrometry - methods | Alkaloids - chemistry | Metabolites | Liver | Resveratrol | Physiological aspects | Comparative analysis | Xenobiotics | Methods | Human | Drugs | Automated | On-line systems | Online | Metabolism | Index Medicus
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7. Full Text Characterization of N‐methylcanadine and N‐methylstylopine metabolites in rat liver S9 by high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry
by Zuo, Meng‐Ting and Liu, Sha‐Sha and Lin, Li and Wang, Zi‐Yuan and Bai, Xia and Sun, Zhi‐Liang and Liu, Zhao‐Ying
Rapid communications in mass spectrometry, ISSN 0951-4198, 12/2018, Volume 32, Issue 23, pp. 2047 - 2054
Spectroscopy | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Technology | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Plant Extracts - chemistry | Chromatography, High Pressure Liquid - methods | Papaveraceae - chemistry | Microsomes, Liver - metabolism | Rats | Male | Microsomes, Liver - chemistry | Rats, Sprague-Dawley | Berberine Alkaloids - metabolism | Plant Extracts - metabolism | Animals | Berberine Alkaloids - chemistry | Alkaloids - metabolism | Molecular Structure | Tandem Mass Spectrometry - methods | Alkaloids - chemistry | Alkaloids | Metabolites | Mass spectrometry | Liver | High performance liquid chromatography | Rodents | Scientific imaging | Metabolism | Quadrupoles | Chromatography | Structural analysis | Index Medicus
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8. Full Text Effects of pentachlorophenol on the quail (Coturnix japonica) liver detoxification pathway
by Jiang, Peng and Wang, Jianshe and Sheng, Nan and Wei, Dongbing and Dai, Jiayin
Chemosphere (Oxford), ISSN 0045-6535, 06/2017, Volume 177, pp. 44 - 50
NF-κB | Pentachlorophenol | Coturnix japonica | Nrf2 | Cytochrome P450 | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Kidney - drug effects | Antioxidants - chemistry | Coturnix - metabolism | Liver - metabolism | Microsomes, Liver - metabolism | Coumarins - chemistry | Male | Pentachlorophenol - chemistry | Deoxyguanosine - chemistry | Cytochrome P-450 CYP1A1 - chemistry | Dose-Response Relationship, Drug | Tissue Distribution | Transcription Factors - metabolism | Cytochrome P-450 Enzyme System - chemistry | Animals | Liver - drug effects | Microsomes, Liver - drug effects | Muscles - drug effects | Cytochrome P-450 CYP3A - chemistry | NF-E2-Related Factor 2 - chemistry | Lipid Peroxidation | Aryl Hydrocarbon Hydroxylases - chemistry | Deoxyguanosine - analogs & derivatives | Wildlife conservation | Analysis | Liver | Cytochrome P-450 | Superoxide | DNA binding proteins | Mass spectrometry | Chromatography | Antioxidants | Gene expression | Index Medicus
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9. Full Text Effect of Cytochrome P450 Reductase Deficiency on 2‑Amino‑9H‑pyrido[2,3‑b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice
by Turesky, Robert J and Konorev, Dmitri and Fan, Xiaoyu and Tang, Yijin and Yao, Lihua and Ding, Xinxin and Xie, Fang and Zhu, Yi and Zhang, Qing-Yu
Chemical research in toxicology, ISSN 0893-228X, 12/2015, Volume 28, Issue 12, pp. 2400 - 2410
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Microsomes, Liver - metabolism | DNA Adducts - chemistry | Male | Microsomes, Liver - chemistry | NADPH-Ferrihemoprotein Reductase - deficiency | Liver - chemistry | Carbolines - chemistry | Animals | Oxygenases - metabolism | Mass Spectrometry | Chromatography, Liquid | Mice | Microsomes, Liver - enzymology | Molecular Structure | Carbolines - blood | Index Medicus
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10. Full Text Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation
by Xia, Qingsu and He, Xiaobo and Ma, Liang and Chen, Shoujun and Fu, Peter P
Chemical research in toxicology, ISSN 0893-228X, 07/2018, Volume 31, Issue 7, pp. 619 - 628
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Pyrrolizidine Alkaloids - metabolism | Humans | Microsomes, Liver - metabolism | Liver Neoplasms - chemically induced | Monocrotaline - analogs & derivatives | Pyrrolizidine Alkaloids - chemistry | Chromatography, High Pressure Liquid | Carcinogens - metabolism | DNA Adducts - metabolism | Hep G2 Cells | Valine - chemistry | Tandem Mass Spectrometry | DNA - chemistry | Animals | DNA Adducts - analysis | Cattle | Carcinogens - chemistry | Liver Neoplasms - pathology | Glutathione - chemistry | Monocrotaline - chemistry | Index Medicus
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11. Full Text Biotransformation of 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47) by Human Liver Microsomes: Identification of Cytochrome P450 2B6 as the Major Enzyme Involved
by Erratico, Claudio A and Szeitz, András and Bandiera, Stelvio M
Chemical research in toxicology, ISSN 0893-228X, 05/2013, Volume 26, Issue 5, pp. 721 - 731
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Antibodies - pharmacology | Halogenated Diphenyl Ethers - metabolism | Oxidation-Reduction | Microsomes, Liver - drug effects | Biotransformation - drug effects | Humans | Microsomes, Liver - metabolism | Microsomes, Liver - enzymology | Molecular Structure | Halogenated Diphenyl Ethers - chemistry | Kinetics | Cytochrome P-450 CYP2B6 - metabolism | Index Medicus
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