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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2532 - 2536
...), the most active of these compounds, showed in vitro inhibition in the single-unit nanomolar range, similar to the activity in the reference drug pentamidine, and presented low toxicity and adequate metabolic stability... 
LEISHMANIA-INFANTUM | CELLS | DNA-BINDING | NIMESULIDE | ASSAY | POLYAMINES | HUMAN AFRICAN TRYPANOSOMIASIS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | Trypanosomiasis, African - drug therapy | Mitochondria, Liver - metabolism | Humans | Microsomes, Liver - metabolism | Neurons - cytology | Structure-Activity Relationship | Hepatocytes - metabolism | Hepatocytes - cytology | Naphthalimides - chemical synthesis | Liver - drug effects | Microsomes, Liver - drug effects | Trypanosomiasis, African - mortality | Inhibitory Concentration 50 | Female | Trypanosomiasis, African - pathology | Neurons - metabolism | Neurons - drug effects | Trypanosoma brucei brucei - growth & development | Hepatocytes - drug effects | Pentamidine - pharmacology | Cell Line | Trypanosoma brucei brucei - metabolism | Drug Stability | Liver - metabolism | Parasite Load | Macrophages - cytology | Trypanosoma brucei brucei - drug effects | Mitochondria, Liver - drug effects | Trypanosomiasis, African - parasitology | Macrophages - metabolism | Animals | Naphthalimides - pharmacology | Trypanocidal Agents - pharmacology | Survival Analysis | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Primary Cell Culture | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2016, Volume 60, Issue 9, pp. 5285 - 5293
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2015, Volume 288, Issue 1, pp. 12 - 18
The risk of drug-induced liver injury (DILI) is of great concern to the pharmaceutical industry... 
Mitochondria | Membrane permeability transition | Benzbromarone | Drug-induced liver toxicity | Reactive metabolite | CYTOCHROMES P450 | SUSCEPTIBILITY | BIOACTIVATION | MECHANISMS | IN-VITRO | INHIBITION | CONSEQUENCES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCED-LIVER-INJURY | DERIVATIVES | CYCLOSPORINE | Activation, Metabolic | Liver - pathology | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Mitochondrial Swelling - drug effects | Mitochondria, Liver - metabolism | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | Membrane Potential, Mitochondrial - drug effects | Cytochrome P-450 CYP2C9 Inhibitors - pharmacology | Liver - drug effects | Microsomes, Liver - drug effects | Benzbromarone - toxicity | NADP - metabolism | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Mitochondria, Liver - pathology | Benzbromarone - metabolism | Liver - metabolism | Rats, Sprague-Dawley | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Cytochrome P-450 CYP3A - metabolism | Kinetics | Drugs | Metabolites | Analysis | Liver | Cytochrome P-450 | Mitochondrial DNA | Permeability | Pharmaceutical industry | Index Medicus | DEXAMETHASONE | METABOLITES | INJURIES | PERMEABILITY | IMINES | MITOCHONDRIA | RATS | METABOLIC ACTIVATION | TOXICITY | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | DNA | GLUCOSE | MICROSOMES | DRUGS | LIVER | PHOSPHATES | OXIDOREDUCTASES
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0176939 - e0176939
.... TBHQ has been shown to have both chemoprotective and carcinogenic effects. Furthermore, it has potential anti- inflammatory, antiatherogenic, and neuroprotective activities... 
HUMAN NEUROBLASTOMA-CELLS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | ANTIOXIDANT-RESPONSIVE ELEMENT | INDUCED APOPTOSIS | CONSTITUTIVE ANDROSTANE RECEPTOR | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | COORDINATE REGULATION | INFLAMMATORY RESPONSE | NF-KAPPA-B | Liver - metabolism | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | Transcriptome - drug effects | Hydroquinones - pharmacology | Blotting, Western | Thiosulfonic Acids - pharmacology | Animals | Inactivation, Metabolic - drug effects | Liver - drug effects | Signal Transduction - drug effects | Microsomes, Liver - drug effects | Mice | Mice, Inbred BALB C | Real-Time Polymerase Chain Reaction | Reactive oxygen species | Cytochrome P-450 | Dosage and administration | Research | Gene expression | Xenobiotics | Apoptosis | Transcription factors | Target recognition | Liver | AKT protein | Proteins | Antioxidants | Signal transduction | Drug metabolism | Edible oils | Cytochromes P450 | Enzymes | Detoxification | CYP1A2 protein | Metabolism | Chemicals | 1-Phosphatidylinositol 3-kinase | Androgens | Sodium | Cytochromes | Ligands | Transduction | Fats | Retinoic acid | Neuroprotection | Phosphorylation | Wnt protein | Genes | Gene regulation | Homology | Neuroblastoma | Kinases | Carcinogens | Biological effects | Pathways | Metabolites | Rodents | Cascades | Cell cycle | Cosmetics | Food | Cytochrome P450 | Inflammation | Biophysics | Phenolic compounds | Ribonucleic acid--RNA | Signaling | Phenols | Molecular biology | Index Medicus | RNA | Ribonucleic acid
Journal Article
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 02/2013, Volume 344, Issue 2, pp. 388 - 396
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 2014, Volume 138, Issue 2, pp. 425 - 445
Journal Article
Toxicological Sciences, ISSN 1096-6080, 8/2008, Volume 104, Issue 2, pp. 261 - 273
Journal Article
Journal Article